Score E
Sequences producing significant alignments: (bits) Value
sp|P77836|PDP_BACST PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASE (PY... 449 e-125
pdb|1BRW|B Chain B, The Crystal Structure Of Pyrimidine Nuc... 437 e-122
sp|P39142|PDP_BACSU PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASE (PY... 408 e-113
gb|AAD17954| (AF105341) pyrimidine nucleoside phosphorylase... 406 e-112
gb|AAD36720.1|AE001807_11 (AE001807) pyrimidine-nucleoside ... 399 e-110
gb|AAF10021.1|AE001903_9 (AE001903) pyrimidine-nucleoside p... 340 1e-92
gb|AAF30777.1|AE002134_1 (AE002134) thymidine phosphorylase... 329 2e-89
emb|CAA17086.1| (AL021841) deoA [Mycobacterium tuberculosis] 312 3e-84
sp|P47297|TYPH_MYCGE THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|... 292 4e-78
sp|P75052|TYPH_MYCPN THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|... 277 1e-73
pdb|1TPT| Thymidine Phosphorylase (E.C.2.4.2.4) >gi|41397... 271 9e-72
sp|P07650|TYPH_ECOLI THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|... 271 9e-72
sp|P47717|TYPH_MYCPI THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|... 270 1e-71
pir||A37131 thymidine phosphorylase (EC 2.4.2.4) - Escheric... 268 5e-71
sp|P19971|TYPH_HUMAN THYMIDINE PHOSPHORYLASE PRECURSOR (TDR... 265 5e-70
ref|NP_001944.1|| endothelial cell growth factor 1 (platele... 265 5e-70
sp|P43050|TYPH_MYCHO THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|... 213 2e-54
sp|Q58081|TYPH_METJA PUTATIVE THYMIDINE PHOSPHORYLASE (TDRP... 177 1e-43
dbj|BAA30710| (AP000006) 503aa long hypothetical pyrimidine... 172 4e-42
gi|1575579 (U67196) thymidine/pyrimidine phosphorylase homo... 169 3e-41
emb|CAB49487.1| (AJ248284) thymidine phosphorylase (deoA) [... 169 5e-41
gi|2649233 (AE001011) thymidine phosphorylase (deoA-1) [Arc... 161 1e-38
gi|2649232 (AE001011) thymidine phosphorylase (deoA-2) [Arc... 141 1e-32
gb|AAC17870.1| (AF052077) phosphoribosylanthranilate transf... 53 3e-06
sp|Q08654|TRPG_THEMA ANTHRANILATE SYNTHASE COMPONENT II [IN... 53 6e-06
emb|CAA52203| (X74075) anthranilate synthase component II a... 52 1e-05
pir||S34748 anthranilate phosphoribosyltransferase (EC 2.4.... 50 3e-05
sp|P00500|TRPD_ACICA ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE... 45 0.001
sp|P22096|TRPD_VIBPA ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE... 44 0.003
sp|P77836|PDP_BACST PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASE (PYNP) >gi|2126872|pir||JT0875
Pyridine nucleoside phosphorylase (EC 2.7.-.-) III -
Bacillus stearothermophilus >gi|2126873|pir||JC4992
pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) -
Bacillus stearothermophilus >gi|1620901|dbj|BAA13512.1|
(D87961) Pyrimidine nucleoside phosphorylase [Bacillus
stearothermophilus]
Length = 433
Score = 449 bits (1142), Expect = e-125
Identities = 238/427 (55%), Positives = 300/427 (69%), Gaps = 4/427 (0%)
Query: 4 RMVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMA 63
RMVDLI+KKRD ++ EI ++IE Y KG +PDYQMSALAMAI+F+GM ETA LTMA
Sbjct: 2 RMVDLIEKKRDGHALTKEEIQFIIEGYTKGDIPDYQMSALAMAIFFRGMNEEETAELTMA 61
Query: 64 MVHSGKEFDLTDISGIKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTL 123
MVHSG DL+ I GIKVDKHSTGGVGD TL+L PLVAS GVPVAKMSGRGLGHTGGT+
Sbjct: 62 MVHSGDTIDLSRIEGIKVDKHSTGGVGDTTTLVLGPLVASVGVPVAKMSGRGLGHTGGTI 121
Query: 124 DKLESIPGFKFEKTEKEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIPLIA 183
DKLES+PGF E T EFID V + IA++GQS L ADK LYALRDVTATV+ IPLIA
Sbjct: 122 DKLESVPGFHVEITNDEFIDLVNKNKIAVVGQSGNLTPADKKLYALRDVTATVNSIPLIA 181
Query: 184 SSVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITNMSQ 243
SS+MSKKIAAG+DAI+LDV G GAFMK + DA+ LA+ MVD+G +GR+T+A+I++MSQ
Sbjct: 182 SSIMSKKIAAGADAIVLDVKTGVGAFMKDLNDAKALAKAMVDIGNRVGRKTMAIISDMSQ 241
Query: 244 PLGFAIGNRNEMTEAVHTLQGKAPKEFQEFIAELAQIMLQLAGLEKSIPE----ILEHFT 299
PLG+AIGN E+ EA+ TL+G+ P++FQE L M+ LA S+ E + +
Sbjct: 242 PLGYAIGNALEVKEAIDTLKGEGPEDFQELCLVLGSHMVYLAEKASSLEEARHMLEKAMK 301
Query: 300 NGLAYGKFVEMVKAQGGDPTAFDYLTAPLQVKYQVEIKADKSGFISEEKALGIGLLAMKL 359
+G A F + AQGGD + D + Q KY +E++A + G++SE A +G AM L
Sbjct: 302 DGSALQTFKTFLAAQGGDASVVDDPSKLPQAKYIIELEAKEDGYVSEIVADAVGTAAMWL 361
Query: 360 GAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNREIPDELVTEFNDSLVISDQQ 419
GAGRATK ID G+ L KKVGD V GE + +YSNRE D++ + +++ IS
Sbjct: 362 GAGRATKESTIDLAVGLVLRKKVGDAVKKGESLVTIYSNREQVDDVKQKLYENIRISATP 421
Query: 420 VHQKEIL 426
V ++
Sbjct: 422 VQAPTLI 428
pdb|1BRW|B Chain B, The Crystal Structure Of Pyrimidine Nucleoside
Phosphorylase In A Closed Conformation
>gi|6729724|pdb|1BRW|A Chain A, The Crystal Structure Of
Pyrimidine Nucleoside Phosphorylase In A Closed
Conformation
Length = 433
Score = 437 bits (1112), Expect = e-122
Identities = 232/427 (54%), Positives = 294/427 (68%), Gaps = 4/427 (0%)
Query: 4 RMVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMA 63
RMVDLI KKRD ++ EI+W++ Y G +PDYQMSALAMAIYF+GMT ETA LTMA
Sbjct: 2 RMVDLIAKKRDGKALTKEEIEWIVRGYTNGDIPDYQMSALAMAIYFRGMTEEETAALTMA 61
Query: 64 MVHSGKEFDLTDISGIKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTL 123
MV SG+ DL+ I G+KVDKHSTGGVGD TL+L PLVAS GVPVAKMSGRGLGHTGGT+
Sbjct: 62 MVQSGEMLDLSSIRGVKVDKHSTGGVGDTTTLVLGPLVASVGVPVAKMSGRGLGHTGGTI 121
Query: 124 DKLESIPGFKFEKTEKEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIPLIA 183
DKLES+PGF E ++ EFI V E GIAIIGQ+ +L ADK LYALRDVTATV+ IPLIA
Sbjct: 122 DKLESVPGFHVEISKDEFIRLVNENGIAIIGQTGDLTPADKKLYALRDVTATVNSIPLIA 181
Query: 184 SSVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITNMSQ 243
SS+MSKKIAAG+DAI+LDV G GAFMK +++AR LA+ MVD+GK +GR T+AVI++MSQ
Sbjct: 182 SSIMSKKIAAGADAIVLDVKTGAGAFMKKLDEARRLARVMVDIGKRVGRRTMAVISDMSQ 241
Query: 244 PLGFAIGNRNEMTEAVHTLQGKAPKEFQEFIAELAQIMLQLAGLEKSIPE----ILEHFT 299
PLG+A+GN E+ EA+ TL+G P + E L M+ LA S+ E + E
Sbjct: 242 PLGYAVGNALEVKEAIETLKGNGPHDLTELCLTLGSHMVYLAEKAPSLDEARRLLEEAIR 301
Query: 300 NGLAYGKFVEMVKAQGGDPTAFDYLTAPLQVKYQVEIKADKSGFISEEKALGIGLLAMKL 359
