Score E
Sequences producing significant alignments: (bits) Value
gi|4096796 (U40157) orf1; unknown function; similar to con... 423 e-117
emb|CAB46502.1| (AJ132503) TaC protein [Myxococcus xanthus] 176 3e-43
sp|P22791|HMCM_RAT HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MITO... 145 8e-34
sp|P54869|HMCM_MOUSE HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MI... 144 1e-33
pir||B55729 hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5)... 144 1e-33
emb|CAB46505.1| (AJ132503) TaF protein [Myxococcus xanthus] 141 1e-32
sp|P40830|PKSG_BACSU PUTATIVE POLYKETIDE BIOSYNTHESIS PROTE... 139 5e-32
gi|1458280 (U64842) Similar to hydroxymethlglutaryl-CoA syn... 137 1e-31
sp|P54871|HMCS_CAEEL HYDROXYMETHYLGLUTARYL-COA SYNTHASE (HM... 137 1e-31
gi|555835 (U12790) HMG CoA synthase [Mus musculus] 133 2e-30
sp|P54961|HMC1_BLAGE HYDROXYMETHYLGLUTARYL-COA SYNTHASE 1 (... 133 3e-30
emb|CAA65250| (X96386) 3-hydroxy-3-methylglutaryl-CoA-synth... 130 2e-29
sp|O02734|HMCM_PIG HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MITO... 130 2e-29
ref|NP_013580.1|HMGS| 3-hydroxy-3-methylglutaryl coenzyme A... 129 3e-29
ref|NP_005509.1|| 3-hydroxy-3-methylglutaryl-Coenzyme A syn... 129 3e-29
sp|P54874|HMCS_SCHPO HYDROXYMETHYLGLUTARYL-COA SYNTHASE (HM... 128 9e-29
pir||S13887 hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5)... 127 2e-28
sp|P23228|HMCS_CHICK HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CY... 127 2e-28
pir||S27197 hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5)... 126 3e-28
ref|NP_002121.1|| 3-hydroxy-3-methylglutaryl-Coenzyme A syn... 126 3e-28
sp|P54870|HMC2_BLAGE HYDROXYMETHYLGLUTARYL-COA SYNTHASE 2 (... 126 3e-28
sp|P54873|HMCS_ARATH HYDROXYMETHYLGLUTARYL-COA SYNTHASE (HM... 125 8e-28
gi|4098521 (U79160) HMG-CoA synthase [Arabidopsis thaliana]... 122 4e-27
sp|P17425|HMCS_RAT HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTO... 122 7e-27
gi|2688618 (AE001169) 3-hydroxy-3-methylglutaryl-CoA syntha... 121 9e-27
sp|P13704|HMCS_CRIGR HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CY... 118 1e-25
pir||A64493 acyl carrier protein synthase - Methanococcus j... 112 6e-24
emb|CAB57764.1| (Y18930) acyl carrier protein synthase [Sul... 104 1e-21
dbj|BAA82227.1| (D86934) ORF CN041 [Staphylococcus aureus] 100 2e-20
gi|2621881 (AE000857) 3-hydroxy-3-methylglutaryl-CoA-syntha... 97 3e-19
gi|2650679 (AE001109) acyl carrier protein synthase (acaA-2... 95 1e-18
gi|555833 (U12789) HMG CoA synthase [Homo sapiens] 95 1e-18
dbj|BAA80878.1| (AP000062) 365aa long hypothetical acyl car... 84 2e-15
dbj|BAA29768| (AP000003) 350aa long hypothetical acyl carri... 80 4e-14
emb|CAA59499| (X85250) acyl carrier protein synthase [Pyroc... 77 2e-13
emb|CAB50274.1| (AJ248287) acyl carrier protein synthase (a... 76 6e-13
gb|AAF20927.1|AF207529_1 (AF207529) PhlA [Pseudomonas fluor... 68 1e-10
gb|AAB48109.1| (U41818) PhlA [Pseudomonas fluorescens] 66 4e-10
gi|555837 (U12791) HMG CoA synthase [Mus musculus] 59 5e-08
sp|P54872|HMCS_DICDI HYDROXYMETHYLGLUTARYL-COA SYNTHASE (HM... 50 3e-05
sp|O85139|FABH_SALTY 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTH... 48 1e-04
gi|1235848 (U12788) HMG CoA synthase [Homo sapiens] 48 1e-04
gi|4096796 (U40157) orf1; unknown function; similar to condensing-enzymes;
Method: conceptual translation supplied by author.
[Staphylococcus carnosus]
Length = 389
Score = 423 bits (1076), Expect = e-117
Identities = 216/390 (55%), Positives = 278/390 (70%), Gaps = 14/390 (3%)
Query: 1 MKVGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAA 60
M +GID+L F++PN +VDM +LA AR VDP KF IGIGQ +MAV+P +QDI++ ANAA
Sbjct: 1 MTIGIDQLNFYIPNFYVDMAELAEARGVDPNKFLIGIGQSQMAVSPVSQDIVSMGANAAQ 60
Query: 61 SILTEEDKKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFARSIEMKEACYATTAGLTL 120
IL+E+DKK I M+IV TES++D +KASAV +H LLGIQPFAR EMKEACYA T + L
Sbjct: 61 PILSEQDKKDITMVIVATESAIDSAKASAVQIHHLLGIQPFARCFEMKEACYAATPAIQL 120
Query: 121 ARDHVLLNPDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNVALTQ 180
A+D+++ P KVLVIASD A+YGLN+GGEPTQGAG+VAM+I+ +P IL L++D+VA T+
Sbjct: 121 AKDYLVPRPKEKVLVIASDTARYGLNSGGEPTQGAGAVAMVISHNPSILELHDDSVAYTE 180
Query: 181 DIYDFWRPFGQAYPSVDGKFSNETYIDAFAKIWKEYSHRTNLKFEDFAAIAFHTPYTKMG 240
D+YDFWRP G+ YP V GK S + YI +F + W EY+ R + DFAA+ FH P+TKMG
Sbjct: 181 DVYDFWRPSGEIYPLVAGKLSKDAYIKSFQESWNEYAKRHHKSLSDFAALCFHVPFTKMG 240
Query: 241 KKALLPML-ESEKPANAEELMEQFEHGIVYNRRVGNLYTGSLYLSLISLLENSDKLSAGQ 299
+KAL +L +S L E ++ YNR VGN+YTGSLYLSLISLLEN KL+ G
Sbjct: 241 QKALDSILTDSASEDTQARLNEGYKSATDYNRYVGNVYTGSLYLSLISLLEN-HKLNGGD 299
Query: 300 RIGLFSYGSGTVAEFFSGELVEGYENHLLKIEHQSMLDARTRLSIPEYENMFNQYLDLNH 359
IGLFSYGSG+V EFFS LV+ Y++HL H++MLD R LS+ EYE FN++
Sbjct: 300 NIGLFSYGSGSVGEFFSATLVDNYQDHLDVKAHKAMLDNRKALSVEEYEKFFNRF----D 355
Query: 360 NISFNDETDYSV--------SEVVDNHRKY 381
N+ F+ ET+ V E+ DN R Y
Sbjct: 356 NLEFDTETELEVEPKGNFYLKEISDNIRYY 385
emb|CAB46502.1| (AJ132503) TaC protein [Myxococcus xanthus]
Length = 420
Score = 176 bits (442), Expect = 3e-43
Identities = 116/368 (31%), Positives = 194/368 (52%), Gaps = 25/368 (6%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI+ + + +D+ LA R +D ++F + +E V +D +T+ NAA I
Sbjct: 4 VGIEAMNAYCGIARLDVLQLATHRGLDTSRFA-NLLMEEKTVPLPYEDPVTYGVNAARPI 62
Query: 63 L---TEEDKKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFARSIEMKEACYATTAGLT 119
L T ++ +I++++ TESS D KA + +H LG+ R IE+K ACY+ AGL
Sbjct: 63 LDQLTAAERDSIELLVACTESSFDFGKAMSTYLHQHLGLSRNCRLIELKSACYSGVAGLQ 122
Query: 120 LARDHVL--LNPDTKVLVIASDIAKYGLNTGG----------EPTQGAGSVAMLITADPK 167
+A + +L ++P K LV+ASD++++ + GG EP+ GAG+VAML++ P+
Sbjct: 123 MAVNFILSGVSPGAKALVVASDLSRFSIAEGGDASTEDWSFAEPSSGAGAVAMLVSDTPR 182
Query: 168 ILALN-NDNVALTQDIYDFWRPFGQAYPSVDGKFSNETYIDAFAKIWKEYSHRTNLK--F 224
+ ++ N ++ D RP + + D S +Y+D ++EY+ R
Sbjct: 183 VFRVDVGANGYYGYEVMDTCRPVADS-EAGDADLSLLSYLDCCENAFREYTRRVPAANYA 241
Query: 225 EDFAAIAFHTPYTKMGKKALLPMLESEKPANAEELMEQFEH----GIVYNRRVGNLYTGS 280
E F +AFHTP+ M K A M+ N ++ F+ G+ Y +RVGN+ +
Sbjct: 242 ESFGYLAFHTPFGGMVKGAHRTMMRKFSGKNRGDIEADFQRRVAPGLTYCQRVGNIMGAT 301
Query: 281 LYLSLISLLENSDKLSAGQRIGLFSYGSGTVAEFFSGELVEGYENHLLKIEHQSMLDART 340
+ LSL+ +++ D + +RIG FSYGSG +EFFSG + E + + L R
Sbjct: 302 MALSLLGTIDHGD-FATAKRIGCFSYGSGCSSEFFSGVVTEEGQQRQRALGLGEALGRRQ 360
Query: 341 RLSIPEYE 348
+LS+P+Y+
Sbjct: 361 QLSMPDYD 368
sp|P22791|HMCM_RAT HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MITOCHONDRIAL PRECURSOR
(HMG-COA SYNTHASE) (3-HYDROXY-3-METHYLGLUTARYL COENZYME
A SYNTHASE) >gi|111794|pir||A35865
hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5) - rat
>gi|204619 (M33648) 3-hydroxy-3-methylglutaryl-CoA
synthase precursor (EC 4.1.3.5) [Rattus norvegicus]
Length = 508
Score = 145 bits (361), Expect = 8e-34
Identities = 133/457 (29%), Positives = 202/457 (44%), Gaps = 79/457 (17%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI L + P +VD DL NV+ K+ +G+GQ M +DI + +
Sbjct: 54 VGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRL 113
Query: 63 L--TEEDKKAIDMIIVGTESSLDESKASAVVVHDLL--GIQPFARSIEMKEACYATTAGL 118
+ T+ A+ + VGTE+ +D+SKA V+ +L I+ ACY TA L
