Score E
Sequences producing significant alignments: (bits) Value
emb|CAB73455.1| (AL139077) 5-methyltetrahydropteroyltriglut... 876 0.0
pir||S57636 5-methyltetrahydropteroyltriglutamate--homocyst... 648 0.0
gb|AAF33427.1| (AF233324) 94% identity with E. coli 5-methy... 647 0.0
sp|P45331|METE_HAEIN 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE-... 646 0.0
gb|AAC50037.1| (U97200) cobalamin-independent methionine sy... 642 0.0
sp|P25665|METE_ECOLI 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE-... 642 0.0
pir||A42863 5-methyltetrahydropteroyltriglutamate--homocyst... 642 0.0
gb|AAF00639.1|AC009540_16 (AC009540) putative methionine sy... 640 0.0
gi|836660 (M87049) 5-methyltetrahydropteroyltriglutamate- h... 639 0.0
sp|P80877|METE_BACSU 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE-... 632 e-180
gi|1814403 (U84889) methionine synthase [Mesembryanthemum c... 629 e-179
emb|CAB57427.1| (AL121764) 5-methyltetrahydropteroyltriglut... 624 e-178
emb|CAA89019| (Z49150) cobalamine-independent methionine sy... 622 e-177
gb|AAF33834.1| (AF226997) methionine synthase [Cladosporium... 618 e-176
sp|O05564|METE_MYCLE 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE-... 617 e-176
gi|609350 (U15099) methionine synthase [Saccharomyces cerev... 609 e-173
ref|NP_011015.1|MET6| vitamin B12-(cobalamin)-independent i... 608 e-173
sp|O06584|METE_MYCTU 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE-... 599 e-170
gb|AAD36360.1|AE001784_2 (AE001784) 5-methyltetrahydroptero... 588 e-167
gi|2984022 (AE000752) tetrahydropteroyltriglutamate methylt... 584 e-166
sp|Q39586|METE_CHLRE 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE-... 490 e-137
dbj|BAA13829| (D89167) similar to Saccharomyces cerevisiae ... 413 e-114
gi|4098359 (U77388) cobalamin independent methionine syntha... 301 2e-80
prf||1501198A gamma Glu-Cys synthetase [Escherichia coli] 294 2e-78
dbj|BAA02955| (D13798) fused GSH-I [synthetic construct] 294 2e-78
emb|CAA30227| (X07238) delta-P8 [Saccharomyces cerevisiae] 291 2e-77
gb|AAF26735.1| (AF220054) methionine synthase [Coffea arabica] 230 3e-59
dbj|BAA81058.1| (AP000063) 332aa long hypothetical 5-methlt... 160 4e-38
emb|CAB49820.1| (AJ248285) related 5-methyltetrahydropteroy... 136 9e-31
dbj|BAA30188| (AP000004) 338aa long hypothetical 5-methylte... 131 2e-29
dbj|BAA23679| (AB004651) methionine synthase [Hyphomicrobiu... 115 1e-24
gi|3747048 (AF093539) methionine synthase [Zea mays] 83 8e-15
gb|AAD46411.1|AF096261_1 (AF096261) ethylene-responsive met... 80 5e-14
pir||S47051 hypothetical protein 1 - Xanthobacter sp >gi|52... 76 1e-12
emb|CAB38313| (AJ236870) methionin synthase-like enzyme [Ar... 68 4e-10
sp|O26869|Y775_METTH HYPOTHETICAL PROTEIN MTH775 >gi|262186... 67 6e-10
sp|Q58868|YE73_METJA HYPOTHETICAL PROTEIN MJ1473 >gi|212772... 63 1e-08
sp|P55299|Y775_METTM HYPOTHETICAL 34.6 KD PROTEIN IN TYSY 5... 62 2e-08
emb|CAB73455.1| (AL139077) 5-methyltetrahydropteroyltriglutamate--homocystei
methyltransferase [Campylobacter jejuni]
Length = 754
Score = 876 bits (2238), Expect = 0.0
Identities = 430/753 (57%), Positives = 554/753 (73%), Gaps = 2/753 (0%)
Query: 3 MKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISN 62
MK SII++PRIG+NRELKFA+EKYF+ + ++EEL AK++R+ +W+ ++AGID SN
Sbjct: 1 MKNSIISYPRIGANRELKFAIEKYFKNQSSKEELLKSAKDLRIRHWQEIQKAGIDFIPSN 60
Query: 63 DFSFYDQTLDLSIALGAIPGSYKNLELSELDTLFALARGFQDEQNDVKARPMKKWFNTNY 122
DFS YD LD ++ + YKNL L LD FA +RG+Q E DV A MKKWFNTNY
Sbjct: 61 DFSLYDNVLDAAVLFNIVHTKYKNLNLDALDEYFAQSRGYQGENGDVTALAMKKWFNTNY 120
Query: 123 HYLVPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGATKDTVL 182
HYLVPE + II K+ EY EAK G E++P +IG +T L +K T+
Sbjct: 121 HYLVPECDNADIIALTGDKIFKEYLEAKELGIESKPVLIGIFTLFKLIAFKDEKTQKLAK 180
Query: 183 SDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEEXXXXXXXXXXXXQ 242
++ A+ L +LN+L V WL+++EP LV D ++E+ LF Y+E Q
Sbjct: 181 EKLLNAYIELFDKLNELKVTWLELDEPYLVYDLSKEDIALFEEFYQELLNHKKDLKILLQ 240
Query: 243 TYFGDVRDSYKEIIKLDFDGIGLDFIEGRDSLALIQKYGFPKKKILFAGLVNGKNIWRNN 302
+YFGD+RD Y ++++ FD +GLDFIEG+ SLAL+Q+YGF K KILF GL+NGKNI+ N+
Sbjct: 241 SYFGDLRDIYPKLLESKFDALGLDFIEGKQSLALVQQYGFAKDKILFGGLINGKNIYAND 300
Query: 303 YQKTLELLTALDEVA-DIVINTSCSLQHVPVTIKNETKLSKEILKHFSFATEKLNEIDEI 361
Y K+L+L+ L + +I++NTSCSL HVP + + E+KL LK F+FA EKL E+ ++
Sbjct: 301 YAKSLKLIKELQKYTQNIILNTSCSLLHVPYSTEFESKLDSSYLKLFAFAKEKLQELKDL 360
Query: 362 SDIY-FNKNTSFLKKNVELFENERVRENSKLKQKLDKLTEKDFTRQPSLVERRASQSQSL 420
+I ++ + N ELF+N R + K+K +L L ++DFTR PS ER Q + L
Sbjct: 361 KEILNSSEENPLFRANQELFKNIPERLDEKVKARLKALKKEDFTRTPSFKERALIQKEFL 420
Query: 421 NLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKECLKLQEDIGLDVLV 480
LP+LPTTTIGSFPQ+A+VR RL K+ ++ +Y F ++KIKEC+++QE+IGLDVLV
Sbjct: 421 KLPLLPTTTIGSFPQSADVRSNRLAFKQEKISAQNYTEFNQQKIKECIQIQEEIGLDVLV 480
Query: 481 HGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTRPEAMTVRWSAYAQ 540
HGEFERNDMVEYFGE L+G++FTQ WVQSYGTRCVKPP++W DV+R + +T+ WS +AQ
Sbjct: 481 HGEFERNDMVEYFGENLKGFLFTQNGWVQSYGTRCVKPPVIWGDVSRTKPITLAWSKFAQ 540
Query: 541 SQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDLEKAGIKIIQIDEA 600
S + K VKGMLTGPVTILNWSFPREDISLK ST Q+ALA+++EVLDLE AGIKIIQIDEA
Sbjct: 541 SLSQKIVKGMLTGPVTILNWSFPREDISLKESTEQIALAIRDEVLDLENAGIKIIQIDEA 600
Query: 601 ALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEFEDIIPSIDAMDAD 660
ALREKLPLRKSDW+ EYLDWAIPAF LVHS VK +TQIHTHMCYSEF DI+ IDAMDAD
Sbjct: 601 ALREKLPLRKSDWHSEYLDWAIPAFNLVHSGVKAKTQIHTHMCYSEFSDILKEIDAMDAD 660
Query: 661 VISFEASRSELSIIDALKAHHFKTLVGPGVYDIHSPRIPSVKEIQNQLEKILDKLPIEQV 720
VISFEASRS LS++D LKA FKT VGPGVYDIHSPR+PSV+E+ +EKIL+KLP EQ+
Sbjct: 661 VISFEASRSNLSLLDTLKAIRFKTEVGPGVYDIHSPRVPSVEELSLTIEKILNKLPKEQI 720
Query: 721 WVNPDCGLKTRGNAETIPSLRHLVEATRVLRKE 753
W+NPDCGLKTR E I SL++LV AT+ +R++
Sbjct: 721 WINPDCGLKTRAYEEVITSLKNLVTATQKIREQ 753
pir||S57636 5-methyltetrahydropteroyltriglutamate--homocysteine
S-methyltransferase (EC 2.1.1.14) - Madagascar
periwinkle >gi|2129919|pir||S65957
5-methyltetrahydropteroyltriglutamate--homocysteine
S-methyltransferase (EC 2.1.1.14) - Madagascar
periwinkle >gi|886471|emb|CAA58474| (X83499) methionine
synthase [Catharanthus roseus]
Length = 765
Score = 648 bits (1653), Expect = 0.0
Identities = 348/767 (45%), Positives = 483/767 (62%), Gaps = 23/767 (2%)
Query: 3 MKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISN 62
M I+ +PR+G RELKFALE ++ K+ + E+LQ VA ++R WK +AGI SN
Sbjct: 1 MASHIVGYPRMGPKRELKFALESFWDKKSSAEDLQKVAADLRSSIWKQMADAGIKYIPSN 60
Query: 63 DFSFYDQTLDLSIALGAIPGSYKNLELSEL--DTLFALARGFQDEQNDVKARPMKKWFNT 120
FS+YDQ LD + LGA+P Y N E+ DT F++ARG V A M KWF+T
Sbjct: 61 TFSYYDQVLDTATMLGAVPPRY-NFAGGEIGFDTYFSMARG----NASVPAMEMTKWFDT 115
Query: 121 NYHYLVPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGATKD- 179
NYHY+VPE+ + K +NEYKEAK G +T P ++GP TFL+L+ G K
Sbjct: 116 NYHYIVPELGPEVNFSYASHKAVNEYKEAKELGVDTVPVLVGPVTFLLLSKPAKGVEKTF 175
Query: 180 ---TVLSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEEXXXXXXX 236
++L ++ ++ ++ EL G W+Q +EP LVLD + + F Y E
Sbjct: 176 PLLSLLDKILPVYKEVIGELKAAGASWIQFDEPTLVLDLESHQLEAFTKAYSELESTLSG 235
Query: 237 XXXXXQTYFGDV-RDSYKEIIKLD-FDGIGLDFIEGRDSLALIQKYGFPKKKILFAGLVN 294
+TYF D+ ++YK + L G G D + G +L LI K GFP K LFAG+V+
Sbjct: 236 LNVIVETYFADIPAETYKILTALKGVTGFGFDLVRGAKTLDLI-KGGFPSGKYLFAGVVD 294
Query: 295 GKNIWRNNYQKTLELLTALDEVAD---IVINTSCSLQHVPVTIKNETKLSKEILKHFSFA 351
G+NIW N+ +L L +L+ + +V++TSCSL H V + NE KL KEI +FA
Sbjct: 295 GRNIWANDLAASLSTLQSLEGIVGKDKLVVSTSCSLLHTAVDLVNEPKLDKEIKSWLAFA 354
Query: 352 TEKLNEIDEISD-IYFNKNTSFLKKNVELFENERVRE---NSKLKQKLDKLTEKDFTRQP 407
+K+ E++ ++ + K+ +F +N + + N +++ L D R
Sbjct: 355 AQKVVEVNALAKALAGEKDEAFFSENAAAQASRKSSPRVTNQAVQKAAAALRGSDHRRAT 414
Query: 408 SLVERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKEC 467
++ R +Q + LNLPVLPTTTIGSFPQT E+R+VR + K ++ + DY ++E+I +
Sbjct: 415 TVSARLDAQQKKLNLPVLPTTTIGSFPQTLELRRVRREYKAKKISEDDYVKAIKEEISKV 474
Query: 468 LKLQEDIGLDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTR 527
+KLQE++ +DVLVHGE ERNDMVEYFGE+L G+ FT WVQSYG+RCVKPPI++ DV+R
Sbjct: 475 VKLQEELDIDVLVHGEPERNDMVEYFGEQLSGFAFTANGWVQSYGSRCVKPPIIYGDVSR 534
Query: 528 PEAMTVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDL 587
P MTV WS AQS T +P+KGMLTGPVTILNWSF R D + Q+ALA+++EV DL
Sbjct: 535 PNPMTVFWSQTAQSMTKRPMKGMLTGPVTILNWSFVRNDQPRFETCYQIALAIKDEVEDL 594
Query: 588 EKAGIKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEF 647
EKAGI +IQIDEAALRE LPLRK++ + YLDWA+ +FR+ + ++ TQIHTHMCYS F
Sbjct: 595 EKAGINVIQIDEAALREGLPLRKAE-HAFYLDWAVHSFRITNLPLQDTTQIHTHMCYSNF 653
Query: 648 EDIIPSIDAMDADVISFEASRSELSIIDALK-AHHFKTLVGPGVYDIHSPRIPSVKEIQN 706
DII SI MDADV++ E SRS ++ + + +GPGVYDIHSPRIPS +EI +
Sbjct: 654 NDIIHSIIDMDADVMTIENSRSSEKLLSVFREGVKYGAGIGPGVYDIHSPRIPSTEEIAD 713
Query: 707 QLEKILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRKE 753
++ K+L L +WVNPDCGLKTR AE P+L ++V A +++R +
Sbjct: 714 RINKMLAVLDTNILWVNPDCGLKTRKYAEVKPALENMVSAAKLIRTQ 760
gb|AAF33427.1| (AF233324) 94% identity with E. coli
5-methyltetrahydropteroyltriglutamate--homocysteine
S-methyltransferase (METE) (SP:P25665) [Salmonella
typhimurium LT2]
Length = 754
Score = 647 bits (1652), Expect = 0.0
Identities = 339/759 (44%), Positives = 478/759 (62%), Gaps = 10/759 (1%)
Query: 1 MTMKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPI 60
MT+ + FPR+G RELK A E Y+ T E L V +E+R +W+ QK+AGID
Sbjct: 1 MTILTHTLGFPRVGLRRELKKAQESYWAGNTTREALLAVGRELRARHWEQQKQAGIDLLP 60
Query: 61 SNDFSFYDQTLDLSIALGAIPGSYKNLELS-ELDTLFALARGFQDEQNDVKARPMKKWFN 119
DF++YD L S+ LG +P ++N + S ++DTLF + RG A M KWFN
Sbjct: 61 VGDFAWYDHVLTTSLLLGNVPARHQNNDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFN 120
Query: 120 TNYHYLVPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGA-TK 178
TNYHY+VPE +K + +++LL E EA + G + +P ++GP T+L L K +
Sbjct: 121 TNYHYIVPEFSKGQQFRLTWTQLLEEVDEALALGHKIKPVLLGPVTYLWLGKVKGEPFDR 180
Query: 179 DTVLSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEEXXXXXXXXX 238
T+L D++ +Q +L EL + G+EW+QI+EPALVL+ + F Y+
Sbjct: 181 LTLLKDILPVYQHVLAELAKRGIEWVQIDEPALVLELPQAWLDAFKPAYDALAGQVKLLL 240
Query: 239 XXXQTYFGDVRDSYKEIIKLDFDGIGLDFIEGRDSLALIQKYGFPKKKILFAGLVNGKNI 298
TYF V + II L G+ +D I G+D +A + + P +L AGL+NG+N+
Sbjct: 241 T---TYFEGVTPNLDTIIALPVQGLHVDLIHGKDDVAELHQR-LPVDWLLSAGLINGRNV 296
Query: 299 WRNNYQKTLELLTALDEVADIVINTSCSLQHVPVTIKNETKLSKEILKHFSFATEKLNEI 358
WR + + + A+ + + +SCSL H P+ + ET+L E+ F+FA +K E+
Sbjct: 297 WRADLTEKYAQINAIVGKRALWVASSCSLLHSPIDLSVETRLDTEVKSWFAFALQKCGEL 356
Query: 359 DEISDIYFNKNTSFLKK---NVELFENERVRENSKLKQKLDKLTEKDFTRQPSLVERRAS 415
+ D + T+ L++ ++ + R N+ ++++L +T +D R+ R +
Sbjct: 357 ALLRDALNSGETAALEEWSAPIQARRHSRRVHNAAVEKRLAAITAQDSQRENPYEVRAEA 416
Query: 416 QSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKECLKLQEDIG 475
Q LP PTTTIGSFPQT E+R +RL K+G L Y T + E IK+ + QE +G
Sbjct: 417 QRARFKLPAWPTTTIGSFPQTTEIRGLRLDFKKGNLDANHYRTGIAEHIKQAIIEQERLG 476
Query: 476 LDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTRPEAMTVRW 535
LDVLVHGE ERNDMVEYFGE L+G+VFTQ WVQSYG+RCVKPP+V D++RP +TV W
Sbjct: 477 LDVLVHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVVIGDISRPAPITVEW 536
Query: 536 SAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDLEKAGIKII 595
+ YAQS T KPVKGMLTGPVTIL WSFPRED++ + Q+ALA+++EV DLE AGI II
