Score E
Sequences producing significant alignments: (bits) Value
gi|4009480 (AF068902) D-glutamic acid adding enzyme MurD [S... 532 e-150
gi|3090871 (AF035938) uridine diphosphate N-acetylmuramoyl-... 524 e-148
sp|O07108|MURD_ENTFA UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMA... 514 e-145
sp|O07669|MURD_ENTHR UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMA... 494 e-139
sp|Q03522|MURD_BACSU UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMA... 427 e-119
sp|O33595|MURD_STAAU UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMA... 397 e-110
gi|2149895 (U94706) D-glutamic acid adding enzyme [Staphylo... 377 e-104
emb|CAA45555| (X64258) UDP-N-acetylmuramoylalanine--D-gluta... 346 3e-94
dbj|BAA22556| (AB007500) MURD [Staphylococcus aureus] 223 2e-57
sp|Q9ZDC2|MURD_RICPR UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMA... 206 4e-52
emb|CAB51995.1| (AL109663) putative UDP-N-acetylmuramoylala... 194 1e-48
gi|2984290 (AE000771) UDP-N-acetylmuramoylalanine-D-glutama... 176 3e-43
sp|P73668|MURD_SYNY3 UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMA... 168 9e-41
sp|P14900|MURD_ECOLI UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMA... 167 2e-40
gb|AAD35325.1|AE001707_12 (AE001707) UDP-N-acetylmuramoylal... 166 3e-40
emb|CAA35611| (X17609) UDP-N-acetylmuramoyl-L-alanine:D-glu... 166 4e-40
sp|P45063|MURD_HAEIN UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMA... 165 6e-40
pdb|1UAG| Udp-N-Acetylmuramoyl-L-Alanine:d-Glutamate Ligase 164 1e-39
gb|AAD19039| (AE001670) Muramoylalanine-Glutamate Ligase [C... 147 2e-34
sp|O06222|MURD_MYCTU UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMA... 139 3e-32
sp|O51532|MURD_BORBU UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMA... 139 4e-32
gb|AAC68353.1| (AE001348) UDP-N-acetylmuramoylalanine-D-glu... 138 7e-32
emb|CAA18670.1| (AL022602) udp-n-acetylmuramoylalanine-- d-... 133 3e-30
gb|AAF12038.1|AE002079_3 (AE002079) UDP-N-acetylmuramoylala... 124 1e-27
gi|4154982 (AE001479) UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAM... 113 4e-24
gb|AAD07560.1| (AE000564) UDP-N-acetylmuramoylalanine-D-glu... 111 1e-23
gi|4204102 (U10879) UDP-N-acetylmuramoylalanine--D-glutamat... 110 2e-23
emb|CAB74268.1| (AL139075) UDP-N-acetylmuramoylalanine--D-g... 104 1e-21
sp|O67373|MURC_AQUAE UDP-N-ACETYLMURAMATE--ALANINE LIGASE (... 95 1e-18
sp|O51926|MURC_BUCAP UDP-N-ACETYLMURAMATE--ALANINE LIGASE (... 83 6e-15
sp|Q9X827|MURC_STRCO UDP-N-ACETYLMURAMATE--ALANINE LIGASE (... 73 5e-12
gb|AAD53935.1|AF179611_19 (AF179611) UDP-N-acetylmuramate-a... 73 6e-12
gb|AAD53938.1|AF179611_22 (AF179611) UDP-N-acetylmuramoyl-L... 72 8e-12
sp|P45066|MURC_HAEIN UDP-N-ACETYLMURAMATE--ALANINE LIGASE (... 71 2e-11
emb|CAB66325.1| (AJ242646) MurC protein [Brevibacterium lac... 64 2e-09
gi|2177094 (U67892) UDP-MurNAc:L-alanine ligase [Escherichi... 64 2e-09
sp|P37773|MPL_ECOLI UDP-N-ACETYLMURAMATE:L-ALANYL-GAMMA-D-G... 64 2e-09
sp|P17952|MURC_ECOLI UDP-N-ACETYLMURAMATE--ALANINE LIGASE (... 64 2e-09
sp|Q9WY73|MURC_THEMA UDP-N-ACETYLMURAMATE--ALANINE LIGASE (... 64 3e-09
sp|P94335|MURC_CORGL UDP-N-ACETYLMURAMATE--ALANINE LIGASE (... 63 4e-09
sp|Q9ZDS8|MURC_RICPR UDP-N-ACETYLMURAMATE--ALANINE LIGASE (... 62 1e-08
sp|O83873|MURD_TREPA UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMA... 61 2e-08
gb|AAF14862.1|AF110740_1 (AF110740) UDP-N-acetylmuramate:L-... 61 3e-08
sp|O06225|MURC_MYCTU UDP-N-ACETYLMURAMATE--ALANINE LIGASE (... 60 4e-08
emb|CAA18672.1| (AL022602) udp-n-acetylmuramoylalanyl-d-glu... 58 2e-07
gi|4009466 (AF068901) D-Ala-D-Ala adding enzyme [Streptococ... 57 3e-07
sp|P43948|MPL_HAEIN UDP-N-ACETYLMURAMATE:L-ALANYL-GAMMA-D-G... 55 2e-06
emb|CAB73310.1| (AL139077) UDP-N-acetylmuramate--alanine li... 53 3e-06
emb|CAB51997.1| (AL109663) putative UDP-N-acetylmuramoylala... 53 3e-06
gb|AAD08535.1| (AE000648) UDP-MurNac-tripeptide synthetase ... 53 3e-06
emb|CAA74740| (Y14370) UDP-N-acetylmuramyl-tripeptide synth... 53 5e-06
gi|1128955 (M30807) unknown protein [Escherichia coli] 53 6e-06
sp|P20100|YZFW_ECOLI VERY HYPOTHETICAL PROTEIN IN FTSW 5'RE... 52 8e-06
gi|2621604 (AE000836) UDP-N-acetylmuramyl tripeptide synthe... 52 1e-05
sp|Q51831|MURC_PORGI UDP-N-ACETYLMURAMATE--ALANINE LIGASE (... 51 2e-05
gb|AAD35328.1|AE001707_15 (AE001707) UDP-N-acetylmuramoylal... 49 9e-05
sp|P96613|MURF_BACSU UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-... 48 1e-04
sp|P11880|MURF_ECOLI UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-... 48 1e-04
sp|Q55469|MURE_SYNY3 UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE... 48 2e-04
pir||S04846 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diam... 48 2e-04
gi|4156007 (AE001561) UDP-N-ACETYLMURAMYL-TRIPEPTIDE SYNTHE... 47 3e-04
gb|AAC67862.1| (AE001299) UDP-N-acetylmuramoylalanylglutamy... 47 3e-04
sp|O51757|MURC_BORBU UDP-N-ACETYLMURAMATE--ALANINE LIGASE (... 47 3e-04
gi|2177096 (U67893) UDP-MurNAc-Tripeptide:D-Ala-D-Ala-Addin... 47 3e-04
emb|CAB66322.1| (AJ242646) MurD protein [Brevibacterium lac... 46 4e-04
sp|O25340|MURC_HELPY UDP-N-ACETYLMURAMATE--ALANINE LIGASE (... 46 4e-04
sp|P74528|MURC_SYNY3 UDP-N-ACETYLMURAMATE--ALANINE LIGASE (... 46 4e-04
sp|Q03523|MURE_BACSU UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE... 46 6e-04
sp|O26631|Y531_METTH HYPOTHETICAL PROTEIN MTH531 >gi|262160... 46 8e-04
emb|CAA18667.1| (AL022602) udp-n-acetylmuramate-alanine lig... 45 0.001
emb|CAB51998.1| (AL109663) putative UDP-N-acetylmuramoylala... 45 0.002
gb|AAD18562| (AE001625) N-Acetylmuramoylalanylglutamyl DAP ... 45 0.002
sp|O06220|MURF_MYCTU UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-... 45 0.002
sp|P45060|MURE_HAEIN UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE... 44 0.002
sp|Q44777|MURF_BORBU UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-... 44 0.003
gi|1165288 (U43739) MurF [Borrelia burgdorferi] 44 0.003
gi|3820539 (AF080002) UDP-N-acetylmuramyl tripeptide synthe... 43 0.004
sp|O33804|MURF_STRTO PROBABLE UDP-N-ACETYLMURAMOYLALANYL-D-... 43 0.004
sp|Q59650|MURE_PSEAE UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE... 43 0.005
sp|O85298|MURE_BUCAP UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE... 42 0.009
gi|4009480 (AF068902) D-glutamic acid adding enzyme MurD [Streptococcus
pneumoniae]
Length = 450
Score = 532 bits (1355), Expect = e-150
Identities = 263/450 (58%), Positives = 335/450 (74%)
Query: 1 MKKITKFKDQKILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVI 60
MK I +FK++K+LVLGLA+SG +AA +L++LGAIVTVNDGKPFE+N AQ LLEEGIKVI
Sbjct: 1 MKVIDQFKNKKVLVLGLAKSGESAARLLDKLGAIVTVNDGKPFEDNPAAQCLLEEGIKVI 60
Query: 61 TGSHPIDLLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXX 120
TG HP++LLDE+FALMVKNPGI Y NPM+E+A A IPV+TEVELAYLISEAP
Sbjct: 61 TGGHPLELLDEEFALMVKNPGIPYSNPMIEKALAKGIPVLTEVELAYLISEAPIIGITGS 120
Query: 121 XXXXXXXXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFR 180
+I ++L A GQ LSGNIG+PAS+VA+ A+ +TLVMELSSFQLMG+ F
Sbjct: 121 NGKTTTTTMIGEVLTAAGQHGLLSGNIGYPASQVAQIATDKNTLVMELSSFQLMGVQEFH 180
Query: 181 PKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATV 240
P+IA+ITNL H+DYHG + Y AAKW IQ MT+ DFL+LNFNQ+ ++LA KT+ATV
Sbjct: 181 PEIAVITNLMPTHIDYHGLFEEYVAAKWNIQNKMTAADFLVLNFNQDLVKDLASKTEATV 240
Query: 241 LAFSTKEKVNGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNEAI 300
+ FST EKV+GAY +DG++YF E +M +E+ +PG HN+ENALA I +KL+G N+ I
Sbjct: 241 VPFSTLEKVDGAYLEDGQLYFRGEVVMAANEIGVPGSHNVENALATIAVAKLRGVDNQTI 300
Query: 301 VEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLAGGLDRGN 360
E L++F GVKHRLQ++ +I G K YNDSK+TNILATQKALSGFDNSK+ L+AGGLDRGN
Sbjct: 301 KETLSAFGGVKHRLQFVDDIKGVKFYNDSKSTNILATQKALSGFDNSKVVLIAGGLDRGN 360
Query: 361 GFEELEKDLQDLKGMVVFGQTANKLRLTAEKLNIPVFDSENVAKALEEILPQTQAGDTIL 420
F+EL D+ LK MV+ GQ+A +++ A+K + ++ ++A A + GD +L
Sbjct: 361 EFDELVPDITGLKKMVILGQSAERVKRAADKAGVAYVEATDIADATRKAYELATQGDVVL 420
Query: 421 LSPACASWDQYKTFEERGDLFIQAFENLKK 450
LSPA ASWD Y FE RGDLFI LK+
Sbjct: 421 LSPANASWDMYANFEVRGDLFIDTVAELKE 450
gi|3090871 (AF035938) uridine diphosphate
N-acetylmuramoyl-L-alanine:D-glutamate ligase
[Streptococcus pyogenes]
Length = 452
Score = 524 bits (1336), Expect = e-148
Identities = 263/449 (58%), Positives = 331/449 (73%)
Query: 1 MKKITKFKDQKILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVI 60
MK I+ F+++KIL+LGLA+SG AAA +L +LGA+VTVND KPF++N AQ LLEEGIKVI
Sbjct: 1 MKVISNFQNKKILILGLAKSGEAAAKLLTKLGALVTVNDSKPFDQNPAAQALLEEGIKVI 60
Query: 61 TGSHPIDLLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXX 120
GSHP++LLDEDF MVKNPGI YDNPMV+RA A IP++TEVELAY +SEAP
Sbjct: 61 CGSHPVELLDEDFEYMVKNPGIPYDNPMVKRALAKEIPILTEVELAYFVSEAPIIGITGS 120
Query: 121 XXXXXXXXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFR 180
+IAD+LNA GQSA LSGNIG+PAS+V +KA A DTLVMELSSFQL+G+++FR
Sbjct: 121 NGKTTTTTMIADVLNAGGQSALLSGNIGYPASKVVQKAIAGDTLVMELSSFQLVGVNAFR 180
Query: 181 PKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATV 240
P IA+ITNL HLDYHGS + Y AAKW IQ MT D+LILN NQE LA T+ATV
Sbjct: 181 PHIAVITNLMPTHLDYHGSFEDYVAAKWMIQAQMTESDYLILNANQEISATLAKTTQATV 240
Query: 241 LAFSTKEKVNGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNEAI 300
+ FST++ V+GAY KDG +YF ++ I+ ++L +PG HN+ENALA I +KL G ++ I
Sbjct: 241 IPFSTQKVVDGAYLKDGILYFKEQAIIAATDLGVPGSHNIENALATIAVAKLSGIADDII 300
Query: 301 VEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLAGGLDRGN 360
+ L+ F GVKHRLQ +G+I YNDSK+TNILATQKALSGFDNS+L L+AGGLDRGN
Sbjct: 301 AQCLSHFGGVKHRLQRVGQIKDITFYNDSKSTNILATQKALSGFDNSRLILIAGGLDRGN 360
Query: 361 GFEELEKDLQDLKGMVVFGQTANKLRLTAEKLNIPVFDSENVAKALEEILPQTQAGDTIL 420
F++L DL LK M++ G++A +++ A K + ++ NVA+A E Q GDTIL
Sbjct: 361 EFDDLVPDLLGLKQMIILGESAERMKRAANKAEVSYLEARNVAEATELAFKLAQTGDTIL 420
Query: 421 LSPACASWDQYKTFEERGDLFIQAFENLK 449
LSPA ASWD Y FE RGD F+ F+ L+
Sbjct: 421 LSPANASWDMYPNFEVRGDEFLATFDCLR 449
sp|O07108|MURD_ENTFA UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
(D-GLUTAMIC ACID ADDING ENZYME) >gi|2149905 (U94707)
D-glutamic acid adding enzyme [Enterococcus faecalis]
Length = 456
Score = 514 bits (1309), Expect = e-145
Identities = 264/453 (58%), Positives = 333/453 (73%), Gaps = 3/453 (0%)
Query: 1 MKKITKFKDQKILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVI 60
MKKIT ++++K+LVLGLA+SG++AA +L+ELGA+VTVND K F++N +AQ LL GI+V+
Sbjct: 1 MKKITTYQNKKVLVLGLAKSGVSAAKLLHELGALVTVNDAKQFDQNPDAQDLLTLGIRVV 60
Query: 61 TGSHPIDLLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXX 120
TG HPI+LLDE+F L+VKNPGI Y NP+V A IP+ITEVELA I+E P
Sbjct: 61 TGGHPIELLDEEFELIVKNPGILYTNPLVAEALTRKIPIITEVELAGQIAECPIVGITGT 120
Query: 121 XXXXXXXXLIADILNADGQS--AKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDS 178
+I +LNAD + A+L+GNIGFPAS VA++A+A D LVMELSSFQLMGI++
Sbjct: 121 NGKTTTTTMIGLLLNADRTAGEARLAGNIGFPASTVAQEATAKDDLVMELSSFQLMGIET 180
Query: 179 FRPKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKA 238
F P+IA+ITN+F AHLDYHGS+K Y AAKW IQ+NMT++D LILN+NQ + + LA T A
Sbjct: 181 FHPQIAVITNIFEAHLDYHGSRKEYVAAKWAIQKNMTAEDTLILNWNQVELQTLAKTTAA 240
Query: 239 TVLAFSTKEKVNGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNE 298
VL FSTKE V GAY DGK+YFN+EYIM EL +PG HN+ENALAAI KL+ N
Sbjct: 241 NVLPFSTKEAVEGAYLLDGKLYFNEEYIMPADELGIPGSHNIENALAAICVPKLKNVSNA 300
Query: 299 AIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLAGGLDR 358
I + LT+F+GV HR Q++GE+ R+ YNDSKATN LAT+ ALSGFDN KL LLAGGLDR
Sbjct: 301 QIKQSLTNFSGVPHRTQFVGEVQQRRFYNDSKATNFLATEMALSGFDNQKLLLLAGGLDR 360
Query: 359 GNGFEELEKDLQDLKGMVVFGQTANKLRLTAEKLNI-PVFDSENVAKALEEILPQTQAGD 417
GN F+EL L LK +V+FG+T KL A+K NI + +ENV A+ ++ D
Sbjct: 361 GNSFDELVPALLGLKAIVLFGETKKKLAEAAKKPNIETILFAENVQTAVTIAFDYSEKDD 420
Query: 418 TILLSPACASWDQYKTFEERGDLFIQAFENLKK 450
TILLSPACASWDQY FE RG+ F+QA + LK+
Sbjct: 421 TILLSPACASWDQYPNFEVRGEAFMQAVQQLKE 453
sp|O07669|MURD_ENTHR UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
(D-GLUTAMIC ACID ADDING ENZYME)
>gi|2222673|emb|CAA74234| (Y13922) murD [Enterococcus
hirae]
Length = 460
Score = 494 bits (1258), Expect = e-139
Identities = 252/451 (55%), Positives = 325/451 (71%), Gaps = 4/451 (0%)
Query: 2 KKITKFKDQKILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVIT 61
K K +K+LVLGLA+SG +AA +L+ELGA+VTVNDGKPF+E EAQ LL G+KVI
Sbjct: 6 KNFNHSKTKKVLVLGLAKSGFSAAKLLHELGALVTVNDGKPFDEKPEAQELLSLGVKVIA 65
Query: 62 GSHPIDLLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXXX 121
GSHPI+LLDE+F+LMVKNPGI Y +P V++A+ L IPVITEVELAY ++E P
Sbjct: 66 GSHPIELLDEEFSLMVKNPGIPYSHPFVQKAQELGIPVITEVELAYEVAECPIIGITGTN 125
Query: 122 XXXXXXXLIADILNADGQ--SAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSF 179
+ +LNA +A+L+GNIG+PAS VA++A+A D +VMELSSFQLMGI F
Sbjct: 126 GKTTTTTMTGLLLNAGDLPGTARLAGNIGYPASSVAQEATADDKIVMELSSFQLMGITDF 185
Query: 180 RPKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKAT 239
RP +A++TN++ AH+DYH ++K Y AKW +Q+NMT D+LILN+NQE+ R L+ KTKAT
Sbjct: 186 RPHVAVVTNIYEAHIDYHKTRKEYVKAKWHLQQNMTEKDYLILNWNQEELRELSKKTKAT 245
Query: 240 VLAFSTKEKV-NGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNE 298
VL F+T++K+ GA S DG IY+N E IM+++EL +PG HN+ENALAAI +KL G NE
Sbjct: 246 VLPFATEQKLPKGACSLDGSIYYNQEKIMDITELGVPGSHNVENALAAISVAKLYGISNE 305
Query: 299 AIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLAGGLDR 358
AI L F GV HR QY+GE GRK YNDSKATNILAT+ ALSGF +L L+AGGLDR
Sbjct: 306 AIKNALHHFHGVPHRTQYVGEFQGRKFYNDSKATNILATKMALSGFQLDQLVLIAGGLDR 365
Query: 359 GNGFEELEKDLQDLKGMVVFGQTANKLRLTAEKLNIPVF-DSENVAKALEEILPQTQAGD 417
GN F+EL L+ +K ++ FG+T N+L +K IPV +EN A+ L ++ GD
Sbjct: 366 GNSFDELIPALKGIKALITFGETQNRLEDAGKKAGIPVIKTAENAEAAVPIALELSEEGD 425
Query: 418 TILLSPACASWDQYKTFEERGDLFIQAFENL 448
+ILLSPA ASWDQY FE RG+ F++A L
Sbjct: 426 SILLSPANASWDQYPNFEIRGERFMEAVNKL 456
sp|Q03522|MURD_BACSU UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
(D-GLUTAMIC ACID ADDING ENZYME) >gi|478078|pir||D47691
UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC
6.3.2.9) - Bacillus subtilis >gi|580932|emb|CAA78769|
(Z15056) murD [Bacillus subtilis]