+G A F + AQGGD + D L + Y + A G+++E A IG AM L
Sbjct: 302 SGAAIAAFKTFLAAQGGDASVVDDLDKLPKAAYTSTVTAAADGYVAEMAADDIGTAAMWL 361
Query: 360 GAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNREIPDELVTEFNDSLVISDQQ 419
GAGRA K D ID G+ L KK+GD+V GE +A ++SNR ++ + ++ +S Q
Sbjct: 362 GAGRAKKEDVIDLAVGIVLHKKIGDRVQKGEALATIHSNRPDVLDVKEKIEAAIRLSPQP 421
Query: 420 VHQKEIL 426
V + ++
Sbjct: 422 VARPPLI 428
sp|P39142|PDP_BACSU PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASE (PYNP) >gi|1075897|pir||S49457
pyrimidine nucleoside phosphorylase - Bacillus subtilis
>gi|558559|emb|CAA57664| (X82174) pyrimidine nucleoside
phosphorylase [Bacillus subtilis]
>gi|1408508|dbj|BAA08339| (D45912) pyrimidine nucleoside
phosphorylase [Bacillus subtilis]
>gi|2636486|emb|CAB15976| (Z99124) pyrimidine-nucleoside
phosphorylase [Bacillus subtilis]
Length = 434
Score = 408 bits (1037), Expect = e-113
Identities = 226/431 (52%), Positives = 295/431 (68%), Gaps = 5/431 (1%)
Query: 4 RMVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMA 63
RMVD+I KK++ E + EI + + Y G +PDYQ SALAMAI+F+ M+ E A LTMA
Sbjct: 2 RMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMAIFFQDMSDRERADLTMA 61
Query: 64 MVHSGKEFDLTDISGIKVDKHSTGGVGDKVTL-ILAPLVASFGVPVAKMSGRGLGHTGGT 122
MV+SG+ DL+ I GIKVDKHSTGGV +PLVA+ VPVAKMSGRGLGHTGGT
Sbjct: 62 MVNSGETIDLSAIEGIKVDKHSTGGVWRHDNARSSSPLVAALDVPVAKMSGRGLGHTGGT 121
Query: 123 LDKLESIPGFKFEKTEKEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIPLI 182
+DKLE+I GF E T+ EFI V +A+IGQS L ADK LYALRDVT TV+ IPLI
Sbjct: 122 IDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPADKKLYALRDVTGTVNSIPLI 181
Query: 183 ASSVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITNMS 242
ASS+MSKKIAAG+DAI+LDV G GAFMK+ EDA LA+ MV +G ++GR+T+AVI++MS
Sbjct: 182 ASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELAKAMVRIGNNVGRQTMAVISDMS 241
Query: 243 QPLGFAIGNRNEMTEAVHTLQGKAPKEFQEFIAELAQIMLQLA----GLEKSIPEILEHF 298
QPLGFAIGN E+ EA+ TL+G+ P++ E + L M+ LA L+++ ++ E
Sbjct: 242 QPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLGSQMVVLAKKADTLDEARAKLEEVM 301
Query: 299 TNGLAYGKFVEMVKAQGGDPTAFDYLTAPLQVKYQVEIKADKSGFISEEKALGIGLLAMK 358
NG A KF + +K QGGD + D + Q YQ+++ A ++G +SE A IG+ AM
Sbjct: 302 KNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAYQIDVPAKEAGVVSEIVADEIGVAAML 361
Query: 359 LGAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNREIPDELVTEFNDSLVISDQ 418
LGAGRATK D+ID G+ L KKVGDKV GE + LY+NRE DE++ + D++ I+ +
Sbjct: 362 LGAGRATKEDEIDLAVGIMLRKKVGDKVEKGEPLVTLYANRENVDEVIAKVYDNIRIAAE 421
Query: 419 QVHQKEILEII 429
K I +I
Sbjct: 422 AKAPKLIHTLI 432
gb|AAD17954| (AF105341) pyrimidine nucleoside phosphorylase [Listeria
monocytogenes]
Length = 419
Score = 406 bits (1033), Expect = e-112
Identities = 218/415 (52%), Positives = 285/415 (68%), Gaps = 4/415 (0%)
Query: 19 SQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMAMVHSGKEFDLTDISG 78
S EI + I+ Y G +PDYQ SALAMAI+F+ M E A LTMAMV SG DL++I G
Sbjct: 3 STEEIQFFIDGYTNGEIPDYQASALAMAIFFQDMNDQERADLTMAMVGSGDTIDLSEIEG 62
Query: 79 IKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLDKLESIPGFKFEKTE 138
IKVDKHSTGGVGD TL+LAPLVA+ GVPVAKMSGRGLGHTGGT+DKLESI GF E +
Sbjct: 63 IKVDKHSTGGVGDTTTLVLAPLVAAVGVPVAKMSGRGLGHTGGTIDKLESIEGFHIELDK 122
Query: 139 KEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIPLIASSVMSKKIAAGSDAI 198
K+FID V +A+IGQS L ADK +YALRDVT V+ IPLIASS+MSKKIAAG+DAI
Sbjct: 123 KDFIDLVNRDKVAVIGQSGNLTPADKKMYALRDVTGIVNSIPLIASSIMSKKIAAGADAI 182
Query: 199 LLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITNMSQPLGFAIGNRNEMTEA 258
+LDV G GAFMK+ EDA LA MV +G ++GR T+AVI++MSQPLG AIGN E+ EA
Sbjct: 183 VLDVKTGAGAFMKTDEDAENLAHAMVRIGNNVGRNTMAVISDMSQPLGEAIGNALEVKEA 242
Query: 259 VHTLQGKAPKEFQEFIAELAQIMLQLA----GLEKSIPEILEHFTNGLAYGKFVEMVKAQ 314
+ TL+G+ P++ E + L M+ LA L+++ +++E NG A KF + Q
Sbjct: 243 IDTLKGQGPEDLTELVLVLGSQMVVLAKQAETLDEARAKLIEVIENGAALEKFKTFLSNQ 302
Query: 315 GGDPTAFDYLTAPLQVKYQVEIKADKSGFISEEKALGIGLLAMKLGAGRATKTDDIDFEA 374
GGD + D+ Q KYQ+E+ A SGF+S+ A IG+ AM LGAGRATK D+I+
Sbjct: 303 GGDASIVDHPEKLPQAKYQIEVPAKTSGFVSQIVADEIGIAAMILGAGRATKEDEINLAV 362
Query: 375 GVTLTKKVGDKVSAGEVIAQLYSNREIPDELVTEFNDSLVISDQQVHQKEILEII 429
G+ L KKVGD V GE + +++++E + + + +++ ISD + + ++I
Sbjct: 363 GLMLRKKVGDAVKEGESLVTIFADQEDVENVKAKIYENIQISDHAIAPTLVHKVI 417
gb|AAD36720.1|AE001807_11 (AE001807) pyrimidine-nucleoside phosphorylase [Thermotoga
maritima]
Length = 434
Score = 399 bits (1015), Expect = e-110
Identities = 218/429 (50%), Positives = 287/429 (66%), Gaps = 5/429 (1%)
Query: 4 RMVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMA 63
R D+I KKR+ + S+ EI++M+ YVKG +PDYQM+A MA+YF+ + ET Y T
Sbjct: 2 RAYDVILKKRNGEKLSREEIEFMVGGYVKGEIPDYQMAAFLMAVYFRHLDEEETYYFTET 61
Query: 64 MVHSGKEFDLTDISGIKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTL 123
M+ SG+ DL++I G KVDKHSTGGVGDK TL++APLVAS GVPVAKMSGR LGHTGGT+
Sbjct: 62 MMRSGEVLDLSEIPGTKVDKHSTGGVGDKTTLVVAPLVASAGVPVAKMSGRALGHTGGTI 121
Query: 124 DKLESIPGFKFEKTEKEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIPLIA 183
DKLESIPGF+ E + +EFI VK+ GIAI+GQ+ LV ADK +YALRD TATVD I LIA
Sbjct: 122 DKLESIPGFRTELSLEEFIKNVKKYGIAIVGQTGNLVPADKKIYALRDATATVDEISLIA 181
Query: 184 SSVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITNMSQ 243
SS+MSKK+A GSDA +LDV G GAFMK EDA+ LA M+ + + G++ VAV++NM Q
Sbjct: 182 SSIMSKKLAGGSDAFVLDVKFGTGAFMKGFEDAKKLAFLMLRIAQQHGKKAVAVLSNMDQ 241
Query: 244 PLGFAIGNRNEMTEAVHTLQGKAPKEFQEFIAELAQIMLQLAGL---EKSIPEILEHFTN 300
PLG A+GN E+ EA+ TL+G P++ +E L +ML+LAG+ E+ + E
Sbjct: 242 PLGKAVGNSLEVIEAIETLKGNGPEDLKELSLTLGALMLELAGVADFEEGKKILQEKLET 301
Query: 301 GLAYGKFVEMVKAQGGDPTAFDYLTAPLQVKYQ-VEIKADKSGFISEEKALGIGLLAMKL 359
G A KF +VKAQGG+ D L V Q VE A + GF+S+ A +G+ +M L
Sbjct: 302 GEALDKFRLLVKAQGGNERVVDDPWRVLPVAEQVVEFSAAREGFVSKIDAEKVGIASMML 361
Query: 360 GAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLY-SNREIPDELVTEFNDSLVISDQ 418
GAGR K D ID G+ + KK+GD V GE IA+L+ S+R + + ++ VISD