Sbjct: 114 MERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASL 173
Query: 119 TLARDHVLLN--PDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNV 176
A + + + LV+ DIA Y + PT GAG+VAMLI ++
Sbjct: 174 FNAANWMESSYWDGRYALVVCGDIAVYP-SGNPRPTGGAGAVAMLIGPKAPLVLEQGLRG 232
Query: 177 ALTQDIYDFWRP-FGQAYPSVDGKFSNETYIDAFAKI-----------WKEYSHRTNLKF 224
++ YDF++P YP VDGK S + Y+ A + WK+ +
Sbjct: 233 THMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRRKIQNQWKQAGNNQPFTL 292
Query: 225 EDFAAIAFHTPYTKMGKKALLPML-------ESEKPANAEELMEQFEHGI---------- 267
+D + FHTP+ KM +K+L ++ S+K N + +E F+ G+
Sbjct: 293 DDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSSDKQNNLYKGLEAFK-GLKLEETYTNKD 351
Query: 268 -----------VYNRRV----------GNLYTGSLYLSLISLL-ENSDKLSAGQRIGLFS 305
++N++ GN+YT SLY L SLL +S + AG RIG FS
Sbjct: 352 VDKALLKASLDMFNKKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFS 411
Query: 306 YGSGTVAEFFS---------GELVEGYENHLLKIEHQSMLDARTRLSIPEYENMFNQYLD 356
YGSG A FFS G +E + + + + LD+R R+S E+ + NQ
Sbjct: 412 YGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKR--LDSRRRMSPEEFTEIMNQREQ 469
Query: 357 LNHNISFNDETDYS-------VSEVVD--NHRKYKKR 384
H ++F+ D S E VD + RKY +R
Sbjct: 470 FYHKVNFSPPGDTSNLFPGTWYLERVDEMHRRKYARR 506
sp|P54869|HMCM_MOUSE HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MITOCHONDRIAL PRECURSOR
(HMG-COA SYNTHASE) (3-HYDROXY-3-METHYLGLUTARYL COENZYME
A SYNTHASE)
Length = 480
Score = 144 bits (359), Expect = 1e-33
Identities = 126/434 (29%), Positives = 192/434 (44%), Gaps = 70/434 (16%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI L + P +VD DL NV+ K+ +G+GQ M +DI + +
Sbjct: 26 VGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRL 85
Query: 63 L--TEEDKKAIDMIIVGTESSLDESKASAVVVHDLL--GIQPFARSIEMKEACYATTAGL 118
+ T+ A+ + VGTE+ +D+SKA V+ +L I+ ACY TA L
Sbjct: 86 MERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASL 145
Query: 119 TLARDHVLLN--PDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNV 176
A + + + LV+ DIA Y + PT GAG+VAMLI ++
Sbjct: 146 FNAANWMESSYWDGRYALVVCGDIAVYP-SGNARPTGGAGAVAMLIGPKAPLVLEQGLRG 204
Query: 177 ALTQDIYDFWRP-FGQAYPSVDGKFSNETYIDAFAKI-----------WKEYSHRTNLKF 224
++ YDF++P YP VDGK S + Y+ A + WK+ +
Sbjct: 205 THMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRKKIQNQWKQAGNNQPFTL 264
Query: 225 EDFAAIAFHTPYTKMGKKALLPML-------ESEKPANAEELMEQFEHGI---------- 267
+D + FHTP+ KM +K+L ++ S+K N + +E F G+
Sbjct: 265 DDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSSDKQNNLYKGLEAF-RGLKLEETYTNKD 323
Query: 268 -----------VYNRRV----------GNLYTGSLYLSLISLL-ENSDKLSAGQRIGLFS 305
++N++ GN+YT SLY L SLL +S + AG RIG FS
Sbjct: 324 VDKALLKASLDMFNQKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFS 383
Query: 306 YGSGTVAEFFS---------GELVEGYENHLLKIEHQSMLDARTRLSIPEYENMFNQYLD 356
YGSG A FFS G +E + + + + LD+R R+S E+ + NQ
Sbjct: 384 YGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKR--LDSRRRMSPEEFTEIMNQREQ 441
Query: 357 LNHNISFNDETDYS 370
H ++F+ D S
Sbjct: 442 FYHKVNFSPPGDTS 455
pir||B55729 hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5), mitochondrial -
mouse
Length = 471
Score = 144 bits (359), Expect = 1e-33
Identities = 126/434 (29%), Positives = 192/434 (44%), Gaps = 70/434 (16%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI L + P +VD DL NV+ K+ +G+GQ M +DI + +
Sbjct: 17 VGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRL 76
Query: 63 L--TEEDKKAIDMIIVGTESSLDESKASAVVVHDLL--GIQPFARSIEMKEACYATTAGL 118
+ T+ A+ + VGTE+ +D+SKA V+ +L I+ ACY TA L
Sbjct: 77 MERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASL 136
Query: 119 TLARDHVLLN--PDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNV 176
A + + + LV+ DIA Y + PT GAG+VAMLI ++
Sbjct: 137 FNAANWMESSYWDGRYALVVCGDIAVYP-SGNARPTGGAGAVAMLIGPKAPLVLEQGLRG 195
Query: 177 ALTQDIYDFWRP-FGQAYPSVDGKFSNETYIDAFAKI-----------WKEYSHRTNLKF 224
++ YDF++P YP VDGK S + Y+ A + WK+ +
Sbjct: 196 THMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRKKIQNQWKQAGNNQPFTL 255
Query: 225 EDFAAIAFHTPYTKMGKKALLPML-------ESEKPANAEELMEQFEHGI---------- 267
+D + FHTP+ KM +K+L ++ S+K N + +E F G+
Sbjct: 256 DDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSSDKQNNLYKGLEAF-RGLKLEETYTNKD 314
Query: 268 -----------VYNRRV----------GNLYTGSLYLSLISLL-ENSDKLSAGQRIGLFS 305
++N++ GN+YT SLY L SLL +S + AG RIG FS
Sbjct: 315 VDKALLKASLDMFNQKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFS 374
Query: 306 YGSGTVAEFFS---------GELVEGYENHLLKIEHQSMLDARTRLSIPEYENMFNQYLD 356
YGSG A FFS G +E + + + + LD+R R+S E+ + NQ
Sbjct: 375 YGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKR--LDSRRRMSPEEFTEIMNQREQ 432
Query: 357 LNHNISFNDETDYS 370
H ++F+ D S
Sbjct: 433 FYHKVNFSPPGDTS 446
emb|CAB46505.1| (AJ132503) TaF protein [Myxococcus xanthus]
Length = 374
Score = 141 bits (351), Expect = 1e-32
Identities = 109/368 (29%), Positives = 185/368 (49%), Gaps = 41/368 (11%)
Query: 49 QDIITFAANAAASIL---TEEDKKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFARSI 105
+D +T A NAA IL + E ++ I++++ +ES +D SK+ + H+ LG+ R +
Sbjct: 12 EDPVTNAVNAARPILDAMSPEARERIELLVTSSESGVDFSKSISSYAHEHLGLSRHCRFL 71
Query: 106 EMKEACYATTAGLTLARDHVL--LNPDTKVLVIASDIA---KYGLNTGGEPTQGAGSVAM 160
E+K+ACYA T L LA ++ ++P K LVIA+D+ + GL + EP G G VA+
Sbjct: 72 EVKQACYAATGALQLALGYIASGVSPGAKALVIATDVTLVDESGLYS--EPAMGTGGVAV 129
Query: 161 LITADPKILALNNDNVA-LTQDIYDFWRPFGQAYPSVD-GKFSNE--TYIDAFAKIWKEY 216
L+ +P+++ ++ + D++D RP P +D G TY+D + Y
Sbjct: 130 LLGDEPRVMKMDLGAFGNYSYDVFDTARP----SPEIDIGDVDRSLFTYLDCLKHSFAAY 185
Query: 217 SHRTN-LKF-EDFAAIAFHTPYTKMGKKALLPMLESEKPANAEELMEQF----EHGIVYN 270
R + + F F +A HTP+ + K M+ P + +E+ F + + Y
Sbjct: 186 GRRVDGVDFVSTFDYLAMHTPFAGLVKAGHRKMMRELTPCDVDEIEADFGRRVKPSLQYP 245
Query: 271 RRVGNLYTGSLYLSLISLLENSDKLSAGQRIGLFSYGSGTVAEFFSGELVEGYENHLLKI 330
VGNL +GS+YLSL S+++ + K R+G+FSYGSG +EFFSG + + L +
Sbjct: 246 SLVGNLCSGSVYLSLCSIID-TIKPERSARVGMFSYGSGCSSEFFSGVIGPESVSALAGL 304
Query: 331 EHQSMLDARTRLSIPEYENMF-----------NQYLDLNHNISFNDETD-----YSVSEV 374
+ L R +L+ +Y + N+ +D+ + T ++ V
Sbjct: 305 DIGGHLRGRRQLTFDQYVELLKENLRCLVPTKNRDVDVERYLPLVTRTASRPRMLALRRV 364
Query: 375 VDNHRKYK 382
VD HR+Y+
Sbjct: 365 VDYHRQYE 372
sp|P40830|PKSG_BACSU PUTATIVE POLYKETIDE BIOSYNTHESIS PROTEIN PKSG >gi|528991 (U11039)
unknown [Bacillus subtilis] >gi|2634085|emb|CAB13586|
(Z99112) pksG [Bacillus subtilis]
>gi|2634097|emb|CAB13597| (Z99113) pksG [Bacillus
subtilis]
Length = 345
Score = 139 bits (346), Expect = 5e-32
Identities = 100/344 (29%), Positives = 172/344 (49%), Gaps = 36/344 (10%)
Query: 73 MIIVGTESSLDESKASAVVVHDLLGIQPFARSIEMKEACYATTAGLTLARDHVL--LNPD 130
M+I +ES +D K+ + +H+ LG+ R E+K+ACY+ TAG +A + +L +P
Sbjct: 1 MLITCSESGIDFGKSLSTYIHEYLGLNRNCRLFEVKQACYSGTAGFQMAVNFILSQTSPG 60
Query: 131 TKVLVIASDIAKYGLNTGG----------EPTQGAGSVAMLITADPKILALN-NDNVALT 179
K LVIASDI+++ + GG EP+ GAG+VA+L+ +P++ ++ N
Sbjct: 61 AKALVIASDISRFLIAEGGDALSEDWSYAEPSAGAGAVAVLVGENPEVFQIDPGANGYYG 120
Query: 180 QDIYDFWRPFGQAYPSVDGKFSNETYIDAFAKIWKEYSHRT-NLKFED-FAAIAFHTPYT 237
++ D RP + + D S +Y+D + + EY R ++D F +A+HTP+
Sbjct: 121 YEVMDTCRPIPDS-EAGDSDLSLMSYLDCCEQTFLEYQKRVPGANYQDTFQYLAYHTPFG 179