>gi|2633891|emb|CAB13393| (Z99111)
UDP-N-acetylmuramoylalanine D-glutamate ligase [Bacillus
subtilis]
Length = 451
Score = 427 bits (1086), Expect = e-119
Identities = 230/443 (51%), Positives = 295/443 (65%), Gaps = 4/443 (0%)
Query: 10 QKILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPIDLL 69
Q L+LGLA+SG AAA +L+E G V VND KPFEEN+ AQ L E+GI+V+ G HP+ L
Sbjct: 10 QHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFEENEPAQKLSEKGIEVVCGEHPVSLF 69
Query: 70 DE-DFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXXXXXXXXXX 128
D+ +++KNPGI Y+N MV+ AE IPV TE+ELAY ++ A
Sbjct: 70 DQHQITILIKNPGIPYENIMVQEAEKRGIPVWTEIELAYYLTSAKFIGITGSNGKTTTTT 129
Query: 129 LIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIALITN 188
LI ++L AD Q A ++GNIG ASEVA A + +V ELSSFQLMG +FRP+I+LI N
Sbjct: 130 LIYEMLKADSQKALIAGNIGTVASEVAYHADGDEWIVTELSSFQLMGTHAFRPEISLILN 189
Query: 189 LFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATVLAFS-TKE 247
+F AHLDYH +++ YE AK ++ + T+ D I+N + E LA+ KA ++ FS +K
Sbjct: 190 VFDAHLDYHHTRENYEKAKQKVYLHQTASDKAIVNQDDETVVRLAEAGKAEIVPFSVSKT 249
Query: 248 KVNGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNEAIVEVLTSF 307
GAY KD I FN E I+ + E+ LPG HNLEN LAAI K G NEA+ +VLTSF
Sbjct: 250 LEQGAYVKDSMIMFNGEAILPLEEVVLPGAHNLENILAAIAVVKTAGASNEAVKKVLTSF 309
Query: 308 AGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLAGGLDRGNGFEELEK 367
GVKHRLQY+ ++GRK YNDSKATNILAT KALS FD + LLAGGLDRGNGF++L+
Sbjct: 310 TGVKHRLQYVTTVNGRKFYNDSKATNILATSKALSAFDKPVI-LLAGGLDRGNGFDDLKP 368
Query: 368 DLQDLKGMVVFGQTANKLRLTAEKLNIP-VFDSENVAKALEEILPQTQAGDTILLSPACA 426
++ +K ++ FGQTA KL +L I V +NV +A+ + GD ILLSPACA
Sbjct: 369 YMKHVKAVLTFGQTAPKLEKLGNELGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACA 428
Query: 427 SWDQYKTFEERGDLFIQAFENLK 449
SWDQ+KTFEERGD+FI A LK
Sbjct: 429 SWDQFKTFEERGDMFIDAVHMLK 451
sp|O33595|MURD_STAAU UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
(D-GLUTAMIC ACID ADDING ENZYME) >gi|2271510 (AF009671)
UDP-N-acetylmuramoyl-L-alanine : D-glutamate ligase;
MurD [Staphylococcus aureus]
Length = 449
Score = 397 bits (1010), Expect = e-110
Identities = 207/445 (46%), Positives = 296/445 (66%), Gaps = 3/445 (0%)
Query: 1 MKKITKFKDQKILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVI 60
M T +++ +LV+GLA+SG AA +L++LGA VTVNDGK ++ A+ L GI V+
Sbjct: 1 MLNYTGLENKNVLVVGLAKSGYEAAKLLSKLGANVTVNDGKDLSQDAHAKDLESMGISVV 60
Query: 61 TGSHPIDLLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXX 120
+GSHP+ LLD + ++VKNPGI Y +++ A + ++TEVEL+YLISEAP
Sbjct: 61 SGSHPLTLLDNN-PIIVKNPGIPYTVSIIDEAVKRGLKILTEVELSYLISEAPIIAVTGT 119
Query: 121 XXXXXXXXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFR 180
LI D+ + +LSGNIG+ AS+VA++ +D LV ELSSFQL+GI+ ++
Sbjct: 120 NGKTTVTSLIGDMFKKSRLTGRLSGNIGYVASKVAQEVKPTDYLVTELSSFQLLGIEKYK 179
Query: 181 PKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATV 240
P IA+ITN++SAHLDYH + + Y+ AK +I +N T +D+LI N++Q + +++ KA
Sbjct: 180 PHIAIITNIYSAHLDYHENLENYQNAKKQIYKNQTEEDYLICNYHQRQVIE-SEELKAKT 238
Query: 241 LAFSTKEKVNGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNEAI 300
L FST+++V+G Y KDG I + I+ +L LPGEHNLEN LAA++A L G +AI
Sbjct: 239 LYFSTQQEVDGIYIKDGFIVYKGVRIINTEDLVLPGEHNLENILAAVLACILAGVPIKAI 298
Query: 301 VEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLAGGLDRGN 360
++ LT+F+G++HRLQY+G K YNDSKATN LATQ AL+ F+ +W L GGLDRGN
Sbjct: 299 IDSLTTFSGIEHRLQYVGTNRTNKYYNDSKATNTLATQFALNSFNQPIIW-LCGGLDRGN 357
Query: 361 GFEELEKDLQDLKGMVVFGQTANKLRLTAEKLNIPVFDSENVAKALEEILPQTQAGDTIL 420
F+EL +++++ MVVFGQT K V ++ NV A++++ + D +L
Sbjct: 358 EFDELIPYMENVRAMVVFGQTKAKFAKLGNSQGKSVIEANNVEDAVDKVQDIIEPNDVVL 417
Query: 421 LSPACASWDQYKTFEERGDLFIQAF 445
LSPACASWDQY TFEERG+ FI+ F
Sbjct: 418 LSPACASWDQYSTFEERGEKFIERF 442
gi|2149895 (U94706) D-glutamic acid adding enzyme [Staphylococcus aureus]
Length = 450
Score = 377 bits (959), Expect = e-104
Identities = 202/447 (45%), Positives = 293/447 (65%), Gaps = 6/447 (1%)
Query: 1 MKKITKFKDQKILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVI 60
M T +++ +LV+GLA+SG AA +L++LGA VTVNDGK ++ A+ L GI V+
Sbjct: 1 MLNYTGLENKNVLVVGLAKSGYEAAKLLSKLGANVTVNDGKDLSQDAHAKDLESMGISVV 60
Query: 61 TGSHPIDLLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXX 120
+GSHP+ LLD + ++VKNPGI Y +++ A + ++TEVEL+YLISEAP
Sbjct: 61 SGSHPLTLLDNN-PIIVKNPGIPYTVSIIDEAVKRGLKILTEVELSYLISEAPIIAVTGT 119
Query: 121 XXXXXXXXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFR 180
LI D+ + +LSGNIG+ AS+VA++ +D LV ELSSFQL+GI+ ++
Sbjct: 120 NGKTTVTSLIGDMFKKSRLTGRLSGNIGYVASKVAQEVKPTDYLVTELSSFQLLGIEKYK 179
Query: 181 PKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATV 240
P IA+ITN++SAHLDYH + + Y+ AK +I +N T +D+LI N++Q + +++ KA
Sbjct: 180 PHIAIITNIYSAHLDYHENLENYQNAKKQIYKNQTEEDYLICNYHQRQVIE-SEELKAKT 238
Query: 241 LAFSTKEKVNGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNEAI 300
L FST+++V+G Y KDG I + I+ +L LPGEHNLEN LAA++A L G +AI
Sbjct: 239 LYFSTQQEVDGIYIKDGFIVYKGVRIINTEDLVLPGEHNLENILAAVLACILAGVPIKAI 298
Query: 301 VEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLAGGLDRGN 360
++ LT+F+G++HRLQY+G K YNDSKATN LATQ AL+ F+ +W L GGLDRGN
Sbjct: 299 IDSLTTFSGIEHRLQYVGTNRTNKYYNDSKATNTLATQFALNSFNQPIIW-LCGGLDRGN 357
Query: 361 GFEELEKDLQDLKGMVVFGQTANKLRLT--AEKLNIPVFDSENVAKALEEILPQTQAGDT 418
F+EL ++++ ++ + KL L V ++ NV A++++ + D
Sbjct: 358 EFDELIPYMENVSREWLYSD-SRKLSLLNYGNSQGKSVIEANNVEDAVDKVQDIIEPNDV 416
Query: 419 ILLSPACASWDQYKTFEERGDLFIQAF 445
+LLSPACASWDQY TFEERG+ FI+ F
Sbjct: 417 VLLSPACASWDQYSTFEERGEKFIERF 443
emb|CAA45555| (X64258) UDP-N-acetylmuramoylalanine--D-glutamate ligase [Bacillus
subtilis] >gi|383709|prf||1904153A murD gene [Bacillus
subtilis]
Length = 369
Score = 346 bits (877), Expect = 3e-94
Identities = 189/370 (51%), Positives = 241/370 (65%), Gaps = 3/370 (0%)
Query: 82 IRYDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXXXXXXXXXXLIADILNADGQSA 141
I Y+N MV+ AE IPV TE+ELAY ++ A LI ++L AD Q A
Sbjct: 1 IPYENIMVQEAEKRGIPVWTEIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKA 60
Query: 142 KLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIALITNLFSAHLDYHGSQK 201
++GNIG ASEVA A + +V ELSSFQLMG +FRP+I+LI N+F AHLDYH +++
Sbjct: 61 LIAGNIGTVASEVAYHADGDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRE 120
Query: 202 AYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATVLAFS-TKEKVNGAYSKDGKIY 260
YE AK ++ + T+ D I+N + E LA+ KA ++ FS +K GAY KD I
Sbjct: 121 NYEKAKQKVYLHQTASDKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIM 180
Query: 261 FNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNEAIVEVLTSFAGVKHRLQYLGEI 320
FN E I+ + E+ LPG HNLEN LAAI K G NEA+ +VLTSF GVKHRLQY+ +
Sbjct: 181 FNGEAILPLEEVVLPGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTV 240
Query: 321 DGRKVYNDSKATNILATQKALSGFDNSKLWLLAGGLDRGNGFEELEKDLQDLKGMVVFGQ 380
+GRK YNDSKATNILAT K LS FD + LLAGGLDRGNGF++L+ ++ +K ++ FGQ
Sbjct: 241 NGRKFYNDSKATNILATSKRLSAFDKPVI-LLAGGLDRGNGFDDLKPYMKHVKAVLTFGQ 299
Query: 381 TANKLRLTAEKLNIP-VFDSENVAKALEEILPQTQAGDTILLSPACASWDQYKTFEERGD 439
TA KL +L I V +NV +A+ + GD ILLSPACASWDQ+KTFEERGD
Sbjct: 300 TAPKLEKLGNELGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGD 359
Query: 440 LFIQAFENLK 449
+FI A LK
Sbjct: 360 MFIDAVHMLK 369
dbj|BAA22556| (AB007500) MURD [Staphylococcus aureus]
Length = 269
Score = 223 bits (563), Expect = 2e-57
Identities = 117/271 (43%), Positives = 177/271 (65%), Gaps = 2/271 (0%)
Query: 1 MKKITKFKDQKILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVI 60
M T +++ +LV+GLA+SG AA +L++LGA VTVNDGK ++ A+ L GI V+
Sbjct: 1 MLNYTGLENKNVLVVGLAKSGYEAAKLLSKLGANVTVNDGKDLSQDAHAKDLESMGISVV 60
Query: 61 TGSHPIDLLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXX 120
+GSHP+ LLD + ++VKNPGI Y +++ A + ++TEVEL+YLISEAP
Sbjct: 61 SGSHPLTLLDNN-PIIVKNPGIPYTVSIIDEAVKRGLKILTEVELSYLISEAPIIAVTGT 119
Query: 121 XXXXXXXXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFR 180
LI D+ + +LSGNIG+ AS+VA++ +D LV ELSSFQL+GI+ ++
Sbjct: 120 NGKTTVTSLIGDMFKKSRLTGRLSGNIGYVASKVAQEVKPTDYLVTELSSFQLLGIEKYK 179
Query: 181 PKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATV 240
P IA+ITN++SAHLDYH + + Y+ AK +I +N T +D+LI N++Q + +++ KA
Sbjct: 180 PHIAIITNIYSAHLDYHENLENYQNAKKQIYKNQTEEDYLICNYHQRQVIE-SEELKAKT 238
Query: 241 LAFSTKEKVNGAYSKDGKIYFNDEYIMEVSE 271
L FST+++V+G Y KDG I + I+ +
Sbjct: 239 LYFSTQQEVDGIYIKDGFIVYKGVRIINTED 269
sp|Q9ZDC2|MURD_RICPR UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
(D-GLUTAMIC ACID ADDING ENZYME)
>gi|3860967|emb|CAA14867| (AJ235271)
UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE (murD)
[Rickettsia prowazekii]
Length = 445
Score = 206 bits (518), Expect = 4e-52
Identities = 141/450 (31%), Positives = 236/450 (52%), Gaps = 28/450 (6%)
Query: 7 FKDQKILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPI 66
+K QKI + GL ++G++ L ++ +D E N++ K + G++ I
Sbjct: 4 YKKQKIGIFGLGKTGISVYEELKNKYDLIVYDD---LEANRDI-------FKELFGNNLI 53
Query: 67 DLLDE----DFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISE-APXXXXXXXX 121
+L + D +V +PG+ + +V A NIP+I++++L + S+
Sbjct: 54 TVLSDSRWQDLDKIVLSPGVPLTHEVVRIAHHFNIPIISDIDLFFEKSKNLKFIAITGTN 113
Query: 122 XXXXXXXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRP 181
LI+ ILN++G ++GNIG PA + KAS ++ V+ELSSFQL + SF
Sbjct: 114 GKSTTTALISHILNSNGLDYPVAGNIGVPALQA--KAS-NEGYVLELSSFQLDLVKSFTV 170
Query: 182 KIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRN----LADKTK 237
K+A++ N+ HLD + Y AAK +I + M D + ++N + + CR L
Sbjct: 171 KVAVLLNITPDHLDRYQDMNDYIAAKAKIFDRMDKDSYAVINIDNDYCRKIFVLLQKDQS 230
Query: 238 ATVLAFS-TKEKVNGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTK 296
++ FS TK NG D KI+ ND +L G HN EN A+ +K+ G +
Sbjct: 231 IKLIPFSVTKILKNGISIVDDKIHDNDLTYKLPLNKNLQGLHNCENIAASYAVAKIIGLE 290
Query: 297 NEAIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLAGGL 356
++ I+E ++SF + HR+QY+G I+ YNDSKATN ++ +++ DN ++ LAGG+
Sbjct: 291 SKKILESISSFQSLHHRMQYIGSINNISFYNDSKATNAISALQSIKALDN--IYWLAGGI 348
Query: 357 DRGNGFEELEKDLQDLKGMVVFGQTANKLRLTAEK-LNIPVFDSENVA--KALEEILPQT 413
+ G E ++ +K +GQ TA+ ++ + D+ A A ++ + T
Sbjct: 349 PKEGGIEGIKPYFNKIKKAYFYGQAKAMFANTAKNIIDFVICDNLEYAFNIAYKDAVSDT 408
Query: 414 QAGDTILLSPACASWDQYKTFEERGDLFIQ 443
ILL+P+C+S+DQ+K FEERG+LFI+
Sbjct: 409 TEVKNILLAPSCSSYDQFKNFEERGELFIK 438
emb|CAB51995.1| (AL109663) putative UDP-N-acetylmuramoylalanine-D-glutamate ligase
[Streptomyces coelicolor A3(2)]
Length = 471
Score = 194 bits (488), Expect = 1e-48
Identities = 152/473 (32%), Positives = 228/473 (48%), Gaps = 35/473 (7%)
Query: 5 TKFKDQKILVLGLARSGMAAALVLNELGAIVTV-NDGKPFEENKEAQLLLEEGIKVITGS 63
++F + + V GL SG+ AA VL+ LGA VTV NDG +A L G+ V G
Sbjct: 3 SEFSGKHVTVAGLGVSGVPAAKVLHGLGAQVTVVNDGDDERARTQAAELEPLGVTVRLGD 62
Query: 64 HPIDLLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLI------SEAPXXXX 117
D L E L+V PG + P+ A +PV +VELA+ + AP
Sbjct: 63 G--DTLPEGTELIVTAPGWKPTKPLFTAAGQAGVPVWGDVELAWRLRGLNGRKPAPWLAV 120
Query: 118 XXXXXXXXXXXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGID 177
++A IL A G GNIG + D L +ELSS+QL
Sbjct: 121 TGTNGKTTTVQMLASILKAAGLRTAAVGNIGVSLLDAVTGEQEYDVLAVELSSYQLHWAP 180
Query: 178 SFRPKIALITNLFSAHLDYHGSQKAYEAAKWRIQE-----------NMTSDDFLILNFNQ 226
S R A + NL HLD+HGS +AY A K RI E + ++D + +
Sbjct: 181 SLRAHSAAVLNLAPDHLDWHGSMEAYAADKGRIYEGNHVACVYNVADKATEDLVRAADVE 240
Query: 227 EKCRNLA---DKTKATVLAFSTKEKVNGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENA 283
E CR + + L V+ A+ +D + N + + EVS+++ P HN+ NA
Sbjct: 241 EGCRAIGFTLGTPGPSQLGVVEGLLVDRAFVEDRQ--KNAQELAEVSDVNPPAPHNIANA 298
Query: 284 LAAIVASKLQGTKNEAIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSG 343
LAA ++ G A+ + L +F HR+ ++ ++DG +DSKATN AT+ +L+
Sbjct: 299 LAAAGLARAFGVSAAAVRDGLRAFTPDAHRIAHVADVDGVAYVDDSKATNTHATEASLAA 358
Query: 344 FDNSKLWLLAGGLDRGNGFEELEKD-LQDLKGMVVFGQTANKLR--LTAEKLNIPVFDSE 400
++ S +W +AGGL +G F+EL + L+G V+ G +R L +PV D +
Sbjct: 359 YE-SIVW-IAGGLAKGATFDELVAGAAKRLRGAVLIGADRALIREALARHAPEVPVVDLD 416
Query: 401 N-----VAKALEEILPQTQAGDTILLSPACASWDQYKTFEERGDLFIQAFENL 448
+ +A++E + GDT+LL+PACAS D + + +RGD F QA L
Sbjct: 417 RTDTGAMLQAVQEARRLARPGDTVLLAPACASMDMFTNYNQRGDAFAQAVREL 469
gi|2984290 (AE000771) UDP-N-acetylmuramoylalanine-D-glutamate ligase [Aquifex
aeolicus]
Length = 415
Score = 176 bits (442), Expect = 3e-43
Identities = 134/437 (30%), Positives = 210/437 (47%), Gaps = 30/437 (6%)
Query: 11 KILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPIDLLD 70
K LV GL RSG A +L E G V D +++ +L E +V T
Sbjct: 2 KFLVWGLGRSGKGALKLLKERGFEVYAGD-----DSQNPELWREVLGEVDT--------- 47
Query: 71 EDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXXXXXXXXXXLI 130
+V +PGI +P+ + A V+ E+ELAY + L
Sbjct: 48 -----VVLSPGIPPSHPLWKEALKKEKEVVGELELAYRFFKGKVIAITGTDGKSTTTRLT 102
Query: 131 ADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIALITNLF 190
IL +GNIG P SEV + + V+E+SSFQ + +FRP I +
Sbjct: 103 YLILKKFFDEVFEAGNIGKPFSEVVLE-NPEGIAVLEVSSFQGKTLKTFRPNIGAFISFS 161
Query: 191 SAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATVLAFSTKEKVN 250
HLD+H S + Y +K+RI EN T +DFLILN +L + K T + + K +
Sbjct: 162 VDHLDWHPSIEDYLKSKYRIFENQTEEDFLILN-------DLVYEIKKTP-SRARKVLFS 213
Query: 251 GAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNEAIVEVLTSFAGV 310
Y +++ D + L + G HN+ NA A + + G K E EV+ F G+
Sbjct: 214 ELYINSDSVFYKDIRLFNPKNLKIRGLHNVYNASVASLIALTLGLKPEDFEEVIYEFRGL 273
Query: 311 KHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLAGGLDRGNGFEELEKDLQ 370
HRL++LG +G +VYNDSK+T A AL F ++ + L+ GG D+G F L +Q
Sbjct: 274 PHRLEFLGNFNGVEVYNDSKSTTPHALMHALKTFPDNSVILIVGGKDKGADFYSLRHIVQ 333
Query: 371 -DLKGMVVFGQTANKLRLTAEKLNIPVFDSENVAKALEEILPQTQAGDTILLSPACASWD 429
+K + G+T K++ + + + V + +A++ ++ G+ +L SPAC+S+D
Sbjct: 334 KKVKIALAIGETKEKIKDSWKDIT-EVKTCNTLEEAVKLAREVSKLGNVVLFSPACSSFD 392
Query: 430 QYKTFEERGDLFIQAFE 446
++ +EERG+ F + E
Sbjct: 393 MFRNYEERGEKFKELVE 409
sp|P73668|MURD_SYNY3 UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
(D-GLUTAMIC ACID ADDING ENZYME)
>gi|1652794|dbj|BAA17713| (D90908)
UDP-N-acetylmuramoylalanine-D-glutamate ligase
[Synechocystis sp.]