Sbjct: 537 AKYAQSLTDKPVKGMLTGPVTILCWSFPREDVTRETIAKQIALALRDEVADLEAAGIGII 596
Query: 596 QIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEFEDIIPSID 655
QIDE ALRE LPLR+SDW YL+W + AFR+ + K ETQIHTHMCY EF DI+ SI
Sbjct: 597 QIDEPALREGLPLRRSDW-DAYLEWGVEAFRINAAVAKDETQIHTHMCYCEFNDIMDSIA 655
Query: 656 AMDADVISFEASRSELSIIDALKAHHFKTLVGPGVYDIHSPRIPSVKEIQNQLEKILDKL 715
A+DADVI+ E SRS++ ++++ +A + +GPGVYDIHSP +PSV+ I+ L+K ++
Sbjct: 656 ALDADVITIETSRSDMELLESFEAFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAQRI 715
Query: 716 PIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRKEK 754
P +++WVNPDCGLKTRG ET +L ++V+A LR+ K
Sbjct: 716 PAQRLWVNPDCGLKTRGWPETRAALANMVKAAHNLRQAK 754
sp|P45331|METE_HAEIN 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE
METHYLTRANSFERASE (METHIONINE SYNTHASE, VITAMIN-B12
INDEPENDENT ISOZYME) (COBALAMIN-INDEPENDENT METHIONINE
SYNTHASE) >gi|1075341|pir||B64137
5-methyltetrahydropteroyltriglutamate--homocysteine
S-methyltransferase (EC 2.1.1.14) - Haemophilus
influenzae (strain Rd KW20) >gi|1574556 (U32843)
5-methyltetrahydropteroyltriglutamate-homocysteine
methyltransferase (metE) [Haemophilus influenzae Rd]
Length = 756
Score = 646 bits (1648), Expect = 0.0
Identities = 346/760 (45%), Positives = 477/760 (62%), Gaps = 24/760 (3%)
Query: 7 IIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISNDFSF 66
I+ FPR+G+ RELKFA E+Y+RKE+ E++L +AK +R +NWK Q A D DF+F
Sbjct: 6 ILGFPRVGAKRELKFAQERYWRKELAEQDLLDLAKALREKNWKHQAAANADFVAVGDFTF 65
Query: 67 YDQTLDLSIALGAIPGSYK-NLELSELDTLFALARGFQDEQNDVKARPMKKWFNTNYHYL 125
YD LDL +A GAIP + + + LD F LARG +D+ A M KWF+TNYHYL
Sbjct: 66 YDHILDLQVATGAIPARFGFDSQNLTLDQYFQLARGNKDQF----AIEMTKWFDTNYHYL 121
Query: 126 VPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGA-TKDTVLSD 184
VPE K T KAN + +N+ +EAK+ G +P I+GP TFL L K A + +L+
Sbjct: 122 VPEFQKSTAFKANPAHYVNQIREAKALGLNFKPVIVGPLTFLWLGKEKGEAFNRFDLLNQ 181
Query: 185 VIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEEXXXXXXXXXXXXQTY 244
++ + +L L G EW+QI+EPAL LD E + + S+Y E TY
Sbjct: 182 LVPVYVEILNALVAEGAEWIQIDEPALALDLPAEWVEAYKSVYTELSKVNAKLLLA--TY 239
Query: 245 FGDVRDSYKEIIKLDFDGIGLDFIEGRDSLALIQKYGFPKKKILFAGLVNGKNIWRNNYQ 304
FG V + + + L G+ LD + + LA + Y K+L AG++ G+NIWR N
Sbjct: 240 FGSVAEHAELLKALPVAGLHLDLVRAPEQLAAFEDYS----KVLSAGVIEGRNIWRANLN 295
Query: 305 KTLELLTALDEVAD--IVINTSCSLQHVPVTIKNETKLSKEILKHFSFATEKLNEIDEIS 362
K L++L L + I SCSL H P ++ E +L ++ +S+ + L +++E++
Sbjct: 296 KVLDVLEPLKAKLGERLWIAPSCSLLHTPFDLEVEVQLKEKNTALYSWLSFTLQKVEELN 355
Query: 363 DIYFNKNTSFLKKNVELFENE---RVRENSK------LKQKLDKLTEKDFTRQPSLVERR 413
+ N L ++ R SK + ++L L + R+ ER
Sbjct: 356 VLKQALNNGRASVQAALDASQVAADARATSKEIHRPEVAERLANLPKGADQRKSPFAERI 415
Query: 414 ASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKECLKLQED 473
Q+ LNLP+LPTT IGSFPQT E+R R K+GEL ADY+ ++++I+ ++ QE+
Sbjct: 416 VKQNAWLNLPLLPTTNIGSFPQTTEIRHARASFKKGELSLADYEAAMKKEIEYVVRRQEE 475
Query: 474 IGLDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTRPEAMTV 533
+ LDVLVHGE ERNDMVEYFGE L+G+ FT+ WVQSYG+RCVKPP+++ DVTRPE MTV
Sbjct: 476 LDLDVLVHGEAERNDMVEYFGELLDGFAFTKFGWVQSYGSRCVKPPVIYGDVTRPEPMTV 535
Query: 534 RWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDLEKAGIK 593
RWS YAQS T++ +KGMLTGPVTIL WSF R DI Q+ +A+ +EVLDLE AGIK
Sbjct: 536 RWSQYAQSLTNRVMKGMLTGPVTILQWSFVRNDIPRSTVCKQIGVALSDEVLDLEAAGIK 595
Query: 594 IIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEFEDIIPS 653
+IQIDE A+RE LPL+++DW YL WA AFRL V+ +TQIHTHMCYSEF DI+P+
Sbjct: 596 VIQIDEPAIREGLPLKRADW-DAYLQWAGEAFRLSSMGVQDDTQIHTHMCYSEFNDILPA 654
Query: 654 IDAMDADVISFEASRSELSIIDALKAHHFKTLVGPGVYDIHSPRIPSVKEIQNQLEKILD 713
I A+DADVI+ E SRS++ ++ A + +GPGVYDIHSPR+P+ E+++ L K L+
Sbjct: 655 IAALDADVITIETSRSDMELLTAFADFKYPNDIGPGVYDIHSPRVPTATEVEHLLRKALN 714
Query: 714 KLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRKE 753
+P E++WVNPDCGLKTRG ETI L+ +V+ T+ LR E
Sbjct: 715 VIPKERLWVNPDCGLKTRGWTETIDQLKVMVDVTKKLRAE 754
gb|AAC50037.1| (U97200) cobalamin-independent methionine synthase [Arabidopsis
thaliana]
Length = 765
Score = 642 bits (1638), Expect = 0.0
Identities = 342/767 (44%), Positives = 485/767 (62%), Gaps = 23/767 (2%)
Query: 3 MKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISN 62
M I+ +PR+G RELKFALE ++ + T E+LQ V+ ++R WK AG SN
Sbjct: 1 MASHIVGYPRMGPKRELKFALESFWDGKSTAEDLQKVSADLRSSIWKQMSAAGTKFIPSN 60
Query: 63 DFSFYDQTLDLSIALGAIPG--SYKNLELSELDTLFALARGFQDEQNDVKARPMKKWFNT 120
F+ YDQ LD + LGA+P Y E+ LD F++ARG V A M KWF+T
Sbjct: 61 TFAHYDQVLDTTAMLGAVPPRYGYTGGEIG-LDVYFSMARG----NASVPAMEMTKWFDT 115
Query: 121 NYHYLVPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGATKD- 179
NYHY+VPE+ + K +NEYKEAK+ G +T P ++GP ++L+L+ G K
Sbjct: 116 NYHYIVPELGPEVNFSYASHKAVNEYKEAKALGVDTVPVLVGPVSYLLLSKAAKGVDKSF 175
Query: 180 ---TVLSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEEXXXXXXX 236
++L ++ ++ ++ EL G W+Q++EP LV+D ++ + F Y E
Sbjct: 176 ELLSLLPKILPIYKEVITELKAAGATWIQLDEPVLVMDLEGQKLQAFTGAYAELESTLSG 235
Query: 237 XXXXXQTYFGDV-RDSYKEIIKLD-FDGIGLDFIEGRDSLALIQKYGFPKKKILFAGLVN 294
+TYF D+ ++YK + L G D + G +L L+ K GFP+ K LFAG+V+
Sbjct: 236 LNVLVETYFADIPAEAYKTLTSLKGVTAFGFDLVRGTKTLDLV-KAGFPEGKYLFAGVVD 294
Query: 295 GKNIWRNNYQKTLELLTALDEVAD---IVINTSCSLQHVPVTIKNETKLSKEILKHFSFA 351
G+NIW N++ +L L AL+ + +V++TSCSL H V + NETKL EI +FA
Sbjct: 295 GRNIWANDFAASLSTLQALEGIVGKDKLVVSTSCSLLHTAVDLINETKLDDEIKSWLAFA 354
Query: 352 TEKLNEIDEISD-IYFNKNTSFLKKNVELFENERVRE---NSKLKQKLDKLTEKDFTRQP 407
+K+ E++ ++ + K+ + N + R N +++ L D R
Sbjct: 355 AQKVVEVNALAKALAGQKDEALFSANAAALASRRSSPRVTNEGVQKAAAALKGSDHRRAT 414
Query: 408 SLVERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKEC 467
++ R +Q + LNLP+LPTTTIGSFPQT E+R+VR + K ++ + DY ++E+IK+
Sbjct: 415 NVSARLDAQQKKLNLPILPTTTIGSFPQTVELRRVRREYKAKKVSEEDYVKAIKEEIKKV 474
Query: 468 LKLQEDIGLDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTR 527
+ LQE++ +DVLVHGE ERNDMVEYFGE+L G+ FT WVQSYG+RCVKPP+++ DV+R
Sbjct: 475 VDLQEELDIDVLVHGEPERNDMVEYFGEQLSGFAFTANGWVQSYGSRCVKPPVIYGDVSR 534
Query: 528 PEAMTVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDL 587
P+AMTV WSA AQS TS+P+KGMLTGPVTILNWSF R D + Q+ALA+++EV DL
Sbjct: 535 PKAMTVFWSAMAQSMTSRPMKGMLTGPVTILNWSFVRNDQPRHETCYQIALAIKDEVEDL 594
Query: 588 EKAGIKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEF 647
EK GI +IQIDEAALRE LPLRKS+ + YLDWA+ +FR+ + V+ TQIHTHMCYS F
Sbjct: 595 EKGGIGVIQIDEAALREGLPLRKSE-HAFYLDWAVHSFRITNCGVQDSTQIHTHMCYSHF 653
Query: 648 EDIIPSIDAMDADVISFEASRSELSIIDALK-AHHFKTLVGPGVYDIHSPRIPSVKEIQN 706
DII SI MDADVI+ E SRS+ ++ + + +GPGVYDIHSPRIPS +EI +
Sbjct: 654 NDIIHSIIDMDADVITIENSRSDEKLLSVFREGVKYGAGIGPGVYDIHSPRIPSSEEIAD 713
Query: 707 QLEKILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRKE 753
++ K+L L +WVNPDCGLKTR E P+L+++V+A +++R +
Sbjct: 714 RVNKMLAVLEQNILWVNPDCGLKTRKYTEVKPALKNMVDAAKLIRSQ 760
sp|P25665|METE_ECOLI 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE
METHYLTRANSFERASE (METHIONINE SYNTHASE, VITAMIN-B12
INDEPENDENT ISOZYME) (COBALAMIN-INDEPENDENT METHIONINE
SYNTHASE) >gi|2367304 (AE000458)
tetrahydropteroyltriglutamate methyltransferase
[Escherichia coli]
Length = 753
Score = 642 bits (1638), Expect = 0.0
Identities = 337/757 (44%), Positives = 475/757 (62%), Gaps = 10/757 (1%)
Query: 1 MTMKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPI 60
MT+ + FPR+G RELK A E Y+ T EEL V +E+R +W QK+AGID
Sbjct: 1 MTILNHTLGFPRVGLRRELKKAQESYWAGNSTREELLAVGRELRARHWDQQKQAGIDLLP 60
Query: 61 SNDFSFYDQTLDLSIALGAIPGSYKNLELS-ELDTLFALARGFQDEQNDVKARPMKKWFN 119
DF++YD L S+ LG +P ++N + S ++DTLF + RG A M KWFN
Sbjct: 61 VGDFAWYDHVLTTSLLLGNVPARHQNKDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFN 120
Query: 120 TNYHYLVPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGA-TK 178
TNYHY+VPE K K +++LL+E EA + G + +P ++GP T+L L K +
Sbjct: 121 TNYHYMVPEFVKGQQFKLTWTQLLDEVDEALALGHKVKPVLLGPVTWLWLGKVKGEQFDR 180
Query: 179 DTVLSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEEXXXXXXXXX 238
++L+D++ +Q +L EL + G+EW+QI+EPALVL+ + + Y+
Sbjct: 181 LSLLNDILPVYQQVLAELAKRGIEWVQIDEPALVLELPQAWLDAYKPAYDALQGQVKLLL 240
Query: 239 XXXQTYFGDVRDSYKEIIKLDFDGIGLDFIEGRDSLALIQKYGFPKKKILFAGLVNGKNI 298
TYF V + I L G+ +D + G+D +A + K P +L AGL+NG+N+
Sbjct: 241 T---TYFEGVTPNLDTITALPVQGLHVDLVHGKDDVAELHKR-LPSDWLLSAGLINGRNV 296
Query: 299 WRNNYQKTLELLTALDEVADIVINTSCSLQHVPVTIKNETKLSKEILKHFSFATEKLNEI 358
WR + + + + D+ + +SCSL H P+ + ET+L E+ F+FA +K +E+
Sbjct: 297 WRADLTEKYAQIKDIVGKRDLWVASSCSLLHSPIDLSVETRLDAEVKSWFAFALQKCHEL 356
Query: 359 DEISDIYFNKNTSFLKK---NVELFENERVRENSKLKQKLDKLTEKDFTRQPSLVERRAS 415
+ D + +T+ L + ++ + N ++++L +T +D R R +
Sbjct: 357 ALLRDALNSGDTAALAEWSAPIQARRHSTRVHNPAVEKRLAAITAQDSQRANVYEVRAEA 416
Query: 416 QSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKECLKLQEDIG 475
Q LP PTTTIGSFPQT E+R +RL K+G L +Y T + E IK+ + QE +G
Sbjct: 417 QRARFKLPAWPTTTIGSFPQTTEIRTLRLDFKKGNLDANNYRTGIAEHIKQAIVEQERLG 476
Query: 476 LDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTRPEAMTVRW 535
LDVLVHGE ERNDMVEYFGE L+G+VFTQ WVQSYG+RCVKPPIV D++RP +TV W
Sbjct: 477 LDVLVHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPIVIGDISRPAPITVEW 536
Query: 536 SAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDLEKAGIKII 595
+ YAQS T KPVKGMLTGPVTIL WSFPRED+S + Q+ALA+++EV DLE AGI II
Sbjct: 537 AKYAQSLTDKPVKGMLTGPVTILCWSFPREDVSRETIAKQIALALRDEVADLEAAGIGII 596
Query: 596 QIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEFEDIIPSID 655
QIDE ALRE LPLR+SDW YL W + AFR+ + K +TQIHTHMCY EF DI+ SI
Sbjct: 597 QIDEPALREGLPLRRSDW-DAYLQWGVEAFRINAAVAKDDTQIHTHMCYCEFNDIMDSIA 655
Query: 656 AMDADVISFEASRSELSIIDALKAHHFKTLVGPGVYDIHSPRIPSVKEIQNQLEKILDKL 715
A+DADVI+ E SRS++ ++++ + + +GPGVYDIHSP +PSV+ I+ L+K ++
Sbjct: 656 ALDADVITIETSRSDMELLESFEEFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAKRI 715
Query: 716 PIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRK 752
P E++WVNPDCGLKTRG ET +L ++V+A + LR+
Sbjct: 716 PAERLWVNPDCGLKTRGWPETRAALANMVQAAQNLRR 752
pir||A42863 5-methyltetrahydropteroyltriglutamate--homocysteine
S-methyltransferase (EC 2.1.1.14) - Escherichia coli
>gi|145474 (M87625) cobalamin-independent methionine
synthase [Escherichia coli]
Length = 753
Score = 642 bits (1638), Expect = 0.0
Identities = 337/757 (44%), Positives = 475/757 (62%), Gaps = 10/757 (1%)
Query: 1 MTMKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPI 60
MT+ + FPR+G RELK A E Y+ T EEL V +E+R +W QK+AGID
Sbjct: 1 MTILNHTLGFPRVGLRRELKKAQESYWAGNSTREELLAVGRELRARHWDQQKQAGIDLLP 60
Query: 61 SNDFSFYDQTLDLSIALGAIPGSYKNLELS-ELDTLFALARGFQDEQNDVKARPMKKWFN 119
DF++YD L S+ LG +P ++N + S ++DTLF + RG A M KWFN
Sbjct: 61 VGDFAWYDHVLTTSLLLGNVPARHQNKDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFN 120
Query: 120 TNYHYLVPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGA-TK 178
TNYHY+VPE K K +++LL+E EA + G + +P ++GP T+L L K +
Sbjct: 121 TNYHYMVPEFVKGQQFKLTWTQLLDEVDEALALGHKVKPVLLGPVTWLWLGKVKGEQFDR 180
Query: 179 DTVLSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEEXXXXXXXXX 238
++L+D++ +Q +L EL + G+EW+QI+EPALVL+ + + Y+
Sbjct: 181 LSLLNDILPVYQQVLAELAKRGIEWVQIDEPALVLELPQAWLDAYKPAYDALQGQVKLLL 240
Query: 239 XXXQTYFGDVRDSYKEIIKLDFDGIGLDFIEGRDSLALIQKYGFPKKKILFAGLVNGKNI 298
TYF V + I L G+ +D + G+D +A + K P +L AGL+NG+N+
Sbjct: 241 T---TYFEGVTPNLDTITALPVQGLHVDLVHGKDDVAELHKR-LPSDWLLSAGLINGRNV 296