Query: 238 KMGKKALLPMLESEKPANAE----ELMEQFEHGIVYNRRVGNLYTGSLYLSLISLLENSD 293
M K A M+ + + + + G+ Y +RVGN+ +L+L+L S ++
Sbjct: 180 GMVKGAHRTMMRKVAKVKTSGIETDFLTRVKPGLNYCQRVGNIMGAALFLALASTIDQG- 238
Query: 294 KLSAGQRIGLFSYGSGTVAEFFSGELVEGYENHLLKIEHQSMLDARTRLSIPEYENMFN- 352
+ +RIG FSYGSG +EF+SG + + LD R +LS+ EYE +F
Sbjct: 239 RFDTPKRIGCFSYGSGCCSEFYSGITTPQGQERQRTFGIEKHLDRRYQLSMEEYELLFKG 298
Query: 353 ----QYLDLNHNISF----------NDETDYSVSEVVDNHRKYK 382
++ N + F ++ + E+ + HRKY+
Sbjct: 299 SGMVRFGTRNVKLDFEMIPGIMQSTQEKPRLFLEEISEFHRKYR 342
gi|1458280 (U64842) Similar to hydroxymethlglutaryl-CoA synthase; coded for by
C. elegans cDNA cm01e7 [Caenorhabditis elegans]
Length = 462
Score = 137 bits (342), Expect = 1e-31
Identities = 95/359 (26%), Positives = 160/359 (44%), Gaps = 43/359 (11%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI + + P FVD DL NV K+ IG+GQ +M +DI++ + +
Sbjct: 14 VGIGAIELYFPQNFVDQNDLEKFNNVSSGKYTIGLGQQQMGFCSDNEDIVSISLTVTRKL 73
Query: 63 LT--EEDKKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFARSIEMKEACYATTAGLTL 120
+ + +I ++VGTE+ +D+SK+ + DL +++K AC+ L
Sbjct: 74 IETYKISTDSIGCLVVGTETMIDKSKSVKTALMDLFPGNSDIEGVDIKNACFGGAQALLH 133
Query: 121 ARDHVLLN---PDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNVA 177
A D V +N +V+ +DIA Y T GAG++A LI D I +
Sbjct: 134 AIDWVTVNHPLDKKNAIVVVADIAIYE-EGPARCTGGAGAIAFLICPDASIPIDRQFSAC 192
Query: 178 LTQDIYDFWR---PFGQAYPSVDGKFSNETYIDAFAKIWKEYSHRTNLK------FEDFA 228
++ +DF++ P YP VDG S +Y++A + + + N F
Sbjct: 193 HMKNTWDFFKPITPIPSEYPVVDGSLSLSSYLEAVRMTYTYFISKVNRHTTGIDGLNSFD 252
Query: 229 AIAFHTPYTKMGKKALLPMLESEKPANAEEL----------------------------M 260
+ H+P+TKM +K L M ++ ++L
Sbjct: 253 GVFLHSPFTKMVQKGLAVMNYTDSQLRHKQLNGNGVDHKLDENDRAGLAKMIELSAQVWK 312
Query: 261 EQFEHGIVYNRRVGNLYTGSLYLSLISLLENSDKLSAGQRIGLFSYGSGTVAEFFSGEL 319
E+ + +V+NRR+GN+YT SL+ L++ L D ++ + I F+YGSG + F G +
Sbjct: 313 EKTDPYLVFNRRIGNMYTPSLFAQLLAYLAADDCVTGEKSILFFAYGSGLASAIFPGRV 371
sp|P54871|HMCS_CAEEL HYDROXYMETHYLGLUTARYL-COA SYNTHASE (HMG-COA SYNTHASE)
(3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
>gi|1078869|pir||C55729 hydroxymethylglutaryl-CoA
synthase homolog - Caenorhabditis elegans (fragment)
>gi|555829 (U12787) HMG CoA synthase [Caenorhabditis
elegans]
Length = 458
Score = 137 bits (342), Expect = 1e-31
Identities = 95/359 (26%), Positives = 160/359 (44%), Gaps = 43/359 (11%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI + + P FVD DL NV K+ IG+GQ +M +DI++ + +
Sbjct: 10 VGIGAIELYFPQNFVDQNDLEKFNNVSSGKYTIGLGQQQMGFCSDNEDIVSISLTVTRKL 69
Query: 63 LT--EEDKKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFARSIEMKEACYATTAGLTL 120
+ + +I ++VGTE+ +D+SK+ + DL +++K AC+ L
Sbjct: 70 IETYKISTDSIGCLVVGTETMIDKSKSVKTALMDLFPGNSDIEGVDIKNACFGGAQALLH 129
Query: 121 ARDHVLLN---PDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNVA 177
A D V +N +V+ +DIA Y T GAG++A LI D I +
Sbjct: 130 AIDWVTVNHPLDKKNAIVVVADIAIYE-EGPARCTGGAGAIAFLICPDASIPIDRQFSAC 188
Query: 178 LTQDIYDFWR---PFGQAYPSVDGKFSNETYIDAFAKIWKEYSHRTNLK------FEDFA 228
++ +DF++ P YP VDG S +Y++A + + + N F
Sbjct: 189 HMKNTWDFFKPITPIPSEYPVVDGSLSLSSYLEAVRMTYTYFISKVNRHTTGIDGLNSFD 248
Query: 229 AIAFHTPYTKMGKKALLPMLESEKPANAEEL----------------------------M 260
+ H+P+TKM +K L M ++ ++L
Sbjct: 249 GVFLHSPFTKMVQKGLAVMNYTDSQLRHKQLNGNGVDHKLDENDRAGLAKMIELSAQVWK 308
Query: 261 EQFEHGIVYNRRVGNLYTGSLYLSLISLLENSDKLSAGQRIGLFSYGSGTVAEFFSGEL 319
E+ + +V+NRR+GN+YT SL+ L++ L D ++ + I F+YGSG + F G +
Sbjct: 309 EKTDPYLVFNRRIGNMYTPSLFAQLLAYLAADDCVTGEKSILFFAYGSGLASAIFPGRV 367
gi|555835 (U12790) HMG CoA synthase [Mus musculus]
Length = 432
Score = 133 bits (332), Expect = 2e-30
Identities = 112/371 (30%), Positives = 166/371 (44%), Gaps = 59/371 (15%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI L + P +VD DL NV+ K+ +G+GQ M +DI + +
Sbjct: 26 VGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRL 85
Query: 63 L--TEEDKKAIDMIIVGTESSLDESKASAVVVHDLL--GIQPFARSIEMKEACYATTAGL 118
+ T+ A+ + VGTE+ +D+SKA V+ +L I+ ACY TA L
Sbjct: 86 MERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASL 145
Query: 119 TLARDHVLLN--PDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNV 176
A + + + LV+ DIA Y + PT GAG+VAMLI ++
Sbjct: 146 FNAANWMESSYWDGRYALVVCGDIAVYP-SGNARPTGGAGAVAMLIGPKAPLVLEQGLRG 204
Query: 177 ALTQDIYDFWRP-FGQAYPSVDGKFSNETYIDAFAKI-----------WKEYSHRTNLKF 224
++ YDF++P YP VDGK S + Y+ A + WK+ +
Sbjct: 205 THMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRKKIQNQWKQAGNNQPFTL 264
Query: 225 EDFAAIAFHTPYTKMGKKALLPML-------ESEKPANAEELMEQFEHGI---------- 267
+D + FHTP+ KM +K+L ++ S+K N + +E F G+
Sbjct: 265 DDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSSDKQNNLYKGLEAF-RGLKLEETYTNKD 323
Query: 268 -----------VYNRRV----------GNLYTGSLYLSLISLL-ENSDKLSAGQRIGLFS 305
++N++ GN+YT SLY L SLL +S + AG RIG FS
Sbjct: 324 VDKALLKASLDMFNQKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFS 383
Query: 306 YGSGTVAEFFS 316
YGSG A FFS
Sbjct: 384 YGSGLAASFFS 394
sp|P54961|HMC1_BLAGE HYDROXYMETHYLGLUTARYL-COA SYNTHASE 1 (HMG-COA SYNTHASE 1)
(3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE 1)
>gi|630819|pir||S38986 hydroxymethylglutaryl-CoA
synthase (EC 4.1.3.5) - German cockroach
>gi|1772495|emb|CAA52032| (X73679)
hydroxymethylglutaryl-CoA synthase [Blattella germanica]
Length = 453
Score = 133 bits (331), Expect = 3e-30
Identities = 121/429 (28%), Positives = 187/429 (43%), Gaps = 67/429 (15%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI L P+ +VD DL NV K+ +G+GQ M +DI + + +
Sbjct: 6 VGIVALELIFPSQYVDQVDLEVYDNVSAGKYTVGLGQARMGFCTDREDINSLCLTVVSRL 65
Query: 63 LTEED--KKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFARSIEMKEACYATTAGLTL 120
+ I + VGTE+ LD+SK+ V+ L ++ ACY T+ L
Sbjct: 66 MERWSIPYSQIGRLEVGTETLLDKSKSVKTVLMQLFKDNTDIEGVDTVNACYGGTSALFN 125
Query: 121 ARDHVLLN--PDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNVAL 178
A V + LV+A DIA Y + PT GAG+VAML+ A+ ++ +
Sbjct: 126 AISWVESSSWDGRYALVVAGDIAVYAKGS-ARPTGGAGAVAMLVGANAPLVFDRGVRSSH 184
Query: 179 TQDIYDFWRP-FGQAYPSVDGKFSNETYIDAF--------AKIWKEYSHRTNLKFEDFAA 229
Q YDF++P YP+VDGK S + Y+ A +KI K+ + ++ E A
Sbjct: 185 MQHAYDFYKPDLSSLYPTVDGKLSIQCYLSALDHCYQLYCSKIQKQLGEKFDI--ERLDA 242
Query: 230 IAFHTPYTKMGKKALLPM-------------------LESEKPANAEE------------ 258
+ FH PY K+ +K+L + LE+ K E+
Sbjct: 243 VLFHAPYCKLVQKSLARLVLNDFVRASEEERTTKYSSLEALKGVKLEDTYFDREVEKAVM 302
Query: 259 ------LMEQFEHGIVYNRRVGNLYTGSLYLSLISLL-ENSDKLSAGQRIGLFSYGSGTV 311
E+ + ++ +VGN+YT SLY L+SLL S + AG+R+ LFSYGSG
Sbjct: 303 TYSKNMFEEKTKPSLLLANQVGNMYTPSLYGGLVSLLVSKSAQELAGKRVALFSYGSGLA 362
Query: 312 AEFFSGELVEGYENHLLKIEHQSMLDARTRLSIPEYENMFNQYLDLNHNISFNDETDYSV 371
+ FS L+I + + + + ++ Q LDL H +S +E ++
Sbjct: 363 SSMFS-----------LRISSDASAKSSLQRLVSNLSHIKPQ-LDLRHKVS-PEEFAQTM 409
Query: 372 SEVVDNHRK 380
NH K
Sbjct: 410 ETREHNHHK 418
emb|CAA65250| (X96386) 3-hydroxy-3-methylglutaryl-CoA-synthase [Pinus sylvestris]
Length = 474
Score = 130 bits (324), Expect = 2e-29
Identities = 112/393 (28%), Positives = 176/393 (44%), Gaps = 58/393 (14%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI + + P T V DL V K+ IG+GQD M +D+I+ + A S+
Sbjct: 8 VGILAMEIYFPTTCVQQEDLETFDGVSKGKYTIGLGQDCMTFCTDLEDVISMSLTAVTSL 67