Length = 452
Score = 168 bits (421), Expect = 9e-41
Identities = 130/443 (29%), Positives = 207/443 (46%), Gaps = 19/443 (4%)
Query: 14 VLGLARSGMAAALVLNELGAIVTVNDGKPFEENKE-AQLLLEEGIKVITGSHPIDLLDED 72
V+GL RSG+AAA VL+ G VTV D ++ + Q L++EGI + G + +
Sbjct: 6 VIGLGRSGIAAARVLHRDGWQVTVFDQADNDQLRHMGQPLVQEGISLKLGDRLDPVKEAW 65
Query: 73 FALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEA-PXXXXXXXXXXXXXXXLIA 131
+V +PG+ +D P++ A + V E+ELA+ A P L+
Sbjct: 66 PERIVVSPGVPWDIPLLVAAREKGVEVTGELELAWQYLHAVPWVGITGTNGKTTTTSLVQ 125
Query: 132 DILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIALITNLFS 191
I G +A GNIG+ A E+ + D +V E+SS+Q+ + P+I L T
Sbjct: 126 AIFQKAGLNAPACGNIGYAACELVLQNQNYDWIVAEISSYQIESSPTLAPQIGLWTTFTP 185
Query: 192 AHLDYHGSQKAYEAAKWRIQENMTSDDFL-ILNFNQEKCRNLADKTKATVLAFSTK---- 246
HL H + + Y + I+ ++ S + +LN + + ST+
Sbjct: 186 DHLSRHKTLENY----FNIKASLLSRSAIQVLNGDDPHLHSHGPNLYPQAHWTSTQGANH 241
Query: 247 -----EKVNGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNEAIV 301
+ G Y +D + E I ++ +PG+HN +N L AI A++L G +AI
Sbjct: 242 LAGLCDPKQGVYLQDNWVNAFGELIAPINLFKMPGQHNQQNLLMAIAAARLAGIDKKAIT 301
Query: 302 EVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLAGGLDRGNG 361
E L +F GV HRL+ + I+G + NDSKATN A + LS + + G G+
Sbjct: 302 ETLLTFTGVPHRLEPICTINGVQFINDSKATNYDAAEVGLSSMKGPTILIAGGEAKEGDD 361
Query: 362 FEELEKDLQDLKGMVVFGQTANKLRLTAEKLNIPVFD-SENVAKALEE--ILPQTQAGDT 418
L + Q +++ G A + + ++ E +A A++ L
Sbjct: 362 QAWLAQIRQKAVAVLLIGDAAPNFATRLKAVGYENYEIVETMANAVQRGLELASKNNASA 421
Query: 419 ILLSPACASWDQYKTFEERGDLF 441
+LLSPACAS+DQY +FEERG+ F
Sbjct: 422 VLLSPACASFDQYNSFEERGEDF 444
sp|P14900|MURD_ECOLI UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
(D-GLUTAMIC ACID ADDING ENZYME) >gi|68625|pir||CEECME
UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC
6.3.2.9) - Escherichia coli >gi|40856|emb|CAA38865.1|
(X55034) UDP-MurNac-L-Ala-D-Glu (MurD) (AA 1-438)
[Escherichia coli] >gi|42060|emb|CAA35933| (X51584) murD
gene product (AA 1-438) [Escherichia coli]
>gi|216502|dbj|BAA01353| (D10483)
UDP-N-acetylmuramoylalanine-D-glutamate ligase
[Escherichia coli] >gi|1786276 (AE000118)
UDP-N-acetylmuramoylalanine-D-glutamate ligase
[Escherichia coli]
Length = 438
Score = 167 bits (418), Expect = 2e-40
Identities = 131/455 (28%), Positives = 218/455 (47%), Gaps = 34/455 (7%)
Query: 7 FKDQKILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPI 66
++ + ++++GL +G++ G V D + + L E ++ TGS
Sbjct: 4 YQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDK---LPEAVERHTGSLND 60
Query: 67 D-LLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXXXXXXX 125
+ L+ D L+V +PGI +P + A I ++ ++EL ++AP
Sbjct: 61 EWLMAAD--LIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKST 118
Query: 126 XXXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIAL 185
L+ ++ A G + + GNIG PA + + + V+ELSSFQL S + A
Sbjct: 119 VTTLVGEMAKAAGVNVGVGGNIGLPALMLLD--DECELYVLELSSFQLETTSSLQAVAAT 176
Query: 186 ITNLFSAHLD-YHGSQKAYEAAKWRIQEN-----MTSDDFLILNFN--QEKCRNLADKTK 237
I N+ H+D Y + Y AAK RI EN + +DD L + E+C
Sbjct: 177 ILNVTEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERC-------- 228
Query: 238 ATVLAFSTKEKVNGAYSKDGKIYFN--DEYIMEVSELSLPGEHNLENALAAIVASKLQGT 295
++F + G+ + E ++ V E+ L G+HN NALAA+ + G
Sbjct: 229 ---VSFGVNMGDYHLNHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGL 285
Query: 296 KNEAIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFD-NSKLWLLAG 354
+ ++ LT+F G+ HR + + E +G + NDSKATN+ +T+ AL+G + L LL G
Sbjct: 286 PRASSLKALTTFTGLPHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLG 345
Query: 355 GLDRGNGFEELEKDLQ-DLKGMVVFGQTANKLRLTAEKLNIPVFDSENVAKALEEILPQT 413
G + F L + L D + FG+ +L ++ +E + +A+ + P+
Sbjct: 346 GDGKSADFSPLARYLNGDNVRLYCFGRDGAQLAALRPEV---AEQTETMEQAMRLLAPRV 402
Query: 414 QAGDTILLSPACASWDQYKTFEERGDLFIQAFENL 448
Q GD +LLSPACAS DQ+K FE+RG+ F + + L
Sbjct: 403 QPGDMVLLSPACASLDQFKNFEQRGNEFARLAKEL 437
gb|AAD35325.1|AE001707_12 (AE001707) UDP-N-acetylmuramoylalanine--D-glutamate ligase
[Thermotoga maritima]
Length = 430
Score = 166 bits (416), Expect = 3e-40
Identities = 141/445 (31%), Positives = 219/445 (48%), Gaps = 32/445 (7%)
Query: 11 KILVLGLARSGMAAA-LVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPIDLL 69
KI LG +S + +LN A V++ K + + + L E ++ G H LL
Sbjct: 2 KIGFLGFGKSNRSLLKYLLNHQEAKFFVSEAKTLD-GETKKFLEEHSVEYEEGGHTEKLL 60
Query: 70 DEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXXXXX--XXXX 127
D D + +PGI+ D M+E + + + TE++ +L + P
Sbjct: 61 DCDVVYV--SPGIKPDTSMIELLSSRGVKLSTELQF-FLDNVDPKKVVGITGTDGKSTAT 117
Query: 128 XLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIA--L 185
L+ +L+ G L GN G PA E E D V+E+SSFQL S RP ++ L
Sbjct: 118 ALMYHVLSGRGFKTFLGGNFGTPAVEALE--GEYDYYVLEMSSFQLFW--SERPYLSNFL 173
Query: 186 ITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATVLAFST 245
+ N+ HLD+H S K Y +K + T D + N + E+ RNL + ++ + F T
Sbjct: 174 VLNISEDHLDWHSSFKEYVDSKLKPAFLQTEGDLFVYNKHIERLRNL-EGVRSRKIPFWT 232
Query: 246 KEKVNGAYSKDGKIYFNDEYIMEVSELSLPGEHNL---ENALAAIVASKLQGTKNEAIVE 302
E N A K E I+ + +LPG + EN LA V + E+ +E
Sbjct: 233 DE--NFATEK--------ELIVRGKKYTLPGNYPYQMRENILAVSVLYMEMFNELESFLE 282
Query: 303 VLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLAGGLDRGNGF 362
+L F + HR++YLG+IDGR YNDSKAT+ A ALS FD K+ L+ G+ + +
Sbjct: 283 LLRDFKPLPHRMEYLGQIDGRHFYNDSKATSTHAVLGALSNFD--KVVLIMCGIGKKENY 340
Query: 363 E-ELEKDLQDLKGMVVFGQTANKLRLTAEKLNIPVFDSENVAKALEEILPQTQAGDTILL 421
+EK LK +++FG+ + +L K IP EN+ +A E+ + ++ GD ILL
Sbjct: 341 SLFVEKASPKLKHLIMFGEISKELAPFVGK--IPHSIVENMEEAFEKAMEVSEKGDVILL 398
Query: 422 SPACASWDQYKTFEERGDLFIQAFE 446
SP AS+D Y+ + +RG+ F + F+
Sbjct: 399 SPGGASFDMYENYAKRGEHFREIFK 423
emb|CAA35611| (X17609) UDP-N-acetylmuramoyl-L-alanine:D-gluta ligase (AA 1-438)
[Escherichia coli]
Length = 438
Score = 166 bits (415), Expect = 4e-40
Identities = 130/455 (28%), Positives = 217/455 (47%), Gaps = 34/455 (7%)
Query: 7 FKDQKILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPI 66
++ + ++++GL +G++ G V D + + L E ++ TGS
Sbjct: 4 YQGKNVVIIGLGLTGLSCVDFFLAAGVTPRVMDTRMTPPGLDK---LPEAVERHTGSLND 60
Query: 67 D-LLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXXXXXXX 125
+ L+ D L+V +PGI +P + A I ++ ++EL ++AP
Sbjct: 61 EWLMAAD--LIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKST 118
Query: 126 XXXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIAL 185
L+ ++ A G + + GNIG PA + + + V+ELSSFQL S + A
Sbjct: 119 VTTLVGEMAKAAGVNVGVGGNIGLPALMLLD--DECELYVLELSSFQLETTSSLQAVTAT 176
Query: 186 ITNLFSAHLD-YHGSQKAYEAAKWRIQEN-----MTSDDFLILNFN--QEKCRNLADKTK 237
I N+ H+D Y + Y AAK RI EN + +DD L + E+C
Sbjct: 177 ILNVTEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERC-------- 228
Query: 238 ATVLAFSTKEKVNGAYSKDGKIYFN--DEYIMEVSELSLPGEHNLENALAAIVASKLQGT 295
++F + G+ + E ++ V E+ L G+HN NALA + + G
Sbjct: 229 ---VSFGVNMGDYHLNHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALARVALADAAGL 285
Query: 296 KNEAIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFD-NSKLWLLAG 354
+ ++ LT+F G+ HR + + E +G + NDSKATN+ +T+ AL+G + L LL G
Sbjct: 286 PRASSLKALTTFTGLPHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLG 345
Query: 355 GLDRGNGFEELEKDLQ-DLKGMVVFGQTANKLRLTAEKLNIPVFDSENVAKALEEILPQT 413
G + F L + L D + FG+ +L ++ +E + +A+ + P+
Sbjct: 346 GDGKSADFSPLARYLNGDNVRLYCFGRDGAQLAALRPEV---AEQTETMEQAMRLLAPRV 402
Query: 414 QAGDTILLSPACASWDQYKTFEERGDLFIQAFENL 448
Q GD +LLSPACAS DQ+K FE+RG+ F + + L
Sbjct: 403 QPGDMVLLSPACASLDQFKNFEQRGNEFARLAKEL 437
sp|P45063|MURD_HAEIN UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
(D-GLUTAMIC ACID ADDING ENZYME) >gi|1075422|pir||B64185
UDP-N-acetylmuramoylalanine-D-glutamate ligase (murD)
homolog - Haemophilus influenzae (strain Rd KW20)
>gi|1574691 (U32793)
UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD)
[Haemophilus influenzae Rd]
Length = 437
Score = 165 bits (414), Expect = 6e-40
Identities = 130/445 (29%), Positives = 216/445 (48%), Gaps = 29/445 (6%)
Query: 7 FKDQKILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPI 66
++++ I ++GL ++G++ L A + V D + +N L + I + TGS
Sbjct: 4 YQNKNITIIGLGKTGLSCVDYLLSQQANIRVIDTR---KNPTGIDKLPQNIPLHTGSLNQ 60
Query: 67 D-LLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXXXXXXX 125
+ LL+ D ++V +PG+ P ++ A + VI ++EL + P
Sbjct: 61 EWLLESD--MIVISPGLAVKTPEIQTALKAGVEVIGDIELFCRAATKPIVGITGSNGKST 118
Query: 126 XXXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIAL 185
L+ ++ A G + GNIG PA + + + V+ELSSFQL S + A
Sbjct: 119 VTTLVYEMAKAAGVKVGMGGNIGIPALSLLNEDC--ELYVLELSSFQLETTYSLKAAAAT 176
Query: 186 ITNLFSAHLDYHGSQKAYEAAKWRIQEN-----MTSDDFLILNFNQEKCRNLADKTKATV 240
+ N+ H+D + + Y AK RI N + ++D L N+ + ++
Sbjct: 177 VLNVTEDHMDRYMDLEDYRQAKLRIYHNAKVGVLNNEDRLTFGENENQAKH--------T 228
Query: 241 LAFSTKEKVNGAYSKDGKIYF--NDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNE 298
++F+ +++GK Y DE I+ E +L G HN N LAA ++ G +
Sbjct: 229 VSFAENSADYWLKTENGKQYLMVKDEVILPCEEATLVGRHNYMNILAATALAQAIGINLD 288
Query: 299 AIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSG-FDNSKLWLLAGGLD 357
+I L F G+ HR Q + + +G + NDSKATN+ +T AL+G + KL LL GG
Sbjct: 289 SIRTALRHFKGLDHRFQLVHQANGIRWINDSKATNVGSTVAALAGLYIEGKLHLLLGGDG 348
Query: 358 RGNGFEELEKDL-QDLKGMVVFGQTANKLRLTAEKLNIPVFDSENVAKALEEILPQTQAG 416
+G F EL + + Q FG+ L K + + + + +A+E + P Q+G
Sbjct: 349 KGADFSELAELINQPHIICYCFGRDGALL----AKFSSQSYLFDTMEQAIEFLRPTLQSG 404
Query: 417 DTILLSPACASWDQYKTFEERGDLF 441
D +LLSPACAS DQ+ +FE+RG+ F
Sbjct: 405 DMVLLSPACASLDQFASFEKRGEEF 429
pdb|1UAG| Udp-N-Acetylmuramoyl-L-Alanine:d-Glutamate Ligase
Length = 437
Score = 164 bits (412), Expect = 1e-39
Identities = 130/455 (28%), Positives = 217/455 (47%), Gaps = 34/455 (7%)
Query: 7 FKDQKILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPI 66
++ + ++++GL +G++ G V D + + L E ++ TGS
Sbjct: 3 YQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDK---LPEAVERHTGSLND 59
Query: 67 D-LLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXXXXXXX 125
+ L+ D L+V +PGI +P + A I ++ ++EL ++AP
Sbjct: 60 EWLMAAD--LIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKST 117
Query: 126 XXXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIAL 185
L+ ++ A G + + GNIG PA + + + V+ELSSFQL S + A
Sbjct: 118 VTTLVGEMAKAAGVNVGVGGNIGLPALMLLD--DECELYVLELSSFQLETTSSLQAVAAT 175
Query: 186 ITNLFSAHLD-YHGSQKAYEAAKWRIQEN-----MTSDDFLILNFN--QEKCRNLADKTK 237
I N+ H+D Y + Y AA RI EN + +DD L + E+C
Sbjct: 176 ILNVTEDHMDRYPFGLQQYRAAXLRIYENAKVCVVNADDALTMPIRGADERC-------- 227
Query: 238 ATVLAFSTKEKVNGAYSKDGKIYFN--DEYIMEVSELSLPGEHNLENALAAIVASKLQGT 295
++F + G+ + E ++ V E+ L G+HN NALAA+ + G
Sbjct: 228 ---VSFGVNMGDYHLNHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGL 284
Query: 296 KNEAIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFD-NSKLWLLAG 354
+ ++ LT+F G+ HR + + E +G + NDSKATN+ +T+ AL+G + L LL G
Sbjct: 285 PRASSLKALTTFTGLPHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLG 344
Query: 355 GLDRGNGFEELEKDLQ-DLKGMVVFGQTANKLRLTAEKLNIPVFDSENVAKALEEILPQT 413
G + F L + L D + FG+ +L ++ +E + +A+ + P+
Sbjct: 345 GDGKSADFSPLARYLNGDNVRLYCFGRDGAQLAALRPEV---AEQTETMEQAMRLLAPRV 401
Query: 414 QAGDTILLSPACASWDQYKTFEERGDLFIQAFENL 448
Q GD +LLSPACAS DQ+K FE+RG+ F + + L
Sbjct: 402 QPGDMVLLSPACASLDQFKNFEQRGNEFARLAKEL 436
gb|AAD19039| (AE001670) Muramoylalanine-Glutamate Ligase [Chlamydia pneumoniae]
Length = 417
Score = 147 bits (367), Expect = 2e-34
Identities = 128/443 (28%), Positives = 210/443 (46%), Gaps = 50/443 (11%)
Query: 10 QKILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGI--KVITGSHPID 67
Q+IL+LG +G + A L + G + D N L+ + + +++ G+
Sbjct: 3 QRILILGTGITGKSVARFLYQQGHYLIGAD------NSLESLISVDHLHDRLLMGASEFP 56
Query: 68 LLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEA---PXXXXXXXXXXX 124
E+ L++++PGI+ +P VE+A +L IPV+T++++A E P
Sbjct: 57 ---ENIDLVIRSPGIKPYHPWVEQAVSLKIPVVTDIQVALKTPEFQRYPSFGITGSNGKT 113
Query: 125 XXXXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIA 184
+ +LN G A GNIG P + + V+E+SSFQL + P ++
Sbjct: 114 TTTLFLTHLLNTLGIPAIAMGNIGLP---ILDHMGQPGVRVVEISSFQLATQEEHIPALS 170
Query: 185 --LITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATVLA 242
+ N HLDYH + AY AK RIQ+ + D + E+C
Sbjct: 171 GSVFLNFSRNHLDYHRNLDAYFDAKLRIQKCLRQDKTFWV---WEEC------------- 214
Query: 243 FSTKEKVNGAYSKDGKIYFND-EYIMEVSELSLPGE-HNLENALAAI-VASKLQGTKNEA 299
+ +Y +IY + E I++ + P H+ +N AA +A+++ E
Sbjct: 215 -----SLGNSY----QIYSEEIEEILDKGDALKPIYLHDRDNYCAAYALANEVGWVSPEG 265
Query: 300 IVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLAGGLDRG 359
++ + +F HRL+YLG+ DG NDSKAT + A +KAL + +L GG D+G
Sbjct: 266 FLKAIRTFEKPAHRLEYLGKKDGVHYINDSKATTVTAVEKALMAVGKDVIVIL-GGKDKG 324
Query: 360 NGFEELEKDL-QDLKGMVVFGQTANKLRLTAEKLNIPVFDSENVAKALEEILPQTQAGDT 418
F L L Q K ++ G+ + A IP+ S+++ +A+ Q GDT
Sbjct: 325 GDFPALASVLSQTTKHVIAMGECRQTIA-DALSEKIPLTLSKDLQEAVSIAQTIAQEGDT 383
Query: 419 ILLSPACASWDQYKTFEERGDLF 441
+LLSP CAS+DQ+++F+ERG F
Sbjct: 384 VLLSPGCASFDQFQSFKERGAYF 406
sp|O06222|MURD_MYCTU UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
(D-GLUTAMIC ACID ADDING ENZYME)
>gi|2104323|emb|CAB08672| (Z95388) murD [Mycobacterium
tuberculosis]
Length = 486
Score = 139 bits (348), Expect = 3e-32
Identities = 130/486 (26%), Positives = 208/486 (42%), Gaps = 69/486 (14%)
Query: 12 ILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPIDLLDE 71
+LV G +G A A VL GA TV D P A E G+ ++ S + +
Sbjct: 11 VLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHA----ERGLPTVSSSDAVQQIT- 65
Query: 72 DFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEA-------PXXXXXXXXXXX 124
+AL+V +PG P++ A A +P+ +VELA+ + A
Sbjct: 66 GYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGTNGKT 125
Query: 125 XXXXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIA 184
++ +L A G+ A L GNIG +V ++ + + L +ELSSFQL S RP+
Sbjct: 126 TTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPA--ELLAVELSSFQLHWAPSLRPEAG 183
Query: 185 LITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATV-LAF 243
+ N+ HLD+H + Y AAK R+ + + + + L D + A V + F
Sbjct: 184 AVLNIAEDHLDWHATMAEYTAAKARV----LTGGVAVAGLDDSRAAALLDGSPAQVRVGF 239
Query: 244 STKEK------VNGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKN 297
E V A+ D + + +D ++ V+ + +PG + +ALAA ++ G
Sbjct: 240 RLGEPAARELGVRDAHLVD-RAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPA 298
Query: 298 EAIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLAG--- 354
AI + +TSF +HR + + DG +DSKATN A + ++ + +W+ G
Sbjct: 299 GAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRV-VWIAGGLLK 357
Query: 355 ---------------------GLDRGNGFEELEKDLQDLKGMVVFGQTANKLRLTAEKLN 393
G DR E L + D+ + V + T E
Sbjct: 358 GASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVE--- 414
Query: 394 IPVFDSENVAK---------------ALEEILPQTQAGDTILLSPACASWDQYKTFEERG 438
+PV +VAK A+ Q GDT+LL+PA AS+DQ+ + +RG
Sbjct: 415 VPVACVLDVAKDDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRG 474