Query: 299 WRNNYQKTLELLTALDEVADIVINTSCSLQHVPVTIKNETKLSKEILKHFSFATEKLNEI 358
WR + + + + D+ + +SCSL H P+ + ET+L E+ F+FA +K +E+
Sbjct: 297 WRADLTEKYAQIKDIVGKRDLWVASSCSLLHSPIDLSVETRLDAEVKSWFAFALQKCHEL 356
Query: 359 DEISDIYFNKNTSFLKK---NVELFENERVRENSKLKQKLDKLTEKDFTRQPSLVERRAS 415
+ D + +T+ L + ++ + N ++++L +T +D R R +
Sbjct: 357 ALLRDAVNSGDTAALAEWSAPIQARRHSTRVHNPAVEKRLAAITAQDSQRANVYEVRAEA 416
Query: 416 QSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKECLKLQEDIG 475
Q LP PTTTIGSFPQT E+R +RL K+G L +Y T + E IK+ + QE +G
Sbjct: 417 QRARFKLPAWPTTTIGSFPQTTEIRTLRLDFKKGNLDANNYRTGIAEHIKQAIVEQERLG 476
Query: 476 LDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTRPEAMTVRW 535
LDVLVHGE ERNDMVEYFGE L+G+VFTQ WVQSYG+RCVKPPIV D++RP +TV W
Sbjct: 477 LDVLVHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPIVIGDISRPAPITVEW 536
Query: 536 SAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDLEKAGIKII 595
+ YAQS T KPVKGMLTGPVTIL WSFPRED+S + Q+ALA+++EV DLE AGI II
Sbjct: 537 AKYAQSLTDKPVKGMLTGPVTILCWSFPREDVSRETIAKQIALALRDEVADLEAAGIGII 596
Query: 596 QIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEFEDIIPSID 655
QIDE ALRE LPLR+SDW YL W + AFR+ + K +TQIHTHMCY EF DI+ SI
Sbjct: 597 QIDEPALREGLPLRRSDW-DAYLQWGVEAFRINAAVAKDDTQIHTHMCYCEFNDIMDSIA 655
Query: 656 AMDADVISFEASRSELSIIDALKAHHFKTLVGPGVYDIHSPRIPSVKEIQNQLEKILDKL 715
A+DADVI+ E SRS++ ++++ + + +GPGVYDIHSP +PSV+ I+ L+K ++
Sbjct: 656 ALDADVITIETSRSDMELLESFEEFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAKRI 715
Query: 716 PIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRK 752
P E++WVNPDCGLKTRG ET +L ++V+A + LR+
Sbjct: 716 PAERLWVNPDCGLKTRGWPETRAALANMVQAAQNLRR 752
gb|AAF00639.1|AC009540_16 (AC009540) putative methionine synthase [Arabidopsis thaliana]
Length = 765
Score = 640 bits (1634), Expect = 0.0
Identities = 341/767 (44%), Positives = 481/767 (62%), Gaps = 23/767 (2%)
Query: 3 MKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISN 62
M I+ +PR+G RELKFALE ++ + + ++LQ V+ ++R + WK AGI SN
Sbjct: 1 MASHIVGYPRMGPKRELKFALESFWDGKSSADDLQKVSADLRSDIWKQMSAAGIKYIPSN 60
Query: 63 DFSFYDQTLDLSIALGAIPGSY--KNLELSELDTLFALARGFQDEQNDVKARPMKKWFNT 120
FS YDQ LD + LGA+P Y + E+ LD F++ARG V A M KWF+T
Sbjct: 61 TFSHYDQVLDTTAMLGAVPSRYGFTSGEIG-LDVYFSMARG----NASVPAMEMTKWFDT 115
Query: 121 NYHYLVPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGATKD- 179
NYHY+VPE+ + K +NEYKEAK+ G ET P ++GP ++L+L+ G K
Sbjct: 116 NYHYIVPELGPEVKFSYASHKAVNEYKEAKALGVETVPVLVGPVSYLLLSKLAKGVDKSF 175
Query: 180 ---TVLSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEEXXXXXXX 236
++L ++ ++ ++ EL G W+Q++EP V+D + + F Y E
Sbjct: 176 DLLSLLPKILPVYKEVIAELKAAGASWIQLDEPLFVMDLEGHKLQAFSGAYAELESTLSG 235
Query: 237 XXXXXQTYFGDV-RDSYKEIIKLD-FDGIGLDFIEGRDSLALIQKYGFPKKKILFAGLVN 294
+TYF D+ ++YK + L G D + G ++ LI K GFP+ K LFAG+V+
Sbjct: 236 LNVLVETYFADIPAEAYKTLTSLKGVTAFGFDLVRGTKTIDLI-KSGFPQGKYLFAGVVD 294
Query: 295 GKNIWRNNYQKTLELLTALDEVAD---IVINTSCSLQHVPVTIKNETKLSKEILKHFSFA 351
G+NIW N+ +L L +L+ V +V++TSCSL H V + NETKL EI +FA
Sbjct: 295 GRNIWANDLAASLITLQSLEGVVGKDKLVVSTSCSLLHTAVDLINETKLDAEIKSWLAFA 354
Query: 352 TEKLNEIDEISDIYFNK-NTSFLKKNVELFENERVRE---NSKLKQKLDKLTEKDFTRQP 407
+K+ E+D ++ + N SF N + + R N +++ L D R
Sbjct: 355 AQKVVEVDALAKALAGQTNESFFTANADALSSRRSSPRVTNESVQKAAAALKGSDHRRTT 414
Query: 408 SLVERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKEC 467
+ R +Q + LNLP+LPTTTIGSFPQT E+R+VR + K ++ + DY ++E+IK+
Sbjct: 415 EVSARLDAQQKKLNLPILPTTTIGSFPQTVELRRVRREYKAKKISEEDYVKAIKEEIKKV 474
Query: 468 LKLQEDIGLDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTR 527
+ +QED+ +DVLVHGE ERNDMVEYFGE+L G+ FT WVQSYG+RCVKPP+++ DV+R
Sbjct: 475 VDIQEDLDIDVLVHGEPERNDMVEYFGEQLSGFAFTANGWVQSYGSRCVKPPVIYGDVSR 534
Query: 528 PEAMTVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDL 587
P+ MTV WS+ AQS T +P+KGMLTGPVTILNWSF R D + Q+ALA+++EV DL
Sbjct: 535 PKPMTVFWSSTAQSMTKRPMKGMLTGPVTILNWSFVRNDQPRHETCYQIALAIKDEVEDL 594
Query: 588 EKAGIKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEF 647
EK GI +IQIDEAALRE LPLRK++ + YLDWA+ +FR+ + V+ TQIHTHMCYS F
Sbjct: 595 EKGGIGVIQIDEAALREGLPLRKAE-HSFYLDWAVHSFRITNCGVQDSTQIHTHMCYSNF 653
Query: 648 EDIIPSIDAMDADVISFEASRSELSIIDALK-AHHFKTLVGPGVYDIHSPRIPSVKEIQN 706
DII SI MDADVI+ E SRS+ ++ + + +GPGVYDIHSPRIPS EI +
Sbjct: 654 NDIIHSIIDMDADVITIENSRSDEKLLSVFREGVKYGAGIGPGVYDIHSPRIPSTDEIAD 713
Query: 707 QLEKILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRKE 753
++ K+L L +WVNPDCGLKTR E P+L+ +V+A +++R +
Sbjct: 714 RINKMLAVLEQNILWVNPDCGLKTRKYTEVKPALKAMVDAAKLIRSQ 760
gi|836660 (M87049) 5-methyltetrahydropteroyltriglutamate- homocysteine
methyltransferase [Escherichia coli]
Length = 753
Score = 639 bits (1630), Expect = 0.0
Identities = 335/757 (44%), Positives = 474/757 (62%), Gaps = 10/757 (1%)
Query: 1 MTMKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPI 60
MT+ + FPR+G RELK A E Y+ T EEL V +E+R +W QK+AGID
Sbjct: 1 MTILNHTLGFPRVGLRRELKKAQESYWAGNSTREELLAVGRELRARHWDQQKQAGIDLLP 60
Query: 61 SNDFSFYDQTLDLSIALGAIPGSYKNLELS-ELDTLFALARGFQDEQNDVKARPMKKWFN 119
DF++YD L S+ LG +P ++N + S ++DTLF + RG A M KWFN
Sbjct: 61 VGDFAWYDHVLTTSLLLGNVPARHQNKDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFN 120
Query: 120 TNYHYLVPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGA-TK 178
TNYHY+VPE K K +++LL+E EA + G + +P ++GP T+L L K +
Sbjct: 121 TNYHYMVPEFVKGQQFKLTWTQLLDEVDEALALGHKVKPVLLGPVTWLWLGKVKGEQFDR 180
Query: 179 DTVLSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEEXXXXXXXXX 238
++L+D++ +Q +L EL + G+EW+QI+EPALVL+ + + Y+
Sbjct: 181 LSLLNDILPVYQQVLAELAKRGIEWVQIDEPALVLELPQAWLDAYKPAYDALQGQVKLLL 240
Query: 239 XXXQTYFGDVRDSYKEIIKLDFDGIGLDFIEGRDSLALIQKYGFPKKKILFAGLVNGKNI 298
TYF V + I L G+ +D + G+D +A + K P +L AGL+NG+N+
Sbjct: 241 T---TYFEGVTPNLDTITALPVQGLHVDLVHGKDDVAELHKR-LPSDWLLSAGLINGRNV 296
Query: 299 WRNNYQKTLELLTALDEVADIVINTSCSLQHVPVTIKNETKLSKEILKHFSFATEKLNEI 358
WR + + + + D+ + +SCSL H P+ + ET+L E+ F+FA +K +E+
Sbjct: 297 WRADLTEKYAQIKDIVGKRDLWVASSCSLLHSPIDLSVETRLDAEVKSWFAFALQKCHEL 356
Query: 359 DEISDIYFNKNTSFLKK---NVELFENERVRENSKLKQKLDKLTEKDFTRQPSLVERRAS 415
+ D + +T+ L + ++ + N ++++L +T +D R R +
Sbjct: 357 ALLRDALNSGDTAALAEWSAPIQARRHSTRVHNPAVEKRLAAITAQDSQRANVYEVRAEA 416
Query: 416 QSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKECLKLQEDIG 475
Q LP PTTTIGSFPQT E+R +RL K+G L +Y T + E IK+ + QE +G
Sbjct: 417 QRARFKLPAWPTTTIGSFPQTTEIRTLRLDFKKGNLDANNYRTGIAEHIKQAIVEQERLG 476
Query: 476 LDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTRPEAMTVRW 535
LDVLVHGE ERNDMVEYFGE L+G+VFTQ WVQSYG+RCVKPPIV D++RP +TV W
Sbjct: 477 LDVLVHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPIVIGDISRPAPITVEW 536
Query: 536 SAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDLEKAGIKII 595
+ YAQS T KPVKGMLTGPVTIL WSFPRED+S + Q+ALA+++EV DLE AGI II
Sbjct: 537 AKYAQSLTDKPVKGMLTGPVTILCWSFPREDVSRETIAKQIALALRDEVADLEAAGIGII 596
Query: 596 QIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEFEDIIPSID 655
QIDE ALR+ LPLR+SDW YL W + AFR+ + K +TQIHTHMCY EF DI+ SI
Sbjct: 597 QIDEPALRQGLPLRRSDW-DAYLQWGVEAFRINAAVAKDDTQIHTHMCYCEFNDIMDSIA 655
Query: 656 AMDADVISFEASRSELSIIDALKAHHFKTLVGPGVYDIHSPRIPSVKEIQNQLEKILDKL 715
A+D DVI+ E SRS++ ++++ + + +GPGVYDIHSP +PSV+ I+ L+K ++
Sbjct: 656 ALDRDVITIETSRSDMELLESFEEFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAKRI 715
Query: 716 PIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRK 752
P E++WVNPDCGLKTRG ET +L ++V+A + LR+
Sbjct: 716 PAERLWVNPDCGLKTRGWPETRAALANMVQAAQNLRR 752
sp|P80877|METE_BACSU 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE
METHYLTRANSFERASE (METHIONINE SYNTHASE, VITAMIN-B12
INDEPENDENT ISOZYME) (COBALAMIN-INDEPENDENT METHIONINE
SYNTHASE) (SUPEROXIDE-INDUCIBLE PROTEIN 9) (SOI9)
>gi|2632038|emb|CAA05597| (AJ002571) MetC [Bacillus
subtilis] >gi|2633672|emb|CAB13175| (Z99110)
cobalamin-independent methionine synthase [Bacillus
subtilis]
Length = 762
Score = 632 bits (1613), Expect = e-180
Identities = 345/767 (44%), Positives = 484/767 (62%), Gaps = 25/767 (3%)
Query: 2 TMKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPIS 61
T+K S + FPRI NRE K ALE Y++ ++ E+ L K+Q + ID
Sbjct: 3 TIKTSNLGFPRIDLNREWKKALEAYWKGSTDKDTFLKQIDELFLSAVKTQIDQQIDVVPV 62
Query: 62 NDFSFYDQTLDLSIALGAIPGSYKNLELSELDTLFALARGFQDEQNDVKARPMKKWFNTN 121
+DF+ YD LD +++ IP +++L DT FA+ARG +D + M KWFNTN
Sbjct: 63 SDFTQYDHVLDTAVSFNWIPKRFRHLT-DATDTYFAIARGIKDAVSS----EMTKWFNTN 117
Query: 122 YHYLVPEINKDTIIKANFSKLLNEYKEAKSA-GFETRPTIIGPYTFLVLADYKSGATKDT 180
YHY+VPE ++ + +K L +Y+ K G ET+P I+GPYTF+ LA +
Sbjct: 118 YHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGPYTFVTLAKGYEPSEAKA 177
Query: 181 VLSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEE---EKKLFVSIYEEXXXXXXXX 237
+ ++ + LLKEL + GV+W+QI+EPALV +E+ K+LF SI E
Sbjct: 178 IQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRGAKELFESITSELSSLNVLL 237
Query: 238 XXXXQTYFGDVRDSYKEIIKLDFDGIGLDFIEGRD-SLALIQKYGFPKKKILFAGLVNGK 296
QTYF V D+Y+E+I GIGLDF+ + +L ++ +GFP K+L AG+++G+
Sbjct: 238 ----QTYFDSV-DAYEELISYPVQGIGLDFVHDKGRNLEQLKTHGFPTDKVLAAGVIDGR 292
Query: 297 NIWRNNYQKTLELLT---ALDEVADIVINTSCSLQHVPVTIKNETKLSKEILKHFSFATE 353
NIW+ + +++L+ + ++ +V ++ I S SL VPV + L K++L S+A E
Sbjct: 293 NIWKADLEESLDAVLDVLSIAKVDELWIQPSSSLLDVPVAKHPDEHLEKDLLNGLSYAKE 352
Query: 354 KLNEIDEISD------IYFNKNTSFLKKNVELFENERVRENSKLKQKLDKLTEKDFTRQP 407
KL E+ + + ++ K +++ + NS+ K++L++LT+KDF R
Sbjct: 353 KLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGANSEQKKELEQLTDKDFKRPI 412
Query: 408 SLVERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKEC 467
ER A Q++SL LP+LPTTTIGSFPQ+AEVR+ R + ++ E Y F+ + K
Sbjct: 413 PFEERLALQNESLGLPLLPTTTIGSFPQSAEVRRARQKWRKAEWSDEQYQNFINAETKRW 472
Query: 468 LKLQEDIGLDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTR 527
+ +QE++ LDVLVHGEFER DMVEYFGEKL G+ FT+ AWVQSYG+RCV+PP+++ DV
Sbjct: 473 IDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFTKYAWVQSYGSRCVRPPVIYGDVEF 532
Query: 528 PEAMTVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDL 587
E MTV+ + YAQS TSK VKGMLTGPVTILNWSFPR DIS K Q+ LA+++EV L
Sbjct: 533 IEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWSFPRNDISRKEIAFQIGLALRKEVKAL 592
Query: 588 EKAGIKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEF 647
E AGI+IIQ+DE ALRE LPL+ DW EYL WA AFRL S VK ETQIHTHMCYS F
Sbjct: 593 EDAGIQIIQVDEPALREGLPLKTRDW-DEYLTWAAEAFRLTTSSVKNETQIHTHMCYSNF 651
Query: 648 EDIIPSIDAMDADVISFEASRSELSIIDALKAHHFKTLVGPGVYDIHSPRIPSVKEIQNQ 707
EDI+ +I+ +DADVI+ E SRS +D LK H + +G GVYDIHSPR+PS +E+ N
Sbjct: 652 EDIVDTINDLDADVITIEHSRSHGGFLDYLKNHPYLKGLGLGVYDIHSPRVPSTEEMYNI 711
Query: 708 LEKILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRKEK 754
+ L P ++ WVNPDCGLKTR ET+ +L+++VEA + R ++
Sbjct: 712 IVDALAVCPTDRFWVNPDCGLKTRQQEETVAALKNMVEAAKQARAQQ 758
gi|1814403 (U84889) methionine synthase [Mesembryanthemum crystallinum]
Length = 765
Score = 629 bits (1605), Expect = e-179
Identities = 338/767 (44%), Positives = 480/767 (62%), Gaps = 23/767 (2%)
Query: 3 MKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISN 62
M I+ +PR+G RELKFALE ++ + T E+L+ V+ ++R WK +AGI SN
Sbjct: 1 MASHIVGYPRMGPKRELKFALESFWDGKSTAEDLKKVSADLRSSIWKQMADAGIKYIPSN 60
Query: 63 DFSFYDQTLDLSIALGAIPGSY--KNLELSELDTLFALARGFQDEQNDVKARPMKKWFNT 120
FS+YDQ LD + LGA+P Y E+ E D F++ARG V A M KWF+T