Sbjct: 362 GAGRKKKEDRIDHSVGIIVEKKLGDSVKKGEAIARLFVSDRSDVESALKLLKEAYVISDS 421
Query: 419 QVHQKEILE 427
++E
Sbjct: 422 PSEPPRVVE 430
gb|AAF10021.1|AE001903_9 (AE001903) pyrimidine-nucleoside phosphorylase [Deinococcus
radiodurans]
Length = 478
Score = 340 bits (864), Expect = 1e-92
Identities = 189/392 (48%), Positives = 247/392 (62%), Gaps = 3/392 (0%)
Query: 7 DLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMAMVH 66
DLI KKRD G + AE++ ++ + +G VPDYQ+SA MA++ +GMT ETA LT+ M
Sbjct: 52 DLIAKKRDGGAHTHAELEALVLGFTRGEVPDYQLSAWLMAVFLRGMTPQETADLTLVMAA 111
Query: 67 SGKEFDLTDISGIKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLDKL 126
SG++ DL + VDKHSTGGVGDK +L+L P++A+ G+ VAKMSGRGL HTGGT+DKL
Sbjct: 112 SGEQLDLGALPDT-VDKHSTGGVGDKTSLVLTPMLAALGLTVAKMSGRGLAHTGGTIDKL 170
Query: 127 ESIPGFKFEKTEKEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIPLIASSV 186
ESIPG+ E E F+ Q ++ G+A++GQS +L AD LYALRDVTATV +PLIASS+
Sbjct: 171 ESIPGWTPELPEDRFLAQARDIGLALVGQSKDLAPADGKLYALRDVTATVPCLPLIASSI 230
Query: 187 MSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITNMSQPLG 246
MSKK+A+G+ I+LDV VG GAFM + E R LAQ MVD+G GR AV+T M PLG
Sbjct: 231 MSKKLASGARTIVLDVKVGAGAFMTTPEAGRELAQAMVDIGTRAGRRVRAVLTEMDTPLG 290
Query: 247 FAIGNRNEMTEAVHTLQGKAPKEFQEFIAELAQIMLQLAGLEKSIPEILEHFT--NGLAY 304
GN E+ EA+ TL+G P + + LA L G + E T +G A
Sbjct: 291 HLAGNSLEVQEALATLRGAGPSDLTDLCVALAVEALVAHGEDAGQAEARARQTLHDGSAL 350
Query: 305 GKFVEMVKAQGGDPTAFDYLTAPLQVKYQVEIKADKSGFISEEKALGIGLLAMKLGAGRA 364
KF V AQGGDP+ D + E+ A +SGF++ AL +G + LG GR
Sbjct: 351 AKFRAFVAAQGGDPSYVDDPERLDVAPGRAEMLAAQSGFVTRVDALSVGRAVLALGGGRE 410
Query: 365 TKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLY 396
K + ID GV L KK G+ V AGE + +LY
Sbjct: 411 RKGEAIDHGVGVELLKKPGEAVGAGEAVLRLY 442
gb|AAF30777.1|AE002134_1 (AE002134) thymidine phosphorylase [Ureaplasma urealyticum]
Length = 433
Score = 329 bits (835), Expect = 2e-89
Identities = 185/415 (44%), Positives = 266/415 (63%), Gaps = 7/415 (1%)
Query: 5 MVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMAM 64
+V++I KK+++ E S+ EI ++ + +V +PDYQM+A MA+ F G + E Y T AM
Sbjct: 4 VVEIISKKKNNIELSEQEIKFVYDGFVNKTIPDYQMAAFLMAVNFCGYSENEQYYATKAM 63
Query: 65 VHSGKEFDLTDISGIKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLD 124
V SGK DL + I VDKHS+GGVGDKV++IL PL+++ G+ V KMSGRGLGHTGGT+D
Sbjct: 64 VESGKLLDLRVENKIVVDKHSSGGVGDKVSIILTPLLSALGLYVGKMSGRGLGHTGGTVD 123
Query: 125 KLESIPGFKFEKTEKEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIPLIAS 184
KLES+ + K +++Q+K+ G+ + GQSD++V ADK +YALRDVTAT D+ L+
Sbjct: 124 KLESL-NLNLDFDLKTYMNQLKDNGLLLTGQSDDMVVADKYIYALRDVTATSDVFDLMIG 182
Query: 185 SVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITNMSQP 244
S+M+KK+A +D I LDV VG+GAF K+V A LA M+ L K R T+ +TNM QP
Sbjct: 183 SIMAKKLALITDYIFLDVKVGEGAFCKNVAQAESLATKMLKLSKKFNRNTIIHLTNMDQP 242
Query: 245 LGFAIGNRNEMTEAVHTLQGK-APKEFQEFIAELAQIML----QLAGLEKSIPEILEHFT 299
LG AIGN E+ E++ L GK P++ + I + A +L E + +I
Sbjct: 243 LGKAIGNAIEIKESMDYLLGKPVPQDLYDLINQFALDILIDTKFAKNKEDAQSKIDNVIK 302
Query: 300 NGLAYGKFVEMVKAQGGDPTAFDYLTAPLQVKYQVEIKADKSGFISEEKALGIGLLAMKL 359
NGLAY KFV VK GD + + T KY++EI A + G++ + +G++A+ L
Sbjct: 303 NGLAYQKFVNWVKWYKGDYISLENDTY-FNPKYKLEILAKQDGYLDFKSTKELGMIAVDL 361
Query: 360 GAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNREIPDELVTEFNDSLV 414
AGR KTD +DF+AG+ L KK D V EVIA LY++ I DE+V ++++++V
Sbjct: 362 KAGRKVKTDQLDFQAGIYLNKKNNDFVKTNEVIATLYASEPINDEVVNKYHNNVV 416
emb|CAA17086.1| (AL021841) deoA [Mycobacterium tuberculosis]
Length = 427
Score = 312 bits (792), Expect = 3e-84
Identities = 181/392 (46%), Positives = 242/392 (61%), Gaps = 10/392 (2%)
Query: 8 LIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMAMVHS 67
+I+ KRD G S A IDW+++ Y G V D QMSAL MAI ++GM E A T AM+ S
Sbjct: 11 VIRTKRDGGRLSDAAIDWVVKAYTDGRVADEQMSALLMAIVWRGMDRGEIARWTAAMLAS 70
Query: 68 GKEFDLTDISGIKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLDKLE 127
G D TD+ VDKHSTGGVGDK+TL L P+VA+ G V + SGRGLGHTGGTLDKLE
Sbjct: 71 GARLDFTDLPLATVDKHSTGGVGDKITLPLVPVVAACGGAVPQASGRGLGHTGGTLDKLE 130
Query: 128 SIPGFKFEKTEKEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIPLIASSVM 187
SI GF + + +Q+ + G AI + +L AD LYALRD+T TV+ +PLIASS+M
Sbjct: 131 SITGFTANLSNQRVREQLCDVGAAIFA-AGQLAPADAKLYALRDITGTVESLPLIASSIM 189
Query: 188 SKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITNMSQPLGF 247
SKK+A G+ A++LDV VG GAFM+S AR LA TMV+LG + G T A++T M+ PLG
Sbjct: 190 SKKLAEGAGALVLDVKVGSGAFMRSPVQARELAHTMVELGAAHGVPTRALLTEMNCPLGR 249
Query: 248 AIGNRNEMTEAVHTLQGKAPKEFQEFIAELAQIMLQLAGLEKSIPEILEHFTNGLAYGKF 307
+GN E+ EA+ L G P + E LA ML+LAG+ P + +G A +F
Sbjct: 250 TVGNALEVAEALEVLAGGGPPDVVELTLRLAGEMLELAGIHGRDP--AQTLRDGTAMDRF 307
Query: 308 VEMVKAQGGDPTAFDYLTAPLQV-KYQVEIKADKSGFISEEKALGIGLLAMKLGAGRATK 366
+V AQGGD L+ PL + + + A SG + + A+ +GL A +LGAGR+
Sbjct: 308 RRLVAAQGGD------LSKPLPIGSHSETVTAGASGTMGDIDAMAVGLAAWRLGAGRSRP 361
Query: 367 TDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSN 398
+ AGV + ++ G+ V GE + LY+N
Sbjct: 362 GARVQHGAGVRIHRRPGEPVVVGEPLFTLYTN 393
sp|P47297|TYPH_MYCGE THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|1361865|pir||F64205 thymidine
phosphorylase (EC 2.4.2.4) - Mycoplasma genitalium
(SGC3) >gi|1045724 (U39684) thymidine phosphorylase
(deoA) [Mycoplasma genitalium]
Length = 421
Score = 292 bits (739), Expect = 4e-78
Identities = 163/419 (38%), Positives = 252/419 (59%), Gaps = 8/419 (1%)
Query: 5 MVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMAM 64
+++LI KK+ + AEI+W + + + DYQ++A MAI+FKGM E LT AM
Sbjct: 3 IINLINKKQRGKALNLAEINWFVNAVLNKTIADYQITAFLMAIWFKGMNPNELFLLTKAM 62
Query: 65 VHSGKEFDLTDISGIKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLD 124
V +G+ I VDKHSTGG+GDKV+L L P++ S G VAK+SGRGLG+TGGT+D
Sbjct: 63 VDTGEIIKFNHHGKISVDKHSTGGIGDKVSLALVPILTSLGFSVAKLSGRGLGYTGGTID 122
Query: 125 KLESIPGFKFEKTEKEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIPLIAS 184
KLE++ G K E T+++ + + IIGQS ++ DK+LY LRD+T TVD +PLIAS