Query: 439 DLFIQA 444
+ F A
Sbjct: 475 EAFATA 480
sp|O51532|MURD_BORBU UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
(D-GLUTAMIC ACID ADDING ENZYME) >gi|2688512 (AE001160)
UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD)
[Borrelia burgdorferi]
Length = 451
Score = 139 bits (347), Expect = 4e-32
Identities = 117/450 (26%), Positives = 213/450 (47%), Gaps = 25/450 (5%)
Query: 12 ILVLGLARSGMAAALVLNELGAIVTVNDGKPFEE---NKEAQLLLEEGIKVITGSHPI-D 67
I+ LGL G+A + L + GA + + D K E + +A E+ I+ + G H + D
Sbjct: 13 IMGLGLNGGGVALSRFLLKRGAKLVITDLKSETELALSIDALRDFEDQIRYVLGKHDVND 72
Query: 68 LLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXXXXXXXXX 127
+ D ++VKNPG++ +N ++ A+ + T++ L + ++ P
Sbjct: 73 FKNAD--IVVKNPGVKPNNKYLKFAKRIE----TDISLFLMFNKNPIVAVTGTKGKSTLV 126
Query: 128 XLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIALIT 187
L+ L KL GNIG ++ L++ELSS+QL +++F P I++IT
Sbjct: 127 SLLYQALKEKYPGVKLGGNIGVSPLSFFDQLDGKSPLILELSSWQLQSLENFNPIISIIT 186
Query: 188 NLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLAD-KTKATVLAFSTK 246
N+++ H +Y+ + Y K +I N TS +++ +Q C+ + K+K V+ FS
Sbjct: 187 NVYNDHQNYYLNFDDYIIDKSKIFVNQTSG--IVIIQDQAYCKYFSKFKSKVRVILFSEF 244
Query: 247 EKVNG----AYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNEAIVE 302
+ Y +GK+YFND I S + + + V+ L N +
Sbjct: 245 NPCDFDQDIFYCNEGKVYFNDSLIGSFS--NSRAVFIIPKVITFFVSYYLNIDLNRT-GQ 301
Query: 303 VLTSFAGVKHRLQYLGEIDGRKVYNDSKAT---NILATQKALSGFDNSKLWLLAGGLDRG 359
+L++F G++HRL+++ + YND+ +T + + + K+L DN ++ L+ GG D+
Sbjct: 302 ILSNFKGIEHRLEFVKSVQNVMFYNDTASTIPESTVLSVKSLKTKDN-RINLIVGGTDKE 360
Query: 360 NGFEELEKDLQDLKGMVVF-GQTANKLRLTAEKLNIPVFDSENVAKALEEILPQTQAGDT 418
F K ++ ++ G K+ EK +I F +++ A+ + GD
Sbjct: 361 LDFLSFSKIADIVRTWILIRGSATVKIIKILEKSSIQYFLFDSLRDAVNYAFKISSPGDI 420
Query: 419 ILLSPACASWDQYKTFEERGDLFIQAFENL 448
+L SPA AS++ + +RG F NL
Sbjct: 421 VLFSPASASFELFNNEFDRGLQFKNLVNNL 450
gb|AAC68353.1| (AE001348) UDP-N-acetylmuramoylalanine-D-glutamate ligase
[Chlamydia trachomatis]
Length = 416
Score = 138 bits (345), Expect = 7e-32
Identities = 121/451 (26%), Positives = 204/451 (44%), Gaps = 64/451 (14%)
Query: 10 QKILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPIDLL 69
++++V+GL SG + A L + G V D K + + E+ ++ +D +
Sbjct: 4 ERVVVIGLGVSGRSIAHFLAQKGVCVLGVD-KSLHALQNCPYIQEKYLENEEFPSQVDYV 62
Query: 70 DEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYL---ISEAPXXXXXXXXXXXXX 126
V++PG+ ++P V+ A A +IPV+ +++LA+ +E
Sbjct: 63 -------VRSPGVSKEHPWVQAAIASHIPVMADIQLAFQTEKFTERESLAITGTTGKTTT 115
Query: 127 XXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIA-- 184
+ + G A GN+G P + + ++E+SSFQL + P ++
Sbjct: 116 ILFLEYLFKRSGIPAFAMGNVGIPILDGMQNPGVR---IVEISSFQLADQEKSYPVLSGG 172
Query: 185 LITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQ----------EKCRNLAD 234
+I N+ HLDYHG+ Y AK + M + D L + + +K L D
Sbjct: 173 MILNISDNHLDYHGNFSEYFQAKQNLALCMRNPDDLWVGDERFYGHLYLEEVQKYMRLLD 232
Query: 235 KTKATVLAFSTKEKVNGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQG 294
K A +Y +D+Y N A + +K +
Sbjct: 233 KESALK-----------------PLYLHDKY----------------NYCCAYLLAKTEF 259
Query: 295 TKNE-AIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLA 353
+E + +E + +F HR++YLG+ G NDSKAT + AT+ AL G N + +L
Sbjct: 260 PISETSFIEAVATFNKPPHRMEYLGQKQGIHYINDSKATTVSATETALLGVGNQAIVIL- 318
Query: 354 GGLDRGNGFEELEKDLQDL-KGMVVFGQTANKLRLTAEKLNIPVFDSENVAKALEEILPQ 412
GG ++G F L L+ K +V G+ A ++ E+ PV +N+++AL Q
Sbjct: 319 GGRNKGCTFSSLLPALRKAAKSVVAMGECAQEIARDLEEF--PVTVVKNLSEALLCAEEQ 376
Query: 413 TQAGDTILLSPACASWDQYKTFEERGDLFIQ 443
GD I+LSPACAS+DQ++++EERG +F Q
Sbjct: 377 AVPGDVIVLSPACASFDQFRSYEERGAMFKQ 407
emb|CAA18670.1| (AL022602) udp-n-acetylmuramoylalanine-- d-glutamate ligase
[Mycobacterium leprae]
Length = 490
Score = 133 bits (331), Expect = 3e-30
Identities = 125/484 (25%), Positives = 205/484 (41%), Gaps = 61/484 (12%)
Query: 12 ILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPIDLLDE 71
+LV G +G A L G T+ D P Q + G+ ++ + + E
Sbjct: 11 VLVAGGGVTGRAVLAALTRFGMAATLCDDDP----AALQQYADNGVATVSAATATQQMFE 66
Query: 72 ---DFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXX-------XXXXX 121
+ L+V +PG P++ A A +P+ +VELA+ + A
Sbjct: 67 RGRKYVLVVTSPGFAPTTPVLVAASAARVPIWGDVELAWRLDAAGYYGPPRRWLVVTGTN 126
Query: 122 XXXXXXXLIADILNADGQSAKLSGNIGFPASEV-AEKASASDTLVMELSSFQLMGIDSFR 180
++ +L AD + + L GNIG P +V E A SD L +ELSSFQL S R
Sbjct: 127 GKTTTTSMLHAMLAADNRRSLLCGNIGRPVLDVLTEFAEPSDFLAVELSSFQLHWAPSLR 186
Query: 181 PKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATV 240
P+ ++ N+ HLD+H + Y AK R+ + ++ + + L T A V
Sbjct: 187 PEAGVVLNIAEDHLDWHSTMADYTMAKARVLTGRVA----VVGLDDSRAAALLSTTVAPV 242
Query: 241 -LAFSTKEKVNGAYS-KDG----KIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQG 294
+ F E G +DG + + D +M V+ + + G + +ALAA ++ G
Sbjct: 243 RVGFRFGEPAVGELGVRDGYLVDRAFAEDLALMPVTSIPVSGPVGVLDALAAAALARSVG 302
Query: 295 TKNEAIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLAG 354
AI + + F +HR + + DG + +DSKATN A ++ + +W +AG
Sbjct: 303 VGATAIADAVALFRLGRHRAEVVAVADGIRYVDDSKATNPHAALVSVLAYPR-VVW-VAG 360
Query: 355 GLDRGNGFE-ELEKDLQDLKGMVVFGQTANKL--RLTAEKLNIPV--------------- 396
GL +G + E+ + L G V+ G+ + L+ N+PV
Sbjct: 361 GLLKGASVDAEVARMAPQLVGAVLIGRDRAMVAEALSRHAPNVPVVQVVAGEDAGMHAVA 420
Query: 397 ----------------FDSENVAKALEEILPQTQAGDTILLSPACASWDQYKTFEERGDL 440
+ + A+ Q GDT+LL+PA AS+DQ+ + +RGD
Sbjct: 421 VVSGTDVISISDVGGTIGTRVMVAAVAAARDLAQPGDTVLLAPAGASFDQFSGYADRGDT 480
Query: 441 FIQA 444
F A
Sbjct: 481 FATA 484
gb|AAF12038.1|AE002079_3 (AE002079) UDP-N-acetylmuramoylalanine--D-glutamiate ligase
[Deinococcus radiodurans]
Length = 457
Score = 124 bits (309), Expect = 1e-27
Identities = 128/451 (28%), Positives = 196/451 (43%), Gaps = 43/451 (9%)
Query: 11 KILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPIDLLD 70
++L+ GL RSG A L+ G +D +P E +E + G DL
Sbjct: 26 RVLIYGLGRSGRGVAHFLHGEGVSAFWHDLRPAPE--------DEALMRQLGHRQADL-G 76
Query: 71 EDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAY-LISEAPXXXXXXXXXXXXXXXL 129
+ L+V PG+ D+ + +I EV LA L E P L
Sbjct: 77 GTYDLVVAAPGVPIDHRDLRVLAGRGAEIIGEVALAARLRPELPMVGITGTAGKGSTTVL 136
Query: 130 IADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIALITNL 189
IA +L A G A+ GNI P +V + A + V+ELSSFQL + R +A+ITNL
Sbjct: 137 IAQLLRACGLRAREGGNIDPPLLDVVDDAEVA---VVELSSFQLERVPGLRLPVAVITNL 193
Query: 190 FSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATVLAFSTKEKV 249
HLD HGS + Y AAK I S D L+ + +L T+A + F T E++
Sbjct: 194 GVDHLDRHGSVETYHAAKLNITAGQQSGDVLV------RPADLPVPTRAQTVTF-TPERL 246
Query: 250 NGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKL-----QGTKNEAIVEVL 304
+DG + ++ V++L PG H A A + A L + + + L
Sbjct: 247 ---CLRDG------QEVLPVADLP-PGVHPANAAAALLAAEALLRHLGRAVDPAVLADAL 296
Query: 305 TSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLAGGLDRGNGFEE 364
+ VK R + +G++ DS AT +A + AL WL+ GG D+G
Sbjct: 297 RAAQPVKGRFETVGQLGEVGFIEDSIATRTIAVESALRQARPPIAWLV-GGRDKGAELAP 355
Query: 365 LEKDLQD-LKGMVVFGQ----TANKLRLTAEKLNIPVFDS--ENVAKALEEILPQTQAGD 417
L + + ++ FG+ A L L E + D + +A E L
Sbjct: 356 LRAAAEGRVTRVIAFGEDGEALARDLGLPFEVIKAETGDESMDRAVRAGWEALGGAGGTG 415
Query: 418 TILLSPACASWDQYKTFEERGDLFIQAFENL 448
T+LL+P S+DQ++ +++RG F +A + L
Sbjct: 416 TVLLAPVGTSFDQFRDYQQRGASFRRAVQAL 446
gi|4154982 (AE001479) UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
[Helicobacter pylori J99]
Length = 422
Score = 113 bits (279), Expect = 4e-24
Identities = 106/389 (27%), Positives = 174/389 (44%), Gaps = 37/389 (9%)
Query: 67 DLLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXXXXXXXX 126
D D L + +PGI + +P+V +A+ L + ++ + S P
Sbjct: 50 DFNPNDSQLEIVSPGISFTHPLVMKAKHL-MSEYDYIDSLFDHSFTPTMISISGTNGKTT 108
Query: 127 XXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIALI 186
+ L D ++ GNIG P E+ EK S V+E SSF L + P I L+
Sbjct: 109 TTEMLTTLLEDFKAVS-GGNIGTPLIELFEKRSP--LWVLETSSFSLHYTNKAYPLIYLL 165
Query: 187 TNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATVLAFSTK 246
N+ + HL +H + + Y AK ++ L KT +L K
Sbjct: 166 INVEADHLTWHCNFENYLNAKLKVL-------------------TLMPKTSLAILPLKFK 206
Query: 247 EKVNGAYSKDGKIYFN-DEYIMEV-----SELSLPGEHNLENALAAIVASKLQGTKN--- 297
E S+ KI+F+ E ++E + L G L+ ALA +V + KN
Sbjct: 207 EHPIVQNSQAQKIFFDKSEEVLECLKIPSNALFFKGAFLLDAALALLVYEQFLKIKNLKW 266
Query: 298 ----EAIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLA 353
E ++ L +F H+++ + GR +DSKATNI AT +AL F N K+ L+
Sbjct: 267 QDYRENALKRLNAFKIGSHKMEEFRDKQGRLWVDDSKATNIDATLQALKTFKNQKIHLIL 326
Query: 354 GGLDRGNGFEELEKDLQDLK-GMVVFGQTANKLRLTAEKLNIPVFDSENVAKALEEILPQ 412
GG +G L ++ ++ K + G +A+ ++ A + N+ + KA++EI
Sbjct: 327 GGDIKGVNLTPLFEEFKNYKISLYAIGSSASIIQALALEFNVSCQVCLKLEKAVQEIKSV 386
Query: 413 TQAGDTILLSPACASWDQYKTFEERGDLF 441
+ LLSP+ AS DQ+ +++ERG+ F
Sbjct: 387 LLQNEVALLSPSAASLDQFSSYKERGEKF 415
gb|AAD07560.1| (AE000564) UDP-N-acetylmuramoylalanine-D-glutamate ligase (murD)
[Helicobacter pylori 26695]
Length = 422
Score = 111 bits (275), Expect = 1e-23
Identities = 105/389 (26%), Positives = 173/389 (43%), Gaps = 37/389 (9%)
Query: 67 DLLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXXXXXXXX 126
D D L + +PGI + +P+V +A+ L + + + + P
Sbjct: 50 DFNPNDSQLEIVSPGISFTHPLVIKAKHL-VSEYDYINSLFDLVFTPTIISISGTNGKTT 108
Query: 127 XXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIALI 186
+ +L D ++ GNIG P E+ EK S V+E SSF L + P I L+
Sbjct: 109 TTEMLTMLLEDFKAVS-GGNIGTPLIELFEKRSP--LWVLETSSFSLHYTNKAYPLIYLL 165
Query: 187 TNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATVLAFSTK 246
N+ + HL +H + + Y AK ++ L KT +L K
Sbjct: 166 INIEADHLTWHCNFENYLNAKLKVL-------------------TLMPKTSLAILPLKFK 206
Query: 247 EKVNGAYSKDGKIYFN-DEYIME-----VSELSLPGEHNLENALAAIVASKLQGTKN--- 297
E S+ KI+F+ E ++E + L G L+ ALA +V + KN
Sbjct: 207 EHPIIQNSQAQKIFFDKSEEVLERLKIPSNALFFKGAFLLDAALALLVYEQFLKIKNLKW 266
Query: 298 ----EAIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLA 353
E ++ L +F H+++ + GR +DSKATNI AT +AL F N K+ L+
Sbjct: 267 QDYRENALKRLNAFKIGSHKMEEFRDKQGRLWVDDSKATNIDATLQALKTFKNQKIHLIL 326
Query: 354 GGLDRGNGFEELEKDLQDLK-GMVVFGQTANKLRLTAEKLNIPVFDSENVAKALEEILPQ 412
GG +G L ++ ++ K + G +A ++ A + N+ + KA++EI
Sbjct: 327 GGDIKGVNLTPLFEEFKNYKISLYAIGSSAFIIQALALEFNVSCQVCLELEKAVQEIKSV 386
Query: 413 TQAGDTILLSPACASWDQYKTFEERGDLF 441
+ LLSP+ AS DQ+ +++ERG+ F
Sbjct: 387 LSQNEIALLSPSAASLDQFSSYKERGEKF 415
gi|4204102 (U10879) UDP-N-acetylmuramoylalanine--D-glutamate ligase; MurD;
cell wall synthesis protein [Streptomyces coelicolor]
Length = 221
Score = 110 bits (273), Expect = 2e-23
Identities = 68/195 (34%), Positives = 110/195 (55%), Gaps = 10/195 (5%)
Query: 262 NDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNEAIVEVLTSFAGVKHRLQYLGEID 321
N + + EVS+++ P HN+ NALAA ++ G A+ + L +F HR+ ++ ++D
Sbjct: 27 NAQELAEVSDVNPPAPHNIANALAAAGLARAFGVSAAAVRDGLRAFTPDAHRIAHVADVD 86
Query: 322 GRKVYNDSKATNILATQKALSGFDNSKLWLLAGGLDRGNGFEELEKD-LQDLKGMVVFGQ 380
G +DSKATN AT+ +L+ ++ S +W +AGGL +G F+EL + L+G V+ G
Sbjct: 87 GVAYVDDSKATNTHATEASLAAYE-SIVW-IAGGLAKGATFDELVAGAAKRLRGAVLIGA 144
Query: 381 TANKLR--LTAEKLNIPVFDSEN-----VAKALEEILPQTQAGDTILLSPACASWDQYKT 433
+R L +PV D + + +A++E + GDT+LL+PACAS D +
Sbjct: 145 DRALIREALARHAPEVPVVDLDRTDTGAMLQAVQEARRLARPGDTVLLAPACASMDMFTN 204
Query: 434 FEERGDLFIQAFENL 448
+ +RGD F QA L
Sbjct: 205 YNQRGDAFAQAVREL 219
emb|CAB74268.1| (AL139075) UDP-N-acetylmuramoylalanine--D-glutamate ligase
[Campylobacter jejuni]
Length = 402
Score = 104 bits (258), Expect = 1e-21
Identities = 85/305 (27%), Positives = 139/305 (44%), Gaps = 30/305 (9%)
Query: 141 AKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIALITNLFSAHLDYHGSQ 200
A + GN+G P +E+ A ++E SSF L +P+I + + HL +HGS
Sbjct: 117 AVMGGNVGTPLAELNPYAKL---WILETSSFTLHYTHKAKPEIYALLPISPDHLSWHGSF 173
Query: 201 KAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATVLAFSTKEKVNGAYSKDGKIY 260
Y K + + M D +IL K + K++ KD +
Sbjct: 174 DNYVQDKLSVLKRMNECDVVIL-------------PKIYANTPTKAHKISYEDEKDLAVK 220
Query: 261 FNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNEAIVEVLTSFAGVKHRLQYLGEI 320
F ++ ++S L+ +A + L T + ++L SF K++L+ L +
Sbjct: 221 FG----IDTEKISFKSPFLLDAIMALAIEKILLDTLS---YKLLNSFVMEKNKLEELKDS 273
Query: 321 DGRKVYNDSKATNILATQKALSGFDNSKLWLLAGGLDRGNGFEELEKDLQDLKG----MV 376
R ND+KATN A ALS + + K+ L+ GG D+G L +KG +
Sbjct: 274 QNRLWVNDTKATNESAVMAALSRYKDKKIHLIIGGDDKGVDLSNL---FDFMKGFDIELY 330
Query: 377 VFGQTANKLRLTAEKLNIPVFDSENVAKALEEILPQTQAGDTILLSPACASWDQYKTFEE 436
G + K+ A+K N+ + E ++KA+ EI + + LLSPACAS DQ+ ++ E
Sbjct: 331 AIGISTEKMLDYAKKANLKAYKCEVLSKAVNEISNHLRVNEVALLSPACASLDQFNSYAE 390
Query: 437 RGDLF 441
RG +F
Sbjct: 391 RGKVF 395
sp|O67373|MURC_AQUAE UDP-N-ACETYLMURAMATE--ALANINE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE) >gi|2983764
(AE000736) UDP-N-acetylmuramate-alanine ligase [Aquifex
aeolicus]
Length = 454
Score = 95.2 bits (233), Expect = 1e-18
Identities = 115/445 (25%), Positives = 189/445 (41%), Gaps = 53/445 (11%)
Query: 10 QKILVLGLARSGMAA-ALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPIDL 68
+K +G+ GM+ A +L E+G V+ G ENK +LL ++G K+ G P +L
Sbjct: 7 KKFHFIGIGGIGMSGIAQILLEMGYKVS---GSDISENKNTKLLKQKGAKIYIGHRPENL 63
Query: 69 LDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVE-LAYLISEAPXXXXXXXXXXXXXX 127
D ++V + ++ DNP ++ A+ NIPVI E LA L
Sbjct: 64 GDAQ--VVVYSSAVKPDNPEIQEAKRRNIPVIPRGEMLAELFKLKEGIAVSGSHGKTTTT 121
Query: 128 XLIADIL-NAD--------GQSAKLSGNIGFPASEV-AEKASASDTLVMELSSFQLMGID 177
+IA+IL NA G+ +L N E+ +A SD ++L
Sbjct: 122 SMIAEILINAGLEPTVIIGGRLKRLGTNAKLGRGELLVSEADESDGSFLKL--------- 172
Query: 178 SFRPKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTK 237
+P +A+ITN+ HLD++ + + + A + ++ F ++N + L K+
Sbjct: 173 --QPAVAVITNVDKEHLDFYENFERVKEAFEQFMNSVPFYGFAVVNLDDPTLAQLVKKSH 230
Query: 238 ATVLAFSTKE----KVNGAYSKDGKIYFNDEYI---MEVSELSLPGEHNLENALAAIVAS 290
V+ + + Y K+G+ F E+ + L + G HN+ NALAA +
Sbjct: 231 ERVITYGINSPALVRAKNLYLKEGRYEFGVEFKGKELGRIHLGIAGIHNVYNALAATGVA 290
Query: 291 KLQGTKNEAIVEVLTSFAGVKHRLQYLGEIDGRKVYND--SKATNILATQKALSGFDNSK 348
G E I + L F + RL+ G VY+D T I A +L K
Sbjct: 291 LELGVSFEVIKKSLEEFRNAERRLELKGYYKNSPVYDDYGHHPTEIKAVINSLRDMYPDK 350
Query: 349 LWLLAGGLDRGNG----FEELEKDLQDLKGMVVF----GQTANKLRLTAEKL---NIPVF 397
L+ R + FE+ K L+D+ ++V N ++AE+L + VF
Sbjct: 351 NLLVVFQPHRYSRTYYLFEDFVKVLKDIDKLIVTDIYPASENNVYGVSAEELARKSGAVF 410
Query: 398 --DSENVAKALEEILPQTQAGDTIL 420
D E V + + E+ + GD IL
Sbjct: 411 AKDKEEVFEKVREVHDE---GDVIL 432
sp|O51926|MURC_BUCAP UDP-N-ACETYLMURAMATE--ALANINE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE) >gi|2738586
(AF012886) UDP-N-acetylmuramate: L-alanine ligase
[Buchnera aphidicola]
Length = 483
Score = 82.7 bits (201), Expect = 6e-15
Identities = 89/360 (24%), Positives = 152/360 (41%), Gaps = 42/360 (11%)
Query: 1 MKKITKFKDQKIL---VLGLARSGMAA-ALVLNELGAIVTVNDGKPFEENKEAQLLLEEG 56
+KK FK++KIL ++G+A SGM+ AL+L LG ++ G EN + L G