Query: 63 LT--EEDKKAIDMIIVGTESSLDESKAS---AVVVHDLLGIQPFARSIEMKEACYATTAG 117
L E D K I + VG+E+ +D+SK+ + + + G ++ ACY TA
Sbjct: 68 LEKYEIDPKQIGRLEVGSETVIDKSKSIKTWLMHIFEKCG-NTEIEGVDSTNACYGGTAA 126
Query: 118 LTLARDHVLLNP-DTKV-LVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDN 175
L + + + D + LV+A+D A Y PT GA +VAMLI + I +
Sbjct: 127 LFNCINWIESSSWDGRYGLVVATDSAVYA-EGAARPTGGAAAVAMLIGPNAPIATESKYR 185
Query: 176 VALTQDIYDFWRP-FGQAYPSVDGKFSNETYIDAFAKIWKEYSHR------TNLKFEDFA 228
+YDF++P YP VDGK S Y+ A +K + ++ D
Sbjct: 186 GTHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKRFCNKFEKEEGRQFSLLDTD 245
Query: 229 AIAFHTPYTKMGKKALLPMLESE-------KPANAEELMEQF------------------ 263
IAFH+PY K+ +K+ +L ++ +A+E +E F
Sbjct: 246 YIAFHSPYNKLVQKSFGRLLFNDFSRHARSVGKDAQEKLEPFAGLSEQDSYNSRDLEKVS 305
Query: 264 ------------EHGIVYNRRVGNLYTGSLYLSLISLLENSDKLSAGQRIGLFSYGSGTV 311
+ + ++VGN+YT SLY +L S++ N GQR+ +FSYGSG
Sbjct: 306 QQLAKPLYDAKIQPSTLLPKQVGNMYTASLYAALASIIHNKHTTLDGQRVMMFSYGSGLA 365
Query: 312 AEFFSGELVEG-----YENHLLKIEHQSMLDAR 339
+ FS ++ EG N ++ Q+ LD+R
Sbjct: 366 STLFSFKIREGQFPFTLSNITEVMDVQNKLDSR 398
sp|O02734|HMCM_PIG HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MITOCHONDRIAL PRECURSOR
(HMG-COA SYNTHASE) (3-HYDROXY-3-METHYLGLUTARYL COENZYME
A SYNTHASE) >gi|2058658 (U90884)
hydroxymethylglutaryl-CoA synthase [Sus scrofa]
Length = 508
Score = 130 bits (323), Expect = 2e-29
Identities = 115/431 (26%), Positives = 183/431 (41%), Gaps = 68/431 (15%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI L + P +VD DL NV+ ++ +G+GQ M +DI + +
Sbjct: 54 VGILALEVYFPAQYVDQTDLEKFDNVEAGRYTVGLGQTHMGFCSVQEDINSLCLTVVQRL 113
Query: 63 L--TEEDKKAIDMIIVGTESSLDESKASAVVVHDLL--GIQPFARSIEMKEACYATTAGL 118
+ T+ ++ + VGTE+ +D+SK+ V+ +L I+ ACY TA L
Sbjct: 114 MERTQLPWDSVGWLEVGTETIIDKSKSVKTVLMELFQDSGNTDIEGIDTTNACYGGTASL 173
Query: 119 TLARDHVLLN--PDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNV 176
A + V + +V+ DIA Y PT GAG+VAML+ + +
Sbjct: 174 FNAANWVESSAWDGRYAVVVCGDIAVYP-RGNSRPTGGAGAVAMLVGPEAPLALERGLRG 232
Query: 177 ALTQDIYDFWRPFGQA-YPSVDGKFSNETYIDA-----------FAKIWKEYSHRTNLKF 224
++ YDF++P + YP VDGK S + Y+ A K WK+ +
Sbjct: 233 THMENAYDFYKPNATSEYPLVDGKLSIQCYLRALDRCYTLYRQKIEKQWKQAGIERHFTL 292
Query: 225 EDFAAIAFHTPYTKMGKKALLPMLESEKPANAEELMEQFEHGI----------------- 267
+D + FHTP+ K+ +K+L ++ S+ + G+
Sbjct: 293 DDLQFMIFHTPFCKLVQKSLARLMFSDFLLADSDTQSSLYKGLEAFRGQKLEDTYANKDI 352
Query: 268 ----------VYNRRV----------GNLYTGSLYLSLISLLEN-SDKLSAGQRIGLFSY 306
++N++ GN+YT SLY L SLL S + AG RIG FSY
Sbjct: 353 EKAFQKASLDLFNKKTKPSLYLSLHNGNMYTSSLYGCLASLLSQCSAQDLAGSRIGAFSY 412
Query: 307 GSGTVAEFFS---------GELVEGYENHLLKIEHQSMLDARTRLSIPEYENMFNQYLDL 357
GSG A F+S G +E + + + + L +R R+S E+ + NQ
Sbjct: 413 GSGLAASFYSLRVSQDASPGSPLEKLVSSVSDLPER--LASRKRVSPEEFTEIMNQREQY 470
Query: 358 NHNISFNDETD 368
H ++F D
Sbjct: 471 YHKVNFTPPGD 481
ref|NP_013580.1|HMGS| 3-hydroxy-3-methylglutaryl coenzyme A synthase; Hmgsp
>gi|1708241|sp|P54839|HMCS_YEAST
HYDROXYMETHYLGLUTARYL-COA SYNTHASE (HMG-COA SYNTHASE)
(3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
>gi|2131285|pir||S58202 HMGS protein - yeast
(Saccharomyces cerevisiae) >gi|927536|emb|CAA90557|
(Z50178) unknown [Saccharomyces cerevisiae]
>gi|1304355|emb|CAA65437| (X96617)
3-hydroxy-3-methylglutaryl coenzyme A synthase
[Saccharomyces cerevisiae]
Length = 491
Score = 129 bits (322), Expect = 3e-29
Identities = 110/402 (27%), Positives = 177/402 (43%), Gaps = 61/402 (15%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI + ++P V+ +L V K+ IG+GQ M+ +DI + + + +
Sbjct: 49 VGIKGIQIYIPTQCVNQSELEKFDGVSQGKYTIGLGQTNMSFVNDREDIYSMSLTVLSKL 108
Query: 63 LTEE--DKKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFARSIEMKEACYATTAGLTL 120
+ D I + VGTE+ +D+SK+ V+ L G I+ ACY T L
Sbjct: 109 IKSYNIDTNKIGRLEVGTETLIDKSKSVKSVLMQLFGENTDVEGIDTLNACYGGTNALFN 168
Query: 121 ARDHVLLN--PDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNVAL 178
+ + + N +V+ DIA Y PT GAG+VAM I D I+ ++ +
Sbjct: 169 SLNWIESNAWDGRDAIVVCGDIAIYD-KGAARPTGGAGTVAMWIGPDAPIV-FDSVRASY 226
Query: 179 TQDIYDFWRP-FGQAYPSVDGKFSNETYIDAFAKIWKEYSHR----------------TN 221
+ YDF++P F YP VDG FS Y+ A +++K YS +
Sbjct: 227 MEHAYDFYKPDFTSEYPYVDGHFSLTCYVKALDQVYKSYSKKAISKGLVSDPAGSDALNV 286
Query: 222 LKFEDFAAIAFHTPYTKMGKKALLPMLESEKPANAE-------EL--------------- 259
LK+ D+ FH P K+ K+ +L ++ AN + EL
Sbjct: 287 LKYFDYN--VFHVPTCKLVTKSYGRLLYNDFRANPQLFPEVDAELATRDYDESLTDKNIE 344
Query: 260 -----------MEQFEHGIVYNRRVGNLYTGSLYLSLISLLE--NSDKLSAGQRIGLFSY 306
E+ ++ GN+YT S+Y + SLL SD L G+R+GLFSY
Sbjct: 345 KTFVNVAKPFHKERVAQSLIVPTNTGNMYTASVYAAFASLLNYVGSDDLQ-GKRVGLFSY 403
Query: 307 GSGTVAEFFSGELVEGYENHLLKIEHQSMLDARTRLSIPEYE 348
GSG A +S ++V ++ + +++ + L R + +YE
Sbjct: 404 GSGLAASLYSCKIVGDVQHIIKELDITNKLAKRITETPKDYE 445
ref|NP_005509.1|| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
>gi|1708234|sp|P54868|HMCM_HUMAN
HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MITOCHONDRIAL
PRECURSOR (HMG-COA SYNTHASE) (3-HYDROXY-3-METHYLGLUTARYL
COENZYME A SYNTHASE) >gi|1082474|pir||S51103
hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5)
precursor, mitochondrial - human
>gi|619877|emb|CAA58593| (X83618)
hydroxymethylglutaryl-CoA synthase [Homo sapiens]
>gi|2463646 (U81860) 3-hydroxy-3-methylglutaryl CoA
synthase [Homo sapiens]
Length = 508
Score = 129 bits (322), Expect = 3e-29
Identities = 120/454 (26%), Positives = 194/454 (42%), Gaps = 73/454 (16%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI L + P +VD DL NV+ K+ +G+GQ M +DI + +
Sbjct: 54 VGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRL 113
Query: 63 L--TEEDKKAIDMIIVGTESSLDESKASAVVVHDLL--GIQPFARSIEMKEACYATTAGL 118
+ + ++ + VGTE+ +D+SKA V+ +L I+ ACY TA L
Sbjct: 114 MERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASL 173
Query: 119 TLARDHVLLN--PDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNV 176
A + + + +V+ DIA Y + PT GAG+VAMLI +
Sbjct: 174 FNAANWMESSSWDGRYAMVVCGDIAVYP-SGNARPTGGAGAVAMLIGPKAPLALERGLRG 232
Query: 177 ALTQDIYDFWRP-FGQAYPSVDGKFSNETYIDAFAKI-----------WKEYSHRTNLKF 224
+++YDF++P YP VDGK S + Y+ A + WK+
Sbjct: 233 THMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTL 292
Query: 225 EDFAAIAFHTPYTKMGKKALLPMLESEKPANAEELMEQFEHGI----------------- 267
+D + FHTP+ KM +K+L ++ ++ + + + G+
Sbjct: 293 DDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDL 352
Query: 268 ----------VYNRRV----------GNLYTGSLYLSLISLL-ENSDKLSAGQRIGLFSY 306
+++++ GN+YT SLY L SLL +S + AG RIG FSY
Sbjct: 353 DKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSY 412
Query: 307 GSGTVAEFFSGELVEGYE--NHLLKI-----EHQSMLDARTRLSIPEYENMFNQYLDLNH 359
GSG A FFS + + + L K+ + L +R +S E+ + NQ H
Sbjct: 413 GSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYH 472
Query: 360 NISFNDETD--------YSVSEVVDNH-RKYKKR 384
++F+ D + + V + H RKY +R
Sbjct: 473 KVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARR 506
sp|P54874|HMCS_SCHPO HYDROXYMETHYLGLUTARYL-COA SYNTHASE (HMG-COA SYNTHASE)
(3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
>gi|2130208|pir||S61875 hydroxymethylglutaryl-CoA
synthase - fission yeast (Schizosaccharomyces pombe)