Sbjct: 123 KLEAV-GVKTELTDQQAQACLDKNDCFIIGQSKDIAPVDKVLYGLRDITGTVDSLPLIAS 181
Query: 185 SVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITNMSQP 244
S+MSKK+A ++ I +D+ G GAF K+ + A LA+ M + KS R+ +++M+Q
Sbjct: 182 SIMSKKLAVMNEYIFIDLKYGKGAFCKTKKIANELAKLMQSIAKSFKRKLSVKLSDMNQV 241
Query: 245 LGFAIGNRNEMTEAVHTLQGKAPKEFQEFIAELAQIML-------QLAGLEKSIPEILEH 297
LG A+GN E+ EAV+ L+ + Q+FI + I++ Q +K+I +
Sbjct: 242 LGKAVGNVIEVNEAVNFLKQDLDQVGQDFIDLMQTIVINILLETKQAKTKQKAIELYQDV 301
Query: 298 FTNGLAYGKFVEMVKAQGGDPTAFDYLTAPLQVKYQVEIKADKSGFISEEKALGIGLLAM 357
T+ A+ +F+ +++QGG+ F + KY+ IKA+KSG + + + + +
Sbjct: 302 LTSKKAWNRFLSFIESQGGNVELFTQKEGFFKPKYKASIKAEKSGILHFTDPIDLAKIGI 361
Query: 358 KLGAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNREIPDELVTEFNDSLVIS 416
LGAGR KTD ID AG+ L KK + V+ G+ + LYS+ I +E ++ +++I+
Sbjct: 362 NLGAGRMKKTDQIDPMAGLFLMKKDNESVAVGDTVLNLYSSSPISNEYISAAQKTIIIN 420
sp|P75052|TYPH_MYCPN THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|2146664|pir||S73416 thymidine
phosphorylase (EC 2.4.2.4) deoA - Mycoplasma pneumoniae
(SGC3) (ATCC 29342) >gi|1673745 (AE000011) Mycoplasma
pneumoniae, thymidine phosphorylase; similar to GenBank
Accession Number C53312, from M. pirum [Mycoplasma
pneumoniae]
Length = 421
Score = 277 bits (701), Expect = 1e-73
Identities = 160/418 (38%), Positives = 244/418 (58%), Gaps = 8/418 (1%)
Query: 5 MVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMAM 64
+V+LI KK+ ++ EI+W + + + DYQ+SA MA++F+GM + E LT AM
Sbjct: 3 IVNLISKKQRGKALTETEINWFVHSVNNKSLADYQVSAFLMAVWFQGMNSKELFCLTKAM 62
Query: 65 VHSGKEFDLTDISGIKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLD 124
V SG+ S + VDKHSTGG+GDKV++ L P++ + VAK+SGRGLG+TGGT+D
Sbjct: 63 VKSGESLHFNHHSKLSVDKHSTGGIGDKVSIALIPILTALDYSVAKLSGRGLGYTGGTID 122
Query: 125 KLESIPGFKFEKTEKEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIPLIAS 184
KLE++ G K + T E + + + IIGQS+ + DK+LYALRD TATVD +PLIAS
Sbjct: 123 KLEAV-GVKTDFTPTEAQNLLDQNDCFIIGQSEGIAPVDKVLYALRDTTATVDSLPLIAS 181
Query: 185 SVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITNMSQP 244
SVMSKK+A +D I +D+ G GAF K+ A+ LAQ M + K R+ +++M+Q
Sbjct: 182 SVMSKKLAINNDYIFIDLKYGKGAFCKTKTMAKELAQYMYSIAKQFKRKLYIKLSDMNQV 241
Query: 245 LGFAIGNRNEMTEAVHTLQGKAPKEFQEFIAELAQIMLQLAGLEKSIPE-----ILEHFT 299
LG IGN E+ E VH L+ + +FI + QI+ ++ K P L H T
Sbjct: 242 LGKTIGNALEVLEVVHFLKRNWTEVGADFIQLMEQIVTEILIETKRAPNKRAAVALYHAT 301
Query: 300 --NGLAYGKFVEMVKAQGGDPTAFDYLTAPLQVKYQVEIKADKSGFISEEKALGIGLLAM 357
+ +F++ ++ QG F L +Y+ + A +SG +S + + ++++
Sbjct: 302 LEGEKPWQRFLKFIELQGSSWERFLDLKELFNPQYKAPVLASQSGTLSYTSPVDLAMVSI 361
Query: 358 KLGAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNREIPDELVTEFNDSLVI 415
LGAGR KTD ID AG+ L K+ + V AG+ + +LYS++ I + +++I
Sbjct: 362 SLGAGRMVKTDLIDPMAGIKLVKQANEVVKAGDTVLELYSSKPITPAHIEAAQHTIII 419
pdb|1TPT| Thymidine Phosphorylase (E.C.2.4.2.4) >gi|4139737|pdb|1OTP|
Structural And Theoretical Studies Suggest Domain
Movement Produces An Active Conformation Of Thymidine
Phosphorylase >gi|4389347|pdb|1AZY|A Chain A, Structural
And Theoretical Studies Suggest Domain Movement Produces
An Active Conformation Of Thymidine Phosphorylase
>gi|4389348|pdb|1AZY|B Chain B, Structural And
Theoretical Studies Suggest Domain Movement Produces An
Active Conformation Of Thymidine Phosphorylase
>gi|4557968|pdb|2TPT| Structural And Theoretical
Studies Suggest Domain Movement Produces An Active
Conformation Of Thymidine Phosphorylase
Length = 440
Score = 271 bits (685), Expect = 9e-72
Identities = 169/407 (41%), Positives = 232/407 (56%), Gaps = 18/407 (4%)
Query: 7 DLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMAMVH 66
++I+KKRD S EI + I + + Q++ALAM I+F MT E LTMAM
Sbjct: 6 EIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRD 65
Query: 67 SGKEFDLTDI--SGIKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLD 124
SG D + +G VDKHSTGGVGD +L+L P+VA+ G + +SGRGLGHTGGTLD
Sbjct: 66 SGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLD 125
Query: 125 KLESIPGFKFEKTEKEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIPLIAS 184
KLESIPGF + F + +K+ G+AIIGQ+ L ADK YA RD+TATVD IPLI +
Sbjct: 126 KLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITA 185
Query: 185 SVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITNMSQP 244
S+++KK+A G DA+++DV VG GAFM + E + LA+ +V + G T A++T+M+Q
Sbjct: 186 SILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQV 245
Query: 245 LGFAIGNRNEMTEAVHTLQG--KAPKEFQEFIAELAQIMLQLAGLEKSIPE----ILEHF 298
L + GN E+ EAV L G + P+ F +A L ML L K E +
Sbjct: 246 LASSAGNAVEVREAVQFLTGEYRNPRLFDVTMA-LCVEMLISGKLAKDDAEARAKLQAVL 304
Query: 299 TNGLAYGKFVEMVKAQGGDPTAF-----DYLTAPLQVKYQVEIKADKSGFISEEKALGIG 353
NG A F MV AQ G PT F YL + K + AD GF+SE +G
Sbjct: 305 DNGKAAEVFGRMVAAQKG-PTDFVENYAKYLPTAMLTK---AVYADTEGFVSEMDTRALG 360
Query: 354 LLAMKLGAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNRE 400
+ + +G GR +D ID+ G T ++GD+V +A +++ E
Sbjct: 361 MAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDE 407
sp|P07650|TYPH_ECOLI THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|1361254|pir||S56606 thymidine
phosphorylase (EC 2.4.2.4) deoA - Escherichia coli
>gi|537222 (U14003) thymidine phosphorylase [Escherichia
coli] >gi|1790842 (AE000508) thymidine phosphorylase
[Escherichia coli]
Length = 440
Score = 271 bits (685), Expect = 9e-72
Identities = 169/407 (41%), Positives = 232/407 (56%), Gaps = 18/407 (4%)
Query: 7 DLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMAMVH 66
++I+KKRD S EI + I + + Q++ALAM I+F MT E LTMAM
Sbjct: 6 EIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRD 65
Query: 67 SGKEFDLTDI--SGIKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLD 124
SG D + +G VDKHSTGGVGD +L+L P+VA+ G + +SGRGLGHTGGTLD
Sbjct: 66 SGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLD 125
Query: 125 KLESIPGFKFEKTEKEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIPLIAS 184
KLESIPGF + F + +K+ G+AIIGQ+ L ADK YA RD+TATVD IPLI +