Sbjct: 61 TFSYYDQVLDTTAMLGAVPPRYGWTGGEI-EFDVYFSMARG----NASVPAMEMTKWFDT 115
Query: 121 NYHYLVPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGATKD- 179
NYH++VPE+ + K + EYKEAK+ G +T P ++GP ++L+L+ G K
Sbjct: 116 NYHFIVPELGPEVNFSYASHKAVLEYKEAKALGVDTVPVLVGPVSYLLLSKQAKGVDKSF 175
Query: 180 ---TVLSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEEXXXXXXX 236
++L ++ ++ ++ EL + G W+Q +EP LV+D + + F + Y +
Sbjct: 176 DLLSLLPKILPIYKEVVAELKEAGASWIQFDEPLLVMDLESHKLQAFSAAYADLESTLSG 235
Query: 237 XXXXXQTYFGDVR-DSYKEIIKLD-FDGIGLDFIEGRDSLALIQKYGFPKKKILFAGLVN 294
+TYF DV ++YK +I L G G D + G +L L+ K FP K LFAG+V+
Sbjct: 236 LNVVVETYFADVTAEAYKTLISLKGVTGYGFDLVRGTKTLDLV-KAEFPSGKYLFAGVVD 294
Query: 295 GKNIWRNNYQKTLELLTALDEVAD---IVINTSCSLQHVPVTIKNETKLSKEILKHFSFA 351
G+NIW N+ +L L AL+ V +V++TSCS H V + NETKL EI +FA
Sbjct: 295 GRNIWANDLAASLATLEALEGVVGKDKLVVSTSCSFLHTAVDLINETKLDDEIKSWLAFA 354
Query: 352 TEKLNEIDEISD-IYFNKNTSFLKKNVELFENERVRE---NSKLKQKLDKLTEKDFTRQP 407
+K+ E++ ++ + K+ +F N + + N +++ L D R
Sbjct: 355 AQKVLEVNALAKALSGQKDEAFFSANAAALASRKSSPRVTNEAVQKAATALKGSDHRRAT 414
Query: 408 SLVERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKEC 467
++ R +Q + LNLP+LPTTTIGSFPQT E+R+VR + K ++ + +Y ++E+I +
Sbjct: 415 TVSSRLDAQQKKLNLPILPTTTIGSFPQTVELRRVRREYKAKKISEEEYVKAIKEEISKV 474
Query: 468 LKLQEDIGLDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTR 527
+KLQE++ +DVLVHGE ERNDMVEYFGE+L G+ F+ WVQSYG+RCVKPPI++ DV+R
Sbjct: 475 VKLQEELDIDVLVHGEPERNDMVEYFGEQLSGFAFSANGWVQSYGSRCVKPPIIYGDVSR 534
Query: 528 PEAMTVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDL 587
P MTV WS+ AQS T++P+KGMLTGPVTILNWSF R D + Q+ALA++ EV DL
Sbjct: 535 PNPMTVFWSSMAQSMTARPMKGMLTGPVTILNWSFVRNDQPRHETCYQIALAIKNEVEDL 594
Query: 588 EKAGIKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEF 647
EKAGI +IQIDEAALRE LPLRKS+ + YL WA+ +FR+ + V+ TQIHTHMCYS F
Sbjct: 595 EKAGINVIQIDEAALREGLPLRKSE-HDFYLKWAVHSFRITNVGVQDTTQIHTHMCYSNF 653
Query: 648 EDIIPSIDAMDADVISFEASRSELSIIDALK-AHHFKTLVGPGVYDIHSPRIPSVKEIQN 706
DII SI MDADVI+ E SRS+ ++ + + +GPGVYDIHSPRIP +E+ +
Sbjct: 654 NDIIHSIIDMDADVITIENSRSDEKLLSVFREGVKYGAGIGPGVYDIHSPRIPPTEELAD 713
Query: 707 QLEKILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRKE 753
++ K+L L +WVNPDCGLKTR E P+L ++V A + LR+E
Sbjct: 714 RIRKMLAVLESNVLWVNPDCGLKTRKYGEVNPALSNMVAAAKQLRQE 760
emb|CAB57427.1| (AL121764) 5-methyltetrahydropteroyltriglutamate--homocystei
methyltransferase(ec 2.1.1.14) [Schizosaccharomyces
pombe]
Length = 764
Score = 624 bits (1593), Expect = e-178
Identities = 325/769 (42%), Positives = 486/769 (62%), Gaps = 26/769 (3%)
Query: 3 MKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISN 62
+K +++ FPRIG NRELK A E Y+ + + EEL AK++RLE+WK QK G+D SN
Sbjct: 2 VKSAVLGFPRIGKNRELKKATEAYWSGKTSAEELLATAKQLRLEHWKLQKAQGVDIIPSN 61
Query: 63 DFSFYDQTLDLSIALGAIPGSYKNLELSELDTLFALARGFQDEQN------DVKARPMKK 116
DFS YDQ +D S + IP Y+ LS LDT FA+ RG Q DV A M K
Sbjct: 62 DFSLYDQIMDHSFSFNVIPPRYRLSGLSSLDTYFAMGRGMQRAATADKAAVDVPAGEMVK 121
Query: 117 WFNTNYHYLVPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGA 176
WF++NYH+L PE++++T K + +K L+E+ EAK AG TRP ++GP T+L +A G+
Sbjct: 122 WFDSNYHFLRPEVSEETDFKLSSTKALDEFLEAKEAGIITRPVLVGPVTYLFIAKAAKGS 181
Query: 177 TKDTV--LSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEEXXXXX 234
+ + L ++ + L+K+L + G E++QI+EP L LD +E + S E
Sbjct: 182 SIKPIELLPKLLPVYVELIKKLTEAGAEYIQIDEPILTLDLPQE---ILASYKEAYETLG 238
Query: 235 XXXXXXXQTYFGDVRDSYKEIIKLDFDGIGLDFIEGRDSLALIQKYGFPKKKILFAGLVN 294
TYFG ++ + + L G+ +D + ++L + +I+ G+V+
Sbjct: 239 KIGKLILTTYFGSLQSNADVLKGLPIAGVHVDVVRAPENLDRALAV-LGENQIISVGVVS 297
Query: 295 GKNIWRNNYQKTLELLT-ALDEVAD--IVINTSCSLQHVPVTIKNETKLSKEILKHFSFA 351
G+NIW+ ++QK ++ A+ V + + +S S+ H+P ++ E +++ EI + F+FA
Sbjct: 298 GRNIWKTDFQKATAIIEKAISAVGSERVQVASSSSILHIPHSLSGEDQINPEIKRWFAFA 357
Query: 352 TEKLNEIDEISDIYFNKNTSFLKKNVELFENE-RVRENSKL------KQKLDKLTEKDFT 404
EK E+ ++ N + ++ +E + + R S + +++ K+T +
Sbjct: 358 VEKCAELAILTKAA-NDGPASVRAELEANAADCKARAESPITNVEAVRERQSKVTPQMHE 416
Query: 405 RQPSLVERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKI 464
R+ R A Q SL LP+ PTTTIGSFPQT E+R R + +G + Q +YD F+ ++I
Sbjct: 417 RKSPFETRYAKQQASLKLPLFPTTTIGSFPQTKEIRVTRNRFAKGLISQEEYDAFIRKEI 476
Query: 465 KECLKLQEDIGLDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTD 524
+ +K QE++GLDVLVHGE ERNDMV+YFGE++EG+VFT WVQSYG+RCV+PPI+ D
Sbjct: 477 SDVVKFQEEVGLDVLVHGEPERNDMVQYFGERMEGFVFTVNGWVQSYGSRCVRPPIIVGD 536
Query: 525 VTRPEAMTVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEV 584
V RP MTV+ S YAQS TSKP+KGMLT P+TIL WSFPR+D+ Q+AL +++EV
Sbjct: 537 VYRPAPMTVKESQYAQSITSKPMKGMLTAPITILRWSFPRDDVHDSVQAQQIALGLRDEV 596
Query: 585 LDLEKAGIKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCY 644
LDLEKAGIK+IQ DE ALRE LPLR+++W EYL WAI AFRL + V+ +TQIH+H CY
Sbjct: 597 LDLEKAGIKVIQCDEPALREGLPLRRAEW-DEYLKWAIDAFRLATAAVQDDTQIHSHFCY 655
Query: 645 SEFEDIIPSIDAMDADVISFEASRSELSIIDALKAHHFKTLVGPGVYDIHSPRIPSVKEI 704
S+F DI +I +DADV+S E S+S++ +++ L + + +GPG++DIHSPR+P V E
Sbjct: 656 SDFNDIFDAIQRLDADVVSIENSKSDMKLLNVLS--RYTSCIGPGLFDIHSPRVPPVSEF 713
Query: 705 QNQLEKILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRKE 753
+ +++ I+ +P + +W+NPDCGLKTRG ET L++++ A R R++
Sbjct: 714 KERIDAIVKHVPKDHLWLNPDCGLKTRGWPETTADLKNMIAAAREAREQ 762
emb|CAA89019| (Z49150) cobalamine-independent methionine synthase [Solenostemon
scutellarioides]
Length = 784
Score = 622 bits (1586), Expect = e-177
Identities = 341/767 (44%), Positives = 478/767 (61%), Gaps = 24/767 (3%)
Query: 3 MKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISN 62
M I+ +PR+G RELKFALE ++ + + E+L+ + + + K +AGI SN
Sbjct: 21 MASHIVGYPRMGPKRELKFALESFWDGKSSAEDLEKCQLILGI-HLKQMSDAGIKYIPSN 79
Query: 63 DFSFYDQTLDLSIALGAIPGSYKNLELSEL--DTLFALARGFQDEQNDVKARPMKKWFNT 120
FS+YDQ LD + LGA+P Y N E+ T F++ARG V A M KWF+T
Sbjct: 80 TFSYYDQVLDTTAMLGAVPPRY-NWTGGEIGFSTYFSMARG----NASVPAMEMTKWFDT 134
Query: 121 NYHYLVPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGATKD- 179
NYH++VPE+ D K +NEYKEAK+ G +T P ++GP ++L+L+ G K
Sbjct: 135 NYHFIVPELGPDVKFSYASHKAVNEYKEAKALGVDTVPVLVGPVSYLILSKPAKGVEKTF 194
Query: 180 ---TVLSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEEXXXXXXX 236
++L ++ ++ ++ EL G W+Q +EP LVLD + F Y E
Sbjct: 195 PLLSLLDKILPIYKEVIAELKAAGASWIQFDEPTLVLDLESHQLDAFTKAYAELESSLSG 254
Query: 237 XXXXXQTYFGDV-RDSYKEIIKLD-FDGIGLDFIEGRDSLALIQKYGFPKKKILFAGLVN 294
+TYF DV +YK + L G G D + G ++ LI K GFP K LFAG+V+
Sbjct: 255 LSTLIETYFADVPAPAYKTLTSLSGISGFGFDLVRGAQTIELI-KGGFPSGKYLFAGVVD 313
Query: 295 GKNIWRNNYQKTLELLTALDEVAD---IVINTSCSLQHVPVTIKNETKLSKEILKHFSFA 351
G+NIW N+ ++ L AL+ + +V++TS SL H V + NE KL +EI +FA
Sbjct: 314 GRNIWANDLASSITTLQALEGIVGKDKLVVSTSSSLLHTAVDLVNEPKLDQEIKSWLAFA 373
Query: 352 TEKLNEIDEISD-IYFNKNTSFLKKNV--ELFENERVRENSKLKQKLDK-LTEKDFTRQP 407
+K+ E++ ++ + +K+ +F N + R N++ QK L + R
Sbjct: 374 AQKIVEVNALAKALTGHKDEAFFSPNAAAQASRKSSPRVNNEAVQKAAAALRGSEHRRVT 433
Query: 408 SLVERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKEC 467
++ R +Q + LNLP+LPTTTIGSFPQT E+R+VR + K + + +Y ++E+I +
Sbjct: 434 NVSARLDAQQKKLNLPILPTTTIGSFPQTVELRRVRREFKPTRISEEEYVKAIKEEINKV 493
Query: 468 LKLQEDIGLDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTR 527
+KLQE++ +DVLVHGE ERNDMVEYFGE+L G+ FT WVQSYG+RCVKPPI++ DV+R
Sbjct: 494 VKLQEELDIDVLVHGEPERNDMVEYFGEQLSGFAFTANGWVQSYGSRCVKPPIIYGDVSR 553
Query: 528 PEAMTVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDL 587
P+ MTV WS AQS T +P+KGMLTGPVTILNWSF R D + Q+ALA+++EV DL
Sbjct: 554 PKPMTVFWSTAAQSMTQRPMKGMLTGPVTILNWSFVRNDQPRFETCYQIALAIKDEVEDL 613
Query: 588 EKAGIKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEF 647
EKAGI +IQIDEAALRE LPLRKS+ + YLDWA+ +FR+ + V+ TQIHTHMCYS F
Sbjct: 614 EKAGITVIQIDEAALREGLPLRKSE-HAFYLDWAVHSFRITNVGVQDTTQIHTHMCYSNF 672
Query: 648 EDIIPSIDAMDADVISFEASRSELSIIDALK-AHHFKTLVGPGVYDIHSPRIPSVKEIQN 706
DII SI MDADVI+ E SRS+ ++ + + +GPGVYDIHSPRIPS +EI +
Sbjct: 673 NDIIHSIINMDADVITIENSRSDEKLLSVFREGVKYGAGIGPGVYDIHSPRIPSTEEIAD 732
Query: 707 QLEKILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRKE 753
++ K+L L +WVNPDCGLKTR AE P+L ++V A ++LR +
Sbjct: 733 RINKMLAVLETNILWVNPDCGLKTRKYAEVKPALENMVAAAKLLRTQ 779
gb|AAF33834.1| (AF226997) methionine synthase [Cladosporium fulvum]
Length = 768
Score = 618 bits (1577), Expect = e-176
Identities = 325/768 (42%), Positives = 488/768 (63%), Gaps = 18/768 (2%)
Query: 3 MKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISN 62
++ S++ FPR+G R+LK A E Y+ +++ +EL K +RLE+WK QK+AG+D SN
Sbjct: 2 VQSSVLGFPRMGRLRDLKKANEAYWGDKLSRDELLAEGKRLRLEHWKIQKDAGVDIIPSN 61
Query: 63 DFSFYDQTLDLSIALGAIPGSYKNLELSELDTLFALARGFQDEQNDVKARPMKKWFNTNY 122
DF++YD LD AIP Y + +L +LD FA+ RG Q + DV + M KWF++NY
Sbjct: 62 DFAYYDHVLDHIQMFNAIPERYSSAKLHKLDEYFAMGRGHQKDGVDVPSLEMVKWFDSNY 121
Query: 123 HYLVPEINKDTIIKANFS-KLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGATKD-- 179
HY+ P + + K + + K + E+ E K AG RP ++GP +FL L T D
Sbjct: 122 HYVKPTLQDNQTFKLSENPKPVAEFLEXKEAGIH-RPVLLGPVSFLALGKADRNQTVDPI 180
Query: 180 TVLSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEEXXXXXXXXX- 238
T+L ++ ++ LLK+L Q G E +QI+EP LV D + + F YE+
Sbjct: 181 TLLEKLLPVYEELLKKLKQAGAETVQIDEPVLVFDLPSKTRNAFKPAYEKLTALQGKEGP 240
Query: 239 -XXXQTYFGDVRDSYKEI--IKLDFDGIGLDFIEGRDSLALIQKYGFPKKKILFAGLVNG 295
TYFGD+ ++ + + +D + + L ++ +IL AG+V+G
Sbjct: 241 QLVLATYFGDIVHNFDVVDAALTKTYALHVDLVRHPEQLEKGAQH-LGSNQILSAGIVDG 299
Query: 296 KNIWRNNYQKTLELL-TALDEVAD--IVINTSCSLQHVPVTIKNETKLSKEILKHFSFAT 352
+NIW+ N++K +E L TA+ +V +++ TS SL H P T+++E L E+ FSFAT
Sbjct: 300 RNIWKTNFKKAIETLETAVQKVGKDHVIVATSSSLLHTPHTLESEKNLDDEVRDWFSFAT 359
Query: 353 EKLNEIDEISDIYFNKNT---SFLKKNVELFENERVRE---NSKLKQKLDKLTEKDFTRQ 406
+K +E+ ++ + S L+ N + E+ R + N ++++++ + + D+ R+
Sbjct: 360 QKASEVAILAKAVTDGPDAVKSQLEANAKSMESRRTSKRTNNPEVQKRVSSVQKADYERK 419
Query: 407 PSLVERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKE 466
+R A+Q + LNLP PTTTIGSFPQT E+R R + +GE+ + +YD F+E +I++
Sbjct: 420 NPFEQRIAAQKKHLNLPEFPTTTIGSFPQTKEIRVQRNKFTKGEITEKEYDEFIEAEIRD 479
Query: 467 CLKLQEDIGLDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVT 526
+K+QE++GLDV VHGE ERNDMV+YFGE+L+GYVFT AWVQSYG+RCV+PPI+ DV+
Sbjct: 480 NIKIQEELGLDVYVHGEPERNDMVQYFGERLDGYVFTTHAWVQSYGSRCVRPPILVGDVS 539
Query: 527 RPEAMTVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLD 586
RP+ MTV+ S YA SQ+ KP+KGMLTGP+T L WSFPR+D+ QLALA+++EV+D
Sbjct: 540 RPKPMTVKESKYAVSQSKKPMKGMLTGPITCLRWSFPRDDVHQSIQAAQLALALRDEVVD 599
Query: 587 LEKAGIKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSE 646
L+ AG+ +IQIDE ALRE LPLR ++YL WA+ +F+L + V+ TQIH+H CYSE
Sbjct: 600 LQNAGVAVIQIDEPALREGLPLRSGSEREKYLQWAVDSFKLSAAGVEDATQIHSHFCYSE 659
Query: 647 FEDIIPSIDAMDADVISFEASRSELSIIDALKAHHFKTLVGPGVYDIHSPRIPSVKEIQN 706
F+D +I A+DADV+S E S+S+ ++ + +GPGVYDIHSPRIPS +EI++
Sbjct: 660 FQDFFHAIAALDADVLSIENSKSDAKLLKVFIDEKYPRHIGPGVYDIHSPRIPSEQEIKD 719
Query: 707 QLEKILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRKEK 754
+++++L L EQ+W+NPDCGLKTR ET +L H+V A + R +K
Sbjct: 720 RIQEMLQYLTPEQLWINPDCGLKTRQWKETKDALAHMVSAAQHFRSQK 767
sp|O05564|METE_MYCLE 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE
METHYLTRANSFERASE (METHIONINE SYNTHASE, VITAMIN-B12
INDEPENDENT ISOZYME) (COBALAMIN-INDEPENDENT METHIONINE
SYNTHASE) >gi|2052110|emb|CAB08123| (Z94723) MetE
[Mycobacterium leprae]