>gi|974431 (U32187) 3-hydroxy-3-methylglutaryl coenzyme
A synthase [Schizosaccharomyces pombe]
>gi|2330830|emb|CAB11060.1| (Z98530)
hydroxymethylglutaryl-coa synthase (EC 4.1.3.5)
[Schizosaccharomyces pombe]
Length = 447
Score = 128 bits (318), Expect = 9e-29
Identities = 118/407 (28%), Positives = 180/407 (43%), Gaps = 56/407 (13%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
+GI L + PN +V+ L V K+ IG+G +MA +DI +F A + +
Sbjct: 8 IGIKGLVLYTPNQYVEQAALEAHDGVSTGKYTIGLGLTKMAFVDDREDIYSFGLTALSQL 67
Query: 63 LT--EEDKKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFARSIEMKEACYATTAGLTL 120
+ + D I + VGTE+ +D+SK+ V+ L G I+ ACY L
Sbjct: 68 IKRYQIDISKIGRLEVGTETIIDKSKSVKSVLMQLFGDNHNVEGIDCVNACYGGVNALFN 127
Query: 121 ARDHVLLN--PDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNVAL 178
D + + +V+A DIA Y PT GAG VA+L+ + I+
Sbjct: 128 TIDWIESSAWDGRDGIVVAGDIALYA-KGNARPTGGAGCVALLVGPNAPIVFEPGLRGTY 186
Query: 179 TQDIYDFWRP-FGQAYPSVDGKFSNETYIDAFAKIWKEYSHR--------TNLKFEDFAA 229
Q YDF++P YP VDG FS E Y+ A + Y+ R L + F
Sbjct: 187 MQHAYDFYKPDLTSEYPYVDGHFSLECYVKALDGAYANYNVRDVAKNGKSQGLGLDRFDY 246
Query: 230 IAFHTPYTKMGKKALLPMLESE---KPANAE-----ELM-----------EQFEHGIV-- 268
FH P K +KA +L ++ +P+N E EL+ + E G++
Sbjct: 247 CIFHAPTCKQVQKAYARLLYTDSAAEPSNPELEGVRELLSTLDAKKSLTDKALEKGLMAI 306
Query: 269 ----YNRRV----------GNLYTGSLYLSLISLLEN--SDKLSAGQRIGLFSYGSGTVA 312
+N+RV GN+YT S++ L +LL +D+L G+R+G +SYGSG A
Sbjct: 307 TKERFNKRVSPSVYAPTNCGNMYTASIFSCLTALLSRVPADELK-GKRVGAYSYGSGLAA 365
Query: 313 EFFSGELVEGYENHLLKIEHQSMLDARTRLSIPEYENMFNQYLDLNH 359
FFS + K + LD R L+ +YE + ++L H
Sbjct: 366 SFFSFVVKGDVSEIAKKTNLVNDLDNRHCLTPTQYE----EAIELRH 408
pir||S13887 hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5) - chicken
Length = 522
Score = 127 bits (315), Expect = 2e-28
Identities = 103/371 (27%), Positives = 165/371 (43%), Gaps = 58/371 (15%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI L + P+ +VD +L VD K+ IG+GQ +M +DI + +
Sbjct: 17 VGIVALEIYFPSQYVDQTELEKYDGVDAGKYTIGLGQSKMGFCSDREDINSLCLTVVQKL 76
Query: 63 LTEEDKK--AIDMIIVGTESSLDESKASAVVVHDLL--GIQPFARSIEMKEACYATTAGL 118
+ I + VGTE+ +D+SK+ V+ L I+ ACY TA L
Sbjct: 77 MERNSLSYDCIGRLEVGTETIIDKSKSVKTVLMQLFEESGNTDVEGIDTTNACYGGTAAL 136
Query: 119 TLARDHVLLN--PDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNV 176
A + + + LV+A DIA Y PT GAG+VAML+ ++ ++
Sbjct: 137 FNAINWIESSSWDGRYALVVAGDIAVYATG-NARPTGGAGAVAMLVGSNAPLIFERGLRG 195
Query: 177 ALTQDIYDFWRP-FGQAYPSVDGKFSNETYIDAFAKIWKEYSHRTNLKFE---------- 225
Q YDF++P YP VDGK S + Y+ A + + Y ++ + +++
Sbjct: 196 THMQHAYDFYKPDMVSEYPVVDGKLSIQCYLSALDRCYSVYRNKIHAQWQKEGTDRGFTL 255
Query: 226 -DFAAIAFHTPYTKMGKKALLPMLESE--------------------------------- 251
DF + FH+PY K+ +K++ +L ++
Sbjct: 256 NDFGFMIFHSPYCKLVQKSVARLLINDFLSDQNAETANGVFSGLEAFRDVKLEDTYFDRD 315
Query: 252 -----KPANAEELMEQFEHGIVYNRRVGNLYTGSLYLSLISLL-ENSDKLSAGQRIGLFS 305
A+AE ++ + ++ + + GN+YT S+Y L SLL + S + AGQRI FS
Sbjct: 316 VEKAFMKASAELFNQKTKASLLVSNQNGNMYTPSVYGCLASLLAQYSPEHLAGQRISEFS 375
Query: 306 YGSGTVAEFFS 316
YGSG A +S
Sbjct: 376 YGSGFAATLYS 386
sp|P23228|HMCS_CHICK HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC (HMG-COA SYNTHASE)
(3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
>gi|211931 (M60657) 3-hydroxy-3-methylglutaryl-CoA
synthase [Gallus gallus]
Length = 522
Score = 127 bits (315), Expect = 2e-28
Identities = 103/371 (27%), Positives = 165/371 (43%), Gaps = 58/371 (15%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI L + P+ +VD +L VD K+ IG+GQ +M +DI + +
Sbjct: 17 VGIVALEIYFPSQYVDQTELEKYDGVDAGKYTIGLGQSKMGFCSDREDINSLCLTVVQKL 76
Query: 63 LTEEDKK--AIDMIIVGTESSLDESKASAVVVHDLL--GIQPFARSIEMKEACYATTAGL 118
+ I + VGTE+ +D+SK+ V+ L I+ ACY TA L
Sbjct: 77 MERNSLSYDCIGRLEVGTETIIDKSKSVKTVLMQLFEESGNTDVEGIDTTNACYGGTAAL 136
Query: 119 TLARDHVLLN--PDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNV 176
A + + + LV+A DIA Y PT GAG+VAML+ ++ ++
Sbjct: 137 FNAINWIESSSWDGRYALVVAGDIAVYATG-NARPTGGAGAVAMLVGSNAPLIFERGLRG 195
Query: 177 ALTQDIYDFWRP-FGQAYPSVDGKFSNETYIDAFAKIWKEYSHRTNLKFE---------- 225
Q YDF++P YP VDGK S + Y+ A + + Y ++ + +++
Sbjct: 196 THMQHAYDFYKPDMVSEYPVVDGKLSIQCYLSALDRCYSVYRNKIHAQWQKEGTDRGFTL 255
Query: 226 -DFAAIAFHTPYTKMGKKALLPMLESE--------------------------------- 251
DF + FH+PY K+ +K++ +L ++
Sbjct: 256 NDFGFMIFHSPYCKLVQKSVARLLLNDFLSDQNAETANGVFSGLEAFRDVKLEDTYFDRD 315
Query: 252 -----KPANAEELMEQFEHGIVYNRRVGNLYTGSLYLSLISLL-ENSDKLSAGQRIGLFS 305
A+AE ++ + ++ + + GN+YT S+Y L SLL + S + AGQRI FS
Sbjct: 316 VEKAFMKASAELFNQKTKASLLVSNQNGNMYTPSVYGCLASLLAQYSPEHLAGQRISEFS 375
Query: 306 YGSGTVAEFFS 316
YGSG A +S
Sbjct: 376 YGSGFAATLYS 386
pir||S27197 hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5) - human
>gi|30009|emb|CAA47061| (X66435) Hydroxymethylglutaryl
CoA Synthase [Homo sapiens]
Length = 520
Score = 126 bits (314), Expect = 3e-28
Identities = 111/424 (26%), Positives = 189/424 (44%), Gaps = 64/424 (15%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI L + P+ +VD +L VD K+ IG+GQ +M +DI + ++
Sbjct: 17 VGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNL 76
Query: 63 LTEEDKK--AIDMIIVGTESSLDESKASAVVVHDLL--GIQPFARSIEMKEACYATTAGL 118
+ + I + VGTE+ +D+SK+ + L I+ ACY TA +
Sbjct: 77 MERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTAAV 136
Query: 119 TLARDHVLLN--PDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNV 176
A + + + LV+A DIA Y PT G G+VA+LI + ++
Sbjct: 137 FNAVNWIESSSWDGRYALVVAGDIAVYATG-NARPTGGVGAVALLIGPNAPLIFERGLRG 195
Query: 177 ALTQDIYDFWRP-FGQAYPSVDGKFSNETYIDAFAKI-----------WKEYSHRTNLKF 224
Q YDF++P YP VDGK S + Y+ A + W++ ++ +
Sbjct: 196 THMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEANDNDFTL 255
Query: 225 EDFAAIAFHTPYTKMGKKALLPMLESE--------------------------------- 251
DF + FH+PY K+ +K+L ML ++
Sbjct: 256 NDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLKAFGDVKLEDTYFDRDV 315
Query: 252 ----KPANAEELMEQFEHGIVYNRRVGNLYTGSLYLSLISLL-ENSDKLSAGQRIGLFSY 306
A++E ++ + ++ + + GN+YT S+Y SL S+L + S + AG+RIG+FSY
Sbjct: 316 EKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQHLAGKRIGVFSY 375
Query: 307 GSGTVAEFFSGELVEGYE--NHLLKI-----EHQSMLDARTRLSIPEYENMFNQYLDLNH 359
GSG A +S ++ + + L KI + +S LD+RT ++ + D +H
Sbjct: 376 GSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAQDVFAENMKLREDTHH 435
Query: 360 NISF 363
+++
Sbjct: 436 LVNY 439
ref|NP_002121.1|| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
>gi|1708239|sp|Q01581|HMCS_HUMAN
HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC (HMG-COA
SYNTHASE) (3-HYDROXY-3-METHYLGLUTARYL COENZYME A
SYNTHASE) >gi|410028 (L25798) 3-hydroxy-3-methylglutaryl
coenzyme A synthase [Homo sapiens]
Length = 520
Score = 126 bits (314), Expect = 3e-28
Identities = 111/424 (26%), Positives = 190/424 (44%), Gaps = 64/424 (15%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI L + P+ +VD +L VD K+ IG+GQ +M +DI + ++
Sbjct: 17 VGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNL 76
Query: 63 LTEEDKK--AIDMIIVGTESSLDESKASAVVVHDLL--GIQPFARSIEMKEACYATTAGL 118
+ + I + VGTE+ +D+SK+ + L I+ ACY TA +
Sbjct: 77 MERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTAAV 136