Sbjct: 6 IKKNNFFKEKKILKIHLIGIAGSGMSGIALILFNLGYKIS---GSDLLENFMTKKLKNMG 62
Query: 57 IKVITGSHPIDLLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLISEAPXXX 116
I + ++ DF ++ + I DNP ++ A+ NIP++ E+ + +
Sbjct: 63 INIYFQHSEENIKYADFIII--SSAIPSDNPEIKAAKKKNIPILLRAEMLQIFMQFKFGI 120
Query: 117 XXXXXXXXXXX-XLIADILNADG-----------QSAKLSGNIGFPASEVAEKASASDTL 164
+I DILN + +S +GF +AE A SD
Sbjct: 121 AVSGTHGKTTLLAMIFDILNQNKLDPTVINGGLIKSINSHAKLGFSKYFIAE-ADESDGS 179
Query: 165 VMELSSFQLMGIDSFRPKIALITNLFSAHLD-YHGSQKAYEAAKWRIQENMTSDDFLILN 223
+ L+ P A+ITN+ H+D Y+G K + + S IL
Sbjct: 180 FLCLN-----------PTTAIITNIEPDHIDNYNGEFKLLKKTFLDFLNKIPSYGIAILC 228
Query: 224 FNQEKCRNLADKTKATVLAFSTKEKVNGAYSKDGKIYFNDEYIMEVSE--------LSLP 275
+ + N+ K K V+ + + + + F + + + L+LP
Sbjct: 229 TDNKAILNILPKIKCKVITYGFNKSAEFRITSYKQSDFISNFTLIRKKQLNNLEIILNLP 288
Query: 276 GEHNLENALAAIVASKLQGTKNEAIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNIL 335
GEHN NA AAI + Q +E I + L +F G R +Y+G++ +K +K+ ++
Sbjct: 289 GEHNALNATAAIAFATYQKIPDEKIYQSLKNFKGTSRRFEYVGKLFIKKKSIQNKSVMLI 348
sp|Q9X827|MURC_STRCO UDP-N-ACETYLMURAMATE--ALANINE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
>gi|4691386|emb|CAB41553.2| (AL049727) putative
UDP-N-acetylmuramoyl-L-alanine ligase [Streptomyces
coelicolor]
Length = 462
Score = 73.0 bits (176), Expect = 5e-12
Identities = 79/323 (24%), Positives = 130/323 (39%), Gaps = 19/323 (5%)
Query: 15 LGLARSGMAA-ALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPIDLLDEDF 73
+G+ +GM+ A +L + GA V +D K E+ A L G V G H + L D
Sbjct: 15 IGIGGAGMSGIAKILAQRGAEVAGSDAK---ESATADALRALGATVHIG-HAAEHLAADA 70
Query: 74 ALMVKNPGIRYDNPMVERAEALNIPVI--TEVELAYLISEAPXXXXXXXXXXXXXXXLIA 131
+ +V + IR DNP + RA L IPV+ ++ A + P L
Sbjct: 71 SCVVVSSAIREDNPELVRAAELGIPVVHRSDALAALMNGLRPIAVAGTHGKTTTTSMLAV 130
Query: 132 DILNAD-GQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIALITNL- 189
+ D G S + G++ P S + V E + P++A++ N+
Sbjct: 131 SLSELDLGPSYAIGGDLDAPGSNALH--GEGEIFVAEADESD-RSFHKYAPEVAIVLNVE 187
Query: 190 FSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQ---EKCRNLADKTKATVLAFSTK 246
H +Y + YE+ + + + +I ++ E R LA + + S
Sbjct: 188 LDHHANYASMDEIYESFETFAGKIVPGGTLVIAADHEGARELTRRLAGRVRTVTYGESED 247
Query: 247 EKVNGAYSKDGKIYFNDEYIMEVSEL----SLPGEHNLENALAAIVASKLQGTKNEAIVE 302
V + +++ +EL S+PG H NA+AA+ A G +
Sbjct: 248 ADVRILSVVPQGLKSEVTVVLDGAELTFAVSVPGRHYAHNAVAALAAGAALGVPAAELAP 307
Query: 303 VLTSFAGVKHRLQYLGEIDGRKV 325
L ++ GVK RLQ GE G +V
Sbjct: 308 ALAAYTGVKRRLQLKGEAAGVQV 330
gb|AAD53935.1|AF179611_19 (AF179611) UDP-N-acetylmuramate-alanine ligase [Zymomonas mobilis]
Length = 486
Score = 72.6 bits (175), Expect = 6e-12
Identities = 84/322 (26%), Positives = 136/322 (42%), Gaps = 28/322 (8%)
Query: 16 GLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPIDLLDEDFAL 75
G+ SG+A V++ LG V G E L + GIKV+ G H ++ +D A+
Sbjct: 18 GIGMSGIAE--VMHNLGYQV---QGSDISEGYTVDALRQMGIKVLIGHHAENV--KDAAV 70
Query: 76 MVKNPGIRYDNPMVERAEALNIPVITEVE-LAYLISEAPXXXXXXXXXXXXXXXLIADIL 134
+V + I NP VE A IPV+ E LA L+ ++A +L
Sbjct: 71 VVVSSAIHRGNPEVEAALENRIPVVRRAEMLAELMRLKSTVAVAGTHGKTTTTSMVAALL 130
Query: 135 NADG-QSAKLSGNIGFPASEVAEKASASDTLVMEL--SSFQLMGIDSFRPKIALITNLFS 191
+A G ++G I A + SD +V+E S + +D +A++TN+
Sbjct: 131 DAGGIDPTVINGGIINSYGSNA-RLGDSDWMVVEADESDGSFLRLDG---TLAIVTNIDP 186
Query: 192 AHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATVL---AFSTK-- 246
HLD++GS + + A N+ L + +++ + + L FS +
Sbjct: 187 EHLDHYGSFEKVQDAFVEFVSNVPFYGAAFLCIDHPVVQSILPRIRDRRLITYGFSAQAD 246
Query: 247 ------EKVNGAYSKDGKIYFNDEYIMEVSE--LSLPGEHNLENALAAIVASKLQGTKNE 298
++G I D I + L +PG HN++NAL+AI + +
Sbjct: 247 IRAVDITPISGGNRFTAVIRGRDGDIRRIENIFLPMPGRHNIQNALSAIGVALEFSIPDA 306
Query: 299 AIVEVLTSFAGVKHRLQYLGEI 320
AI + F GVK R +GEI
Sbjct: 307 AIRDGFARFGGVKRRFSRVGEI 328
gb|AAD53938.1|AF179611_22 (AF179611) UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
[Zymomonas mobilis]
Length = 269
Score = 72.2 bits (174), Expect = 8e-12
Identities = 67/228 (29%), Positives = 100/228 (43%), Gaps = 15/228 (6%)
Query: 7 FKDQKILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENK---EAQLLLEEGIKVITGS 63
F Q VLGLARSGMA L A V D P ++ + Q +++G VI+
Sbjct: 7 FSGQFYAVLGLARSGMATVAALLASDAKVMAWDNNPETRDRLQQQYQEAIDKGRLVISDP 66
Query: 64 HPIDLLDEDFALMVKNPGIRYD-NPMVERAEALNIPVITEVEL---AYLISE-----APX 114
D+ + V +PGI + +P+ A+ IP+I ++EL A+ E P
Sbjct: 67 MIADIFG--ISAFVVSPGIPINRHPIAALAKERGIPIIGDIELFAQAHGFWERHGRRCPV 124
Query: 115 XXXXXXXXXXXXXXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLM 174
LI IL G + GNIG P A+ V+ELSS+Q+
Sbjct: 125 VGITGTNGKSTTTALIHHILKEAGLPTLMGGNIGLPLL-AADPLPDGGVYVLELSSYQID 183
Query: 175 GIDSFRPKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLIL 222
+ IA++TN+ HLD HG + Y AK R+ +S + ++
Sbjct: 184 LTFTLDCDIAVLTNITPDHLDRHGGFEGYRKAKERLFLLQSSPHYAVI 231
sp|P45066|MURC_HAEIN UDP-N-ACETYLMURAMATE--ALANINE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
>gi|1075421|pir||E64185 UDP-N-acetylmuramate-alanine
ligase (murC) homolog - Haemophilus influenzae (strain
Rd KW20) >gi|1574695 (U32794)
UDP-N-acetylmuramate--alanine ligase (murC) [Haemophilus
influenzae Rd]
Length = 475
Score = 71.0 bits (171), Expect = 2e-11
Identities = 76/322 (23%), Positives = 133/322 (40%), Gaps = 20/322 (6%)
Query: 10 QKILVLGLARSGMA--AALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPID 67
Q+I +G+ +GM+ A ++LNE I G + Q L + G K+ G
Sbjct: 19 QQIHFIGIGGAGMSGIAEILLNEGYQI----SGSDIADGVVTQRLAQAGAKIYIGHAEEH 74
Query: 68 LLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVE-LAYLISEAPXXXXXXXXXXXXX 126
+ E +++V + I+ DNP + ++ IPVI + LA ++
Sbjct: 75 I--EGASVVVVSSAIKDDNPELVTSKQKRIPVIQRAQMLAEIMRFRHGIAVAGTHGKTTT 132
Query: 127 XXLIADILN-ADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIAL 185
+I+ I A ++G + A + A AS L+ E + +P +++
Sbjct: 133 TAMISMIYTQAKLDPTFVNGGLVKSAGKNAH-LGASRYLIAEADESDASFLH-LQPMVSV 190
Query: 186 ITNLFSAHLD-YHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATVLAFS 244
+TN+ H+D Y G + +A + N+ ++ + L K V+ +
Sbjct: 191 VTNMEPDHMDTYEGDFEKMKATYVKFLHNLPFYGLAVMCADDPVLMELVPKVGRQVITYG 250
Query: 245 TKEKVNGAYSKDGKIYFNDEYIMEVSE-------LSLPGEHNLENALAAIVASKLQGTKN 297
E+ + + F Y + L++PG+HN NA AA+ +K +G N
Sbjct: 251 FSEQADYRIEDYEQTGFQGHYTVICPNNERINVLLNVPGKHNALNATAALAVAKEEGIAN 310
Query: 298 EAIVEVLTSFAGVKHRLQYLGE 319
EAI+E L F G R LGE
Sbjct: 311 EAILEALADFQGAGRRFDQLGE 332
emb|CAB66325.1| (AJ242646) MurC protein [Brevibacterium lactofermentum]
Length = 486
Score = 64.0 bits (153), Expect = 2e-09
Identities = 76/347 (21%), Positives = 144/347 (40%), Gaps = 35/347 (10%)
Query: 11 KILVLGLARSGMAA-ALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITG--SHPID 67
++ ++G+ +GM+ A +L G VT +D K +++ L G + G + ++
Sbjct: 16 RVHLIGIGGAGMSGVARILLARGKTVTGSDAK---DSRTLLPLRAVGATIAVGHAAENLE 72
Query: 68 LLDEDFALMVKN-PGIRYDNPMVERAEALNIPVITEVEL-AYLISEAPXXXXXXXXXXXX 125
L E ++V + I DNP + RA IPVI +L L+ +
Sbjct: 73 LSGELPTVVVTSFAAIPQDNPELVRAREEGIPVIRRSDLLGELLEGSTQVLIAGTHGKTS 132
Query: 126 XXXLIADILNADGQSAKLSGNIGFPASEVAEKA--SASDTLVMELSSFQLMGIDSFRPKI 183
+ + A G + IG ++ A + + E + ++P +
Sbjct: 133 TTSMSVVAMQAAGMDPSFA--IGGQLNKAGTNAHHGTGEVFIAEADESDA-SLLRYKPNV 189
Query: 184 ALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKAT---V 240
A++TN+ HLD+ + +AY +T + L++ N L +++
Sbjct: 190 AVVTNVEPDHLDFFKTPEAYFQVFDDFAGRITPNGKLVVCLNDPHAAELGERSVRKGIKT 249
Query: 241 LAFSTKEKVNGAYSKDGKIYFNDEYIM-------------EVSE-LSLPGEHNLENALAA 286
+ + T++ V D ++ EVS L +PG+H + N AA
Sbjct: 250 VGYGTRDAVQAHPEVPAMATVVDSQVVAEGTRATINIDGQEVSVILQIPGDHMVLNGAAA 309
Query: 287 IVASKLQGTKNEAIVEVLTSFAGVKHRLQYLGEIDGRK-----VYND 328
++A L G + +VE L+ F+GV+ R ++ G I+G K +Y+D
Sbjct: 310 LLAGYLVGGDVDKLVEGLSDFSGVRRRFEFHGAIEGGKFNGAAIYDD 356
gi|2177094 (U67892) UDP-MurNAc:L-alanine ligase [Escherichia coli]
Length = 491
Score = 64.0 bits (153), Expect = 2e-09
Identities = 76/316 (24%), Positives = 125/316 (39%), Gaps = 18/316 (5%)
Query: 15 LGLARSGMAA-ALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPIDLLDEDF 73
+G+ +GM A VL G ++ +D P N Q L+ G + P ++ D
Sbjct: 25 VGIGGAGMGGIAEVLANEGYQISGSDLAP---NPVTQQLMNLGATIYFNHRPENV--RDA 79
Query: 74 ALMVKNPGIRYDNPMVERAEALNIPVITEVE-LAYLISEAPXXXXXXXXXXXXXXXLIAD 132
+++V + I DNP + A IPVI E LA L+ +++
Sbjct: 80 SVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSS 139
Query: 133 ILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIALITNLFSA 192
I G A+ V + L+ E + +P +A++TN+ +
Sbjct: 140 IYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDASFLH-LQPMVAIVTNIEAD 198
Query: 193 HLD-YHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKT--KATVLAFSTKEKV 249
H+D Y G + + N+ ++ + R L + + T FS V
Sbjct: 199 HMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQTTTYGFSEDADV 258
Query: 250 NGA-YSKDGK-----IYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNEAIVEV 303
Y + G + D+ M V+ L+ PG HN NA AA+ + +G +EAI+
Sbjct: 259 RVEDYQQIGPQGHFTLLRQDKEPMRVT-LNAPGRHNALNAAAAVAVATEEGIDDEAILRA 317
Query: 304 LTSFAGVKHRLQYLGE 319
L SF G R +LGE
Sbjct: 318 LESFQGTGRRFDFLGE 333
sp|P37773|MPL_ECOLI UDP-N-ACETYLMURAMATE:L-ALANYL-GAMMA-D-GLUTAMYL-MESO-DIAMINOPIMELATE
LIGASE (MUREIN PEPTIDE LIGASE) >gi|1361182|pir||S56459
hypothetical protein o457 - Escherichia coli >gi|537075
(U14003) ORF_o457 [Escherichia coli] >gi|1790680
(AE000494) putative ligase [Escherichia coli]
Length = 457
Score = 64.0 bits (153), Expect = 2e-09
Identities = 83/350 (23%), Positives = 139/350 (39%), Gaps = 22/350 (6%)
Query: 11 KILVLGLARSGMAA-ALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPIDLL 69
+I +LG+ + M A++ +LG VT +D + + LL ++GI++I G L
Sbjct: 2 RIHILGICGTFMGGLAMLARQLGHEVTGSDANVYPPM--STLLEKQGIELIQGYDASQLE 59
Query: 70 DEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELA--YLISEAPXXXXXXXXXXXXXX 127
+ +++ N R NP VE NIP ++ + +++ +
Sbjct: 60 PQPDLVIIGNAMTR-GNPCVEAVLEKNIPYMSGPQWLHDFVLRDRWVLAVAGTHGKTTTA 118
Query: 128 XLIADILNADGQSAKLSGNIGFPAS-EVAEKASASDTLVMELSSFQLMGIDS------FR 180
+ IL G G P + EV+ SD V+E + D +
Sbjct: 119 GMATWILEQCGYKPGFVIG-GVPGNFEVSAHLGESDFFVIEADEYDCAFFDKRSKFVHYC 177
Query: 181 PKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLI-----LNFNQEKCRNLADK 235
P+ ++ NL H D KA + + + +I +N Q +
Sbjct: 178 PRTLILNNLEFDHADIFDDLKAIQKQFHHLVRIVPGQGRIIWPENDINLKQTMAMGCWSE 237
Query: 236 TKATVLAFSTKEKVNGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGT 295
+ + K + + ++ + E + EV + SL GEHN+ N L AI A++ G
Sbjct: 238 QELVGEQGHWQAKKLTTDASEWEVLLDGEKVGEV-KWSLVGEHNMHNGLMAIAAARHVGV 296
Query: 296 KNEAIVEVLTSFAGVKHRLQYLGEIDGRKVYND--SKATNILATQKALSG 343
L SF + RL+ GE +G VY+D T ILAT AL G
Sbjct: 297 APADAANALGSFINARRRLELRGEANGVTVYDDFAHHPTAILATLAALRG 346
sp|P17952|MURC_ECOLI UDP-N-ACETYLMURAMATE--ALANINE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
>gi|68624|pir||CEECAM UDP-N-acetylmuramate--alanine
ligase (EC 6.3.2.8) - Escherichia coli
>gi|40859|emb|CAA38868.1| (X55034)
UDP-N-acetylmuramate--alanine ligase [Escherichia coli]
>gi|42056|emb|CAA36868| (X52644) (UDP-N-acetylmuramate:
L-alanine ligase) (AA 1-491) [Escherichia coli]
>gi|216505|dbj|BAA01356| (D10483)
UDP-N-acetylmuramate-alanine ligase [Escherichia coli]
>gi|1786279 (AE000118) L-alanine adding enzyme,
UDP-N-acetyl-muramate:alanine ligase [Escherichia coli]
>gi|228660|prf||1808265A murC gene [Escherichia coli]
Length = 491
Score = 64.0 bits (153), Expect = 2e-09
Identities = 76/316 (24%), Positives = 125/316 (39%), Gaps = 18/316 (5%)
Query: 15 LGLARSGMAA-ALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPIDLLDEDF 73
+G+ +GM A VL G ++ +D P N Q L+ G + P ++ D
Sbjct: 25 VGIGGAGMGGIAEVLANEGYQISGSDLAP---NPVTQQLMNLGATIYFNHRPENV--RDA 79
Query: 74 ALMVKNPGIRYDNPMVERAEALNIPVITEVE-LAYLISEAPXXXXXXXXXXXXXXXLIAD 132
+++V + I DNP + A IPVI E LA L+ +++
Sbjct: 80 SVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSS 139
Query: 133 ILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIALITNLFSA 192
I G A+ V + L+ E + +P +A++TN+ +
Sbjct: 140 IYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDASFLH-LQPMVAIVTNIEAD 198
Query: 193 HLD-YHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKT--KATVLAFSTKEKV 249
H+D Y G + + N+ ++ + R L + + T FS V
Sbjct: 199 HMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQTTTYGFSEDADV 258
Query: 250 NGA-YSKDGK-----IYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNEAIVEV 303
Y + G + D+ M V+ L+ PG HN NA AA+ + +G +EAI+
Sbjct: 259 RVEDYQQIGPQGHFTLLRQDKEPMRVT-LNAPGRHNALNAAAAVAVATEEGIDDEAILRA 317
Query: 304 LTSFAGVKHRLQYLGE 319
L SF G R +LGE
Sbjct: 318 LESFQGTGRRFDFLGE 333
sp|Q9WY73|MURC_THEMA UDP-N-ACETYLMURAMATE--ALANINE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
>gi|4980729|gb|AAD35322.1|AE001707_9 (AE001707)
UDP-N-acetylmuramate--alanine ligase [Thermotoga
maritima]
Length = 457
Score = 63.6 bits (152), Expect = 3e-09
Identities = 96/411 (23%), Positives = 157/411 (37%), Gaps = 56/411 (13%)
Query: 11 KILVLGLARSGMAAALVLNELGAIVTVND--GKPFEENKEAQLLLEEGIKVITGSHPIDL 68
KI +G+ GM+A + L+E ND G EE + L + GI + +
Sbjct: 2 KIHFVGIGGIGMSA-VALHEFS---NGNDVYGSNIEETERTAYLRKLGIPIFVPHSADNW 57
Query: 69 LDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAYLIS-----EAPXXXXXXXXXX 123
D D L++K P +R DNP + RA +P+ E L Y +
Sbjct: 58 YDPD--LVIKTPAVRDDNPEIVRARMERVPI--ENRLHYFRDTLKREKKEEFAVTGTDGK 113
Query: 124 XXXXXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKI 183
++A +L +S + + E + +V EL + F P
Sbjct: 114 TTTTAMVAHVLKHLRKSPTVFLGGIMDSLEHGNYEKGNGPVVYELDESEEF-FSEFSPNY 172
Query: 184 ALITNLFSAHLDYHG-SQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKT----KA 238
+ITN HL+ +G S Y +A +I N D ++ E +L D T K
Sbjct: 173 LIITNARGDHLENYGNSLTRYRSAFEKISRNT---DLVVTFAEDELTSHLGDVTFGVKKG 229
Query: 239 TV---LAFSTKEKVNGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGT 295
T + +++ + K+GK Y +L +PG HN+ NALA I G
Sbjct: 230 TYTLEMRSASRAEQKAMVEKNGKRYLE-------LKLKVPGFHNVLNALAVIALFDSLGY 282
Query: 296 KNEAIVEVLTSFAGVKHRLQYLGEIDGRKVY-------NDSKATNILATQKALSGFDNSK 348
++E L F GV R +Y + N+L T K + F+N K
Sbjct: 283 DLAPVLEALEEFRGVHRRFSIAFHDPETNIYVIDDYAHTPDEIRNLLQTAKEV--FENEK 340
Query: 349 LWLLAGGLDRGNGFEELEKDLQDLKGMVVFGQTANKLRLTAEKLNIPVFDS 399
+ ++ + + + LE++ G A L+L E + V+D+
Sbjct: 341 IVVIF----QPHRYSRLERE---------DGNFAKALQLADEVVVTEVYDA 378
sp|P94335|MURC_CORGL UDP-N-ACETYLMURAMATE--ALANINE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
>gi|3868935|dbj|BAA34293| (AB015023) MurC
[Corynebacterium glutamicum]
Length = 486
Score = 63.2 bits (151), Expect = 4e-09
Identities = 76/347 (21%), Positives = 143/347 (40%), Gaps = 35/347 (10%)
Query: 11 KILVLGLARSGMAA-ALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITG--SHPID 67
++ ++G+ +GM+ A +L G VT +D K +++ L G + G + ++
Sbjct: 16 RVHLIGIGGAGMSGVARILLARGKTVTGSDAK---DSRTLLPLRAVGATIAVGHAAENLE 72
Query: 68 LLDEDFALMVKN-PGIRYDNPMVERAEALNIPVITEVEL-AYLISEAPXXXXXXXXXXXX 125
L E ++V + I DNP + RA IPVI +L L+ +
Sbjct: 73 LSGELPTVVVTSFAAIPQDNPELVRAREEGIPVIRRSDLLGELLEGSTQVLIAGTHGKTS 132