Length = 760
Score = 617 bits (1575), Expect = e-176
Identities = 333/760 (43%), Positives = 461/760 (59%), Gaps = 29/760 (3%)
Query: 6 SIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISNDFS 65
++ PRIG RELK A E Y+ K + EL++VA +R + W AG+DS N FS
Sbjct: 13 TVTGSPRIGPRRELKRATEGYWAKRTSRSELESVASTLRRDMWSDLAAAGLDSVPVNTFS 72
Query: 66 FYDQTLDLSIALGAIPGSYKNLELSELDTLFALARGFQDEQNDVKARPMKKWFNTNYHYL 125
+YDQ LD + LGA+P + +LD FALARG ND+K M KWF+TNYHYL
Sbjct: 73 YYDQMLDTAFMLGALPARVAQVS-DDLDQYFALARG----NNDIKPLEMTKWFDTNYHYL 127
Query: 126 VPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLAD-YKSGATKDTVLSD 184
VPEI T N K+L E KEA +RP IIGP TFL+L+ G L +
Sbjct: 128 VPEIEPATTFSLNPGKILGELKEALEQRIPSRPVIIGPVTFLLLSKGINGGGAPIQRLEE 187
Query: 185 VIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEEXXXXXXXXXXXXQTY 244
++ + TLL L + G W+Q +EPALV D + + L ++Y TY
Sbjct: 188 LVGIYCTLLSLLAENGARWVQFDEPALVTDLSPDAPALAEAVYTALGSVSKRPAIYVATY 247
Query: 245 FGDVRDSYKEIIKLDFDGIGLDFIEGRD-SLALIQKYGFPKKKILFAGLVNGKNIWRNNY 303
FG+ S + + + IG+DF+ G D S+A + + K L AG+V+G+NIWR +
Sbjct: 248 FGNPGASLAGLARTPIEAIGVDFVCGADTSVAAVPELA---GKTLVAGIVDGRNIWRTDL 304
Query: 304 QKTL-ELLTALDEVADIVINTSCSLQHVPVTIKNETKLSKEILKHFSFATEKLNEI---- 358
+ L +L T L A + ++TSCS HVP +++ ET L + +F EK+ E+
Sbjct: 305 ESALSKLATLLGSAATVAVSTSCSTLHVPYSLEPETDLDDNLRSWLAFGAEKVAEVVVLA 364
Query: 359 -------DEISDIYFNKNTSFLKKNVELFENERVRENSKLKQKLDKLTEKDFTRQPSLVE 411
D ++D N + + ++ N +++ ++D + T + +
Sbjct: 365 RALRDGRDAVADEIAASNAAVASRR-----SDPRLHNGQVRARIDSIVASG-THRGDAAQ 418
Query: 412 RRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKECLKLQ 471
RR SQ L+LP LPTTTIGS+PQT+ +RK R + E+ +A+Y + +++++ + +KLQ
Sbjct: 419 RRTSQDARLHLPPLPTTTIGSYPQTSAIRKARAALQDAEIDEAEYISRMKKEVADAIKLQ 478
Query: 472 EDIGLDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTRPEAM 531
E +GLDVLVHGE ERNDMV+YF E+L G+ TQ WVQSYG+RCV+PPI++ DV+RP M
Sbjct: 479 EQLGLDVLVHGEPERNDMVQYFAEQLGGFFATQNGWVQSYGSRCVRPPILYGDVSRPHPM 538
Query: 532 TVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDLEKAG 591
T+ W YAQS T KPVKGMLTGPVTIL WSF R+D L + Q+ALA+++E +DL+ AG
Sbjct: 539 TIEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAG 598
Query: 592 IKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEFEDII 651
I IIQ+DE ALRE LPLR++D EYL WA+ AFRL S V TQIHTH+CYSEF ++I
Sbjct: 599 IAIIQVDEPALRELLPLRRAD-QDEYLCWAVKAFRLATSGVADSTQIHTHLCYSEFGEVI 657
Query: 652 PSIDAMDADVISFEASRSELSIIDALKAHHFKTLVGPGVYDIHSPRIPSVKEIQNQLEKI 711
+I +DADV S EA+RS + ++D L A F +GPGVYDIHSPR+PS EI L
Sbjct: 658 GAIADLDADVTSIEAARSHMEVLDDLNAVGFANSIGPGVYDIHSPRVPSTDEIAKSLRAA 717
Query: 712 LDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLR 751
L +P++++WVNPDCGLKTR E SL+++V A R +R
Sbjct: 718 LKAIPMQRLWVNPDCGLKTRSVDEVSASLQNMVAAARQVR 757
gi|609350 (U15099) methionine synthase [Saccharomyces cerevisiae]
Length = 767
Score = 609 bits (1553), Expect = e-173
Identities = 337/774 (43%), Positives = 473/774 (60%), Gaps = 34/774 (4%)
Query: 3 MKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISN 62
++ +++ FPRIG NRELK A E Y+ +IT +EL V K++R +NWK QKEAG+D SN
Sbjct: 2 VQSAVLGFPRIGPNRELKKATEGYWNGKITVDELFKVGKDLRTQNWKLQKEAGVDIIPSN 61
Query: 63 DFSFYDQTLDLSIALGAIPGSYKNLELSELDTLFALARGFQ------DEQNDVKARPMKK 116
DFSFYDQ LDLS+ IP Y +LS +DTLFA+ RG Q ++ DV A M K
Sbjct: 62 DFSFYDQVLDLSLLFNVIPDRYTKYDLSPIDTLFAMGRGLQRKATETEKAVDVTALEMVK 121
Query: 117 WFNTNYHYLVPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGA 176
WF++NYHY+ P +K T K N K ++E+ EAK G TRP ++GP ++L L A
Sbjct: 122 WFDSNYHYVRPTFSKTTQFKLNGQKPVDEFLEAKELGIHTRPVLLGPVSYLFLGK----A 177
Query: 177 TKDTV-------LSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEE 229
KD++ L ++ + +L +L G +QI+EP LVLD + Y
Sbjct: 178 DKDSLDLEPLSLLEQLLPLYTEILSKLASAGATEVQIDEPVLVLDLPANAQAAIKKAYTY 237
Query: 230 XXXXXXXXXXXXQTYFGDVRDSYKEIIKLDFDGIGLDFIEGRDSLALIQKYGFPKKKILF 289
TYFG V + I L + +DF+ + + K+ L
Sbjct: 238 FGEQSNLPKITLATYFGTVVPNLDAIKGLPVAALHVDFVRAPEQFDEVVA-AIGNKQTLS 296
Query: 290 AGLVNGKNIWRNNYQKTLELLT-ALDEV-AD-IVINTSCSLQHVPVTIKNETKLSKEILK 346
G+V+G+NIW+N+++K+ ++ A++++ AD +V+ TS SL H PV + NETKL EI
Sbjct: 297 VGIVDGRNIWKNDFKKSSAIVNKAIEKLGADRVVVATSSSLLHTPVDLNNETKLDAEIKG 356
Query: 347 HFSFATEKLNEIDEISDIYFNKNTSFL----KKNVELFENERVRENSKLKQKLDKLTEKD 402
FSFAT+KL+E+ I+ ++ + K+VE + ++ +K+++ + EK
Sbjct: 357 FFSFATQKLDEVVVITKNVSGQDVAAALEANAKSVESRGKSKFIHDAAVKRRVASIDEKM 416
Query: 403 FTRQPSLVERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEE 462
TR +R Q + NLP+ PTTTIGSFPQT ++R R + +G + +Y+ F+
Sbjct: 417 STRAAPFEQRLPEQQKVFNLPLFPTTTIGSFPQTKDIRINRNKFNKGTISAEEYEKFINS 476
Query: 463 KIKECLKLQEDIGLDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVW 522
+I++ ++ QE+IGLDVLVHGE ERNDMV+YFGE++ GY FT WVQSYG+R V+PPI+
Sbjct: 477 EIEKVIRFQEEIGLDVLVHGEPERNDMVQYFGEQINGYAFTVNGWVQSYGSRYVRPPIIV 536
Query: 523 TDVTRPEAMTVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQE 582
D++RP+AM+V+ S YAQS TSKPVKGMLTGP+T L WSFPR+D+ K +QLALA+++
Sbjct: 537 GDLSRPKAMSVKESVYAQSITSKPVKGMLTGPITCLRWSFPRDDVDQKTQAMQLALALRD 596
Query: 583 EVLDLEKAGIKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHM 642
EV DLE AGIK+IQ+DE ALRE LPLR+ Y WA AFR+ S V +TQIH+H
Sbjct: 597 EVNDLEAAGIKVIQVDEPALREGLPLREGTERSAYYTWAAEAFRVATSGVANKTQIHSHF 656
Query: 643 CYSEFEDIIPSIDAMDADVISFEASRSELSIIDALKAHHFKTL---VGPGVYDIHSPRIP 699
CYS+ + I A+DADV+S E S+ + DA FK +G G++DIHSPRIP
Sbjct: 657 CYSDLDP--NHIKALDADVVSIEFSKKD----DANYIAEFKNYPNHIGLGLFDIHSPRIP 710
Query: 700 SVKEIQNQLEKILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRKE 753
S E ++ IL P E+ WVNPDCGLKTRG ET SL H+VEA + R++
Sbjct: 711 SKDEFIAKISTILKSYPAEKFWVNPDCGLKTRGWEETRLSLTHMVEAAKYFREQ 764
ref|NP_011015.1|MET6| vitamin B12-(cobalamin)-independent isozyme of methionine synthase
(also called N5-methyltetrahydrofolate homocysteine
methyltransferase or 5-methyltetrahydropteroyl
triglutamate homocysteine methyltransferase); Met6p
>gi|730018|sp|P05694|METE_YEAST
5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE
METHYLTRANSFERASE (METHIONINE SYNTHASE, VITAMIN-B12
INDEPENDENT ISOZYME) (COBALAMIN-INDEPENDENT METHIONINE
SYNTHASE) (DELTA-P8 PROTEIN) >gi|1071830|pir||S50594
5-methyltetrahydropteroyltriglutamate--homocysteine
S-methyltransferase (EC 2.1.1.14) - yeast (Saccharomyces
cerevisiae) >gi|603329 (U18839) Met6p:
5-methyltetrahydropteroyl triglutamate--homocysteine
methyltransferase [Saccharomyces cerevisiae] >gi|976441
(U32508) N5-methyltetrahydrofolate homocysteine
methyltransferase [Saccharomyces cerevisiae]
Length = 767
Score = 608 bits (1551), Expect = e-173
Identities = 337/774 (43%), Positives = 472/774 (60%), Gaps = 34/774 (4%)
Query: 3 MKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISN 62
++ +++ FPRIG NRELK A E Y+ +IT +EL V K++R +NWK QKEAG+D SN
Sbjct: 2 VQSAVLGFPRIGPNRELKKATEGYWNGKITVDELFKVGKDLRTQNWKLQKEAGVDIIPSN 61
Query: 63 DFSFYDQTLDLSIALGAIPGSYKNLELSELDTLFALARGFQ------DEQNDVKARPMKK 116
DFSFYDQ LDLS+ IP Y +LS +DTLFA+ RG Q ++ DV A M K
Sbjct: 62 DFSFYDQVLDLSLLFNVIPDRYTKYDLSPIDTLFAMGRGLQRKATETEKAVDVTALEMVK 121
Query: 117 WFNTNYHYLVPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGA 176
WF++NYHY+ P +K T K N K ++E+ EAK G TRP ++GP ++L L A
Sbjct: 122 WFDSNYHYVRPTFSKTTQFKLNGQKPVDEFLEAKELGIHTRPVLLGPVSYLFLGK----A 177
Query: 177 TKDTV-------LSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEE 229
KD++ L ++ + +L +L G +QI+EP LVLD + Y
Sbjct: 178 DKDSLDLEPLSLLEQLLPLYTEILSKLASAGATEVQIDEPVLVLDLPANAQAAIKKAYTY 237
Query: 230 XXXXXXXXXXXXQTYFGDVRDSYKEIIKLDFDGIGLDFIEGRDSLALIQKYGFPKKKILF 289
TYFG V + I L + +DF+ + + K+ L
Sbjct: 238 FGEQSNLPKITLATYFGTVVPNLDAIKGLPVAALHVDFVRAPEQFDEVVA-AIGNKQTLS 296
Query: 290 AGLVNGKNIWRNNYQKTLELLT-ALDEV-AD-IVINTSCSLQHVPVTIKNETKLSKEILK 346
G+V+G+NIW+N+++K+ ++ A++++ AD +V+ TS SL H PV + NETKL EI
Sbjct: 297 VGIVDGRNIWKNDFKKSSAIVNKAIEKLGADRVVVATSSSLLHTPVDLNNETKLDAEIKG 356
Query: 347 HFSFATEKLNEIDEISDIYFNKNTSFL----KKNVELFENERVRENSKLKQKLDKLTEKD 402
FSFAT+KL+E+ I+ ++ + K+VE + ++ +K ++ + EK
Sbjct: 357 FFSFATQKLDEVVVITKNVSGQDVAAALEANAKSVESRGKSKFIHDAAVKARVASIDEKM 416
Query: 403 FTRQPSLVERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEE 462
TR +R Q + NLP+ PTTTIGSFPQT ++R R + +G + +Y+ F+
Sbjct: 417 STRAAPFEQRLPEQQKVFNLPLFPTTTIGSFPQTKDIRINRNKFNKGTISAEEYEKFINS 476
Query: 463 KIKECLKLQEDIGLDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVW 522
+I++ ++ QE+IGLDVLVHGE ERNDMV+YFGE++ GY FT WVQSYG+R V+PPI+
Sbjct: 477 EIEKVIRFQEEIGLDVLVHGEPERNDMVQYFGEQINGYAFTVNGWVQSYGSRYVRPPIIV 536
Query: 523 TDVTRPEAMTVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQE 582
D++RP+AM+V+ S YAQS TSKPVKGMLTGP+T L WSFPR+D+ K +QLALA+++
Sbjct: 537 GDLSRPKAMSVKESVYAQSITSKPVKGMLTGPITCLRWSFPRDDVDQKTQAMQLALALRD 596
Query: 583 EVLDLEKAGIKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHM 642
EV DLE AGIK+IQ+DE ALRE LPLR+ Y WA AFR+ S V +TQIH+H
Sbjct: 597 EVNDLEAAGIKVIQVDEPALREGLPLREGTERSAYYTWAAEAFRVATSGVANKTQIHSHF 656
Query: 643 CYSEFEDIIPSIDAMDADVISFEASRSELSIIDALKAHHFKTL---VGPGVYDIHSPRIP 699
CYS+ + I A+DADV+S E S+ + DA FK +G G++DIHSPRIP
Sbjct: 657 CYSDLDP--NHIKALDADVVSIEFSKKD----DANYIAEFKNYPNHIGLGLFDIHSPRIP 710
Query: 700 SVKEIQNQLEKILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRKE 753
S E ++ IL P E+ WVNPDCGLKTRG ET SL H+VEA + R++
Sbjct: 711 SKDEFIAKISTILKSYPAEKFWVNPDCGLKTRGWEETRLSLTHMVEAAKYFREQ 764
sp|O06584|METE_MYCTU 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE
METHYLTRANSFERASE (METHIONINE SYNTHASE, VITAMIN-B12
INDEPENDENT ISOZYME) (COBALAMIN-INDEPENDENT METHIONINE
SYNTHASE) >gi|2117227|emb|CAB09044| (Z95585) metE
[Mycobacterium tuberculosis]
Length = 759
Score = 599 bits (1528), Expect = e-170
Identities = 329/761 (43%), Positives = 453/761 (59%), Gaps = 31/761 (4%)
Query: 6 SIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISNDFS 65
+I PRIG RELK A E Y+ + EL+ VA +R + W + AG+DS N FS
Sbjct: 13 TITGSPRIGPRRELKRATEGYWAGRTSRSELEAVAATLRRDTWSALAAAGLDSVPVNTFS 72
Query: 66 FYDQTLDLSIALGAIPGSYKNLELSELDTLFALARGFQDEQNDVKARPMKKWFNTNYHYL 125
+YDQ LD ++ LGA+P + LD FA ARG + + M KWF+TNYHYL
Sbjct: 73 YYDQMLDTAVLLGALPPRVSPVS-DGLDRYFAAARG----TDQIAPLEMTKWFDTNYHYL 127
Query: 126 VPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGATKDTV-LSD 184
VPEI T + K+L E KEA G RP IIGP TFL+L+ GA L +
Sbjct: 128 VPEIGPSTTFTLHPGKVLAELKEALGQGIPARPVIIGPITFLLLSKAVDGAGAPIERLEE 187
Query: 185 VIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEEXXXXXXXXXXXXQTY 244
++ + LL L G +W+Q +EPALV D + + L ++Y TY
Sbjct: 188 LVPVYSELLSLLADGGAQWVQFDEPALVTDLSPDAPALAEAVYTALCSVSNRPAIYVATY 247
Query: 245 FGDVRDSYKEIIKLDFDGIGLDFIEGRDSLALIQKYGFPKK--KILFAGLVNGKNIWRNN 302
FGD + + + + IG+D + G D+ G P+ K L AG+V+G+N+WR +
Sbjct: 248 FGDPGAALPALARTPVEAIGVDLVAGADTSVA----GVPELAGKTLVAGVVDGRNVWRTD 303
Query: 303 YQKTL-ELLTALDEVADIVINTSCSLQHVPVTIKNETKLSKEILKHFSFATEKLNEI--- 358
+ L L T L A + ++TSCS HVP +++ ET L + +F EK+ E+
Sbjct: 304 LEAALGTLATLLGSAATVAVSTSCSTLHVPYSLEPETDLDDALRSWLAFGAEKVREVVVL 363
Query: 359 --------DEISDIYFNKNTSFLKKNVELFENERVRENSKLKQKLDKLTEKDFTRQPSLV 410
D ++D + + + + + N +++ +++ + R +
Sbjct: 364 ARALRDGHDAVADEIASSRAAIASR-----KRDPRLHNGQIRARIEAIVASGAHRG-NAA 417
Query: 411 ERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKECLKL 470
+RRASQ L+LP LPTTTIGS+PQT+ +R R + GE+ +A+Y + ++I E + L
Sbjct: 418 QRRASQDARLHLPPLPTTTIGSYPQTSAIRVARAALRAGEIDEAEYVRRMRQEITEVIAL 477