Query: 119 TLARDHVLLN--PDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNV 176
A + + + LV+A DIA Y PT G G+VA+LI + ++
Sbjct: 137 FNAVNWIESSSWDGRYALVVAGDIAVYATG-NARPTGGVGAVALLIGPNAPLIFERGLRG 195
Query: 177 ALTQDIYDFWRP-FGQAYPSVDGKFSNETYIDAFAKIWKEYSHRTNLKFE---------- 225
Q YDF++P YP VDGK S + Y+ A + + Y + + +++
Sbjct: 196 THMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFTL 255
Query: 226 -DFAAIAFHTPYTKMGKKALLPMLESE--------------------------------- 251
DF + FH+PY K+ +K+L ML ++
Sbjct: 256 NDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDV 315
Query: 252 ----KPANAEELMEQFEHGIVYNRRVGNLYTGSLYLSLISLL-ENSDKLSAGQRIGLFSY 306
A++E ++ + ++ + + GN+YT S+Y SL S+L + S + AG+RIG+FSY
Sbjct: 316 EKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSY 375
Query: 307 GSGTVAEFFSGELVEGYE--NHLLKI-----EHQSMLDARTRLSIPEYENMFNQYLDLNH 359
GSG A +S ++ + + L KI + +S LD+RT ++ + D +H
Sbjct: 376 GSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVFAENMKLREDTHH 435
Query: 360 NISF 363
+++
Sbjct: 436 LVNY 439
sp|P54870|HMC2_BLAGE HYDROXYMETHYLGLUTARYL-COA SYNTHASE 2 (HMG-COA SYNTHASE 2)
(3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE 2)
>gi|627145|pir||A53565 hydroxymethylglutaryl-CoA
synthase (EC 4.1.3.5) - German cockroach
>gi|488134|emb|CAA54652| (X77516)
hydroxymethylglutaryl-CoA synthase [Blattella germanica]
Length = 455
Score = 126 bits (313), Expect = 3e-28
Identities = 120/419 (28%), Positives = 188/419 (44%), Gaps = 66/419 (15%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI + P+ +VD +L V P K+ +G+GQD+M V +DI + A +
Sbjct: 8 VGIIGIEMIFPSLYVDQAELETYDEVSPGKYTMGLGQDKMGVCTDREDINSLCLTAVDKL 67
Query: 63 LTEE--DKKAIDMIIVGTESSLDESKASAVVVHDLL--GIQPFARSIEMKEACYATTAGL 118
+ D I + VGTE+ LD+ K+ V+ L I+ ACY TA L
Sbjct: 68 MERNNIDYNDIGWLEVGTETILDKVKSVKTVLMQLFEESGNTDVEGIDTINACYRGTAAL 127
Query: 119 TLARDHVLLN--PDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNV 176
A + + +V+A+DIA Y PT GAG++ MLI A+ I+
Sbjct: 128 FNALIWIESSSWDGRYAIVVAADIAIYAKEC--SPTGGAGALLMLIGANAPIVIDRGVRA 185
Query: 177 ALTQDIYDFWRP-FGQAYPSVDGKFSNETYIDA-------FAKIWKEYSHR-----TNLK 223
+ + YDF++P YP VDGK S + Y+ A F ++Y R T +
Sbjct: 186 SHMKHAYDFYKPDLMSEYPVVDGKLSVQCYLSALDHCYPRFCSKTEKYLKRCGKENTKID 245
Query: 224 FEDFAAIAFHTPYTKMGKKALLPMLES---EKPANAEELME----QFEH----------- 265
+ F A FH+PY K+ +K++ ++ + + P ++L + +FE
Sbjct: 246 LDYFDAFVFHSPYCKLVQKSVARLVLNDFIQYPEKYQDLQQLRNLKFEDTYFDRDIEKIF 305
Query: 266 --------------GIVYNRRVGNLYTGSLYLSLISLLENSD-KLSAGQRIGLFSYGSGT 310
++ +VGN+YT SLY L+SLL + D AG+ I +FSYGSG
Sbjct: 306 MDKSKQLFEKKTKPSLMLANQVGNMYTTSLYGGLVSLLISEDIGELAGKCICMFSYGSGF 365
Query: 311 VAEFFS---------GELVEGYENHLLKIEHQSMLDARTRLSIPEYENMFNQYLDLNHN 360
A FS G + +L I+ Q + R +LS E+EN+ + + NH+
Sbjct: 366 AASMFSLHISTDSSPGSTLSRLVTNLTHIKPQ--VQQRVKLSPGEFENIM-EIREQNHH 421
sp|P54873|HMCS_ARATH HYDROXYMETHYLGLUTARYL-COA SYNTHASE (HMG-COA SYNTHASE)
(3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
>gi|2129617|pir||JC4567 hydroxymethylglutaryl-CoA
synthase (EC 4.1.3.5) - Arabidopsis thaliana
>gi|1143390|emb|CAA58763| (X83882)
hydroxymethylglutaryl-CoA synthase [Arabidopsis
thaliana] >gi|1586548|prf||2204245A hydroxy
methylglutaryl CoA synthase [Arabidopsis thaliana]
Length = 461
Score = 125 bits (310), Expect = 8e-28
Identities = 102/364 (28%), Positives = 156/364 (42%), Gaps = 51/364 (14%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI + + P T V L K+ IG+GQD +A +D+I+ + NA S+
Sbjct: 5 VGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNAVTSL 64
Query: 63 LTEE--DKKAIDMIIVGTESSLDESKASAVVVHDLLGI--QPFARSIEMKEACYATTAGL 118
+ D I + VG+E+ +D+SK+ + L ++ ACY TA L
Sbjct: 65 FEKYKIDPNQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTAAL 124
Query: 119 TLARDHVLLNP-DTKV-LVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNV 176
+ V N D + LVI +D A Y PT GA ++AMLI D I+ +
Sbjct: 125 LNCVNWVESNSWDGRYGLVICTDSAVYA-EGPARPTGGAAAIAMLIGPDAPIVFESKLRA 183
Query: 177 ALTQDIYDFWRP-FGQAYPSVDGKFSNETYIDAFAKIWKEYSHR------TNLKFEDFAA 229
+ +YDF++P YP VDGK S Y+ A +K ++ D
Sbjct: 184 SHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEKIEGKEFSINDADY 243
Query: 230 IAFHTPYTKMGKKALLPMLESEKPANAEELME---------------------------- 261
I FH+PY K+ +K+ +L ++ NA + E
Sbjct: 244 IVFHSPYNKLVQKSFARLLYNDFLRNASSIDEAAKEKFTPYSSLTLDESYQSRDLEKVSQ 303
Query: 262 ---------QFEHGIVYNRRVGNLYTGSLYLSLISLLENSDKLSAGQRIGLFSYGSGTVA 312
+ + + + VGN+YT SLY + SL+ N AG+R+ +FSYGSG+ A
Sbjct: 304 QISKPFYDAKVQPTTLIPKEVGNMYTASLYAAFASLIHNKHNDLAGKRVVMFSYGSGSTA 363
Query: 313 EFFS 316
FS
Sbjct: 364 TMFS 367
gi|4098521 (U79160) HMG-CoA synthase [Arabidopsis thaliana] >gi|4098523
(U79161) HMG-CoA synthase [Arabidopsis thaliana]
>gi|5002517|emb|CAB44320.1| (AL078606)
hydroxymethylglutaryl-CoA synthase [Arabidopsis
thaliana]
Length = 461
Score = 122 bits (304), Expect = 4e-27
Identities = 101/364 (27%), Positives = 155/364 (41%), Gaps = 51/364 (14%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI + + P T V L K+ IG+GQD +A +D+I+ + NA S+
Sbjct: 5 VGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNAVTSL 64
Query: 63 LTEE--DKKAIDMIIVGTESSLDESKASAVVVHDLLGI--QPFARSIEMKEACYATTAGL 118
+ D I + VG+E+ +D+SK+ + L ++ ACY TA L
Sbjct: 65 FEKYKIDPNQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTAAL 124
Query: 119 TLARDHVLLNP-DTKV-LVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNV 176
+ V N D + LVI +D A Y PT GA ++AMLI D I+ +
Sbjct: 125 LNCVNWVESNSWDGRYGLVICTDSAVYA-EGPARPTGGAAAIAMLIGPDAPIVFESKLRA 183
Query: 177 ALTQDIYDFWRP-FGQAYPSVDGKFSNETYIDAFAKIWKEYSHR------TNLKFEDFAA 229
+ +YDF++P YP VDGK S Y+ A +K ++ D
Sbjct: 184 SHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEKIEGKEFSINDADY 243
Query: 230 IAFHTPYTKMGKKALLPMLESEKPANAEELME---------------------------- 261
I FH+PY K+ +K+ +L ++ NA + E
Sbjct: 244 IVFHSPYNKLVQKSFARLLYNDFLRNASSIDEAAKEKFTPYSSLTLDESYQSRDLEKVSQ 303
Query: 262 ---------QFEHGIVYNRRVGNLYTGSLYLSLISLLENSDKLSAGQRIGLFSYGSGTVA 312
+ + + + VGN+YT SLY + SL+ AG+R+ +FSYGSG+ A
Sbjct: 304 QIAKPFYDAKVQPTTLIPKEVGNMYTASLYAAFASLIHKKHNDLAGKRVVMFSYGSGSTA 363
Query: 313 EFFS 316
FS
Sbjct: 364 TMFS 367
sp|P17425|HMCS_RAT HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC (HMG-COA SYNTHASE)
(3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
>gi|111795|pir||S12736 hydroxymethylglutaryl-CoA
synthase (EC 4.1.3.5), cytosolic - rat
>gi|55947|emb|CAA36852| (X52625) cytosolic 3-hydroxy
3-methylglutaryl coenzyme A synthase (AA 1-520) [Rattus
norvegicus]
Length = 520
Score = 122 bits (302), Expect = 7e-27
Identities = 105/375 (28%), Positives = 167/375 (44%), Gaps = 67/375 (17%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI L + P+ +VD +L VD K+ IG+GQ M +DI + +
Sbjct: 17 VGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCTDREDINSLCLTVVQKL 76
Query: 63 LTEEDKK--AIDMIIVGTESSLDESKASAVVVHDLLGIQPFARS-------IEMKEACYA 113
+ I + VGTE+ +D+SK+ V +L+ Q F S I+ ACY
Sbjct: 77 MERNSLSYDCIGRLEVGTETIIDKSKS---VKSNLM--QLFEESGNTDIEGIDTTNACYG 131
Query: 114 TTAGLTLARDHVLLN--PDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILAL 171
TA + A + + + LV+A DIA Y + PT G G+VA+LI + ++
Sbjct: 132 GTAAVFNAVNWIESSSWDGRYALVVAGDIAIYA-SGNARPTGGVGAVALLIGPNAPVIFD 190