Sbjct: 126 KLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITA 185
Query: 185 SVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITNMSQP 244
S+++KK+A G DA+++DV VG GAFM + E + LA+ +V + G T A++T+M+Q
Sbjct: 186 SILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQV 245
Query: 245 LGFAIGNRNEMTEAVHTLQG--KAPKEFQEFIAELAQIMLQLAGLEKSIPE----ILEHF 298
L + GN E+ EAV L G + P+ F +A L ML L K E +
Sbjct: 246 LASSAGNAVEVREAVQFLTGEYRNPRLFDVTMA-LCVEMLISGKLAKDDAEARAKLQAVL 304
Query: 299 TNGLAYGKFVEMVKAQGGDPTAF-----DYLTAPLQVKYQVEIKADKSGFISEEKALGIG 353
NG A F MV AQ G PT F YL + K + AD GF+SE +G
Sbjct: 305 DNGKAAEVFGRMVAAQKG-PTDFVENYAKYLPTAMLTK---AVYADTEGFVSEMDTRALG 360
Query: 354 LLAMKLGAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNRE 400
+ + +G GR +D ID+ G T ++GD+V +A +++ E
Sbjct: 361 MAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDE 407
sp|P47717|TYPH_MYCPI THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|1086261|pir||C53312 thymidine
phosphorylase (EC 2.4.2.4) - Mycoplasma pirum (strain
BER) (SGC3) >gi|401784 (L13289) thymidine phosphorylase
[Mycoplasma pirum]
Length = 419
Score = 270 bits (684), Expect = 1e-71
Identities = 161/422 (38%), Positives = 249/422 (58%), Gaps = 15/422 (3%)
Query: 5 MVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMAM 64
++++I+ K++ + SQ +I++ I V +PDYQ+SAL MAI+F G+ E +LT AM
Sbjct: 3 IIEIIELKKNKKKLSQDQINFCISGLVNKSIPDYQISALLMAIWFNGLDDNELYFLTKAM 62
Query: 65 VHSGKEFDL-TDISGIKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTL 123
+ SGK + + I +DKHSTGG+GDKV++ L P++ SF + VAK+SGRGLG TGGT+
Sbjct: 63 IDSGKIYKFHPEYKKILIDKHSTGGIGDKVSIALRPILVSFDLGVAKLSGRGLGFTGGTI 122
Query: 124 DKLESIPGFKFEKTEKEFIDQVKETGIA---IIGQSDELVKADKLLYALRDVTATVDIIP 180
DKLESI T+ + + K IA I+GQ++++V ADKLLYALRDVT TVD +P
Sbjct: 123 DKLESIN----VNTDIDLKNSKKILNIANMFIVGQTNDIVPADKLLYALRDVTGTVDSLP 178
Query: 181 LIASSVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITN 240
LIA+S++SKK A SD I +D+ G GAF +E A+ ++ M +L K R+ V+++
Sbjct: 179 LIAASILSKKFALESDYIFIDIKYGQGAFCHDIETAKKISNIMKNLAKKFKRKVYFVLSD 238
Query: 241 MSQPLGFAIGNRNEMTEAVHTLQGKAP--KEFQEFIAELAQIMLQLAGLEKSIPEILEHF 298
M++ LG +GN E+ EA+ L+ + F++ + +L ++L K+ E E
Sbjct: 239 MNEVLGNTVGNAIEVKEAIDFLKNNSDVGTYFKKLMFDLVTLILLKTKKCKTKKEAKEKI 298
Query: 299 T----NGLAYGKFVEMVKAQGGDPTAFDYLTAPLQVKYQVEIKADKSGFISEEKALGIGL 354
N +A+ F ++ Q G+ T + KY I A KSG IS + + +
Sbjct: 299 NYVLENKIAFNNFCNWIELQNGNIAKIKNDTF-FKPKYWTNIAAWKSGKISYKSIIELAE 357
Query: 355 LAMKLGAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNREIPDELVTEFNDSLV 414
+ + LG+GR K D IDF+AG+ L K +K+ + I LYS++ I +L+ + +
Sbjct: 358 IGVDLGSGRRKKEDKIDFQAGIYLHAKSNEKIKIKDKILTLYSSKPIKQDLIDKAKKIIK 417
Query: 415 IS 416
IS
Sbjct: 418 IS 419
pir||A37131 thymidine phosphorylase (EC 2.4.2.4) - Escherichia coli
Length = 441
Score = 268 bits (679), Expect = 5e-71
Identities = 170/408 (41%), Positives = 233/408 (56%), Gaps = 19/408 (4%)
Query: 7 DLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMAMVH 66
++I+KKRD S EI + I + + Q++ALAM I+F MT E LTMAM
Sbjct: 6 EIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRD 65
Query: 67 SGKEFDLTDI--SGIKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLD 124
SG D + +G VDKHSTGGVGD +L+L P+VA+ G + +SGRGLGHTGGTLD
Sbjct: 66 SGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLD 125
Query: 125 KLESIPGFK-FEKTEKEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIPLIA 183
KLESIPGF F + F + +K+ G+AIIGQ+ L ADK YA RD+TATVD IPLI
Sbjct: 126 KLESIPGFDIFFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLIT 185
Query: 184 SSVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITNMSQ 243
+S+++KK+A G DA+++DV VG GAFM + E + LA+ +V + G T A++T+M+Q
Sbjct: 186 ASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQ 245
Query: 244 PLGFAIGNRNEMTEAVHTLQG--KAPKEFQEFIAELAQIMLQLAGLEKSIPE----ILEH 297
L + GN E+ EAV L G + P+ F +A L ML L K E +
Sbjct: 246 VLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMA-LCVEMLISGKLAKDDAEARAKLQAV 304
Query: 298 FTNGLAYGKFVEMVKAQGGDPTAF-----DYLTAPLQVKYQVEIKADKSGFISEEKALGI 352
NG A F MV AQ G PT F YL + K + AD GF+SE +
Sbjct: 305 LDNGKAAEVFGRMVAAQKG-PTDFVENYAKYLPTAMLTK---AVYADTEGFVSEMDTRAL 360
Query: 353 GLLAMKLGAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNRE 400
G+ + +G GR +D ID+ G T ++GD+V +A +++ E
Sbjct: 361 GMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDE 408
sp|P19971|TYPH_HUMAN THYMIDINE PHOSPHORYLASE PRECURSOR (TDRPASE) (TP) (PLATELET-DERIVED
ENDOTHELIAL CELL GROWTH FACTOR) (PD-ECGF) (GLIOSTATIN)
>gi|87362|pir||S03904 platelet-derived endothelial cell
growth factor precursor - human >gi|226324|prf||1506442A
endothelial cell growth factor [Homo sapiens]
Length = 482
Score = 265 bits (670), Expect = 5e-70
Identities = 153/400 (38%), Positives = 230/400 (57%), Gaps = 14/400 (3%)
Query: 4 RMVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMA 63
++ +LI+ KRD G S+A+I + V G Q+ A+ MAI +GM ET+ LT A
Sbjct: 35 QLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQA 94
Query: 64 MVHSGKEFDLTDISGIK-VDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGT 122
+ SG++ + + + VDKHSTGGVGDKV+L+LAP +A+ G V +SGRGLGHTGGT
Sbjct: 95 LAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGT 154
Query: 123 LDKLESIPGFKFEKTEKEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIPLI 182
LDKLESIPGF ++ ++ + + G I+GQS++LV AD +LYA RDVTATVD +PLI
Sbjct: 155 LDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLI 214
Query: 183 ASSVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITNMS 242
+S++SKK+ G A+++DV G A + E AR LA+T+V +G S+G A +T M
Sbjct: 215 TASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMD 274
Query: 243 QPLGFAIGNRNEMTEAVHTLQGKAPKEFQEFIAELAQIMLQLAG----LEKSIPEILEHF 298
+PLG +G+ E+ EA+ + G P + ++ + L +L L+G + +
Sbjct: 275 KPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAAL 334
Query: 299 TNGLAYGKFVEMVKAQGGDPTAFDYLTAPL---------QVKYQVEIKADKSGFISEEKA 349
+G A G+F M+ AQG DP L + + + Q E+ A G + +A