Query: 471 QEDIGLDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTRPEA 530
QE +GLDVLVHGE ERNDMV+YF E+L G+ TQ WVQSYG+RCV+PPI++ DV+RP A
Sbjct: 478 QERLGLDVLVHGEPERNDMVQYFAEQLAGFFATQNGWVQSYGSRCVRPPILYGDVSRPRA 537
Query: 531 MTVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDLEKA 590
MTV W YAQS T KPVKGMLTGPVTIL WSF R+D L + Q+ALA+++E +DL+ A
Sbjct: 538 MTVEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSA 597
Query: 591 GIKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEFEDI 650
GI +IQ+DE ALRE LPLR++D EYL WA+ AFRL S V TQIHTH+CYSEF ++
Sbjct: 598 GIAVIQVDEPALRELLPLRRAD-QAEYLRWAVGAFRLATSGVSDATQIHTHLCYSEFGEV 656
Query: 651 IPSIDAMDADVISFEASRSELSIIDALKAHHFKTLVGPGVYDIHSPRIPSVKEIQNQLEK 710
I +I +DADV S EA+RS + ++D L A F VGPGVYDIHSPR+PS +E+ + L
Sbjct: 657 IGAIADLDADVTSIEAARSHMEVLDDLNAIGFANGVGPGVYDIHSPRVPSAEEMADSLRA 716
Query: 711 ILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLR 751
L +P E++WVNPDCGLKTR E SL ++V A R +R
Sbjct: 717 ALRAVPAERLWVNPDCGLKTRNVDEVTASLHNMVAAAREVR 757
gb|AAD36360.1|AE001784_2 (AE001784) 5-methyltetrahydropteroyltriglutamate--homocysteine
methyltransferase [Thermotoga maritima]
Length = 734
Score = 588 bits (1499), Expect = e-167
Identities = 331/767 (43%), Positives = 467/767 (60%), Gaps = 52/767 (6%)
Query: 3 MKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRL---ENWKSQKEAGIDSP 59
MK FP+IG RE K ALE +++ +ITEE+ + ++R+ EN++ +D
Sbjct: 1 MKAYAFGFPKIGEKREFKKALEDFWKGKITEEQFEEEMNKLRMYMVENYRKN----VDVI 56
Query: 60 ISNDFSFYDQTLDLSIALGAIPGSYKNLELSELDTLFALARGFQDEQNDVKARPMKKWFN 119
SN+ S+YD LD ++ +GA+P + E L T F +ARG KA M K+FN
Sbjct: 57 PSNELSYYDFVLDTAVMVGAVPERFG--EYRGLSTYFDMARGG-------KALEMTKFFN 107
Query: 120 TNYHYLVPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGATK- 178
TNYHYLVPEI + +K L +Y KS G ET P +IGP+TFL L+ +
Sbjct: 108 TNYHYLVPEIETEEFYLLE-NKPLEDYLFFKSKGIETAPWVIGPFTFLYLSKRNGEWIRR 166
Query: 179 ----DTVLSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEEXXXXX 234
+ +L ++ ++ + ++L + G + + + EPA V D + L +++Y E
Sbjct: 167 PNQMEKLLESLVSVYKEVFEKLVENGCKEILVNEPAFVCDLEKAHWDLILNVYRELSEFP 226
Query: 235 XXXXXXXQTYFGDVRDSYKEIIKLDFDGIGLDFIEGRDSLALIQKYGFPKKKILFAGLVN 294
TY+ V D Y+ + L + DF+ ++L ++K+GFP+ K L AG++N
Sbjct: 227 LTVF----TYYDSVSD-YEACVSLPVKRLHFDFVSNEENLKNLEKHGFPEDKKLVAGVIN 281
Query: 295 GKNIWRNNYQKTLELLTALDEVADIVINTSCSLQHVPVTIKNETKLSKEILKHFSFATEK 354
G+ W+ + +K L+ L A I+ SC L H+PVT++ E L + + +FA EK
Sbjct: 282 GRQPWKVDLRKVASLVEKLGASA---ISNSCPLFHLPVTLELENNLPGGLKEKLAFAKEK 338
Query: 355 LNEIDEISDIYFNK-----NTSFLKKNVELFENERVRENSKLKQKLDKLTEKDFTRQPSL 409
L E+ + D K N SF V+L ERVR L E F R+
Sbjct: 339 LEELKMLKDFLEGKTFDLPNVSFEDFAVDLQAVERVRN----------LPEDSFRREKEY 388
Query: 410 VERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKECLK 469
ER Q + LNLP+ PTTTIGSFPQT EVRK+R + ++GE+ + +Y+ F++E+IK+ ++
Sbjct: 389 TERDRIQRERLNLPLFPTTTIGSFPQTPEVRKMRSKYRKGEISKEEYEAFIKEQIKKAIE 448
Query: 470 LQEDIGLDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTRPE 529
LQE+IGLDVLVHGEFER DMVE+F EKL G TQ WV SYG+RC +PPI++ VTRPE
Sbjct: 449 LQEEIGLDVLVHGEFERTDMVEFFAEKLNGIATTQNGWVLSYGSRCYRPPIIYGTVTRPE 508
Query: 530 AMTVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDLEK 589
MT++ YAQS T KPVKGMLTGPVTI++WS+ REDI + Q+ALA+ EEV DLE+
Sbjct: 509 PMTLKEITYAQSLTEKPVKGMLTGPVTIMSWSYYREDIPEREIAYQIALAINEEVKDLEE 568
Query: 590 AGIKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEFED 649
AGIKI+QIDE A REK P++KS W EY +WAI AF L + +PETQIH HMCYS+F +
Sbjct: 569 AGIKIVQIDEPAFREKAPIKKSKW-PEYFEWAINAFNLA-ANARPETQIHAHMCYSDFNE 626
Query: 650 IIPSIDAMDADVISFEASRSELSIIDALKAHHFK---TLVGPGVYDIHSPRIPSVKEIQN 706
II I ++ DVIS EASRS+ II A + +FK +G GV+DIHSP +PS+ E++
Sbjct: 627 IIEYIHQLEFDVISIEASRSKGEIISAFE--NFKGWIKQIGVGVWDIHSPAVPSINEMRE 684
Query: 707 QLEKILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRKE 753
+E++L LP E +W+NPDCGLKTR E IPSLR++V + +R++
Sbjct: 685 IVERVLRVLPKELIWINPDCGLKTRNWDEVIPSLRNMVALAKEMREK 731
gi|2984022 (AE000752) tetrahydropteroyltriglutamate methyltransferase [Aquifex
aeolicus]
Length = 761
Score = 584 bits (1489), Expect = e-166
Identities = 334/773 (43%), Positives = 468/773 (60%), Gaps = 40/773 (5%)
Query: 3 MKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISN 62
+K FP++G RE K LE Y++ +I++EEL +E+ L +E ++ SN
Sbjct: 2 VKTYAFGFPKLGEKREFKRLLENYWKGKISQEELIKGMEELNLWRANLYRE-NVEIIPSN 60
Query: 63 DFSFYDQTLDLSIALGAIPGSYKNLELSELDTLFALARGFQDEQNDVKARPMKKWFNTNY 122
+ S+YD LD ++ +GAIP + E LDT F +ARG A + KWFNTNY
Sbjct: 61 ELSYYDFMLDTTVMVGAIPSRFG--EYRGLDTYFEMARG-------KNALELTKWFNTNY 111
Query: 123 HYLVPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLA------------ 170
HYLVPE+ + K ++ L +YK K G T P +IG +TFL L+
Sbjct: 112 HYLVPELEGENF-KLLINRPLEDYKFFKEKGINTVPHVIGLFTFLKLSKAPKRVEEEGLP 170
Query: 171 -------DYKSGATKDTVLSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLF 223
D K K T ++ ++ LL+ L GV + EEPALV D + + ++
Sbjct: 171 VIILEKLDTKERLEKFT--KALLPVYKELLESLKNEGVNRVHFEEPALVTDLEDYDWEIL 228
Query: 224 VSIYEEXXXXXXXXXXXXQTYFGDVRDSYKEIIKLDFDGIGLDFIEGRDSLALIQKYGFP 283
IY E TY+ V D Y + + L + D + ++L I++ GFP
Sbjct: 229 NEIYSELSKVGVDLGIL--TYYDSVSD-YDKFVNLPVKALHFDLVSNEENLKNIKEKGFP 285
Query: 284 KKKILFAGLVNGKNIWRNNYQKTLELLTALDEV-ADIVINTSCSLQHVPVTIKNETKLSK 342
+ K L AG++NG+ WR N ++ ++LL L +V A++V++ SC L H+PVT++ E +L +
Sbjct: 286 EDKELIAGIINGRQPWRANLREKVKLLEELLKVSANLVVSNSCPLYHLPVTVEPEDELPE 345
Query: 343 EILKHFSFATEKLNEIDEISDIYFNKNTSFLK-KNVELFENERVRENSKLKQKLDKLTEK 401
+ + SFA EKL EI I + K + + ++ E +N +++++L L+EK
Sbjct: 346 GLKERLSFAKEKLREIRLIKEALEGKEEALREVESSEKVMTAVFAQNPEVRRRLASLSEK 405
Query: 402 DFTRQPSLVERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLE 461
DF R+ ER Q L LP+ PTTTIGSFPQT +VRK+R + G++ + +Y F++
Sbjct: 406 DFQRELPYKERDKIQRDILKLPLFPTTTIGSFPQTEDVRKMRTAYRTGKISEEEYKNFIK 465
Query: 462 EKIKECLKLQEDIGLDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIV 521
+KIK +++QEDIGLDVLVHGEFER+DMVEYF KL+G T+ WV SYG+R +PPI+
Sbjct: 466 QKIKYAIEVQEDIGLDVLVHGEFERSDMVEYFAIKLDGIATTKHGWVLSYGSRVYRPPII 525
Query: 522 WTDVTRPEAMTVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQ 581
+ DV+RP MT+ YAQS T+KPVKGMLTGPVTILNWS+ RED+ + Q+ALA+
Sbjct: 526 YGDVSRPAPMTLEEITYAQSLTNKPVKGMLTGPVTILNWSYYREDVPKREIAYQIALALL 585
Query: 582 EEVLDLEKAGIKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTH 641
+EV DLE AGIK+IQIDE A RE PL+K DW EY DWA+ AFRL S+ KPETQIHTH
Sbjct: 586 DEVKDLENAGIKVIQIDEPAFREGAPLKKRDW-PEYFDWAVKAFRLA-SRAKPETQIHTH 643
Query: 642 MCYSEFEDIIPSIDAMDADVISFEASRSELSIIDAL-KAHHFKTLVGPGVYDIHSPRIPS 700
MCYSEF +II I MD DVIS EASRS+ II+ K + +G GVYDIHSP IP+
Sbjct: 644 MCYSEFNEIIEYIYQMDFDVISIEASRSKGEIIEVFEKFKGWDRQIGIGVYDIHSPAIPT 703
Query: 701 VKEIQNQLEKILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRKE 753
+E++ + + + LP E +WVNPDCGLKTR E IP+LR++V+ + LR+E
Sbjct: 704 KEEMKAIMLRAMKVLPKELLWVNPDCGLKTRRWEEVIPALRNMVDMAKELREE 756
sp|Q39586|METE_CHLRE 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE
METHYLTRANSFERASE (METHIONINE SYNTHASE, VITAMIN-B12
INDEPENDENT ISOZYME) (COBALAMIN-INDEPENDENT METHIONINE
SYNTHASE) >gi|2129456|pir||S65083
5-methyltetrahydropteroyltriglutamate--homocysteine
S-methyltransferase (EC 2.1.1.14) - Chlamydomonas
reinhardtii >gi|1017759 (U36197) cobalamin-independent
methionine synthase [Chlamydomonas reinhardtii]
>gi|1587968|prf||2207381A Met synthase [Chlamydomonas
reinhardtii]
Length = 814
Score = 490 bits (1248), Expect = e-137
Identities = 300/790 (37%), Positives = 440/790 (54%), Gaps = 59/790 (7%)
Query: 3 MKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISN 62
+ + I FPRIG+ R+LKFA+E YF+ + E EL VA +++ + W QK AGI + I
Sbjct: 2 LSTTTIGFPRIGNQRQLKFAMESYFKGDSGEAELLAVAHKVQSDAWALQKAAGI-AVIGL 60
Query: 63 DFSFYDQTLDLSIALGAIPGSYKNLELSELDTLFALARGFQDEQNDVKARPMKKWFNTNY 122
D + YDQ LD LGAIP +K+L S L +A+ARG A M K+F+TNY
Sbjct: 61 DGTLYDQVLDTITWLGAIPPRFKHL--SGLQRYYAMARGGA-------ALDMSKFFDTNY 111
Query: 123 HYLVPEINKDTI--------IKANFSKLLNEYKEAKSAGFETR--PTIIGPYTFLVLADY 172
HYLVPE+ D + ++ +FS L++ ++ P +IGP TF+ L+
Sbjct: 112 HYLVPELGPDVLGPATAGPPLQPDFSGPLDKLARGQAVVGRDGAVPILIGPVTFVSLSR- 170
Query: 173 KSGATKDTVLSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEEXXX 232
D ++ ++ + LL++L G +Q+ EP L + F + Y +
Sbjct: 171 GCELPLDQAVARLLPTYCALLQQLAAAGAPEVQLHEPVLATSEGTGMPTEFETAYAQMAQ 230
Query: 233 XXXXXXXXXQTYFGDVRDSYKEIIKLDFDGIGLDFIEG------RDSLALIQKYGFPKKK 286
TY+ D+ +Y ++L + LDF+ +LAL+Q++GFP K
Sbjct: 231 AAGSVPLHLVTYYDDLGAAYPWAVQLPVAAVTLDFLGPPGAAVPSQTLALLQQHGFPADK 290
Query: 287 ILFAGLVNGKNIWRNNYQKTLELLTALDEVA----DIVINTSCSLQHVPVTIKNETKLSK 342
L AG+V+G+++W+++ L LD A +V+ +S LQH+P + E + K
Sbjct: 291 RLGAGVVDGRSVWKDDGTAVALLRALLDTGAVSSDRLVVTSSAPLQHLPYDLGLELEAPK 350
Query: 343 ---------EILKHFSFATEKLNEIDEISDIYFNKNTSFLKKNVELF------ENERVRE 387
+ FA +K+ EI ++ + + L+ + + R
Sbjct: 351 TPEATAPAARAGRPPGFAKQKVEEIVSVARLAASPQPPLLQLVMAPWCSCSGCSRARAWR 410
Query: 388 NSKLKQKLDKLTEKDFTRQPSLVERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNK 447
+ +L K + + ++ + L L PTTTIGSFPQTAEVR++R Q K
Sbjct: 411 TTPPTSRLSGSAAKPYDVR--------ARDEQLQLAAFPTTTIGSFPQTAEVRRLRQQLK 462
Query: 448 RGELRQADYDTFLEEKIKECLKLQEDIGLDVLVHGEFERNDMVEYFGEKLEGYVFTQKAW 507
G L QA+Y+ + I + +QE +G+DVLVHGE ER DMVEYFG +L G +FT+ W
Sbjct: 463 SGRLTQAEYEGLIAGHIAHAVGVQEALGIDVLVHGEAERTDMVEYFGMQLGGMLFTRAGW 522
Query: 508 VQSYGTRCVKPPIVWTDVTRPEAMTVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDI 567
VQSYG+RCV+PP+V D+T T A ++PVKG+LTGPVTILNWSFPR+DI
Sbjct: 523 VQSYGSRCVRPPLVVDDITYRGPSTCWEYKVAIPTAAQPVKGLLTGPVTILNWSFPRKDI 582
Query: 568 SLKASTLQLALAVQEEVLDLEKAGIKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRL 627
S A +QL LA+++EV LE AG IIQ+D+ ALRE LPL W YL WA+ AFRL
Sbjct: 583 SRAAQAMQLGLALRQEVAALEAAGCTIIQVDDPALREGLPLNGERW-ASYLSWAVDAFRL 641
Query: 628 VHSKVKPETQIHTHMCYSEFEDIIPSIDAMDADVISFEASRSELSIIDALKAHHFKTLVG 687
TQ+ TH+CYS+F+DI+P+ID MDADV++ E SRS+ ++ AL A + +G
Sbjct: 642 CTGVAAAGTQVVTHLCYSDFQDILPAIDRMDADVLTIENSRSDKPMMAALAAAGYGRDIG 701
Query: 688 PGVYDIHSPRIPSVKEIQNQLEKILDKLPI----EQVWVNPDCGLKTRGNAETIPSLRHL 743
PGVYD+HSP +PSV+ I++++ +D + +++WVNPDCGLKTRG ETI +L ++
Sbjct: 702 PGVYDVHSPVVPSVEFIKSRIRSFVDSGILSGRYDRIWVNPDCGLKTRGWPETIAALANM 761
Query: 744 VEATRVLRKE 753
VEA R E
Sbjct: 762 VEAAAQARAE 771
dbj|BAA13829| (D89167) similar to Saccharomyces cerevisiae
5-methyltetrahydropteroyltriglutamate-homocysteine
s-methyltransferase, SWISS-PROT Accession Number P05694
[Schizosaccharomyces pombe]
Length = 454
Score = 413 bits (1049), Expect = e-114
Identities = 204/453 (45%), Positives = 304/453 (67%), Gaps = 14/453 (3%)
Query: 287 ILFAGLVNGKNIWRNNYQKTLELLT-ALDEVAD--IVINTSCSLQHVPVTIKNETKLSKE 343
I+ G+V+G+NIW+ ++QK ++ A+ V + + +S S+ H+P ++ E +++ E
Sbjct: 1 IISVGVVSGRNIWKTDFQKATAIIEKAISAVGSERVQVASSSSILHIPHSLSGEDQINPE 60
Query: 344 ILKHFSFATEKLNEIDEISDIYFNKNTSFLKKNVE-------LFENERVRENSKLKQKLD 396
I + F+FA EK E+ ++ N + ++ +E + ++++
Sbjct: 61 IKRWFAFAVEKCAELAILTKAA-NDGPASVRAELEGNAADCKARAESPITNVESVRERQS 119
Query: 397 KLTEKDFTRQPSLVERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADY 456
K+T + R+ R A Q SL LP+ PTTTIGSFPQT E+R R + +G + Q +Y
Sbjct: 120 KVTPQMHGRKSPFETRYAKQQASLKLPLFPTTTIGSFPQTKEIRVTRNRFAKGLISQEEY 179
Query: 457 DTFLEEKIKECLKLQEDIGLDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCV 516
D F+ ++I + +K QE++GLDVLVHGE ERNDMV+YFGE++EG+VFT WVQSYG+R V