Query: 172 NNDNVALTQDIYDFWRP-FGQAYPSVDGKFSNETYIDAFAKIWKEYSHRTNLKFE----- 225
Q YDF++P YP VDGK S + Y+ A + + Y + +++
Sbjct: 191 RGLRGTHMQHAYDFYKPDMLSEYPVVDGKLSIQCYLSALDRCYSVYRKKIRAQWQKEGKD 250
Query: 226 ------DFAAIAFHTPYTKMGKKALLPMLESE---------------------------- 251
DF + FH+PY K+ +K+L M ++
Sbjct: 251 KDFTLNDFGFMIFHSPYCKLVQKSLARMFLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTY 310
Query: 252 ---------KPANAEELMEQFEHGIVYNRRVGNLYTGSLYLSLISLL-ENSDKLSAGQRI 301
A+AE ++ + ++ + + GN+YT S+Y SL S+L + S + AG+RI
Sbjct: 311 FDRDVEKAFMKASAELFNQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRI 370
Query: 302 GLFSYGSGTVAEFFS 316
G+FSYGSG A +S
Sbjct: 371 GVFSYGSGLAATLYS 385
gi|2688618 (AE001169) 3-hydroxy-3-methylglutaryl-CoA synthase [Borrelia
burgdorferi]
Length = 407
Score = 121 bits (301), Expect = 9e-27
Identities = 104/378 (27%), Positives = 171/378 (44%), Gaps = 27/378 (7%)
Query: 1 MKVGIDKLGFFVPNTFVDMRDLAN-----ARNVDPAKFQIGIG---QDEMAVNPATQDII 52
M++GI + F+P ++D L + V K I Q +D +
Sbjct: 1 MRIGISDIRIFLPLNYLDFSVLLENPLYFSNEVFFKKINRAIDATLQKGFRFTSPNEDSV 60
Query: 53 TFAANAAASILTEE--DKKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFAR-----SI 105
T A++A I D I +++ GTE+ +D SKA + V L +
Sbjct: 61 TMASSAVKLIFDNNNLDLSKIRILLGGTETGVDHSKAISSYVFGALKQSGICLGNNFLTF 120
Query: 106 EMKEACYATTAGL-TLARDHVLLNPDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITA 164
+++ AC L T+A N +V +SDIA Y T E TQGAG+ A+LI
Sbjct: 121 QVQHACAGAAMSLHTVASVLSHSNNSEYGIVFSSDIAHYSNLTTAEITQGAGATAILIEK 180
Query: 165 DPKILALNNDNVAL-TQDIYDFWRPFGQAYPSVDGKFSNETYIDAFAKIWKEYSHRTNLK 223
+PK+L++N + T D+ DF+RPFG V G++S E Y +A ++++ + L
Sbjct: 181 NPKLLSINLSEFGVYTDDVDDFFRPFGSVEAKVRGQYSVECYNNANENALRDFAFKKQLS 240
Query: 224 FEDFAA---IAFHTPYTKMGKKALLPML-----ESEKPANAEELMEQFEHGIVYNRRVGN 275
+D + H P+ KM ++ +L + E NA F G+ VGN
Sbjct: 241 MKDLFSNYRFVLHVPFAKMPIDSMHYILKKYYSDDESVRNAYLESIDFYDGVEAAMEVGN 300
Query: 276 LYTGSLYLSLISLLEN--SDKLSAGQRIGLFSYGSGTVAEFFSGELVEGYENHLLKIEHQ 333
LYTGS++LSL L+ S K G++I SYGSG + + + + + + + +
Sbjct: 301 LYTGSIFLSLAFYLKRVFSKKDITGEKILFCSYGSGNIMIIYELTIEKSAFDVIKLWDLE 360
Query: 334 SMLDARTRLSIPEYENMF 351
++ R + EY++ F
Sbjct: 361 GLIKNRNNANFEEYKDFF 378
sp|P13704|HMCS_CRIGR HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC (HMG-COA SYNTHASE)
(3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
>gi|90200|pir||A25332 hydroxymethylglutaryl-CoA synthase
(EC 4.1.3.5) - Chinese hamster >gi|387072 (L00334)
3-hydroxy-3-methylglutaryl coenzyme A synthase (HMG CoA)
[Mesocricetus auratus]
Length = 520
Score = 118 bits (292), Expect = 1e-25
Identities = 103/375 (27%), Positives = 165/375 (43%), Gaps = 67/375 (17%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI L + P+ +VD +L VD K+ IG+GQ M +DI + ++
Sbjct: 17 VGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCTDREDINSLCLTVVQNL 76
Query: 63 LTEEDKK--AIDMIIVGTESSLDESKASAVVVHDLLGIQPFARS-------IEMKEACYA 113
+ I + VGTE+ +D+SK+ V +L+ Q F S I+ ACY
Sbjct: 77 MERNSLSYDCIGRLEVGTETIIDKSKS---VKSNLM--QLFEESGNTDIEGIDTTNACYG 131
Query: 114 TTAGLTLARDHVLLN--PDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILAL 171
TA + A + + + LV+A DIA Y PT G G+VA+LI + ++
Sbjct: 132 GTAAVFNAVNWIESSSWDGRYALVVAGDIAIYATG-NARPTGGVGAVALLIGPNAPLIFD 190
Query: 172 NNDNVALTQDIYDFWRP-FGQAYPSVDGKFSNETYIDAFAKI-----------WKEYSHR 219
Q YDF++P YP VDGK S + Y+ A + W++ +
Sbjct: 191 RGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYRKKIRAQWQKEGND 250
Query: 220 TNLKFEDFAAIAFHTPYTKMGKKALLPMLESE---------------------------- 251
+ DF + H+PY K+ +K+L M ++
Sbjct: 251 NDFTLNDFGFMISHSPYCKLVQKSLARMFLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTY 310
Query: 252 ---------KPANAEELMEQFEHGIVYNRRVGNLYTGSLYLSLISLL-ENSDKLSAGQRI 301
A++E ++ + ++ + + GN+YT S+Y SL S+L + S + AG+RI
Sbjct: 311 FDRDVEKAFMKASSELFNQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRI 370
Query: 302 GLFSYGSGTVAEFFS 316
G+FSYGSG A +S
Sbjct: 371 GVFSYGSGLAATLYS 385
pir||A64493 acyl carrier protein synthase - Methanococcus jannaschii
>gi|1592177 (U67595) putative beta-ketoacyl
acyl-carrier-protein synthase (fabH) [Methanococcus
jannaschii]
Length = 345
Score = 112 bits (277), Expect = 6e-24
Identities = 93/325 (28%), Positives = 145/325 (44%), Gaps = 37/325 (11%)
Query: 4 GIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASIL 63
GI G ++P + + ++A N DP + G+ E AV +D T A AA + L
Sbjct: 3 GIVGYGAYIPKYRIKVEEIARVWNKDPESIKKGLLVYEKAVPSLDEDTATIAVEAARNAL 62
Query: 64 --TEEDKKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFARSIEMKEACYATTAGLTLA 121
E D K I + VG+ES K +A +V + + P + +++ AC A TAG+ +
Sbjct: 63 KRAEIDPKDIGAVYVGSESHPYAVKPTATIVAEAIDATPDLTAADLEFACKAGTAGIQMC 122
Query: 122 RDHVLLNPDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITA----------DPKILAL 171
++ S + KYGL G + QGA A+ TA ++A
Sbjct: 123 MG-----------LVESGLIKYGLAIGADTAQGAPGDALEYTAAAGGAAYIIGKSNVIAE 171
Query: 172 NNDNVALTQDIYDFWRPFGQAYPSVDGKFSNE-TYIDAFAKIWKEYSHRTNLKFEDFAAI 230
N + T D DFWR G+ YP G+F+ E Y K + K ED+
Sbjct: 172 FNGTYSYTTDTPDFWRREGKPYPRHGGRFTGEPAYFRHVINAAKGLMEKMGTKPEDYDYC 231
Query: 231 AFHTPYTKMGKKALLPMLESEKPANAEELMEQFEHGIVYNRRVGNLYTGSLYLSLISLLE 290
FH P K + K +E EQ++ G++ +GN Y+G++ L L ++L+
Sbjct: 232 VFHQPNGKF-------YIRVAKILGFKE--EQYKIGLL-TPYIGNTYSGAVPLGLSNVLD 281
Query: 291 NSDKLSAGQRIGLFSYGSGTVAEFF 315
N + G+RI SYGSG ++ F
Sbjct: 282 NCE---GGERILAVSYGSGAGSDAF 303
emb|CAB57764.1| (Y18930) acyl carrier protein synthase [Sulfolobus solfataricus]
Length = 350
Score = 104 bits (258), Expect = 1e-21
Identities = 92/331 (27%), Positives = 149/331 (44%), Gaps = 27/331 (8%)
Query: 1 MKVGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAA 60
M GI G ++P + + D+A D A + +G E +V +D T A ++
Sbjct: 1 MLSGILGWGAYIPRYRIKVEDIAKMWGYDEAVVK-SLGLTEKSVPGHDEDSTTIAWESSI 59
Query: 61 SIL--TEEDKKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFARSIEMKEACYATTAGL 118
+ + + D I +++ G+ES + K ++ ++ D LGI ++ + +M+ AC A + GL
Sbjct: 60 NAIKRAQVDTSKIRLVLFGSESKVYAVKPTSTILIDALGINNYSATADMEFACRAASVGL 119
Query: 119 TLARDHVLLNPDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLI--TADPKILALNNDNV 176
LA VL N D+ LVI +D A+ E + A VA ++ T + A+ +
Sbjct: 120 RLASSFVLHNNDSYALVIGADTAQSNPGDVLELSSAAAGVAFVVGKTDEKHSAAVIEYSS 179
Query: 177 ALTQDIYDFWRPFGQAYPSVDGKFSNE-TYIDAFAKIWKEYSHRTNLKFEDFAAIAFHTP 235
+ T D DFWR G YP F+ E Y + + LK DF FH P
Sbjct: 180 SYTSDTPDFWRRDGTPYPVHGEGFTGEPAYFHHIISAVNDLLQNSGLKISDFDYFVFHQP 239
Query: 236 YTK----MGKKALLPMLESEKPANAEELMEQFEHGIVYNRRVGNLYTGSLYLSLISLLEN 291
K + KK +P +E+ + G+V + +GN Y S L L +L
Sbjct: 240 NGKFPIQVAKKLGVP-------------LEKVKQGLV-SPYIGNPYNASALLGLAKVL-- 283
Query: 292 SDKLSAGQRIGLFSYGSGTVAEFFSGELVEG 322
D G+RI + +GSG ++ FS + EG
Sbjct: 284 -DIAKPGERILVAPFGSGAGSDAFSILVSEG 313
dbj|BAA82227.1| (D86934) ORF CN041 [Staphylococcus aureus]
Length = 129
Score = 100 bits (247), Expect = 2e-20
Identities = 52/120 (43%), Positives = 78/120 (64%), Gaps = 5/120 (4%)
Query: 267 IVYNRRVGNLYTGSLYLSLISLLENSDKLSAGQRIGLFSYGSGTVAEFFSGELVEGYENH 326
+++NR VGN+YTGSLYLSLISLL+N +++ LFSYGSG V E FSG +V+GY+
Sbjct: 8 VLWNRDVGNIYTGSLYLSLISLLQNHT-FQPEEKVCLFSYGSGAVGEIFSGSIVKGYDKA 66