Query: 126 XXXLIADILNADGQSAKLSGNIGFPASEVAEKA--SASDTLVMELSSFQLMGIDSFRPKI 183
+ + A G + IG ++ A + + E + ++P +
Sbjct: 133 TTSMSVVAMQAAGMDPSFA--IGGQLNKAGTNAHHGTGEVFIAEADESDA-SLLRYKPNV 189
Query: 184 ALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKAT---V 240
A++TN+ HLD+ + +AY +T + L++ N L +++
Sbjct: 190 AVVTNVEPDHLDFFKTPEAYFQVFDDFAGRITPNGKLVVCLNDPHAAELGERSVRKGIKT 249
Query: 241 LAFSTKEKVNGAYSKDGKIYFNDEYIM-------------EVSE-LSLPGEHNLENALAA 286
+ + T + V D ++ EVS L +PG+H + N AA
Sbjct: 250 VGYGTADAVQAHPEVPAMATIVDSQVVAEGTRATINIDGQEVSVILQIPGDHMVLNGAAA 309
Query: 287 IVASKLQGTKNEAIVEVLTSFAGVKHRLQYLGEIDGRK-----VYND 328
++A L G + +VE L+ F+GV+ R ++ G I+G K +Y+D
Sbjct: 310 LLAGYLVGGDVDKLVEGLSDFSGVRRRFEFHGAIEGGKFNGAAIYDD 356
sp|Q9ZDS8|MURC_RICPR UDP-N-ACETYLMURAMATE--ALANINE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
>gi|3860809|emb|CAA14709| (AJ235271)
UDP-N-ACETYLMURAMATE--ALANINE LIGASE (murC) [Rickettsia
prowazekii]
Length = 495
Score = 61.7 bits (147), Expect = 1e-08
Identities = 92/359 (25%), Positives = 143/359 (39%), Gaps = 37/359 (10%)
Query: 16 GLARSGMAAALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPIDLLDEDFAL 75
G+ SG+A +L+ LG V G EN + L GIK+ G ++ ++ +
Sbjct: 23 GVGMSGIAE--ILHNLGYKV---QGSDLVENYNTKRLESYGIKIFLGQAKQNI--KNVSY 75
Query: 76 MVKNPGIRYDNPMVERAEALNIPVITEVE-LAYLISEAPXXXXXXXXXXXXXXXLIADIL 134
+V + I +NP ++ A IP+I E LA L+ LIA +
Sbjct: 76 VVISSAINQNNPEIKEALERKIPIIRRAEMLAELMRLKCSVAVSGSHGKTTTTSLIACLF 135
Query: 135 NADGQSAK-LSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIALITNLFSAH 193
A G ++G I S A S S+ L+ E I IA+ITN+ H
Sbjct: 136 EAAGLCPTVINGGIINNKSTNAYLGS-SNYLIAEADESDATFIH-IPSTIAIITNIDPEH 193
Query: 194 LDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLAD-------------KTKATV 240
LDY+ + A N+ F + + + R L D A +
Sbjct: 194 LDYYQDFEILIGAFRSFITNLPFYGFAVCCIDHKIVRKLVDDITERKIITYGIDSEDAHI 253
Query: 241 LAFSTKEKVNGAYSKDGKIYFNDEY---IMEVSELSLPGEHNLENALAAIVASKLQGTKN 297
+AF+ + + + D KI + I+E + PG HN+ N+LAAI
Sbjct: 254 IAFNINTDIASS-TFDVKISLPNVLGTTIIEKITIPTPGRHNILNSLAAIAVGIELDFGI 312
Query: 298 EAIVEVLTSFAGVKHRLQYLGEIDGRKVYND-------SKATNILATQKALSGFDNSKL 349
+AI +F GVK R + E + + +D KAT LAT K ++ N K+
Sbjct: 313 KAIKNGFNNFKGVKRRFTKVAEYNKAVIIDDYAHHPEEIKAT--LATAKNIANQQNGKV 369
sp|O83873|MURD_TREPA UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
(D-GLUTAMIC ACID ADDING ENZYME) >gi|3323217 (AE001259)
UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD)
[Treponema pallidum]
Length = 532
Score = 60.9 bits (145), Expect = 2e-08
Identities = 56/232 (24%), Positives = 100/232 (42%), Gaps = 17/232 (7%)
Query: 8 KDQKILVLGLARSGMAAALVLNELGAIVTVNDGKPFEENKEA--QLLLEEGIKVITGSHP 65
K I+ LG+ G AAA E GA +TV D + + + +L I+ G H
Sbjct: 11 KTVTIMGLGVHGGGCAAACFCAEAGARLTVTDLRNADALTPSLKRLRAYPSIRFTLGEHR 70
Query: 66 IDLLDEDFALMVKNPGIR-YDNPMVERAEALNIPVITEVELAYLISEAPXXXXXXXXXXX 124
++ E+ +++KNP ++ N + A+ + T++ L +S AP
Sbjct: 71 LEDF-ENAHVVIKNPIVKGAHNIYLSAAQRAGARIETDISLFLRLSPAPLLAVSGSKGKS 129
Query: 125 XXXXLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDS------ 178
+ L A G A L GN E + + +V+ELSS+QL + +
Sbjct: 130 STASALCYSLRALGFPAFLGGNSTVSPLEFVRHTTPATPVVLELSSWQLADLRAVDAQDH 189
Query: 179 -------FRPKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILN 223
RP+IA++T + + H +++ ++Y A K + + + D L+ N
Sbjct: 190 TVHHAGLLRPEIAIMTPIMADHQNWYADMESYVADKQVLYAHQGTHDTLLCN 241
Score = 59.3 bits (141), Expect = 6e-08
Identities = 38/144 (26%), Positives = 72/144 (49%), Gaps = 3/144 (2%)
Query: 300 IVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDNSKLWLLAGGLDRG 359
+ + L S+ G++HRL++ E G + YNDS +T AT AL FD S + L+ GG D+
Sbjct: 381 LAQALESYTGIEHRLEFFYEKGGLRFYNDSASTVPEATIAALEAFDESVV-LIVGGTDKN 439
Query: 360 NGFEELEKDLQDLKGM-VVFGQTANKLRLTAEKLNIPVFDS-ENVAKALEEILPQTQAGD 417
++ L + + ++ G +L+ +P + ++ L+++ + ++
Sbjct: 440 ADYQPLAQAAAKAHALYLLAGSATARLQPLLHAAQVPFYGPFTSLEVLLQDLRARQKSPG 499
Query: 418 TILLSPACASWDQYKTFEERGDLF 441
I+ SP AS++ + ERG F
Sbjct: 500 VIVFSPGAASFELFAHEFERGTTF 523
gb|AAF14862.1|AF110740_1 (AF110740) UDP-N-acetylmuramate:L-alanine ligase MurC [Pseudomonas
aeruginosa]
Length = 487
Score = 60.5 bits (144), Expect = 3e-08
Identities = 76/322 (23%), Positives = 131/322 (40%), Gaps = 18/322 (5%)
Query: 10 QKILVLGLARSGMAA-ALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPIDL 68
++I +G+ +GM A VL LG V+ G + + + L + G ++ G H +
Sbjct: 23 RRIHFVGIGGAGMCGIAEVLLNLGYEVS---GSDLKASAVTERLEKFGAQIFIG-HQAEN 78
Query: 69 LDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVE-LAYLISEAPXXXXXXXXXXXXXX 127
D L+V + I NP V A IPV+ E LA L+
Sbjct: 79 ADGADVLVVSS-AINRANPEVASALERRIPVVPRAEMLAELMRYRHGIAVAGTHGKTTTT 137
Query: 128 XLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIALIT 187
LIA + A G A+ + AS LV E + +P +A++T
Sbjct: 138 SLIASVFAAGGLDPTFVIGGRLNAAGTNAQLGASRYLVAEADESDASFLH-LQPMVAVVT 196
Query: 188 NLFSAHL-DYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATVLAFSTK 246
N+ + H+ Y G + N+ ++ + R + + + +
Sbjct: 197 NIDADHMATYGGDFNKLKKTFVEFLHNLPFYGLAVMCVDDPVVREILPQIARPTVTYGLS 256
Query: 247 EKVN----GAYSKDGKIYFN----DEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNE 298
E + + + +F + ++VS +++PG HN+ N+LA IV + +G +E
Sbjct: 257 EDADVRAINIRQEGMRTWFTVLRPEREPLDVS-VNMPGLHNVLNSLATIVIATDEGISDE 315
Query: 299 AIVEVLTSFAGVKHRLQYLGEI 320
AIV+ L+ F GV R Q GE+
Sbjct: 316 AIVQGLSGFQGVGRRFQVYGEL 337
sp|O06225|MURC_MYCTU UDP-N-ACETYLMURAMATE--ALANINE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
>gi|2104326|emb|CAB08641| (Z95388) murC [Mycobacterium
tuberculosis]
Length = 494
Score = 60.1 bits (143), Expect = 4e-08
Identities = 73/333 (21%), Positives = 132/333 (38%), Gaps = 30/333 (9%)
Query: 10 QKILVLGLARSGMAA-ALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITG--SHPI 66
+++ ++G+ +GM+ A +L + G +V+ +D K E++ L G + G + +
Sbjct: 11 RRVHMVGIGGAGMSGIARILLDRGGLVSGSDAK---ESRGVHALRARGALIRIGHDASSL 67
Query: 67 DLLDEDF-ALMVKNPGIRYDNPMVERAEALNIPVITE-VELAYLISEAPXXXXXXXXXXX 124
DLL A++ + I NP + A IPV+ LA L++
Sbjct: 68 DLLPGGATAVVTTHAAIPKTNPELVEARRRGIPVVLRPAVLAKLMAGRTTLMVTGTHGKT 127
Query: 125 XXXXLIADILNADGQSAKLSGNIGFPASEVAEKA--SASDTLVMELSSFQLMGIDSFRPK 182
++ L G + +G E A + D V E + + P
Sbjct: 128 TTTSMLIVALQHCGLDPSFA--VGGELGEAGTNAHHGSGDCFVAEADESD-GSLLQYTPH 184
Query: 183 IALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATVLA 242
+A+ITN+ S HLD++GS +AY A E + L++ + LA + +
Sbjct: 185 VAVITNIESDHLDFYGSVEAYVAVFDSFVERIVPGGALVVCTDDPGGAALAQRATELGIR 244
Query: 243 FSTKEKVNGAYSKDGKIYFNDEYI-----------------MEVSELSLPGEHNLENALA 285
V G + + + + V LS+PG H NAL
Sbjct: 245 VLRYGSVPGETMAATLVSWQQQGVGAVAHIRLASELATAQGPRVMRLSVPGRHMALNALG 304
Query: 286 AIVASKLQGTKNEAIVEVLTSFAGVKHRLQYLG 318
A++A+ G + +++ L F GV+ R + +G
Sbjct: 305 ALLAAVQIGAPADEVLDGLAGFEGVRRRFELVG 337
emb|CAA18672.1| (AL022602) udp-n-acetylmuramoylalanyl-d-glutamyl
-2,6-diaminopimelate--d-alanyl-d-alanyl ligase
[Mycobacterium leprae]
Length = 517
Score = 57.8 bits (137), Expect = 2e-07
Identities = 62/259 (23%), Positives = 104/259 (39%), Gaps = 42/259 (16%)
Query: 129 LIADILNADGQSA----KLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFR---- 180
L+A +L G+ + +G P + V ++D L++E+S+ + I +
Sbjct: 148 LVAVVLELLGEVVAPPESFNNELGHPWT-VLRATRSTDYLILEMSARRPGNIAALAAIAP 206
Query: 181 PKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATV 240
PKI ++ N+ +AHL GS++A K + + + +ILN + +AD T A V
Sbjct: 207 PKIGVVLNVGTAHLGEFGSREAIARTKTELPQAIMQSGVVILNVDDPAVAAMADATVARV 266
Query: 241 LAFSTKEKVNGAYSKDGKIYFNDEYIMEVS-----------------------ELSLPGE 277
+ S G+YS G D + VS +L + G+
Sbjct: 267 IRVS-----RGSYSHPGSPNSPDVWTGPVSLDELARPRFTLHTRDPRAGATEIQLGVYGD 321
Query: 278 HNLENALAAIVASKLQGTKNEAIVEVLTSFAGV-KHRLQYLGEIDGRKVYNDSKATNILA 336
H + NAL A G E + L + V +HR+Q DG V +D+ N +
Sbjct: 322 HQVANALCAAAVGLECGASVEEVAVALAATGPVSRHRMQVTTRADGVTVIDDTYNANPDS 381
Query: 337 TQKALSGFDNSKLWLLAGG 355
+ L W+ GG
Sbjct: 382 MRAGLQAL----AWIAHGG 396
gi|4009466 (AF068901) D-Ala-D-Ala adding enzyme [Streptococcus pneumoniae]
Length = 457
Score = 57.0 bits (135), Expect = 3e-07
Identities = 64/322 (19%), Positives = 128/322 (38%), Gaps = 30/322 (9%)
Query: 129 LIADILNADGQSAKLSGN----IGFPASEVAEKASASDTLVMELSSFQLMGI----DSFR 180
++A +L+ ++ K GN IG P + V ++ LV+E+ L I + R
Sbjct: 117 MLAHLLSTRYKTYKTQGNYNNEIGLPYT-VLHMPEGTEKLVLEMGQDHLGDIHLLSELAR 175
Query: 181 PKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATV 240
PK A++T + AHL + + K +I + M S L+ + L K
Sbjct: 176 PKTAIVTLVGEAHLAFFKDRSEIAKGKMQIADGMASGSLLLAPADPIVEDYLPTDKKVVR 235
Query: 241 LAFSTKEKVNGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNEAI 300
+ ++ + + F ++ +V +L + G++N NA+ A + +G E I
Sbjct: 236 FGQGAELEITDLVERKDSLTFKANFLEQVLDLPVTGKYNATNAMIASYVALQEGVSEEQI 295
Query: 301 VEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFD-------NSKLWLLA 353
+ ++R ++ +G + +D N A + L F K+ +LA
Sbjct: 296 HQAFQDLELTRNRTEWKKAANGADILSDVYNANPTAMKLILETFSAIPANEGGKKIAVLA 355
Query: 354 GGLDRGNGFEELEKDL------QDLKGMVVFGQTANKLRLTAEKL----NIPVF----DS 399
+ GN +L + L ++ +G+ +L A ++ ++ F D
Sbjct: 356 DMKELGNQSVQLHNQMILSLSPDVLDTVIFYGEDIAELAQLASQMFPIGHVYYFKKTEDQ 415
Query: 400 ENVAKALEEILPQTQAGDTILL 421
+ ++++ A D ILL
Sbjct: 416 DQFEDLVKQVKESLSANDQILL 437
sp|P43948|MPL_HAEIN UDP-N-ACETYLMURAMATE:L-ALANYL-GAMMA-D-GLUTAMYL-MESO-DIAMINOPIMELATE
LIGASE (MUREIN PEPTIDE LIGASE) >gi|1074271|pir||B64002
hypothetical protein HI0121 - Haemophilus influenzae
(strain Rd KW20) >gi|1573076 (U32698) conserved
hypothetical protein [Haemophilus influenzae Rd]
Length = 453
Score = 54.7 bits (129), Expect = 2e-06
Identities = 73/352 (20%), Positives = 141/352 (39%), Gaps = 32/352 (9%)
Query: 12 ILVLGLARSGMAA-ALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPIDLLD 70
I +LG+ + M A++ ++G VT +D + + L E+GI++I L
Sbjct: 4 IHILGICGTFMGGVAMIAKQMGYHVTGSDTNVYPPM--STFLEEQGIEIIPNYDVAQLQP 61
Query: 71 EDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAY--LISEAPXXXXXXXXXXXXXXX 128
++V N ++ NP VE N+ + + + L+ +
Sbjct: 62 APDMVIVGN-AMKRGNPCVEYVLENNLKYTSGPQWLHDHLLRDRWVLAVSGTHGKTTTTG 120
Query: 129 LIADILNADGQSAK-----LSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDS----- 178
++ +L +G + ++GN G A + S ++E + D
Sbjct: 121 MLTWVLEQNGLKSGFLIGGIAGNFGISA-----RLGDSPYFIIEADEYDTAFFDKRSKFV 175
Query: 179 -FRPKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTK 237
+ P+ ++ N+ H D KA + + + + ++ + +++ +
Sbjct: 176 HYNPRTLIVNNISFDHADIFDDLKAIQRQFHHMIRTIPASGLVLSSASEQSAKETLALGC 235
Query: 238 ATVLAFSTK------EKVNGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASK 291
+ F K E++ S ++ + E + EV + ++ G+HN+ NAL AI A+
Sbjct: 236 WSQQQFLGKDNEWFAERITNDASHFA-VFHHGEKVAEV-KWNVVGQHNMHNALMAIAAAH 293
Query: 292 LQGTKNEAIVEVLTSFAGVKHRLQYLGEIDGRKVYND--SKATNILATQKAL 341
G E + L SF K RL+ GE++ VY+D ILAT AL
Sbjct: 294 HTGVAIEDACKALGSFVNAKRRLEVKGEVNSITVYDDFAHHPEAILATLTAL 345
emb|CAB73310.1| (AL139077) UDP-N-acetylmuramate--alanine ligase [Campylobacter
jejuni]
Length = 432
Score = 53.5 bits (126), Expect = 3e-06
Identities = 80/346 (23%), Positives = 150/346 (43%), Gaps = 40/346 (11%)
Query: 10 QKILVLGLARSGMAA-ALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPIDL 68
Q I +G+ G++A A L E G ++ G +E+K + L +EG+KV H ++
Sbjct: 3 QNIHFIGIGGIGISALARFLREKGFKIS---GSDLKESKITKELEKEGVKVSIPHHKDNI 59
Query: 69 LDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVE-LAYLISEAPXXXXXXXXXXXXXX 127
L++D L++ + I+ +NP + A+ L I ++ E L ++ +
Sbjct: 60 LNKD--LVIYSAAIKEENPEFKYAKELGIKCLSRKEALPLILEDKRVFAVAGAHGKSTTS 117
Query: 128 XLIADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFRPKIALIT 187
++A +L D S + + S + K S + LV E ++S P +A++T
Sbjct: 118 SILASLL--DDASVIIGAILKEFGSNMIYKESQN--LVFEADESDSSFLNS-NPYLAIVT 172
Query: 188 NLFSAHLDYHGSQ-----KAY----EAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKA 238
N + HLD++G++ AY + AK R+ + ++D + N+ E
Sbjct: 173 NAEAEHLDHYGNEVSKLHHAYTQFLDVAKIRV---INAEDEFLKNYKNE----------- 218
Query: 239 TVLAFSTKEKVNGAYSKDGKIYFNDEYIMEVSELSL--PGEHNLENALAAIVASKLQGTK 296
++ + +K+ N + F + ++ E + G H +A AI+A+ L
Sbjct: 219 SIKLYPSKDIKNCTMCIENFKPFTSFELKDLGEFKVFGMGYHLALDASLAILAA-LNFLD 277
Query: 297 NEAIVEVLTSFAGVKHRLQYLGEIDGRKVYND--SKATNILATQKA 340
E I L ++ G+K R L + + +D T I AT A
Sbjct: 278 IETIRTRLKNYQGIKKRFDILHADENLVLIDDYGHHPTEIKATLSA 323
emb|CAB51997.1| (AL109663) putative
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,
6-diaminopimelate-D -alanyl-alanyl ligase [Streptomyces
coelicolor A3(2)]
Length = 471
Score = 53.5 bits (126), Expect = 3e-06
Identities = 59/235 (25%), Positives = 101/235 (42%), Gaps = 26/235 (11%)
Query: 129 LIADILNADGQSA----KLSGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFR---- 180
LIA +L + ++ +G P + + + LV+E+ + GI R
Sbjct: 119 LIAQVLRRKAPTVFTPGSMNNEVGLPLTALTA-TDETKFLVLEMGA---RGIGHIRYLTE 174
Query: 181 ---PKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDD---FLILNFNQEKCRNLAD 234
PKI + N+ SAH+ G ++ AK + E + + ILN + R +A
Sbjct: 175 LTPPKIGAVLNVGSAHIGEFGGREQIAQAKGELVEALPPAEEGGAAILNADDPLVRAMAS 234
Query: 235 KTKATVLAFSTKEKV-----NGAYSKDGKIYFNDEYIMEVSELS--LPGEHNLENALAAI 287
+TKA V+ F + N + G+ F+ S+++ L GEH++ NALAA
Sbjct: 235 RTKAKVILFGESGEADVRAENVRLTDTGQPSFSLHTPSGASDVTMRLYGEHHVSNALAAA 294
Query: 288 VASKLQGTKNEAIVEVLTSFAGV-KHRLQYLGEIDGRKVYNDSKATNILATQKAL 341
+ G + I L+ + + R++ DG V ND+ N +T+ AL
Sbjct: 295 AVAHELGMSADEIATALSEAGSLSRWRMEVTERPDGVTVVNDAYNANPESTKAAL 349
gb|AAD08535.1| (AE000648) UDP-MurNac-tripeptide synthetase (murE) [Helicobacter
pylori 26695]
Length = 447
Score = 53.5 bits (126), Expect = 3e-06
Identities = 78/305 (25%), Positives = 126/305 (40%), Gaps = 58/305 (19%)
Query: 165 VMELSSFQLM-----GIDSFRPKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDF 219
+ME+SS ++ G+D + ++TN+ S HLD+H S + Y AK +
Sbjct: 140 IMEVSSHAIVQKRIAGLDF---ALKILTNITSDHLDFHQSIENYRDAK---NSFFKDEGL 193
Query: 220 LILN-------FNQEKCRNLADKTKA--TVLAFSTKEKVNGA--YSKDGKIYFNDEYIME 268
++N FN A KA V AFS ++ + Y +D D E
Sbjct: 194 KVINRDETNALFNPVNAHTYALDKKAHLNVQAFSLNPSISASLCYQQD----LRDPNFKE 249
Query: 269 VSELSLP--GEHNLENALAAIVASK-LQGTKNEAIVEVLTSFAGVKHRLQYLGEIDGRKV 325
++ + P G +NL N LA ++ K L E IV +L +F GVK RL+ + + +
Sbjct: 250 IALMHSPLLGRYNLYNILAGVLGVKLLTQLPLETIVPLLENFYGVKGRLEI---VHSKPL 306
Query: 326 YNDSKATNILATQKALSGFDNSKLWLLAG-GLDRGNGFEELEKDLQDLKGMVVFGQTANK 384
A I Q+ F N K+ L G G DR +K + G + A+K
Sbjct: 307 VVVDFAHTIDGMQQVFESFKNQKITALFGAGGDR-------DKTKRPEMGAIA-SYYAHK 358
Query: 385 LRLTAEKLNIPVFDSENVAKALEEILPQTQAGDTILLSPACASWDQYKTFEERGDLFIQA 444
+ LT++ SEN +++IL +++ ++R + A
Sbjct: 359 IILTSDNPR-----SENEEDIIKDILKGINDSSKVIVE------------KDRKKAILNA 401
Query: 445 FENLK 449
ENLK
Sbjct: 402 LENLK 406
emb|CAA74740| (Y14370) UDP-N-acetylmuramyl-tripeptide synthetase [Staphylococcus
aureus]
Length = 492
Score = 53.1 bits (125), Expect = 5e-06
Identities = 42/171 (24%), Positives = 85/171 (49%), Gaps = 12/171 (7%)
Query: 159 SASDTLVMELSSFQLM--GIDSFRPKIALITNLFSAHLDYHGSQKAYEAAK----WRIQE 212