Sbjct: 180 DAFIRKEISDVVKFQEEVGLDVLVHGEPERNDMVQYFGERMEGFVFTVNGWVQSYGSRGV 239
Query: 517 KPPIVWTDVTRPEAMTVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQL 576
+PPI+ DV RP MTV+ S YAQS TSKP+KGMLT P+TIL WSFPR+D+ Q+
Sbjct: 240 RPPIIVGDVYRPAPMTVKESQYAQSITSKPMKGMLTAPITILRWSFPRDDVHDSVQAQQI 299
Query: 577 ALAVQEEVLDLEKAGIKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPET 636
AL +++EVLDLEKAGIK+IQ DE ALRE LP R+++W EYL WAI AFRL + V+ +T
Sbjct: 300 ALGLRDEVLDLEKAGIKVIQCDEPALREGLPPRRAEW-DEYLKWAIDAFRLATAAVQDDT 358
Query: 637 QIHTHMCYSEFEDIIPSIDAMDADVISFEASRSELSIIDALKAHHFKTLVGPGVYDIHSP 696
QIH+H CYS+F DI +I +DADV+S E S+S++ +++ L + + +GPG++DIHSP
Sbjct: 359 QIHSHFCYSDFNDIFDAIQRLDADVVSIENSKSDMKLLNVLS--RYTSCIGPGLFDIHSP 416
Query: 697 RIPSVKEIQNQLEKILDKLPIEQVWVNPDCGLK 729
R+P V E + +++ I+ +P + +W+NPDCGL+
Sbjct: 417 RVPPVSEFKERIDAIVKHVPKDHLWLNPDCGLE 449
gi|4098359 (U77388) cobalamin independent methionine synthase [Chlamydomonas
moewusii]
Length = 707
Score = 301 bits (762), Expect = 2e-80
Identities = 168/358 (46%), Positives = 227/358 (62%), Gaps = 19/358 (5%)
Query: 403 FTRQPSLVERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEE 462
F R + RR+ Q Q PT+TIGSFPQTAEVR+ R Q +G L Y ++
Sbjct: 319 FRRSEAFAVRRSKQPQ---FRAFPTSTIGSFPQTAEVRRARAQLTKGLLTLEQYQARMDA 375
Query: 463 KIKECLKLQEDIGLDVLVHGEFERNDMVEYFGEKLEGYV-FTQKAWVQSYGTRCVKPPIV 521
I + +QE + +DVLVHGE ER DMVEYFGE+LEG FT AWVQSYG+R V+P
Sbjct: 376 LITHAIGVQEGLDIDVLVHGEAERTDMVEYFGEQLEGLTAFTANAWVQSYGSRYVRPHHC 435
Query: 522 WTDVTRPEAMTVR-W-SAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALA 579
P MTVR W S+ + T + VKGMLTGPVTILNWSFPR+D+S + +QLALA
Sbjct: 436 VDVACAP--MTVREWRSSQTPACTGRFVKGMLTGPVTILNWSFPRKDVSRRVQAMQLALA 493
Query: 580 VQEEVLDLEKAGIKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIH 639
+I+Q+DE ALRE LPL+ W + YL WA+ AFRL + +P+ QI
Sbjct: 494 CARRW-----TRCRIVQVDEPALREGLPLKNERW-QSYLTWAVDAFRLSTAVARPDVQIV 547
Query: 640 THMCYSEFEDIIPSIDAMDADVISFEASRSELSIIDALKAHHFKTLVGPGVYDIHSPRIP 699
TH+CYS FEDI+ ++D MDADV++ E SRS ++ AL + +GPGVYD+HSP +P
Sbjct: 548 THLCYSNFEDILQAVDDMDADVLTIENSRSGDEMVRALSNAGYCKDLGPGVYDVHSPVVP 607
Query: 700 SVKEIQNQLEKILD-----KLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRK 752
V+ +++ + K +++WVNPDCGLKTR +E IP+LR++V+A +++R+
Sbjct: 608 PVEWFVDKIASFVATCEQFKDCPDRLWVNPDCGLKTRAWSEVIPALRNMVQAAQIMRE 665
Score = 47.6 bits (111), Expect = 4e-04
Identities = 32/96 (33%), Positives = 49/96 (50%), Gaps = 6/96 (6%)
Query: 96 FALARGFQDEQNDVKARPMKKWFNTNYHYLVPEINKDTIIKANFSKLLNEYKEA-KSAGF 154
FALARG + A M K ++NYH LVPE+ D + +FS L++ + K G
Sbjct: 5 FALARGTEG----CTALDMSKHLDSNYHSLVPELELDFTPEPDFSLLIDRVEAGQKLLGK 60
Query: 155 ETR-PTIIGPYTFLVLADYKSGATKDTVLSDVIVAF 189
E P ++GP T ++LA G + L ++ A+
Sbjct: 61 EAAVPLVVGPLTLVLLARLAPGLSPSAALHRILPAY 96
prf||1501198A gamma Glu-Cys synthetase [Escherichia coli]
Length = 500
Score = 294 bits (745), Expect = 2e-78
Identities = 175/492 (35%), Positives = 270/492 (54%), Gaps = 25/492 (5%)
Query: 3 MKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISN 62
++ +++ FPRIG NRELK A E Y+ +IT +EL V K++R +NWK QKEAG+D SN
Sbjct: 2 VQSAVLGFPRIGPNRELKKATEGYWNGKITVDELFKVGKDLRTQNWKLQKEAGVDIIPSN 61
Query: 63 DFSFYDQTLDLSIALGAIPGSYKNLELSELDTLFALARGFQ------DEQNDVKARPMKK 116
DFSFYDQ LD + Y +LS +DTLFA+ RG Q ++ DV A M K
Sbjct: 62 DFSFYDQVLDFVFVVQCHSDRYTKYDLSPIDTLFAMGRGLQRKATETEKAVDVTALEMVK 121
Query: 117 WFNTNYHYLVPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGA 176
WF++NYHY+ P +K T K N K ++E+ EAK G TRP ++GP ++L L A
Sbjct: 122 WFDSNYHYVRPTFSKTTQFKLNGQKPVDEFLEAKELGIHTRPVLLGPVSYLFLGK----A 177
Query: 177 TKD-------TVLSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEE 229
KD ++L ++ + +L +L G +QI+EP LVLD + Y
Sbjct: 178 DKDSLDLEPLSLLEQLLPLYTQILSKLASAGATEVQIDEPVLVLDLPANAQAAIKKAYTY 237
Query: 230 XXXXXXXXXXXXQTYFGDVRDSYKEIIKLDFDGIGLDFIEGRDSLALIQKYGFPKKKILF 289
TYFG V + I L + +DF+ + + K+ L
Sbjct: 238 TGEQSNLPKITLATYFGTVVPNLDAIKGLPVAALHVDFVRAPEQFDEVVA-AIGNKQTLS 296
Query: 290 AGLVNGKNIWRNNYQKTLELLT-ALDEV-AD-IVINTSCSLQHVPVTIKNETKLSKEILK 346
G+V+G+NIW+N+++K+ ++ A++++ AD +V+ TS SL H PV + NETKL EI
Sbjct: 297 VGIVDGRNIWKNDFKKSSAIVNKAIEKLGADRVVVATSSSLLHTPVDLNNETKLDAEIKG 356
Query: 347 HFSFATEKLNEIDEISDIYFNKNTSFL----KKNVELFENERVRENSKLKQKLDKLTEKD 402
FSFAT+KL+E+ I+ ++ + K+VE + ++ +K ++ + EK
Sbjct: 357 FFSFATQKLDEVVVITKNVSGQDVAAALEANAKSVESRGKSKFIHDAAVKARVASIDEKM 416
Query: 403 FTRQPSLVERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEE 462
TR +R Q + NLP+ PTTTIGSFPQT ++R R + +G + +Y+ F+
Sbjct: 417 STRAAPFEQRLPEQQKVFNLPLFPTTTIGSFPQTKDIRINRNKFNKGTISAEEYEKFINS 476
Query: 463 KIKECLKLQEDI 474
+I++ ++ QED+
Sbjct: 477 EIEKVIRFQEDL 488
dbj|BAA02955| (D13798) fused GSH-I [synthetic construct]
Length = 500
Score = 294 bits (744), Expect = 2e-78
Identities = 175/492 (35%), Positives = 270/492 (54%), Gaps = 25/492 (5%)
Query: 3 MKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISN 62
++ +++ FPRIG NRELK A E Y+ +IT +EL V K++R +NWK QKEAG+D SN
Sbjct: 2 VQSAVLGFPRIGPNRELKKATEGYWNGKITVDELFKVGKDLRTQNWKLQKEAGVDIIPSN 61
Query: 63 DFSFYDQTLDLSIALGAIPGSYKNLELSELDTLFALARGFQ------DEQNDVKARPMKK 116
DFSFYDQ LD + Y +LS +DTLFA+ RG Q ++ DV A M K
Sbjct: 62 DFSFYDQVLDFVFVVQCHSDRYTKYDLSPIDTLFAMGRGLQRKATETEKAVDVTALEMVK 121
Query: 117 WFNTNYHYLVPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGA 176
WF++NYHY+ P +K T K N K ++E+ EAK G TRP ++GP ++L L A
Sbjct: 122 WFDSNYHYVRPTFSKTTQFKLNGQKPVDEFLEAKELGIHTRPVLLGPVSYLFLGK----A 177
Query: 177 TKD-------TVLSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEE 229
KD ++L ++ + +L +L G +QI+EP LVLD + Y
Sbjct: 178 DKDSLDLEPLSLLEQLLPLYTEILSKLASAGATEVQIDEPVLVLDLPANAQAAIKKAYTY 237
Query: 230 XXXXXXXXXXXXQTYFGDVRDSYKEIIKLDFDGIGLDFIEGRDSLALIQKYGFPKKKILF 289
TYFG V + I L + +DF+ + + K+ L
Sbjct: 238 FGEQSNLPKITLATYFGTVVPNLDAIKGLPVAALHVDFVRAPEQFDEVVA-AIGNKQTLS 296
Query: 290 AGLVNGKNIWRNNYQKTLELLT-ALDEV-AD-IVINTSCSLQHVPVTIKNETKLSKEILK 346
G+V+G+NIW+N+++K+ ++ A++++ AD +V+ TS SL H PV + NETKL EI
Sbjct: 297 VGIVDGRNIWKNDFKKSSAIVNKAIEKLGADRVVVATSSSLLHTPVDLNNETKLDAEIKG 356
Query: 347 HFSFATEKLNEIDEISDIYFNKNTSFL----KKNVELFENERVRENSKLKQKLDKLTEKD 402
FSFAT+KL+E+ I+ ++ + K+VE + ++ +K ++ + EK
Sbjct: 357 FFSFATQKLDEVVVITKNVSGQDVAAALEANAKSVESRGKSKFIHDAAVKARVASIDEKM 416
Query: 403 FTRQPSLVERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEE 462
TR +R Q + NLP+ PTTTIGSFPQT ++R R + +G + +Y+ F+
Sbjct: 417 STRAAPFEQRLPEQQKVFNLPLFPTTTIGSFPQTKDIRINRNKFNKGTISAEEYEKFINS 476
Query: 463 KIKECLKLQEDI 474
+I++ ++ QED+
Sbjct: 477 EIEKVIRFQEDL 488
emb|CAA30227| (X07238) delta-P8 [Saccharomyces cerevisiae]
Length = 486
Score = 291 bits (736), Expect = 2e-77
Identities = 174/490 (35%), Positives = 268/490 (54%), Gaps = 25/490 (5%)
Query: 3 MKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISN 62
++ +++ FPRIG NRELK A E Y+ +IT +EL V K++R +NWK QKEAG+D SN
Sbjct: 2 VQSAVLGFPRIGPNRELKKATEGYWNGKITVDELFKVGKDLRTQNWKLQKEAGVDIIPSN 61
Query: 63 DFSFYDQTLDLSIALGAIPGSYKNLELSELDTLFALARGFQ------DEQNDVKARPMKK 116
DFSFYDQ LD + Y +LS +DTLFA+ RG Q ++ DV A M K
Sbjct: 62 DFSFYDQVLDFVFVVQCHSDRYTKYDLSPIDTLFAMGRGLQRKATETEKAVDVTALEMVK 121
Query: 117 WFNTNYHYLVPEINKDTIIKANFSKLLNEYKEAKSAGFETRPTIIGPYTFLVLADYKSGA 176
WF++NYHY+ P +K T K N K ++E+ EAK G TRP ++GP ++L L A
Sbjct: 122 WFDSNYHYVRPTFSKTTQFKLNGQKPVDEFLEAKELGIHTRPVLLGPVSYLFLGK----A 177
Query: 177 TKD-------TVLSDVIVAFQTLLKELNQLGVEWLQIEEPALVLDQTEEEKKLFVSIYEE 229
KD ++L ++ + +L +L G +QI+EP LVLD + Y
Sbjct: 178 DKDSLDLEPLSLLEQLLPLYTEILSKLASAGATEVQIDEPVLVLDLPANAQAAIKKAYTY 237
Query: 230 XXXXXXXXXXXXQTYFGDVRDSYKEIIKLDFDGIGLDFIEGRDSLALIQKYGFPKKKILF 289
TYFG V + I L + +DF+ + + K+ L
Sbjct: 238 FGEQSNLPKITLATYFGTVVPNLDAIKGLPVAALHVDFVRAPEQFDEVVA-AIGNKQTLS 296
Query: 290 AGLVNGKNIWRNNYQKTLELLT-ALDEV-AD-IVINTSCSLQHVPVTIKNETKLSKEILK 346
G+V+G+NIW+N+++K+ ++ A++++ AD +V+ TS SL H PV + NETKL EI
Sbjct: 297 VGIVDGRNIWKNDFKKSSAIVNKAIEKLGADRVVVATSSSLLHTPVDLNNETKLDAEIKG 356
Query: 347 HFSFATEKLNEIDEISDIYFNKNTSFL----KKNVELFENERVRENSKLKQKLDKLTEKD 402
FSFAT+KL+E+ I+ ++ + K+VE + ++ +K ++ + EK
Sbjct: 357 FFSFATQKLDEVVVITKNVSGQDVAAALEANAKSVESRGKSKFIHDAAVKARVASIDEKM 416
Query: 403 FTRQPSLVERRASQSQSLNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEE 462
TR +R Q + NLP+ PTTTIGSFPQT ++R R + +G + +Y+ F+
Sbjct: 417 STRAAPFEQRLPEQQKVFNLPLFPTTTIGSFPQTKDIRINRNKFNKGTISAEEYEKFINS 476
Query: 463 KIKECLKLQE 472
+I++ ++ QE
Sbjct: 477 EIEKVIRFQE 486
gb|AAF26735.1| (AF220054) methionine synthase [Coffea arabica]
Length = 218
Score = 230 bits (581), Expect = 3e-59
Identities = 118/212 (55%), Positives = 153/212 (71%), Gaps = 2/212 (0%)
Query: 543 TSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDLEKAGIKIIQIDEAAL 602
T P+KGMLTGPVTILNWSF R D + Q+ALA+++EV DLEKAGI +IQIDEAAL
Sbjct: 3 TQSPMKGMLTGPVTILNWSFVRNDQPRFETCYQIALAIKDEVEDLEKAGINVIQIDEAAL 62
Query: 603 REKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEFEDIIPSIDAMDADVI 662
RE LPLRK++ + YLDWA+ +FR+ + V+ TQIHTHMCYS F DII SI MDADVI
Sbjct: 63 REGLPLRKAE-HAFYLDWAVHSFRITNCGVQDTTQIHTHMCYSNFNDIIHSIIDMDADVI 121
Query: 663 SFEASRSELSIIDALK-AHHFKTLVGPGVYDIHSPRIPSVKEIQNQLEKILDKLPIEQVW 721
+ E SRS+ ++ + + +GPGVYDIHSPRIPS +EI +++ K+L L +W
Sbjct: 122 TIENSRSDEKLLSVFREGVKYGAGIGPGVYDIHSPRIPSTEEIADRVNKMLAVLDTNILW 181
Query: 722 VNPDCGLKTRGNAETIPSLRHLVEATRVLRKE 753
VNPDCGLKTR AE P+L+++V A + +R +
Sbjct: 182 VNPDCGLKTRKYAEVKPALQNMVAAAKQIRTQ 213
dbj|BAA81058.1| (AP000063) 332aa long hypothetical
5-methltetrahydropteroyltriglutamate--
homocysteinemethyltr ansferase [Aeropyrum pernix]
Length = 332
Score = 160 bits (401), Expect = 4e-38
Identities = 106/344 (30%), Positives = 174/344 (49%), Gaps = 21/344 (6%)
Query: 417 SQSLNLPV-LPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKECLKLQEDIG 475
S S ++P PTT +GS+P+ + + + GE+ + ++ E I+ ++ G
Sbjct: 2 SHSYSVPKKFPTTVVGSYPKIGPASEAIKKRRAGEISEEEFHRIARESIRMVVEDYIWAG 61
Query: 476 LDVLVHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTRPEAMTVRW 535
+D++ GE R DMV YF E+LEGY + WV+ + + PIV V M +
Sbjct: 62 VDIISDGEQTREDMVVYFAERLEGY--REGDWVRVFDNVYFRKPIVAGRVRWVRPMIIED 119
Query: 536 SAYAQS-QTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDLEKAGIKI 594
YA+S +PVK ++TGP T+L WSF + LA A++ E+ + G +
Sbjct: 120 WEYARSISAGRPVKFIITGPYTMLEWSFDLHYGDRRELIFDLARAIRREIDEALARGAEY 179
Query: 595 IQIDEAALREKLPLRKSDWYKEYLD---WAIPAFRLVHSKVKPETQIHTHMCYSEFEDII 651
IQ+DE AL + +++ KE LD + A R+V H+CY E E I+
Sbjct: 180 IQVDEPALSTRPFKEEAELLKEALDIIFKGVGAKRIV------------HICYGELERIL 227
Query: 652 PSIDAMDADVISFEASRSELSIIDALKAHHFKTLVGPGVYDIHSPRIPSVKEIQNQLEKI 711
P I D E S ++ LK + + +G GV D+HS ++ SV E++ ++++
Sbjct: 228 PYILDYPVDQFDLEMKNSNFRLLPYLKEYGYDKEIGYGVIDVHSFQVESVGEVKEAIDRL 287
Query: 712 --LDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRKE 753
+D + E+V+V+PDCGLK L+++VEA R+ R+E
Sbjct: 288 MKMDIVGPEKVYVDPDCGLKRLPRDVARAKLKNMVEAARLAREE 331
emb|CAB49820.1| (AJ248285) related
5-methyltetrahydropteroyltriglutamate-homocysteine
methyltransferase, putative [Pyrococcus abyssi]
Length = 338
Score = 136 bits (338), Expect = 9e-31
Identities = 96/343 (27%), Positives = 167/343 (47%), Gaps = 31/343 (9%)
Query: 420 LNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKECLKLQEDIGLDVL 479
+ LP+LPT+ IGS+P+ + ++ + G++ + D+ +++ L+ E G+D+
Sbjct: 1 MELPILPTSVIGSYPKPRWLLRMYKLRELGKIPEEDFKEAVKDASVAVLREHERAGVDIP 60
Query: 480 VHGEFERNDMVEYFGEKLEGYVF--TQKAWVQSYGTRCV-------KPPIVWTDVTRPEA 530