Sbjct: 335 DDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRA 394
Query: 350 LGIGLLAMKLGAGRATKTDDIDFEAGVTLTKKVGDKVSAG 389
L + L+ +LGAGR+ + + G L VG ++ G
Sbjct: 395 LPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRG 434
ref|NP_001944.1|| endothelial cell growth factor 1 (platelet-derived) >gi|189701
(M63193) endothelial cell growth factor [Homo sapiens]
>gi|6862560|gb|AAB03344.2| (U62317) endothelial cell
growth factor 1 [Homo sapiens]
Length = 482
Score = 265 bits (670), Expect = 5e-70
Identities = 153/400 (38%), Positives = 230/400 (57%), Gaps = 14/400 (3%)
Query: 4 RMVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMA 63
++ +LI+ KRD G S+A+I + V G Q+ A+ MAI +GM ET+ LT A
Sbjct: 35 QLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQA 94
Query: 64 MVHSGKEFDLTDISGIK-VDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGT 122
+ SG++ + + + VDKHSTGGVGDKV+L+LAP +A+ G V +SGRGLGHTGGT
Sbjct: 95 LAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGT 154
Query: 123 LDKLESIPGFKFEKTEKEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIPLI 182
LDKLESIPGF ++ ++ + + G I+GQS++LV AD +LYA RDVTATVD +PLI
Sbjct: 155 LDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLI 214
Query: 183 ASSVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITNMS 242
+S++SKK+ G A+++DV G A + E AR LA+T+V +G S+G A +T M
Sbjct: 215 TASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMD 274
Query: 243 QPLGFAIGNRNEMTEAVHTLQGKAPKEFQEFIAELAQIMLQLAG----LEKSIPEILEHF 298
+PLG +G+ E+ EA+ + G P + ++ + L +L L+G + +
Sbjct: 275 KPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAAL 334
Query: 299 TNGLAYGKFVEMVKAQGGDPTAFDYLTAPL---------QVKYQVEIKADKSGFISEEKA 349
+G A G+F M+ AQG DP L + + + Q E+ A G + +A
Sbjct: 335 DDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRA 394
Query: 350 LGIGLLAMKLGAGRATKTDDIDFEAGVTLTKKVGDKVSAG 389
L + L+ +LGAGR+ + + G L VG ++ G
Sbjct: 395 LPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRG 434
sp|P43050|TYPH_MYCHO THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|629359|pir||S42196 thymidine
phosphorylase (EC 2.4.2.4) - Mycoplasma hominis (SGC3)
>gi|2127601|pir||S72521 thymidine phosphorylase (EC
2.4.2.4) - Mycoplasma hominis (SGC3) (fragment)
>gi|415854|emb|CAA81645| (Z27121) Thymidine
Phosphorylase [Mycoplasma hominis]
Length = 272
Score = 213 bits (538), Expect = 2e-54
Identities = 116/261 (44%), Positives = 162/261 (61%), Gaps = 4/261 (1%)
Query: 163 DKLLYALRDVTATVDIIPLIASSVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQT 222
DK +YALRDVT TV IPLIASS+MSKK+A GS+ ILLDV G+GAFMK + +A+ L +
Sbjct: 1 DKKIYALRDVTGTVQSIPLIASSIMSKKLATGSNCILLDVKCGNGAFMKDINEAKKLGKL 60
Query: 223 MVDLGKSIGRETVAVITNMSQPLGFAIGNRNEMTEAVHTLQGKAPKEFQEFIAELAQIML 282
M+++GK + R+ ITNM QPLG IGN+ E+ EA+ TL G PK+F E I +L
Sbjct: 61 MIEIGKKLNRKIAVEITNMQQPLGKTIGNKIEVLEAIDTLNGHGPKDFTEIIYSSGSTLL 120
Query: 283 QLAGLEKSIPE----ILEHFTNGLAYGKFVEMVKAQGGDPTAFDYLTAPLQVKYQVEIKA 338
LA K E I E N AY KF+E + QGG+ F+ + +Y+ EI A
Sbjct: 121 VLAQKAKDEVEARKMIDEVINNKKAYNKFLEWISRQGGNIKVFEKDSKWFNPQYKQEIIA 180
Query: 339 DKSGFISEEKALGIGLLAMKLGAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSN 398
+SG++ + + GL+AMKLGAGR+ K D ID+EAG+ L K + V+ G+V+ +YS+
Sbjct: 181 SQSGYLKIKSRIDFGLVAMKLGAGRSKKEDSIDYEAGIYLNKSSNEYVNKGDVLFTMYSS 240
Query: 399 REIPDELVTEFNDSLVISDQQ 419
+ I EL E ++ S+ +
Sbjct: 241 KPINPELQKELLSAIEFSESK 261
sp|Q58081|TYPH_METJA PUTATIVE THYMIDINE PHOSPHORYLASE (TDRPASE) >gi|2129307|pir||C64383
thymidine phosphorylase (EC 2.4.2.4) - Methanococcus
jannaschii >gi|1591381 (U67514) thymidine phosphorylase
(deoA) [Methanococcus jannaschii]
Length = 503
Score = 177 bits (445), Expect = 1e-43
Identities = 130/401 (32%), Positives = 210/401 (51%), Gaps = 27/401 (6%)
Query: 9 IQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMAMVHSG 68
I+KK D + + EI +I+ V G + + ++SA ++Y GM E +T+ M +G
Sbjct: 92 IRKKMDGNKLKKEEIFEIIDEMVDGKLTNIEISAFVTSLYINGMDMDEIEAMTIRMAETG 151
Query: 69 KEFDLTDISGIKVDKHSTGGV-GDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLDKLE 127
++ + G D HS GGV G+K L++ P+VAS G+ + K S R + GT D +E
Sbjct: 152 ---EMVNWEGHIFDVHSIGGVPGNKYALLVVPIVASAGLKIPKTSSRAITSAAGTADVVE 208
Query: 128 SIPGFKFEKTEKEFIDQVKET-GIAIIGQSDELVKADKLLYALRDVTATVDIIPLIASSV 186
+ + + T +E VKET G + G + +L AD + + +D PL+ SSV
Sbjct: 209 VLT--RVDLTIEEIKRVVKETNGCMVWGGALDLAPADDITINVERPLG-IDPEPLLLSSV 265
Query: 187 MSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITNMSQPLG 246
M+KK+A G + +L+D+ G GA +KS+++A LA+ ++L + T IT QP+G
Sbjct: 266 MAKKLAMGVNKLLIDIPTGYGAKVKSIKEASSLARKFIELSDRLRIVTECAITYGGQPIG 325
Query: 247 FAIGNRNEMTEAVHTLQG--KAPKEFQEFIAELAQIMLQLAGLE-----KSIPEILEHFT 299
AIG E EA+ L+ +AP E LA I+L++ G+ K + E L
Sbjct: 326 RAIGPALEAKEALLALEDYTQAPTSLVEKSISLAGILLEMGGVAPTGEGKELAEDL--LA 383
Query: 300 NGLAYGKFVEMVKAQGGDPTAFDYLTAPLQVKYQVEIKADKSGFISEEKALGIGLLAMKL 359
G A+ KF+E++ AQGG + D + KY+ +I + G+++ GI +A +
Sbjct: 384 RGKAHDKFMEIIVAQGGKEVSSDEIEVG---KYKADIHSPIDGYVTRISNAGITKIAKEA 440
Query: 360 GAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNRE 400
GA D +AG+ L KVG+KV G+V+ +YS+ E
Sbjct: 441 GAPN-------DKKAGIYLNVKVGNKVEKGDVLYTIYSDSE 474
dbj|BAA30710| (AP000006) 503aa long hypothetical pyrimidine-nucleoside
phosphorylase [Pyrococcus horikoshii]
Length = 503
Score = 172 bits (432), Expect = 4e-42
Identities = 135/409 (33%), Positives = 212/409 (51%), Gaps = 28/409 (6%)
Query: 2 TYRMVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLT 61
T V I+KK + + EI+ +I + V + + ++SA AI G++ E A LT
Sbjct: 84 TPESVKYIKKKMKGEKLRKVEIETIIRDIVDRKLRNTEISAFITAIEINGLSMDEIAALT 143
Query: 62 MAMVHSGKEFDLTDISGIKV-DKHSTGGV-GDKVTLILAPLVASFGVPVAKMSGRGLGHT 119
+AM +G D+ DI + D HS GGV G+K +++ P+VA+ G+ + K S R +
Sbjct: 144 IAMAETG---DMLDIDRKPIMDVHSIGGVPGNKTNILVVPIVAAAGLTIPKTSSRAITSA 200
Query: 120 GGTLDKLESIPGFKFEKTEKEFIDQVKETGIAII-GQSDELVKADKLLYALRDVTATVDI 178
GT D +E + K E + I V++ G ++ G + L AD L + + ++D