+ ++++ +E+SS L+ + S +A+ +NL HLD+HG+ +AY AK ++ E
Sbjct: 168 AGAESMTLEVSSHGLVLGRLRSVEFDVAIFSNLTQDHLDFHGTMEAYGHAKSLLFSQLGE 227
Query: 213 NMTSDDFLILNFNQEKCRNLADKTKATVLAFSTKEKV-----NGAYSKDGKIY-FNDEYI 266
+++ + +++LN + L T V ++ E+ N S G + F +
Sbjct: 228 DLSKEKYVVLNNDDSFSEYLRTVTPYEVFSYGIDEEAQFMAKNIQESLQGVSFDFVTPFG 287
Query: 267 MEVSELSLPGEHNLENALAAIVASKLQGTKNEAIVEVLTSFAGVKHRLQYL 317
+ G+ N+ N +AA++A +GT E I++ + + V+ RL+ L
Sbjct: 288 TYPVKSPYVGKFNISNIMAAMIAVWSKGTSLETIIKAVENLEPVEGRLEVL 338
gi|1128955 (M30807) unknown protein [Escherichia coli]
Length = 63
Score = 52.7 bits (124), Expect = 6e-06
Identities = 23/50 (46%), Positives = 35/50 (70%)
Query: 399 SENVAKALEEILPQTQAGDTILLSPACASWDQYKTFEERGDLFIQAFENL 448
+E + +A+ + P+ Q GD +LLSPACAS DQ+K FE+RG+ F + + L
Sbjct: 13 TETMEQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKEL 62
sp|P20100|YZFW_ECOLI VERY HYPOTHETICAL PROTEIN IN FTSW 5'REGION
Length = 63
Score = 52.3 bits (123), Expect = 8e-06
Identities = 23/50 (46%), Positives = 35/50 (70%)
Query: 399 SENVAKALEEILPQTQAGDTILLSPACASWDQYKTFEERGDLFIQAFENL 448
+E + +A+ + P+ Q GD +LLSPACAS DQ+K FE+RG+ F + + L
Sbjct: 13 TETMEQAMRLLAPRVQPGDWVLLSPACASLDQFKNFEQRGNEFARLAKEL 62
gi|2621604 (AE000836) UDP-N-acetylmuramyl tripeptide synthetase related
protein [Methanobacterium thermoautotrophicum]
Length = 682
Score = 51.5 bits (121), Expect = 1e-05
Identities = 28/80 (35%), Positives = 45/80 (56%), Gaps = 1/80 (1%)
Query: 266 IMEVSELSLPGEHNLENALAAIVASKLQGTKNEAIVEVLTSFAGVKHRLQYLGEIDGRKV 325
+ E L +PG N+ENALAAI + + G E I + F G++ R +++ E+DG +V
Sbjct: 4 LRERINLRVPGIFNIENALAAITVALILGFDMEDIKRSIEDFRGIRGRFEFIDEVDGVRV 63
Query: 326 YNDSKATNILATQKALSGFD 345
Y D+ A N + +K G +
Sbjct: 64 YMDA-AHNPESMEKLFEGME 82
sp|Q51831|MURC_PORGI UDP-N-ACETYLMURAMATE--ALANINE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
>gi|2780743|dbj|BAA24358| (D84504) MurC [Porphyromonas
gingivalis]
Length = 433
Score = 50.8 bits (119), Expect = 2e-05
Identities = 39/163 (23%), Positives = 75/163 (45%), Gaps = 11/163 (6%)
Query: 161 SDTLVMELSSFQLMGIDSFRPKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFL 220
SD +V+E F +P +A+IT+ H+D +G+ + Y + + S L
Sbjct: 157 SDLVVVEADEFD-RSFHHLKPFMAIITSADPDHMDIYGTAENYRDSFEHFTSLIQSGGAL 215
Query: 221 ILNFNQEKCRNLADKTKATVLAFSTKEKVNGAYS-----KDGKIYFNDEYI---MEVSEL 272
+L + L + ++ +S+ ++ ++ +DG+++F Y +E EL
Sbjct: 216 VLKYGAPVNPRLG--SDVSLFTYSSDDRQADYFASDIMIRDGRLFFTWHYPGGQLEEVEL 273
Query: 273 SLPGEHNLENALAAIVASKLQGTKNEAIVEVLTSFAGVKHRLQ 315
+P N+ENA+AA+ + L G E + + SF G R +
Sbjct: 274 GVPVRINVENAVAAMAIAHLNGVTVEELRSGIASFKGSHRRFE 316
gb|AAD35328.1|AE001707_15 (AE001707) UDP-N-acetylmuramoylalanyl-D-glutamate--2,
6-diaminopimelate ligase [Thermotoga maritima]
Length = 490
Score = 48.8 bits (114), Expect = 9e-05
Identities = 40/160 (25%), Positives = 72/160 (45%), Gaps = 16/160 (10%)
Query: 166 MELSSFQLMG--IDSFRPKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILN 223
+E+SS L+ ++ R + + TN+ HLD+HG+ + Y AK + + + D +LN
Sbjct: 176 LEVSSHALVQQRVEGVRFDVGIFTNISRDHLDFHGTFENYLKAKLHLFDLLKDDGVAVLN 235
Query: 224 FNQEKCRNLAD--KTKATVLAFSTKEKVNGAYSKDGKIYFNDEYIMEVSELSLP------ 275
+LAD K+ + F T + + + ++++E + L
Sbjct: 236 ------ESLADAFNRKSRKITFGTSKNADYRLGNIEVSWEGTQFVLETPDGLLKVFTRAI 289
Query: 276 GEHNLENALAAIVASKLQGTKNEAIVEVLTSFAGVKHRLQ 315
G+ N NA AAI A G + + L +F GV+ R +
Sbjct: 290 GDFNAYNAAAAIAALHQLGYDPKDLASSLETFTGVEGRFE 329
sp|P96613|MURF_BACSU UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE--D-ALANYL-D-ALANYL LIGASE
(UDP-MURNAC-PENTAPEPTIDE SYNTHETASE)
(D-ALANYL-D-ALANINE-ADDING ENZYME)
>gi|1881267|dbj|BAA19294| (AB001488) PROBABLE
UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-2, 6-DIAMINOLIGASE
(EC 6.3.2.15). [Bacillus subtilis]
>gi|2632757|emb|CAB12264| (Z99106)
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-
diaminopimelate-D-alanyl-D-alanyl ligase [Bacillus
subtilis]
Length = 457
Score = 48.4 bits (113), Expect = 1e-04
Identities = 59/255 (23%), Positives = 106/255 (41%), Gaps = 17/255 (6%)
Query: 129 LIADILNADGQSAKLSGN----IGFPASEVAEKASASDTLVMELSSFQLMGIDSF----R 180
+I +L + K GN IG P + +A + ++ V+E+ ID
Sbjct: 123 MIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPEN-TEIAVLEMGMSAKGEIDLLSRLAN 181
Query: 181 PKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLAD-KTKAT 239
P A+ITN+ +H+ GS++ AK I + D LI ++ +N +TK
Sbjct: 182 PDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKEDGVLIYIGDEPLLQNAYSCQTKTY 241
Query: 240 VLAFSTKEKVNGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNEA 299
++ + +F + I + + G+HN+ NA+AAI A G E
Sbjct: 242 GTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPILGKHNVMNAMAAIAAGAYFGIAPED 301
Query: 300 IVEVLTSFAGVKHRLQYLGEIDGRKVYND---SKATNILAT---QKALSGFDNSKLWLLA 353
+ L+ RL+ + G + ND + T++ A ++L G+ K+ +L
Sbjct: 302 AAKGLSGLKVTGMRLELIKTDSGLSIINDAYNASPTSMKAAIQLTESLEGY-GKKMLVLG 360
Query: 354 GGLDRGNGFEELEKD 368
L+ G+ E K+
Sbjct: 361 DMLELGDLEETFHKE 375
sp|P11880|MURF_ECOLI UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE--D-ALANYL-D-ALANYL LIGASE
(UDP-MURNAC-PENTAPEPTIDE SYNTHETASE)
(D-ALANYL-D-ALANINE-ADDING ENZYME) >gi|1743865 (U67891)
UDP-MurNAc-Tripeptide:D-Ala-D-Ala-Adding enzyme
[Escherichia coli] >gi|1786274 (AE000118)
D-alanine:D-alanine-adding enzyme [Escherichia coli]
Length = 452
Score = 48.4 bits (113), Expect = 1e-04
Identities = 54/222 (24%), Positives = 88/222 (39%), Gaps = 17/222 (7%)
Query: 129 LIADILNADGQSAKLSGN----IGFPASEVAEKASASDTLVMELSSFQ----LMGIDSFR 180
+ A IL+ G + +GN IG P + + D V+EL + + R
Sbjct: 117 MTAAILSQCGNTLYTAGNLNNDIGVPMT-LLRLTPEYDYAVIELGANHQGEIAWTVSLTR 175
Query: 181 PKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATV 240
P+ AL+ NL +AHL+ GS AK I + + I+N + N +
Sbjct: 176 PEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWLNWQSVIGSRK 235
Query: 241 LAFSTKEKVNGAYSKDG--KIYFNDEYIMEVSE------LSLPGEHNLENALAAIVASKL 292
+ + N ++ E+ ++ L LPG HN+ NALAA S
Sbjct: 236 VWRFSPNAANSDFTATNIHVTSHGTEFTLQTPTGSVDVLLPLPGRHNIANALAAAALSMS 295
Query: 293 QGTKNEAIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNI 334
G +AI L + V RL + + + + +DS N+
Sbjct: 296 VGATLDAIKAGLANLKAVPGRLFPIQLAENQLLLDDSYNANV 337
sp|Q55469|MURE_SYNY3 UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE
(UDP-N-ACETYLMURAMYL-TRIPEPTIDE SYNTHETASE)
(MESO-DIAMINOPIMELATE-ADDING ENZYME)
>gi|1001328|dbj|BAA10815| (D64006) UDP-MurNac-tripeptide
synthetase [Synechocystis sp.]
Length = 505
Score = 47.6 bits (111), Expect = 2e-04
Identities = 39/140 (27%), Positives = 61/140 (42%), Gaps = 8/140 (5%)
Query: 184 ALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKA-TVLA 242
A+ TNL HLD+HG+ + Y AAK + + ++N + + L D+ V
Sbjct: 212 AVFTNLTQDHLDFHGTMENYFAAKALLFKESYLQGRAVINQDDPYGQRLIDRLPLDQVYT 271
Query: 243 FSTKEKVNGAYSKD---GKIYFNDEYIMEVSEL----SLPGEHNLENALAAIVASKLQGT 295
+S + Y+KD ++ E L G+ NL N LAAI + G
Sbjct: 272 YSVNDSTADFYTKDLDYQPTGVKGTFVTPQGEFPFLSPLVGQFNLANVLAAIASGLHLGL 331
Query: 296 KNEAIVEVLTSFAGVKHRLQ 315
A+V+ L F GV R++
Sbjct: 332 DPAAMVKDLLDFPGVPGRME 351
pir||S04846 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,
6-diaminopimelate--D-alanyl-D-alanine ligase (EC
6.3.2.15) precursor - Escherichia coli
>gi|40854|emb|CAA38863.1| (X55034)
UDP-MurNac-pentapeptide presynthetase (AA -20 to 432)
[Escherichia coli] >gi|42048|emb|CAA33473| (X15432)
UDP-MurNAC-pentapeptide presynthetase (AA -20 to 432)
[Escherichia coli] >gi|216500|dbj|BAA01351| (D10483)
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,
6-diaminopimelate-D-alanyl D alanine ligase precursor
[Escherichia coli]
Length = 452
Score = 47.6 bits (111), Expect = 2e-04
Identities = 54/222 (24%), Positives = 88/222 (39%), Gaps = 17/222 (7%)
Query: 129 LIADILNADGQSAKLSGN----IGFPASEVAEKASASDTLVMELSSFQ----LMGIDSFR 180
+ A IL+ G + +GN IG P + + D V+EL + + R
Sbjct: 117 MTAAILSQCGNTLYTAGNLNNDIGVPMT-LLRLTPEYDYAVIELGANHQGEIAWTVSLTR 175
Query: 181 PKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATV 240
P+ AL+ NL +AHL+ GS AK I + + I+N + N +
Sbjct: 176 PERALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWLNWQSVIGSRK 235
Query: 241 LAFSTKEKVNGAYSKDG--KIYFNDEYIMEVSE------LSLPGEHNLENALAAIVASKL 292
+ + N ++ E+ ++ L LPG HN+ NALAA S
Sbjct: 236 VWRFSPNAANSDFTATNIHVTSHGTEFTLQTPTGSVDVLLPLPGRHNIANALAAAALSMS 295
Query: 293 QGTKNEAIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNI 334
G +AI L + V RL + + + + +DS N+
Sbjct: 296 VGATLDAIKAGLANLKAVPGRLFPIQLAENQLLLDDSYNANV 337
gi|4156007 (AE001561) UDP-N-ACETYLMURAMYL-TRIPEPTIDE SYNTHETASE [Helicobacter
pylori J99]
Length = 447
Score = 47.3 bits (110), Expect = 3e-04
Identities = 75/305 (24%), Positives = 124/305 (40%), Gaps = 58/305 (19%)
Query: 165 VMELSSFQLM-----GIDSFRPKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDF 219
+ME+SS ++ G+D + ++TN+ S HLD+H + + Y AK +
Sbjct: 140 IMEVSSHAIVQKRIAGLDF---ALKILTNITSDHLDFHQNIENYRDAK---NSFFKDEGL 193
Query: 220 LILN-------FNQEKCRNLADKTKA--TVLAFSTKEKVNGA--YSKDGKIYFNDEYIME 268
++N FN R A KA V AFS ++ + Y D D + E
Sbjct: 194 KVINRDETNALFNPINARTYALDKKAHLNVQAFSLNPSISASLCYQHD----LRDPNLKE 249
Query: 269 VSELSLP--GEHNLENALAAIVASK-LQGTKNEAIVEVLTSFAGVKHRLQYLGEIDGRKV 325
+ + P G +NL N LA ++ K L E I +L +F GVK RL+ + + +
Sbjct: 250 TALIHSPLLGRYNLYNILAGVLGVKLLTQLPLETIAPLLENFYGVKGRLEI---VHSKPL 306
Query: 326 YNDSKATNILATQKALSGFDNSKLWLLAG-GLDRGNGFEELEKDLQDLKGMVVFGQTANK 384
A Q+ F N K+ L G G DR +K + G + A++
Sbjct: 307 VVVDFAHTTDGMQQVFESFKNQKITALFGAGGDR-------DKTKRPKMGAIA-SCYAHQ 358
Query: 385 LRLTAEKLNIPVFDSENVAKALEEILPQTQAGDTILLSPACASWDQYKTFEERGDLFIQA 444
+ LT++ SEN +++IL +++ ++R + A
Sbjct: 359 IILTSDNPR-----SENEEDIIKDILKGINNSSKVIVE------------KDRKKAILNA 401
Query: 445 FENLK 449
ENLK
Sbjct: 402 LENLK 406
gb|AAC67862.1| (AE001299) UDP-N-acetylmuramoylalanylglutamyl DAP Ligase [Chlamydia
trachomatis]
Length = 483
Score = 46.9 bits (109), Expect = 3e-04
Identities = 43/148 (29%), Positives = 76/148 (51%), Gaps = 17/148 (11%)
Query: 151 ASEVAEKASASDTLVMELSSFQLMGIDSFRPK---IALITNLFSAHLDYHGSQKAYEAAK 207
A V + SA+ VME+SS M + R ++TN+ S HLD+HGS + Y AAK
Sbjct: 163 AEMVKQNLSAA---VMEVSSIG-MALGRVRETEFLAGVLTNITSDHLDFHGSLEEYIAAK 218
Query: 208 WRIQENMTSDDFLILNFNQEKCRNLADKTKATVLAFSTKEKVNGAYSKDG-KIY-----F 261
+ ++ ++N + E + + ++A ++++ ++ + Y D K+Y +
Sbjct: 219 KQFFASLPEKGIAVVNLDCEYAPSFLNGSQARAVSYAIHQEAD--YRADRLKLYSSGSSY 276
Query: 262 NDEYIMEV--SELSLPGEHNLENALAAI 287
+ Y +V E SL GEHN+ N LA++
Sbjct: 277 DIWYQGQVFPCETSLIGEHNVYNVLASL 304
sp|O51757|MURC_BORBU UDP-N-ACETYLMURAMATE--ALANINE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE) >gi|2688761
(AE001180) UDP-N-acetylmuramate--alanine ligase (murC)
[Borrelia burgdorferi]
Length = 468
Score = 46.9 bits (109), Expect = 3e-04
Identities = 62/298 (20%), Positives = 126/298 (41%), Gaps = 25/298 (8%)
Query: 69 LDEDFALMVKNPGIRYDNPMVE-RAEALNIPVITEVE-LAYLISEAPXXXXXXXXXXXXX 126
LD F L+V + D V A+ LNIP+++ E L L +
Sbjct: 69 LDRSFDLIVYSSAYNKDGLQVLLEAKELNIPILSYPEALGELSRKYYSIGIAGSHGKTTT 128
Query: 127 XXLIADILNADGQSAKLSGNIGFPASEVAEK---ASASDTLVMELSSFQLMGIDSFRPKI 183
+ + N G + + +G + + A S+ ++E ++ ++ F P +
Sbjct: 129 TAFLGVLFNKLGLNPNVI--VGSSVKDFKDNSAIAGISNIFIVETCEYKKHFLN-FSPNM 185
Query: 184 ALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNF---NQEKCRNLADKTKATV 240
++TN+ H+D+ + +A E A + N+ + LI+N N K + ++ ++
Sbjct: 186 LILTNVDYEHVDFFKNYEALEEAFLQYINNLKKNGILIINSDDNNLLKIKRQINRKDISI 245
Query: 241 LAFSTKE----KVNGAYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTK 296
++ + + +++ + F+ ++ V EL HN+ N AA++A L
Sbjct: 246 FSYGSGDLSDFQISNIAVRSEYFCFSFLGLLNV-ELKTVLFHNVLNFSAALLALNLFLES 304
Query: 297 N--------EAIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSGFDN 346
N EAI + +++G+K R++ + E +G +Y D A + + L G N
Sbjct: 305 NGKSIFDFEEAIKRIAKNYSGIKRRVEVVKEENG-VIYMDDYAHHPREIKNTLFGIKN 361
gi|2177096 (U67893) UDP-MurNAc-Tripeptide:D-Ala-D-Ala-Adding Enzyme
[Escherichia coli]
Length = 452
Score = 46.9 bits (109), Expect = 3e-04
Identities = 53/222 (23%), Positives = 87/222 (38%), Gaps = 17/222 (7%)
Query: 129 LIADILNADGQSAKLSGN----IGFPASEVAEKASASDTLVMELSSFQ----LMGIDSFR 180
+ A IL+ G + +GN IG P + + D V+EL + + R
Sbjct: 117 MTAAILSQCGNTLYTAGNLNNDIGVPMT-LLRLTPEYDYAVIELGANHQGEIAWTVSLTR 175
Query: 181 PKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATV 240
P+ AL+ NL +AHL+ GS AK I + + I+N + N +
Sbjct: 176 PEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWLNWQSVIGSRK 235
Query: 241 LAFSTKEKVNGAYSKDG--KIYFNDEYIMEVSE------LSLPGEHNLENALAAIVASKL 292
+ + N ++ E+ ++ L LPG HN+ NAL A S
Sbjct: 236 VWRFSPNAANSDFTATNIHVTSHGTEFTLQTPTGSVDVLLPLPGRHNIANALTAAALSMS 295
Query: 293 QGTKNEAIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNI 334
G +AI L + V RL + + + + +DS N+
Sbjct: 296 VGATLDAIKAGLANLKAVPGRLFPIQLAENQLLLDDSYNANV 337
emb|CAB66322.1| (AJ242646) MurD protein [Brevibacterium lactofermentum]
Length = 110
Score = 46.5 bits (108), Expect = 4e-04
Identities = 29/85 (34%), Positives = 48/85 (56%), Gaps = 8/85 (9%)
Query: 365 LEKDLQDLKGMVVFG----QTANKLRLTAEKLNIPVFDSENVAKALEEILPQ----TQAG 416
++K Q +K +V G + L+ A + ++ V D +A+EEI+ + ++ G
Sbjct: 10 VKKHEQRIKAALVLGADRAEIVAALKEHAPQASVFVTDKTEPFEAMEEIVTEAFSISEPG 69
Query: 417 DTILLSPACASWDQYKTFEERGDLF 441
DT+LL+PA AS D +K +RGDLF
Sbjct: 70 DTVLLAPAAASLDMFKGMGQRGDLF 94
sp|O25340|MURC_HELPY UDP-N-ACETYLMURAMATE--ALANINE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
>gi|2313743|gb|AAD07686.1| (AE000576)
UDP-N-acetylmuramate-alanine ligase (murC) [Helicobacter
pylori 26695]
Length = 449
Score = 46.5 bits (108), Expect = 4e-04
Identities = 73/333 (21%), Positives = 135/333 (39%), Gaps = 51/333 (15%)
Query: 4 ITKFKDQKILVLGLARSGMAA-ALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITG 62
+ +D KI +G+ G++ A L GA ++ G + + L G+++
Sbjct: 9 LKNLQDCKIHFIGIGGIGISGLAKYLKAQGATIS---GSDIAISPSVKYLKALGVEINIP 65
Query: 63 SHPIDLLDEDFALMVKNPGIRYDNPMVERAEALNIPVITEVELAY-LISEAPXXXXXXXX 121
P + ++D +++ + I+ DN ++RA+ L IP+++ + Y ++ +
Sbjct: 66 HDPKAINNQD--VIIHSAIIKEDNKEIQRAKELEIPILSRKDALYSILKDKRVFSVCGAH 123
Query: 122 XXXXXXXLIADILNADG-----QSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMGI 176
+++ I + G S + N+ + SA+D+LV E +
Sbjct: 124 GKSSITAMLSAICPSFGAIIGAHSKEFDSNV---------RESANDSLVFEADESDSSFL 174
Query: 177 DSFRPKIALITNLFSAHLDYHGSQK-----AYEAAKWRIQENMT-SDDFLILNFNQEKCR 230
S P A++ N HL+++G AYE Q+ + +D + N+++
Sbjct: 175 FS-NPYAAIVPNTEPEHLEHYGHDLERFFFAYEYFLDHAQKRVIYKEDPFLKNYSK---- 229
Query: 231 NLADKTKATVLAFSTKEKVNGAY-SKDGKIYFNDEYIMEVSELSL-----PGEHNLENAL 284
+ K+ N Y KDG+ Y + E+ +L GEHN NA
Sbjct: 230 --------NAIVLEKKDIYNIQYILKDGEPYTS----FELKDLGAFLVWGLGEHNATNAS 277
Query: 285 AAIVASKLQGTKNEAIVEVLTSFAGVKHRLQYL 317
AI+ S L E I L +F G+K R L
Sbjct: 278 LAIL-SALDELHLEEIRNNLLNFKGIKKRFDIL 309
sp|P74528|MURC_SYNY3 UDP-N-ACETYLMURAMATE--ALANINE LIGASE
(UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
>gi|1653723|dbj|BAA18634| (D90916)
UDP-N-acetylmuramate-alanine ligase [Synechocystis sp.]