GE R++M E+F K+ G+ F + W +Y + K P+V E
Sbjct: 61 WDGEMWRSEMTEHFTAKISGFKFYGPVRVWGNAYFNKAAAVDKLEYKEPLVLE-----EF 115
Query: 531 MTVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDLEKA 590
+ VR ++ T + VK +TGP TI WSF ++ + LA + +E+ LE+
Sbjct: 116 LWVR-----ENTTREIVKVPITGPYTIAEWSFNEYYPDKESFVMDLAKIINKELKTLEEH 170
Query: 591 GIKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEFEDI 650
G IQ+DE A+ + + + A+ A +K ++ H+CYS + +
Sbjct: 171 GATYIQLDEPAMLN---------HPDEVPLAVEAINRAVKGIK--IKVGLHVCYSNYYLL 219
Query: 651 IPSIDAMDADVISFEASRSELSIIDALKAHHFKTLVGPGVYDIHSPRIPSVKEIQNQLEK 710
D + + E + + +D LK K L G GV D+H+PRI +V EI ++K
Sbjct: 220 ADYFDDIRVTQFALEFANRQFRDMDFLKKLSGKEL-GFGVVDVHNPRIETVDEIVRAIKK 278
Query: 711 ILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRKE 753
+ L E +++NPDCGLK L ++V+A R++RKE
Sbjct: 279 AFNYLEPEWLYINPDCGLKLLDRRIAYQKLVNMVKAVRIVRKE 321
dbj|BAA30188| (AP000004) 338aa long hypothetical
5-methyltetrahydropteroyltriglutamate--homocysteine
S-methyltransferase [Pyrococcus horikoshii]
Length = 338
Score = 131 bits (327), Expect = 2e-29
Identities = 93/343 (27%), Positives = 163/343 (47%), Gaps = 31/343 (9%)
Query: 420 LNLPVLPTTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKECLKLQEDIGLDVL 479
+ LP+LPT+ IGS+P+ + ++ G++ + D+ +++ L+ E G+D+
Sbjct: 1 MELPILPTSVIGSYPKPRWLLRMYRLRDLGKIPEEDFKEAVKDASVSVLREHERAGVDIP 60
Query: 480 VHGEFERNDMVEYFGEKLEGYVF--TQKAWVQSYGTRCV-------KPPIVWTDVTRPEA 530
GE R +M E+F K+ G+ F + W +Y + K P+V + +
Sbjct: 61 WDGEMWRTEMTEHFTAKIGGFKFYGPVRVWGNAYFNKAAAVDKLEYKEPLVLEEFLWVKK 120
Query: 531 MTVRWSAYAQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDLEKA 590
T R + VK +TGP TI WSF ++ + LA + +E+ LE
Sbjct: 121 NTTR----------EVVKIPITGPYTIAEWSFNEYYPDKESFIMDLAKIINKELKMLENH 170
Query: 591 GIKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEFEDI 650
G IQ+DE A+ + + + A+ A +K ++ H+CYS + +
Sbjct: 171 GALYIQLDEPAMLN---------HPDEVPLAVEAINKAVKGIK--IKVGLHVCYSNYYLL 219
Query: 651 IPSIDAMDADVISFEASRSELSIIDALKAHHFKTLVGPGVYDIHSPRIPSVKEIQNQLEK 710
D + + E + + +D LK K L G GV D+H+PRI SV+EI ++K
Sbjct: 220 ADYFDEIRVTQFALEFANRQFRDMDFLKKLSNKEL-GFGVVDVHNPRIESVEEIVKAIKK 278
Query: 711 ILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRKE 753
+ + + E +++NPDCG+K L ++V+AT ++RKE
Sbjct: 279 VFEYVEPELLYINPDCGMKLLDRNIAYNKLVNMVKATELVRKE 321
dbj|BAA23679| (AB004651) methionine synthase [Hyphomicrobium methylovorum]
Length = 109
Score = 115 bits (286), Expect = 1e-24
Identities = 52/107 (48%), Positives = 75/107 (69%)
Query: 646 EFEDIIPSIDAMDADVISFEASRSELSIIDALKAHHFKTLVGPGVYDIHSPRIPSVKEIQ 705
EF DI+ +I A+DADVIS E SRS++ ++D + +GPGVYDIHSPR P V E+
Sbjct: 1 EFNDIMDAIAALDADVISIETSRSQMELLDGFSDFKYPNEIGPGVYDIHSPRCPCVGEMT 60
Query: 706 NQLEKILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLRK 752
+ K ++L EQ+W+NPDCGLKTR E +P+L+++VEA + +R+
Sbjct: 61 GLIAKARERLAPEQIWINPDCGLKTRKWDEVLPALKNMVEAAKKMRE 107
gi|3747048 (AF093539) methionine synthase [Zea mays]
Length = 145
Score = 83.1 bits (202), Expect = 8e-15
Identities = 52/142 (36%), Positives = 77/142 (53%), Gaps = 12/142 (8%)
Query: 306 TLELLTALDEVADIVINTSCSLQHVPVTIKNETKLSKEILKHFSFATEKLNEIDEIS--- 362
TL L A+ +V++TSCSL H V + NETKL EI +FA +K+ E++ ++
Sbjct: 8 TLHSLEAVAGKDKLVVSTSCSLMHTAVDLVNETKLDDEIKSWLAFAAQKVVEVNALAKAL 67
Query: 363 -----DIYFNKNTSFLKKNVELFENERVRENSKLKQKLDKLTEKDFTRQPSLVERRASQS 417
++YF N + + RV N ++++ L D R ++ R +Q
Sbjct: 68 AGQKDEVYFAANAA---AQASRRSSPRVT-NEEVQKAAAALRGSDHRRSTTVSARLDAQQ 123
Query: 418 QSLNLPVLPTTTIGSFPQTAEV 439
+ LNLPVLPTTTIGSFPQT E+
Sbjct: 124 KKLNLPVLPTTTIGSFPQTVEL 145
gb|AAD46411.1|AF096261_1 (AF096261) ethylene-responsive methionine synthase [Lycopersicon
esculentum]
Length = 68
Score = 80.4 bits (195), Expect = 5e-14
Identities = 36/66 (54%), Positives = 48/66 (72%)
Query: 686 VGPGVYDIHSPRIPSVKEIQNQLEKILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVE 745
+GPGVYDIHSPRIPS +EI ++ K+L L +WVNPDCGLKTR E P+L+++V
Sbjct: 3 IGPGVYDIHSPRIPSTEEIAVRVNKMLAVLDTNILWVNPDCGLKTRKYTEVKPALQNMVS 62
Query: 746 ATRVLR 751
A + +R
Sbjct: 63 AAKTIR 68
pir||S47051 hypothetical protein 1 - Xanthobacter sp >gi|520948|emb|CAA56241|
(X79863) orf1 [Xanthobacter sp. Py2]
Length = 376
Score = 75.7 bits (183), Expect = 1e-12
Identities = 84/373 (22%), Positives = 146/373 (38%), Gaps = 58/373 (15%)
Query: 425 LPTTTIGSFPQTA--EVRKVRLQNKRGELRQADYDTFLEEKIKECLKLQEDIGLDVL--- 479
+PT+ +G++P + + R E A LE+ + + QE GLD++
Sbjct: 10 IPTSMVGNYPNPRWWDAQFARTWTGDQEPPDALIQESLEDAVAAIARDQERAGLDIISDG 69
Query: 480 -VHGEFERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTRPEAMTVRWSAY 538
VHG+ + Y+ +L GY +R + + +V R A+ V +
Sbjct: 70 RVHGDNYAEQALYYYYRRL-GYDLKGGYLGFPIYSR-LHAGTLTGEVRRHGAIMVEQAKA 127
Query: 539 AQSQTSKPVKGMLTGPVTILNWSFPREDISLKASTLQLALAVQEEVLDLEKAGIKIIQID 598
+ T KP K TG + + S + + +A A+ E++ +++ G+ IQID
Sbjct: 128 LKKATGKPTKVQYTGVQALTQATNDLHYKSSRDRAMAIAKAINEDIREVDALGVDFIQID 187
Query: 599 EAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEF----------- 647
E W + DWAI AF VK +I H+C+ +
Sbjct: 188 EFT-----------WPYFFEDWAIEAFNAAVDGVK-NAKIIAHVCWGNWGGTPAYYPDET 235
Query: 648 ----------------------EDIIPSIDAMDADVISFEA---SRSELSIIDALKAHHF 682
I+P DV++ E+ +LS + +K H
Sbjct: 236 AASGEIFDLTKRKAEATKATATGSIVPKAYEARLDVLNLESCGRRSDDLSGLHVMKNHPL 295
Query: 683 KTLVG--PGVYDIHSPRIPSVKEIQNQLEKILDKLPIEQVWVNPDCGLKTRGNAETIPSL 740
V GV D+ S + E+ N++ ++L+ +P +++ V DCGL L
Sbjct: 296 PDNVSFWAGVIDVKSTITETADEVANRIRRLLEIVPADRLGVTTDCGLILLQRYIAQDKL 355
Query: 741 RHLVEATRVLRKE 753
LVE T+++R E
Sbjct: 356 HALVEGTKIVRAE 368
emb|CAB38313| (AJ236870) methionin synthase-like enzyme [Arabidopsis thaliana]
Length = 75
Score = 67.5 bits (162), Expect = 4e-10
Identities = 34/75 (45%), Positives = 44/75 (58%)
Query: 3 MKKSIIAFPRIGSNRELKFALEKYFRKEITEEELQTVAKEIRLENWKSQKEAGIDSPISN 62
M I+ +PRIG RELKFALE ++ + ++LQ VA +R WK AGI SN
Sbjct: 1 MSSHIVGYPRIGPKRELKFALESFWDGKTNVDDLQNVAANLRKSIWKHMAHAGIKYIPSN 60
Query: 63 DFSFYDQTLDLSIAL 77
FS+YDQ LD + L
Sbjct: 61 TFSYYDQMLDTTRCL 75
sp|O26869|Y775_METTH HYPOTHETICAL PROTEIN MTH775 >gi|2621866 (AE000856)
cobalamin-independent methionine synthase
[Methanobacterium thermoautotrophicum]
Length = 308
Score = 66.7 bits (160), Expect = 6e-10
Identities = 82/337 (24%), Positives = 148/337 (43%), Gaps = 51/337 (15%)
Query: 427 TTTIGSFP---QTAEVRKVRLQNKRGELRQADYDTFLEEKIKECLKLQEDIGLDVLVHGE 483
TT +GS+P + E RL N G YD + I+ ++ Q G+D++ G+
Sbjct: 3 TTVVGSYPTEPRGPETLGERLLNFFGS-----YDRY-RPAIEAAVRDQFRAGVDIISDGQ 56
Query: 484 FERNDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTRPE----AMTVRWSAYA 539
R DMV +F + G GT I+++ +T P A +R+ AY
Sbjct: 57 V-RGDMVGHFAAAIGGMKIED-------GTS-----IIYSRITPPAGSIGAADLRY-AYR 102
Query: 540 -----QSQTSKPVKGMLTGPVTILNWSFPR---EDISLKASTLQLALAVQEEVLDLEKAG 591
S+ VKG++TGP T++ S + + + +A ++ E L+ AG
Sbjct: 103 ILRGLTDDESRGVKGIITGPSTMIYASRIEGFYDPQKRDRAVMDMAGVLKIEAKHLQDAG 162
Query: 592 IKIIQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEFEDII 651
+IQIDE L + +D + H + ++ H+C + +++
Sbjct: 163 AAMIQIDEPFLSTGI-----------VDMKTAGRAIDHIAAGLDIEVSLHVC-GDIRNVL 210
Query: 652 PSIDAMDADVISFE-ASR-SELSIIDALKAHHFKTLVGPGVYDIHSPRIPSVKEIQNQLE 709
+ DV+ E A R S L +++ + VG G D + R+ S++EI+N ++
Sbjct: 211 SDLLRFKVDVLDLEFAGRPSNLEVLE--EKWRGDKGVGFGCVDTTTERVESMEEIRNLIK 268
Query: 710 KILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEA 746
+ D + E ++++PDCG++ LR++V A
Sbjct: 269 RGADIVGEENLYIDPDCGMRKLPRKAAFSKLRNMVMA 305
sp|Q58868|YE73_METJA HYPOTHETICAL PROTEIN MJ1473 >gi|2127725|pir||H64483
5-methyltetrahydropteroyltriglutamate--homocysteine
S-methyltransferase (EC 2.1.1.14) - Methanococcus
jannaschii >gi|1592112 (U67588)
5-methyltetrahydropteroyltriglutamate-homocysteine
methyltransferase (metE) [Methanococcus jannaschii]
Length = 311
Score = 62.8 bits (150), Expect = 1e-08
Identities = 79/348 (22%), Positives = 162/348 (45%), Gaps = 66/348 (18%)
Query: 427 TTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKECLKLQEDIGLDVLVHGEFER 486
TT +GS+P + + K+ +Y +E +K+ +K G++++ G+ R
Sbjct: 6 TTVVGSYPVVKKEETFLDKVKKVFGLYDEYKYAIERAVKDQVKA----GVNIISDGQV-R 60
Query: 487 NDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTRPEAMTVRWSAYAQSQTSK- 545
DMVE F + G+ G R V + +P +T++ YA+S K
Sbjct: 61 GDMVEIFTNNMYGFD----------GKRVVGR----VEFIKP--ITLKDILYAKSIAKKL 104
Query: 546 ----PVKGMLTGPVTILN-------WSFPREDISLKASTLQLALAVQEEVLDLEKAGIKI 594
+KG++TGP TI + +S R++ + +A A+++EV L+K + I
Sbjct: 105 NPNVEIKGIITGPCTIASSVRVESCYSDNRDENLI----YDIAKALRKEVEALKKH-VPI 159
Query: 595 IQIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEFEDIIPSI 654
IQIDE L + D ++ +D + + + H+C + + +II +
Sbjct: 160 IQIDEPIL--STGMYDFDVARKAIDIIVDGLNI---------KFAMHVCGNVY-NIIDEL 207
Query: 655 DAMDADVIS--FEASRSELSIIDALKAHHFKTLVGPGVYDIHSPRIPSVKEIQNQLEK-- 710
+ + D++ F +++ L I+++++ VG G + ++ SV+EI++ +E+
Sbjct: 208 NKFNVDILDHEFASNKKNLVILESMEKK-----VGFGCVNTKVKKVESVEEIKSLIEEGI 262
Query: 711 -------ILDKLPIEQVWVNPDCGLKTRGNAETIPSLRHLVEATRVLR 751
L+K + + ++PDCG++ L+++VEAT++++
Sbjct: 263 EILKNNEKLNKNLSDNILIDPDCGMRLLPIDVAFNKLKNMVEATKLIK 310
sp|P55299|Y775_METTM HYPOTHETICAL 34.6 KD PROTEIN IN TYSY 5'REGION (ORF1)
>gi|2127678|pir||S62191 cobalamin-independent methionine
synthase homolog - Methanobacterium thermoautotrophicum
>gi|1103707|emb|CAA63062| (X92082) cobalamin-independent
methionine synthase [Methanobacterium
thermoautotrophicum]
Length = 319
Score = 61.7 bits (147), Expect = 2e-08
Identities = 76/332 (22%), Positives = 135/332 (39%), Gaps = 41/332 (12%)
Query: 427 TTTIGSFPQTAEVRKVRLQNKRGELRQADYDTFLEEKIKECLKLQEDIGLDVLVHGEFER 486
TT +GS+P T R+ +R YD I+ ++ Q G+D++ G+ R
Sbjct: 13 TTVVGSYPATP--REPETLRERISSFIGSYDA-CRPAIETAVRDQVRAGVDIISDGQV-R 68
Query: 487 NDMVEYFGEKLEGYVFTQKAWVQSYGTRCVKPPIVWTDVTRPEAMT--------VRWSAY 538
DMV +F E + G + I+++ +T P ++
Sbjct: 69 GDMVGHFAEAMGGMMVKDGV------------SIIFSRITPPAGSIGSDDLIYRIKILRK 116
Query: 539 AQSQTSKPVKGMLTGPVTILNWSFPREDIS---LKASTLQLALAVQEEVLDLEKAGIKII 595
SK VKG++TGP T+ + S S + + + +A A++ E L+ AG +I
Sbjct: 117 LTDDESKGVKGIITGPSTMAHASKIEGFYSPQKRERAIMDMADALRVEAEHLQDAGALMI 176
Query: 596 QIDEAALREKLPLRKSDWYKEYLDWAIPAFRLVHSKVKPETQIHTHMCYSEFEDIIPSID 655
QIDE L + +D + + + H+C + +I +
Sbjct: 177 QIDEPFLSTGM-----------VDMGTARRAVKRISGALDVDVSLHVC-GDISGVIGELL 224
Query: 656 AMDADVISFE-ASRSELSIIDALKAHHFKTLVGPGVYDIHSPRIPSVKEIQNQLEKILDK 714
D++ E A R + A K K L G G D + + S I+N +E+ D
Sbjct: 225 TFPVDMLDLEFAGRPSNLEVLAEKWRGDKKL-GFGCVDTSTEVVESTDTIKNLIERGADI 283
Query: 715 LPIEQVWVNPDCGLKTRGNAETIPSLRHLVEA 746
+ ++++PDCG++ LR++V+A
Sbjct: 284 AGEDNLYIDPDCGMRKLPREAAFSKLRNMVKA 315
Posted date: Mar 2, 2000 12:24 PM
Number of letters in database: 140,871,481
Number of sequences in database: 457,798
Lambda K H
0.317 0.135 0.384
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 204416069
Number of Sequences: 457798
Number of extensions: 8675829
Number of successful extensions: 25504
Number of sequences better than 1.0e-02: 38
Number of HSP's better than 0.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 25243
Number of HSP's gapped (non-prelim): 56
length of query: 759
length of database: 140,871,481
effective HSP length: 60
effective length of query: 699
effective length of database: 113,403,601
effective search space: 79269117099
effective search space used: 79269117099
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 99 (43.0 bits)