Sbjct: 201 AGTADVVEVLTNVKLSLDEIKRI--VEKIGACLVWGGALNLAPADDLTIHV-ERRLSLDP 257
Query: 179 IPLIASSVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVI 238
L+ +S+MSKK A GS IL+D+ G GA ++++++AR LA+ ++LGK +G+ I
Sbjct: 258 RGLMLASIMSKKYAIGSQYILIDIPTGKGAKVETMDEARTLAKDFIELGKKLGQYVEVAI 317
Query: 239 TNMSQPLGFAIGNRNEMTEAVHTLQ-GKAPKEFQEFIAELAQIMLQLAGL------EKSI 291
T QP+G+AIG E EA+ TL GK P E LA I+L++ G+ +K
Sbjct: 318 TYGGQPIGYAIGPALEAKEALETLMTGKGPGSLVEKATGLAGILLEMGGVAPKGMGKKVA 377
Query: 292 PEILEHFTNGLAYGKFVEMVKAQGGDPTAFDYLTAPLQVKYQVEIKADKSGFISEEKALG 351
EILE +G AY K E+++ QGGDP P+ K I A G+++
Sbjct: 378 KEILE---SGKAYEKMKEIIEEQGGDPN-IKPEDIPIGDK-TYTIHAQTGGYVTGIDNRA 432
Query: 352 IGLLAMKLGAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNRE 400
I +A + GA D AGV L KVG+KV G+ + +++ E
Sbjct: 433 ITAIAREAGAPE-------DKGAGVRLHVKVGEKVKEGDPLITIHAESE 474
gi|1575579 (U67196) thymidine/pyrimidine phosphorylase homolog [Thermotoga
maritima]
Length = 137
Score = 169 bits (425), Expect = 3e-41
Identities = 82/132 (62%), Positives = 102/132 (77%)
Query: 4 RMVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMA 63
R D+I KKR+ + S+ EI++M+ YVKG +PDYQM+A MA+YF+ + ET Y T
Sbjct: 2 RAYDVILKKRNGEKLSREEIEFMVGGYVKGEIPDYQMAAFLMAVYFRHLDEEETYYFTET 61
Query: 64 MVHSGKEFDLTDISGIKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTL 123
M+ SG DL++I G KV+KHSTGGVGDK TL++APLVAS GVPVAKMSGR LGHTGGT+
Sbjct: 62 MMSSGVVLDLSEIPGTKVNKHSTGGVGDKTTLVVAPLVASAGVPVAKMSGRALGHTGGTI 121
Query: 124 DKLESIPGFKFE 135
DKLESIPGF+ E
Sbjct: 122 DKLESIPGFRTE 133
emb|CAB49487.1| (AJ248284) thymidine phosphorylase (deoA) [Pyrococcus abyssi]
Length = 507
Score = 169 bits (423), Expect = 5e-41
Identities = 135/409 (33%), Positives = 210/409 (51%), Gaps = 28/409 (6%)
Query: 2 TYRMVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLT 61
T V I+KK + + EI+ ++ + V + + ++SAL AI G+ E A LT
Sbjct: 88 TPESVRYIKKKMRGEKLRKVEIETIVRDIVDRKLRNTEISALVTAIEVNGLDMDEIAALT 147
Query: 62 MAMVHSGKEFDLTDISGIKV-DKHSTGGV-GDKVTLILAPLVASFGVPVAKMSGRGLGHT 119
+AM +G D+ DI + D HS GGV G+K +I+ P+VA+ G+ + K S R +
Sbjct: 148 IAMAETG---DMLDIDRKPIMDVHSIGGVPGNKTNIIVVPIVAAAGLTIPKTSSRAITSA 204
Query: 120 GGTLDKLESIPGFKFEKTEKEFIDQVKETGIAII-GQSDELVKADKLLYALRDVTATVDI 178
GT D +E E + I V++ G ++ G + L AD L + + ++D
Sbjct: 205 AGTADVVEVFTNVTLSLDEIKRI--VEKIGACLVWGGALNLAPADDLTIHV-ERRLSLDP 261
Query: 179 IPLIASSVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVI 238
L+ +S+MSKK A GS IL+D+ G GA ++++E+AR LA+ ++LGK +G+ I
Sbjct: 262 RGLMLASIMSKKYAIGSQYILIDIPTGKGAKVETMEEARSLAKDFIELGKKLGQYVEVAI 321
Query: 239 TNMSQPLGFAIGNRNEMTEAVHTLQ-GKAPKEFQEFIAELAQIMLQLAGL------EKSI 291
T QP+G+ +G E EA+ TL GK P E LA I+L++ G+ +K
Sbjct: 322 TYGGQPIGYTVGPALEAKEALETLMTGKGPGSLVEKALGLAGILLEMGGVAPRGMGKKVA 381
Query: 292 PEILEHFTNGLAYGKFVEMVKAQGGDPTAFDYLTAPLQVKYQVEIKADKSGFISEEKALG 351
EILE +G AY K E+++ QGGDP P+ K I A SG+++
Sbjct: 382 REILE---SGKAYEKIKEIIEEQGGDPN-IKPEDIPIGDK-TYTIHAQTSGYVTGIDNKA 436
Query: 352 IGLLAMKLGAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNRE 400
I +A + GA D AGV L KVG+KV G+ + +++ E
Sbjct: 437 ITAIAREAGAPE-------DKGAGVKLHVKVGEKVKEGDPLFTIHAESE 478
gi|2649233 (AE001011) thymidine phosphorylase (deoA-1) [Archaeoglobus
fulgidus]
Length = 504
Score = 161 bits (403), Expect = 1e-38
Identities = 119/403 (29%), Positives = 204/403 (50%), Gaps = 22/403 (5%)
Query: 4 RMVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMA 63
+ V+LI+KK + SQ EI ++E+ + + +++A ++ +GM E +LT +
Sbjct: 87 KSVELIKKKTRGEKLSQDEIRRIVEDITNNALSEVELTAFVISSMLRGMDFDEIEWLTRS 146
Query: 64 MVHSGK--EFDLTDISGIKVDKHSTGGV-GDKVTLILAPLVASFGVPVAKMSGRGLGHTG 120
M+ +G+ EFD G VDKHS GGV G+K++L++ P VA+ G+ + K + R +
Sbjct: 147 MIETGERIEFD----RGTVVDKHSIGGVPGNKISLLIVPTVAAAGLLIPKTASRAITSAS 202
Query: 121 GTLDKLESIPGFKFEKTE-KEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDII 179
GT D +E + E KE ++V G+ G + + AD + + ++D
Sbjct: 203 GTADTMEVLANVNLSVDEIKEITERVG--GVIAWGGATNIAPADDKIIRVEH-PLSIDPR 259
Query: 180 PLIASSVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVIT 239
P + +SVM+KK + G+ +++D+ VG+GA ++ VE R LA ++LG+ +G +A IT
Sbjct: 260 PQLLASVMAKKGSVGAKHVVIDIPVGEGAKIEKVEVGRSLANDFIELGRRLGLNVMAAIT 319
Query: 240 NMSQPLGFAIGNRNEMTEAVHTLQG-KAPKEFQEFIAELAQIMLQLAGL-EKSIPEILEH 297
QP+G AIG E EA+ T++ + P E +A I+ ++ G+ +
Sbjct: 320 YGGQPVGRAIGPALEAREALKTMEDRRGPSSLVEKSLGIAGILFEMTGIATNGYQHARKI 379
Query: 298 FTNGLAYGKFVEMVKAQGGDPTAFDYLTAPLQVKYQVEIKADKSGFISEEKALGIGLLAM 357
F +G KF E+V AQGGD + A Y + + + G + I +A
Sbjct: 380 FESGKTLEKFREIVAAQGGDESVKAEDVAVGDKTYTLTSQVE--GAVVSVNNKSIVKIAR 437
Query: 358 KLGAGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNRE 400
GA + D AGV + KK G+ V G+ + +Y+ +E
Sbjct: 438 TAGAPK-------DKGAGVYVHKKRGEVVKVGDPLLTIYAEKE 473
gi|2649232 (AE001011) thymidine phosphorylase (deoA-2) [Archaeoglobus
fulgidus]
Length = 505
Score = 141 bits (352), Expect = 1e-32
Identities = 108/400 (27%), Positives = 193/400 (48%), Gaps = 17/400 (4%)
Query: 4 RMVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMA 63
+ V+ I+KK + ++ + EI +I + ++ D ++SA +A GM E ++ A
Sbjct: 87 KSVEYIRKKLNGAKYEREEIKDIIGSISSDVLSDIEISAFILANEIVGMQNDEIQWMIEA 146
Query: 64 MVHSGKEFDLTDISGIKVDKHSTGGV-GDKVTLILAPLVASFGVPVAKMSGRGLGHTGGT 122
MV G+ G VD HS GG+ G++ +LI P VA+ G+ + K + R + GT
Sbjct: 147 MVEVGERVVFE--RGTVVDMHSIGGLPGNRFSLIAVPTVAAAGLLIPKTASRAITTASGT 204
Query: 123 LDKLESIPGFKFEKTE-KEFIDQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIPL 181
D +E + E KE ++V G+ + AD+ + + + + P
Sbjct: 205 ADTMEVLANVNLSVDEIKEITEEVG--GVIAWNAPTGIAPADEKIIRV-EYQLELSPKPH 261
Query: 182 IASSVMSKKIAAGSDAILLDVTVGDGAFMKSVEDARLLAQTMVDLGKSIGRETVAVITNM 241
+ +SV+SKK+ +G+ + +D+ VG A +++V+ R A M+++G+++ + +T+
Sbjct: 262 LMASVLSKKLGSGARFVAIDIPVGKKAKVENVDVGRGFANAMMEIGRNLNLKVATALTDG 321
Query: 242 SQPLGFAIGNRNEMTEAVHTLQGKAPKEFQEFIAELAQIMLQLAGL-EKSIPEILEHFTN 300
SQPLG AIG E E + ++ K + E +A I+ ++ G+ + F +
Sbjct: 322 SQPLGRAIGPALEAREVLEVMERKVEGDLLEKSLGIAGILFEMTGIATNGYQHARKIFES 381