Length = 505
Score = 46.5 bits (108), Expect = 4e-04
Identities = 25/71 (35%), Positives = 38/71 (53%), Gaps = 2/71 (2%)
Query: 272 LSLPGEHNLENALAAIVASKLQGTKNEAIVEVLTSFAGVKHRLQYLGEIDGRKVYND--S 329
++LPG+HN+ NALAA+ +L G I + + SF G K R + G +G +D
Sbjct: 318 VTLPGDHNISNALAAVAVGRLLGLDFPVIAQAIASFNGAKRRFECKGYCNGITFIDDYAH 377
Query: 330 KATNILATQKA 340
+ +LAT A
Sbjct: 378 HPSELLATLAA 388
sp|Q03523|MURE_BACSU UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE
(UDP-N-ACETYLMURAMYL-TRIPEPTIDE SYNTHETASE)
(MESO-DIAMINOPIMELATE-ADDING ENZYME)
>gi|477729|pir||B47691
UDP-N-acetylmuramoylalanyl-D-glutamate--2,
6-diaminopimelate ligase (EC 6.3.2.13) - Bacillus
subtilis >gi|40162|emb|CAA78767| (Z15056) murE [Bacillus
subtilis] >gi|2633889|emb|CAB13391| (Z99111)
UDP-N-acetylmuramoylananine-D-glutamate-2,6-
diaminopimelate ligase [Bacillus subtilis]
Length = 494
Score = 46.1 bits (107), Expect = 6e-04
Identities = 57/218 (26%), Positives = 87/218 (39%), Gaps = 25/218 (11%)
Query: 162 DTLVMELSSFQLM--GIDSFRPKIALITNLFSAHLDYHGSQKAYEAAKWRIQE------N 213
DT +ME+SS L + IA+ TNL HLDYH + Y AK + N
Sbjct: 171 DTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAKSLLFSQLGGAFN 230
Query: 214 MTSDDFLILNFNQEKCRNLADKTKATVLAFSTKEKVNGAYSKDGKIYFNDEYIMEVSE-- 271
+LN + E T A + + K + +K+ I V+
Sbjct: 231 HEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDAD-VMAKNISITAQGTSFDLVTNKG 289
Query: 272 -----LSLPGEHNLENALAAIVASKLQGTKNEAIVEVLTSFAGVKHRLQYLGEIDGRKVY 326
+SL G+ N+ N LAA+ G E I E + GV+ R + + + V
Sbjct: 290 TKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVRGRFELVNQQQEFPVI 349
Query: 327 NDSKAT-----NILATQKALSGFDNSKLWLLAG-GLDR 358
D T N+L T + ++ KL+++ G G DR
Sbjct: 350 VDYAHTPDSLENVLETCRDMT---EGKLFVVVGCGGDR 384
sp|O26631|Y531_METTH HYPOTHETICAL PROTEIN MTH531 >gi|2621605 (AE000836)
UDP-N-acetylmuramyl tripeptide synthetase related
protein [Methanobacterium thermoautotrophicum]
Length = 312
Score = 45.7 bits (106), Expect = 8e-04
Identities = 56/257 (21%), Positives = 99/257 (37%), Gaps = 18/257 (7%)
Query: 8 KDQKILVLGLARSGMAAALVLNELGAIVTVNDGK-----PFEENKEAQLLLEEGIKVITG 62
++ K+LV+G +G AA +LN L V VND + P + K + +EG+ G
Sbjct: 3 RNMKVLVIGAGNAGRPAARLLNHLNNRVLVNDVRELHELPLKAQKRIAEMEDEGVMFRFG 62
Query: 63 SHPI-DLLDEDFALMVKNPGIRYDNPMVERA-EALNIPVITEVELAYLISE---APXXXX 117
H + D+L D + +P I D P+ + EA ++ IT ++ ++E P
Sbjct: 63 GHSMEDILWADAVFI--SPNIPQDAPVRKMVREAGDLVHITTSDIGRTLNELIGLPMVGV 120
Query: 118 XXXXXXXXXXXLIADILNADGQSAKLSG------NIGFPASEVAEKASASDTLVMELSSF 171
+I IL++ ++ S G V D V EL
Sbjct: 121 AGTDGKTTTTNMIDHILSSRYRTVSFSSLQDSLVIEGLVELVVNGDIDDRDLAVFELPHG 180
Query: 172 QLMGIDSFRPKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRN 231
+ + ++TNL H+D + Y + I++ M L L + +
Sbjct: 181 TIRMAEGLELSAGVVTNLTPDHMDEFSNYDEYIERNFSIKDLMAPGGVLALCGDDPVISS 240
Query: 232 LADKTKATVLAFSTKEK 248
L D + + + E+
Sbjct: 241 LLDDLEVENVVYGVGER 257
emb|CAA18667.1| (AL022602) udp-n-acetylmuramate-alanine ligase [Mycobacterium
leprae]
Length = 235
Score = 44.9 bits (104), Expect = 0.001
Identities = 55/211 (26%), Positives = 87/211 (41%), Gaps = 33/211 (15%)
Query: 10 QKILVLGLARSGMAA-ALVLNELGAIVTVNDGKPFEENKEAQLLLEEGIKVITGSHPIDL 68
Q++ ++G+ SGM+ A +L + G +V+ +D K E++ L G + G H L
Sbjct: 11 QRVHMVGIGGSGMSGIARILLDRGGLVSGSDAK---ESRVVHALRARGALIRIG-HDASL 66
Query: 69 LD----EDFALMVKNPGIRYDNPMVERAEALNIPVITE-VELAYLISEAPXXXXXXXXXX 123
LD A++ I NP + A IPV+ LA L+
Sbjct: 67 LDLLPGGATAVITIRTAIPKTNPELVEARRRGIPVLLRSAVLARLMDGCTTLMVAGTHGK 126
Query: 124 XXXXXLIADILN---------ADGQSAKLSGNI--GFPASEVAEKASASDTLVMELSSFQ 172
++ L G+ A + N G A VAE A SD ++E
Sbjct: 127 TTTTSMLVVALQHCGCDPSFVVGGELAVVGTNAHHGLGACFVAE-ADESDGSLLE----- 180
Query: 173 LMGIDSFRPKIALITNLFSAHLDYHGSQKAY 203
+ P +A++TN+ S HLD++GS AY
Sbjct: 181 ------YTPNVAVVTNIDSDHLDFYGSVDAY 205
emb|CAB51998.1| (AL109663) putative
UDP-N-acetylmuramoylalanyl-D-glutamate-2,
6-diaminopimelate ligase [Streptomyces coelicolor A3(2)]
Length = 506
Score = 44.5 bits (103), Expect = 0.002
Identities = 42/170 (24%), Positives = 77/170 (44%), Gaps = 12/170 (7%)
Query: 161 SDTLVMELSSFQLM--GIDSFRPKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDD 218
++ + ME+SS L+ +D+ IA+ TNL H+++H + Y AK ++ S
Sbjct: 185 TEAVAMEVSSHALVLGRVDACVFDIAVFTNLSPEHMEFHSGMEDYFQAKAQLFTPKRS-R 243
Query: 219 FLILNFNQEKCRNLADKTKATVLAFSTKEKVNGAYSKD----GKI-----YFNDEYIMEV 269
++N + E R LA + V+ +S + + + D G + +
Sbjct: 244 LGVVNVDDEYGRRLAKEATVPVVTYSAEGHPDADWRADEVEVGPLDSTFTVLGPKGERIA 303
Query: 270 SELSLPGEHNLENALAAIVASKLQGTKNEAIVEVLTSFAGVKHRLQYLGE 319
++ L G N+ N LAAIVA G ++ + + + GV RL+ + E
Sbjct: 304 AKSPLAGPFNVANTLAAIVALAAAGLDPQSAADGVAAVPGVPGRLERVDE 353
gb|AAD18562| (AE001625) N-Acetylmuramoylalanylglutamyl DAP Ligase [Chlamydia
pneumoniae]
Length = 483
Score = 44.5 bits (103), Expect = 0.002
Identities = 36/136 (26%), Positives = 62/136 (45%), Gaps = 12/136 (8%)
Query: 162 DTLVMELSSFQLMG--IDSFRPKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDF 219
D +VME+SS L + A++TN+ HLD+HG+ + Y AAK ++ +
Sbjct: 171 DAVVMEVSSIGLASGRVAYTNFDTAVLTNITLDHLDFHGTFETYVAAKAKLFSLVPPSGM 230
Query: 220 LILNFNQEKCRNLADKTKATVLAFSTKEKVNG-----AYSKDGKIY---FNDEYIMEVSE 271
+++N + + KA V+ + + + S G Y + D+ I
Sbjct: 231 VVINTDSPYASQCIESAKAPVITYGIESAADYRATDIQLSSSGTKYTLVYGDQKI--ACS 288
Query: 272 LSLPGEHNLENALAAI 287
S G++N+ N LAAI
Sbjct: 289 SSFIGKYNVYNLLAAI 304
sp|O06220|MURF_MYCTU UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE--D-ALANYL-D-ALANYL LIGASE
(UDP-MURNAC-PENTAPEPTIDE SYNTHETASE)
(D-ALANYL-D-ALANINE-ADDING ENZYME)
>gi|2104321|emb|CAB08670| (Z95388) murF [Mycobacterium
tuberculosis]
Length = 510
Score = 44.5 bits (103), Expect = 0.002
Identities = 47/202 (23%), Positives = 84/202 (41%), Gaps = 13/202 (6%)
Query: 144 SGNIGFPASEVAEKASASDTLVMELSSFQLMGIDSFR----PKIALITNLFSAHLDYHGS 199
+ +G P + V +D L++E+++ I + P I ++ N+ +AHL GS
Sbjct: 165 NNELGHPWT-VLRATRRTDYLILEMAARHHGNIAALAEIAPPSIGVVLNVGTAHLGEFGS 223
Query: 200 QKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATVLAFS---TKEKVNGAYSKD 256
++ K + + + ++LN + +A T A V+ S T + G S D
Sbjct: 224 REVIAQTKAELPQAVPHSGAVVLNADDPAVAAMAKLTAARVVRVSRDNTGDVWAGPVSLD 283
Query: 257 ----GKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNEAIVEVLTSFAGV-K 311
+ + L + G+H + NAL A + G E + LT+ V +
Sbjct: 284 ELARPRFTLHAHDAQAEVRLGVCGDHQVTNALCAAAVALECGASVEQVAAALTAAPPVSR 343
Query: 312 HRLQYLGEIDGRKVYNDSKATN 333
HR+Q DG V +D+ N
Sbjct: 344 HRMQVTTRGDGVTVIDDAYNAN 365
sp|P45060|MURE_HAEIN UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE
(UDP-N-ACETYLMURAMYL-TRIPEPTIDE SYNTHETASE)
(MESO-DIAMINOPIMELATE-ADDING ENZYME)
>gi|1075415|pir||H64184 UDP-MurNac-tripeptide synthetase
(murE) homolog - Haemophilus influenzae (strain Rd KW20)
>gi|1574688 (U32793) UDP-N-acetylmuramyl-tripeptide
synthetase (murE) [Haemophilus influenzae Rd]
Length = 488
Score = 44.1 bits (102), Expect = 0.002
Identities = 60/248 (24%), Positives = 99/248 (39%), Gaps = 23/248 (9%)
Query: 130 IADILNADGQSAKLSGNIGFPASEVAEKASASDTLVMELSSFQLMG--IDSFRPKIALIT 187
I + N G + ++ ++ A K + +D +E+SS L +++ K A+ T
Sbjct: 149 IVEAKNTTGSAVEIQSSLS------AFKHAGADFTSIEVSSHGLAQHRVEALHFKAAIFT 202
Query: 188 NLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKATVLAFSTKE 247
NL HLDYH S + Y AAK R+ + + +I ++ + L + A ++ +
Sbjct: 203 NLTRDHLDYHQSMENYAAAKKRLFTELDTQIKVINADDEIGYQWLTELPDAIAVSMNADF 262
Query: 248 KVNG----------AYSKDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKN 297
KV + K I F + V L G N+ N L + G
Sbjct: 263 KVGSHQWMKAINIHYHFKGADITFESSWGNGVLHSPLIGAFNVSNLLLVMTTLLSFGYPL 322
Query: 298 EAIVEVLTSFAGVKHRLQYLGEIDGRKVYNDSKATNILATQKALSG---FDNSKLWLLAG 354
E ++ S GV R++ + + V D T A +KAL +LW + G
Sbjct: 323 ENLLATAKSLKGVCGRMEMIQYPNKPTVIVDYAHTPD-ALEKALIAAREHCQGELWCIFG 381
Query: 355 -GLDRGNG 361
G DR G
Sbjct: 382 CGGDRDRG 389
sp|Q44777|MURF_BORBU UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE--D-ALANYL-D-ALANYL LIGASE
(UDP-MURNAC-PENTAPEPTIDE SYNTHETASE)
(D-ALANYL-D-ALANINE-ADDING ENZYME) >gi|2688162
(AE001137)
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,
6-diaminopimelate--D-alanyl-D-alanine ligase (murF)
[Borrelia burgdorferi]
Length = 464
Score = 43.8 bits (101), Expect = 0.003
Identities = 66/277 (23%), Positives = 115/277 (40%), Gaps = 24/277 (8%)
Query: 143 LSGNIGFPAS----EVAEKASASDTLVMELSSFQLMGIDSFRPKIALITNLFSAHLDYHG 198
L+ +IG P S E E+ + + V + L+ +P+I +ITN+ AH+
Sbjct: 153 LNSDIGLPLSILRVEGNEEYAVFEVGVSYVGEMDLLS-QILKPEIVIITNISYAHMQAFK 211
Query: 199 SQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKAT-----VLAFSTKEKVNGAY 253
+A K +I + + ++N + C L + K ++ F + ++
Sbjct: 212 ELQAIAFEKSKIIGK--NIEIFVVNEMNDYCVYLEKRAKIANPNVKIVYFDFENLSIKSF 269
Query: 254 S-KDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNEAIVEVLTSFAGVKH 312
S DGK F+ Y + L G HN+ NA+ I + G + + I E L A K
Sbjct: 270 SFLDGKFSFDFVYKGFEYSILLLGRHNIFNAIGCINLALFLGMREKEIKEGLIETAFQKG 329
Query: 313 RLQYLGEIDGRKVYNDSKATNI---LATQKAL--SGFDNSKLWLLAGGLDRGNGFEELEK 367
R + L + +G + NDS N+ +A + + N K +L + G + K
Sbjct: 330 RAEILTK-NGYLILNDSYNGNMGSFMALKNMILDLNIQNKKFIVLGSFKELGELAYKTHK 388
Query: 368 DLQDLKGMVVFGQTANKLRLTAEKLNIPVFDSENVAK 404
DL +K+ L E+ + V DSEN+ +
Sbjct: 389 DLI----QEAISMNFDKIFLIGEEF-LDVRDSENLVE 420
gi|1165288 (U43739) MurF [Borrelia burgdorferi]
Length = 397
Score = 43.8 bits (101), Expect = 0.003
Identities = 66/277 (23%), Positives = 115/277 (40%), Gaps = 24/277 (8%)
Query: 143 LSGNIGFPAS----EVAEKASASDTLVMELSSFQLMGIDSFRPKIALITNLFSAHLDYHG 198
L+ +IG P S E E+ + + V + L+ +P+I +ITN+ AH+
Sbjct: 87 LNSDIGLPLSILRVEGNEEYAVFEVGVSYVGEMDLLS-QILKPEIVIITNISYAHMQAFK 145
Query: 199 SQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKAT-----VLAFSTKEKVNGAY 253
+A K +I + + ++N + C L + K ++ F + ++
Sbjct: 146 ELQAIAFEKSKIIGK--NIEIFVVNEMNDYCVYLEKRAKIANPNVKIVYFDFENLSIKSF 203
Query: 254 S-KDGKIYFNDEYIMEVSELSLPGEHNLENALAAIVASKLQGTKNEAIVEVLTSFAGVKH 312
S DGK F+ Y + L G HN+ NA+ I + G + + I E L A K
Sbjct: 204 SFLDGKFSFDFVYKGFEYSILLLGRHNIFNAIGCINLALFLGMREKEIKEGLIETAFQKG 263
Query: 313 RLQYLGEIDGRKVYNDSKATNI---LATQKAL--SGFDNSKLWLLAGGLDRGNGFEELEK 367
R + L + +G + NDS N+ +A + + N K +L + G + K
Sbjct: 264 RAEILTK-NGYLILNDSYNGNMGSFMALKNMILDLNIQNKKFIVLGSFKELGELAYKTHK 322
Query: 368 DLQDLKGMVVFGQTANKLRLTAEKLNIPVFDSENVAK 404
DL +K+ L E+ + V DSEN+ +
Sbjct: 323 DLI----QEAISMNFDKIFLIGEEF-LDVRDSENLVE 354
gi|3820539 (AF080002) UDP-N-acetylmuramyl tripeptide synthetase MurC
[Heliobacillus mobilis]
Length = 455
Score = 43.4 bits (100), Expect = 0.004
Identities = 43/176 (24%), Positives = 66/176 (37%), Gaps = 31/176 (17%)
Query: 271 ELSLPGEHNLENALAAIVASKLQGTKNEAIVEVLTSFAGVKHRLQYLGEIDGRKVY---- 326
ELS PG +N+ NALAAI ++ +AI L + R++ + DGR+ +
Sbjct: 264 ELSTPGFYNIYNALAAIASAIRLDLPEKAIRAGLQGYRTNFGRMERIELEDGRRAFLALI 323
Query: 327 ----------------NDSKATNILATQKALSGFDNSKLWLLAGGLDRGNGFEELEKDLQ 370
K ++ A G D S LW FE LE
Sbjct: 324 KNPTGCDEVIRTLVQNRGPKRLLVIINDNAADGRDISWLW--------DADFESLEPVYP 375
Query: 371 DLKGMVVFGQTANKLRLTAEKLNIP---VFDSENVAKALEEILPQTQAGDTILLSP 423
+L+ + G + L IP + NV A+ L T+ G+T+ + P
Sbjct: 376 ELRSVFTSGLRGEDMALRLNYTGIPAESIRYEANVESAIRSALEMTEPGETLYILP 431
sp|O33804|MURF_STRTO PROBABLE UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE--D-ALANYL-D-ALANYL LIGASE
(UDP-MURNAC-PENTAPEPTIDE SYNTHETASE)
(D-ALANYL-D-ALANINE-ADDING ENZYME) >gi|2228594 (U82965)
MurX [Streptomyces toyocaensis]
Length = 443
Score = 43.4 bits (100), Expect = 0.004
Identities = 46/195 (23%), Positives = 88/195 (44%), Gaps = 20/195 (10%)
Query: 129 LIADILNADGQSAKLSGNI----GFPASEVAEKASASDTLVMELSS------FQLMGIDS 178
L+A +L+A G + +G++ G P + + +A A+ LV+E+ + +L G+ +
Sbjct: 117 LLAAVLSAHGPTVATTGSLNNELGVPLTMLRAQA-ATRFLVLEMGARHEGDIAELTGLVA 175
Query: 179 FRPKIALITNLFSAHLDYHGSQKAYEAAKWRIQENMTSDDFLILNFNQEKCRNLADKTKA 238
P IA++ N+ AH+ GS+ A AK + + + +LN + + +++ T
Sbjct: 176 --PDIAVVLNVGVAHVGEFGSRAAIARAKGELVQGLVPGGTAVLNADDPRVASMSVLTDG 233
Query: 239 TVLAFSTKEK-----VNGAYSKDGKIYFNDEYIMEVSELSLP--GEHNLENALAAIVASK 291
VL F + ++ + G+ + + L+LP G H NA AA A+
Sbjct: 234 PVLTFGRTDPADVQVLDVVFDGLGRPSCTLRTVDTSARLALPLVGAHQALNASAAAAAAL 293
Query: 292 LQGTKNEAIVEVLTS 306
G + LT+
Sbjct: 294 AAGVPLDLATTALTT 308
sp|Q59650|MURE_PSEAE UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE
(UDP-N-ACETYLMURAMYL-TRIPEPTIDE SYNTHETASE)
(MESO-DIAMINOPIMELATE-ADDING ENZYME)
>gi|1084033|pir||S54873
UDP-N-acetylmuramoylalanyl-D-glutamate--2,
6-diaminopimelate ligase (EC 6.3.2.13) - Pseudomonas
aeruginosa (fragment) >gi|840843|emb|CAA58873| (X84053)
UDP-N-acetylmuramoylalanyl-D-glutamate--
2,6-diaminopimelate ligase [Pseudomonas aeruginosa]
Length = 325
Score = 43.0 bits (99), Expect = 0.005
Identities = 44/150 (29%), Positives = 69/150 (45%), Gaps = 25/150 (16%)
Query: 157 KASASDTLVMELSSFQLMGIDSFRPK-----IALITNLFSAHLDYHGSQKAYEAAKWRIQ 211
K + + + ME+SS G+D R IA+ TNL HLDYHGS +AY AAK ++
Sbjct: 165 KQAGARAVAMEVSSH---GLDQGRVAALGFDIAVFTNLSRDHLDYHGSMEAYAAAKAKL- 220
Query: 212 ENMTSDDF--LILNFNQEKCRNLA-DKTKATVLAFSTKEKVNGAYSKDGKIYFNDEYIME 268
D ++N + + R LA ++ + ++ +S + Y ++ + F D I
Sbjct: 221 --FAWPDLRCRVINLDDDFGRRLAGEEQDSELITYSLTDSSAFLYCREAR--FGDAGIEA 276
Query: 269 ---------VSELSLPGEHNLENALAAIVA 289
+ L G NL N LAA+ A
Sbjct: 277 ALVTPHGEGLLRSPLLGRFNLSNLLAAVGA 306
sp|O85298|MURE_BUCAP UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE
(UDP-N-ACETYLMURAMYL-TRIPEPTIDE SYNTHETASE)
(MESO-DIAMINOPIMELATE-ADDING ENZYME)
>gi|3435169|gb|AAC32338| (AF060492) meso-diaminopimelate
adding enzyme [Buchnera aphidicola]
Length = 292
Score = 42.2 bits (97), Expect = 0.009
Identities = 32/93 (34%), Positives = 46/93 (49%), Gaps = 11/93 (11%)
Query: 164 LVMELSSFQLMG--IDSFRPKIALITNLFSAHLDYHGSQKAYEAAKWRI--QENMTSDDF 219
+ ME+SS L+ + + I + TNL HLDYH + K YE+AKW Q +
Sbjct: 180 VTMEVSSHGLVQNRVKNIPFYIGIFTNLTQDHLDYHKNMKQYESAKWSFFSQHKIKK--- 236
Query: 220 LILNFNQEKC----RNLADKTKATVLAFSTKEK 248
+ILN N + R L+DK V + K+K
Sbjct: 237 IILNANDKYAKKWLRKLSDKYTIAVTIQNEKQK 269
Posted date: Mar 2, 2000 12:24 PM
Number of letters in database: 140,871,481
Number of sequences in database: 457,798
Lambda K H
0.315 0.133 0.366
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 109924773
Number of Sequences: 457798
Number of extensions: 4325202
Number of successful extensions: 10774
Number of sequences better than 1.0e-02: 80
Number of HSP's better than 0.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 37
Number of HSP's that attempted gapping in prelim test: 10603
Number of HSP's gapped (non-prelim): 94
length of query: 450
length of database: 140,871,481
effective HSP length: 61
effective length of query: 389
effective length of database: 112,945,803
effective search space: 43935917367
effective search space used: 43935917367
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (22.0 bits)
S2: 97 (42.2 bits)