Query: 301 GLAYGKFVEMVKAQGGDPTAFDYLTAPLQVKYQVEIKADKSGFISEEKALGIGLLAMKLG 360
G KF E+V AQGGD + A Y + A K G++ E + +A G
Sbjct: 382 GKTLEKFREIVAAQGGDESVKAEDVAVGDKTY--TLHAAKEGYVREIDIAALNEIARTAG 439
Query: 361 AGRATKTDDIDFEAGVTLTKKVGDKVSAGEVIAQLYSNRE 400
A + D AGV + KK G+ V G+ + +Y+ +E
Sbjct: 440 APK-------DKGAGVYVHKKRGEVVKVGDPLLTIYAEKE 472
gb|AAC17870.1| (AF052077) phosphoribosylanthranilate transferase [Streptomyces
coelicolor] >gi|4539216|emb|CAB39874.1| (AL049497)
phosphoribosylanthranilate transferase [Streptomyces
coelicolor]
Length = 354
Score = 53.5 bits (126), Expect = 3e-06
Identities = 38/140 (27%), Positives = 63/140 (44%), Gaps = 7/140 (5%)
Query: 14 DSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMAMVHSGKEFDL 73
D + S + W ++ ++G D Q++ A+ + FKG T E + L M + ++
Sbjct: 26 DGRDLSADDTAWALDVIMRGEATDVQIAGFAVGLRFKGETVEEISGLVRTMY---EHANV 82
Query: 74 TDISGIKVDKHSTGGVGDK---VTLILAPLVASFGVPVAKMSGRGLGHTGGTLDKLESIP 130
++ G VD TGG G K ++ + A ++A G V K R G D LE +
Sbjct: 83 IEVPGKTVDIVGTGGDGAKTVNISTMSAIVLAGTGAKVVKHGNRAASSASGASDVLEKL- 141
Query: 131 GFKFEKTEKEFIDQVKETGI 150
G E T + + +E GI
Sbjct: 142 GVNLELTPQRVAEVAEEAGI 161
sp|Q08654|TRPG_THEMA ANTHRANILATE SYNTHASE COMPONENT II [INCLUDES: GLUTAMINE
AMIDOTRANSFERASE; ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE
] >gi|4980633|gb|AAD35234.1|AE001699_11 (AE001699)
anthranilate synthase component II [Thermotoga maritima]
Length = 589
Score = 52.7 bits (124), Expect = 6e-06
Identities = 46/154 (29%), Positives = 72/154 (45%), Gaps = 9/154 (5%)
Query: 6 VDLIQKKRDSGEFSQA--EIDWMIENYV-KGIVPDYQMSALAMAIYFKGMTTVETAYLTM 62
+D++ + EF E + N++ G D Q++ +A+ K T E M
Sbjct: 248 IDIVSALKKLVEFEDLTFEESRQVMNFIMSGNATDAQIAGFLVALRMKEETGDELG--GM 305
Query: 63 AMVHSGKEFDLTDISGIKVDKHSTGGVGD---KVTLILAPLVASFGVPVAKMSGRGLGHT 119
A V K + S VD TGG G ++ A +VA+ G+PVAK R +
Sbjct: 306 ASVMREKSIHIKAPSPRTVDTCGTGGDGFGTFNISTTTAFVVAAAGIPVAKHGNRSVSSK 365
Query: 120 GGTLDKLESIPGFKFEKTEKEFIDQVKETGIAII 153
G+ D LE+ G+K EKT +E ++KETG + +
Sbjct: 366 VGSADVLEA-GGYKLEKTPEEMERELKETGFSFL 398
emb|CAA52203| (X74075) anthranilate synthase component II and anthranilate
phosphoribosyltransferase [Thermotoga maritima]
Length = 589
Score = 51.5 bits (121), Expect = 1e-05
Identities = 46/154 (29%), Positives = 71/154 (45%), Gaps = 9/154 (5%)
Query: 6 VDLIQKKRDSGEFSQA--EIDWMIENYV-KGIVPDYQMSALAMAIYFKGMTTVETAYLTM 62
+D++ + EF E + N++ G D Q++ +A+ K T E M
Sbjct: 248 IDIVSALKKLVEFEDLTFEESRQVMNFIMSGNATDAQIAGFLVALRMKEETGDELG--GM 305
Query: 63 AMVHSGKEFDLTDISGIKVDKHSTGGVGD---KVTLILAPLVASFGVPVAKMSGRGLGHT 119
A V K + S VD TGG G ++ A +VA+ G+PVAK R +
Sbjct: 306 ASVMREKSIHIKAPSPRTVDTCGTGGDGFGTFNISTTTAFVVAAAGIPVAKHGNRSVSSK 365
Query: 120 GGTLDKLESIPGFKFEKTEKEFIDQVKETGIAII 153
G+ D LE+ G+K EKT E ++KETG + +
Sbjct: 366 VGSADVLEA-GGYKLEKTPGEMERELKETGFSFL 398
pir||S34748 anthranilate phosphoribosyltransferase (EC 2.4.2.18) - Thermotoga
maritima
Length = 337
Score = 50.4 bits (118), Expect = 3e-05
Identities = 41/126 (32%), Positives = 60/126 (47%), Gaps = 6/126 (4%)
Query: 31 VKGIVPDYQMSALAMAIYFKGMTTVETAYLTMAMVHSGKEFDLTDISGIKVDKHSTGGVG 90
+ G D Q++ +A+ K T E MA V K + S VD TGG G
Sbjct: 24 MSGNATDAQIAGFLVALRMKEETGDELG--GMASVMREKSIHIKAPSPRTVDTCGTGGDG 81
Query: 91 D---KVTLILAPLVASFGVPVAKMSGRGLGHTGGTLDKLESIPGFKFEKTEKEFIDQVKE 147
++ A +VA+ G+PVAK R + G+ D LE+ G+K EKT E ++KE
Sbjct: 82 FGTFNISTTTAFVVAAAGIPVAKHGNRSVSSKVGSADVLEA-GGYKLEKTPGEMERELKE 140
Query: 148 TGIAII 153
TG + +
Sbjct: 141 TGFSFL 146
sp|P00500|TRPD_ACICA ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE >gi|66596|pir||NPKEDC
anthranilate phosphoribosyltransferase (EC 2.4.2.18) -
Acinetobacter calcoaceticus >gi|141801 (M36636)
anthranilate phosphoribosyltransferase (EC 2.4.2.18)
[Acinetobacter calcoaceticus]
Length = 349
Score = 45.3 bits (105), Expect = 0.001
Identities = 34/138 (24%), Positives = 66/138 (47%), Gaps = 5/138 (3%)
Query: 19 SQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMAMVHSGKEFDLTDISG 78
+QA+++ ++ + ++G + Q+ AL M + KG + E M + D++DI
Sbjct: 17 TQAQMEDVMRSIMQGEATEAQIGALMMGLRMKGESIDEITAAARVMRELAIKIDVSDIQY 76
Query: 79 IKVDKHSTGGVGD---KVTLILAPLVASFGVPVAKMSGRGLGHTGGTLDKLESIPGFKFE 135
+ VD TGG G V+ + ++A+ G +AK RG+ G+ D LE G +
Sbjct: 77 L-VDIVGTGGDGQNLFNVSTASSFVIAAAGATIAKHGNRGVSSKSGSSDLLEQ-AGINLD 134
Query: 136 KTEKEFIDQVKETGIAII 153
++ ++E G+ +
Sbjct: 135 LDMQQTERCIREMGVGFL 152
sp|P22096|TRPD_VIBPA ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE >gi|48488|emb|CAA35033|
(X17149) anthranilate phosphoribosyltransferase [Vibrio
parahaemolyticus]
Length = 332
Score = 43.8 bits (101), Expect = 0.003
Identities = 35/154 (22%), Positives = 65/154 (41%), Gaps = 10/154 (6%)
Query: 5 MVDLIQKKRDSGEFSQAEIDWMIENYVKGIVPDYQMSALAMAIYFKGMTTVETAYLTMAM 64
M +I K + +Q E + + ++G + M++ A+ KG T E A A+
Sbjct: 1 MEAIINKLYEQQSLTQEESQQLFDIIIRGELDPILMASALTALKIKGETPDEIAGAAKAL 60
Query: 65 VHSGK-----EFDLTDISGIKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHT 119
+ + ++D DI G D H+T + + A+ G+ VAK R +
Sbjct: 61 LANANPFPRPDYDFADIVGTGGDGHNTINISTTAAFV----AAACGLKVAKHGNRSVSSK 116
Query: 120 GGTLDKLESIPGFKFEKTEKEFIDQVKETGIAII 153
G+ D L+S G + ++ V + G+A +
Sbjct: 117 SGSSDLLDSF-GINLAMSAEDTRKAVDDIGVAFL 149
Posted date: Mar 2, 2000 12:24 PM
Number of letters in database: 140,871,481
Number of sequences in database: 457,798
Lambda K H
0.317 0.135 0.366
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 108587693
Number of Sequences: 457798
Number of extensions: 4454989
Number of successful extensions: 16474
Number of sequences better than 1.0e-02: 29
Number of HSP's better than 0.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 16393
Number of HSP's gapped (non-prelim): 29
length of query: 430
length of database: 140,871,481
effective HSP length: 61
effective length of query: 369
effective length of database: 112,945,803
effective search space: 41677001307
effective search space used: 41677001307
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 97 (42.2 bits)