Query: 327 LLKIEHQSMLDARTRLSIPEYENMFNQY----LDLNHNISFNDETDYSVSEVVDNHRKYK 382
L K +H +ML++R +LS+ EYE FN++ D ++ + + + + D+ R YK
Sbjct: 67 LDKEKHLNMLESREQLSVEEYETFFNRFDNQEFDFERELTQDPYSKVYLYSIEDHIRTYK 126
gi|2621881 (AE000857) 3-hydroxy-3-methylglutaryl-CoA-synthase
[Methanobacterium thermoautotrophicum]
Length = 349
Score = 96.7 bits (237), Expect = 3e-19
Identities = 89/329 (27%), Positives = 139/329 (42%), Gaps = 39/329 (11%)
Query: 1 MKVGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAA 60
+ GI G ++P+ + + ++A DP G+ +E +V +D T + AA
Sbjct: 3 LMAGIVGYGVYIPSYRIKVEEIARVWGDDPQAISRGLVVEEKSVPGPDEDTATISVEAAR 62
Query: 61 SIL--TEEDKKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFARSIEMKEACYATTAGL 118
+ L ++ D I + VG+ES K +A +V + + P + +++ AC A TAG+
Sbjct: 63 NALRRSQIDPSEIGAVYVGSESHPYAVKPTATIVAEAVEATPEMTAADLEFACKAGTAGI 122
Query: 119 TLARDHVLLNPDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITAD----------PKI 168
++ S I KYGL G + QGA A+ TA
Sbjct: 123 QACMG-----------LVDSGIIKYGLAVGADTAQGAPGDALEYTASAGGAAYVIGGKNC 171
Query: 169 LALNNDNVALTQDIYDFWRPFGQAYPSVDGKFSNE-TYIDAFAKIWKEYSHRTNLKFEDF 227
LA + + T D DF+R G YP G+F+ E Y + +T L +DF
Sbjct: 172 LADIKETYSFTTDTPDFYRREGMPYPRHGGRFTGEPAYFKHVLGAARGMMEKTGLSADDF 231
Query: 228 AAIAFHTPYTKMGKKALLPM-LESEKPANAEELMEQFEHGIVYNRRVGNLYTGSLYLSLI 286
FH P K KA + ES EQ + G++ +GN Y+G+ + L
Sbjct: 232 DYAVFHQPNGKFYLKAARKLGFES----------EQVKPGLL-TPVIGNTYSGATPVGLA 280
Query: 287 SLLENSDKLSAGQRIGLFSYGSGTVAEFF 315
+ L D G RI SYGSG ++ F
Sbjct: 281 ATL---DVAEPGARILAVSYGSGAGSDAF 306
gi|2650679 (AE001109) acyl carrier protein synthase (acaA-2) [Archaeoglobus
fulgidus]
Length = 303
Score = 94.8 bits (232), Expect = 1e-18
Identities = 85/306 (27%), Positives = 128/306 (41%), Gaps = 18/306 (5%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
+GI G +VP + + ++A D K + G+G E +V +D T A AA
Sbjct: 2 IGIVSYGSYVPKFRIRVEEIARVWGEDAKKIKDGLGVHEKSVPGMDEDAATIAVEAAREA 61
Query: 63 LTEE--DKKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFARSIEMKEACYATTAGLTL 120
+ + + I + VG+ES K +A +V + LG+ + +++ AC A TAG+ +
Sbjct: 62 IRRAGINPEEIGAVFVGSESHPYAVKPTATIVGEALGVGNDYFAADLEFACKAGTAGMQI 121
Query: 121 ARDHVLLNPDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNVALTQ 180
V L I +D ++ E AG A +I +P +A + T
Sbjct: 122 CYSMVKAGMIKYGLAIGADTSQARPGDALEYAAAAGGAAFIIGENP--IAEVEATYSFTS 179
Query: 181 DIYDFWRPFGQAYPSVDGKFSN-ETYIDAFAKIWKEYSHRTNLKFEDFAAIAFHTPYTKM 239
D DFWR Q YPS G+F+ Y K + K EDF FH P K
Sbjct: 180 DTPDFWRRDLQPYPSHGGRFTGLPAYFRHVISAAKGLMEKYGYKVEDFDYAVFHMPNAKF 239
Query: 240 GKKALLPMLESEKPANAEELMEQFEHGIVYNRRVGNLYTGSLYLSLISLLENSDKLSAGQ 299
+A + S ME G+V + +GN Y+GS SL+ L D +
Sbjct: 240 PVRAAKMLGFS---------MEHISQGLVV-KAIGNTYSGS---SLLGLAATLDVAEPDE 286
Query: 300 RIGLFS 305
RI L S
Sbjct: 287 RILLVS 292
gi|555833 (U12789) HMG CoA synthase [Homo sapiens]
Length = 363
Score = 94.8 bits (232), Expect = 1e-18
Identities = 92/348 (26%), Positives = 147/348 (41%), Gaps = 69/348 (19%)
Query: 105 IEMKEACYATTAGLTLARDHVLLNP--DTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLI 162
I+ ACY TA L A + + + +V+ DIA Y + PT GAG+VAMLI
Sbjct: 15 IDTTNACYGGTASLFNAANWMESSSWDGRYAMVVCGDIAVYP-SGNARPTGGAGAVAMLI 73
Query: 163 TADPKILALNNDNVALTQDIYDFWRP-FGQAYPSVDGKFSNETYIDAFAKI--------- 212
+ +++YDF++P YP VDGK S + Y+ A +
Sbjct: 74 GPKAPLALERGLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQ 133
Query: 213 --WKEYSHRTNLKFEDFAAIAFHTPYTKMGKKALLPMLESEKPANAEELMEQFEHGI--- 267
WK+ +D + FHTP+ KM +K+L ++ ++ + + + G+
Sbjct: 134 NQWKQAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAF 193
Query: 268 ------------------------VYNRRV----------GNLYTGSLYLSLISLL-ENS 292
+++++ GN+YT SLY L SLL +S
Sbjct: 194 GGLKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHS 253
Query: 293 DKLSAGQRIGLFSYGSGTVAEFFSGELVEGYE--NHLLKI-----EHQSMLDARTRLSIP 345
+ AG RIG FSYGSG A FFS + + + L K+ + L +R +S
Sbjct: 254 AQELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPE 313
Query: 346 EYENMFNQYLDLNHNISFNDETD--------YSVSEVVDNH-RKYKKR 384
E+ + NQ H ++F+ D + + V + H RKY +R
Sbjct: 314 EFTEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARR 361
dbj|BAA80878.1| (AP000062) 365aa long hypothetical acyl carrier protein synthase
[Aeropyrum pernix]
Length = 365
Score = 84.3 bits (205), Expect = 2e-15
Identities = 83/316 (26%), Positives = 131/316 (41%), Gaps = 17/316 (5%)
Query: 4 GIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASIL 63
GI G +VP + R++A +++ + E AV +D T AA + +
Sbjct: 20 GIHGWGAYVPVYRIPTREIARVWGWPDHQWK-ALDVYEKAVGGVDEDSTTMGVEAARNAI 78
Query: 64 TEE--DKKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFARSIEMKEACYATTAGLTLA 121
D +I + G+ES K SA ++ + LGI P + +++ AC A + G+ +
Sbjct: 79 ARARVDPASIGAVFFGSESKPYAVKPSATIIAEALGITPVTMASDLEFACRAASEGMRAS 138
Query: 122 RDHVLLNPDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLITADPKILALNNDNVALTQD 181
V LV+ SD A+ E + +G+ A +I A+ + D
Sbjct: 139 IGLVASGVVGYTLVVGSDTAQASPGDVLEFSASSGAAAFVIGPSKGAAAVFESSFTYVTD 198
Query: 182 IYDFWRPFGQAYPSVDGKFSNE-TYIDAFAKIWKEYSHRTNLKFEDFAAIAFHTPYTKMG 240
DFWR + YPS F+ E Y K +T L DF FH P K
Sbjct: 199 TPDFWRRGLKPYPSHGEGFTGEPAYFHHIESAVKGLFEKTGLSPGDFDYAIFHQPNGK-- 256
Query: 241 KKALLPMLESEKPANAEELMEQFEHGIVYNRRVGNLYTGSLYLSLISLLENSDKLSAGQR 300
P+ ++K MEQ + G+V +GN Y S L L+ +L D G R
Sbjct: 257 ----FPVKVAKKLGFT---MEQVKPGLV-TPFIGNTYNASALLGLVKVL---DVAKPGDR 305
Query: 301 IGLFSYGSGTVAEFFS 316
I + +GSG ++ +S
Sbjct: 306 ILVAPFGSGAGSDAYS 321
dbj|BAA29768| (AP000003) 350aa long hypothetical acyl carrier protein synthetase
[Pyrococcus horikoshii]
Length = 350
Score = 79.6 bits (193), Expect = 4e-14
Identities = 92/336 (27%), Positives = 137/336 (40%), Gaps = 26/336 (7%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI G +VP + ++ + + F I +E AV +D IT AA +
Sbjct: 11 VGIVGYGAYVPMYRIRNEEIGRVWGI--SNFPI----EEKAVPGLDEDAITIGIEAARNA 64
Query: 63 LTEE--DKKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFARSIEMKEACYATTAGLTL 120
L D K I I G+ES K S+ V+ + +G P + + + AC A T L
Sbjct: 65 LKRAKIDPKDIRAIWFGSESKPYAVKPSSTVIAEAIGATPDLEAADFEFACKAGTEALQA 124
Query: 121 ARDHVLLNPDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLI-TADPKILALNNDNVALT 179
A V + I +D A+ E T GAG A +I + +A + +
Sbjct: 125 AIGFVASGMAKYAMAIGADTAQGRPGDHLEFTAGAGGAAFIIGEKSSETVAYFEGSYSYV 184
Query: 180 QDIYDFWRPFGQAYPSVDGKFSNE-TYIDAFAKIWKEYSHRTNLKFEDFAAIAFHTPYTK 238
D DFWR + YP +F+ E Y K L EDF FH P K
Sbjct: 185 TDTPDFWRRQHEHYPRHGNRFTGEPAYFHHVVTAAKTLMDELGLTPEDFDYAVFHQPNVK 244
Query: 239 MGKKALLPMLESEKPANAEELMEQFEHGIVYNRRVGNLYTGSLYLSLISLLENSDKLSAG 298
A ML K E+ G++ + R+GN Y+G+ + + ++L D G
Sbjct: 245 FPLVA-ARMLGIPK--------EKVLPGLL-SGRIGNTYSGATMVGISAVL---DIAKPG 291
Query: 299 QRIGLFSYGSGTVAEFFS---GELVEGYENHLLKIE 331
RI S+GSG ++ FS + +E N K+E
Sbjct: 292 DRILWVSFGSGAGSDAFSIVVQDAIEEKRNLAPKVE 327
emb|CAA59499| (X85250) acyl carrier protein synthase [Pyrococcus furiosus]
Length = 350
Score = 77.3 bits (187), Expect = 2e-13
Identities = 85/322 (26%), Positives = 128/322 (39%), Gaps = 31/322 (9%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI G +VP + ++ V + F I +E AV +D IT AA +
Sbjct: 11 VGIVGYGAYVPMYRIRNEEIGRVWGV--SSFPI----EEKAVPGLDEDAITIGIEAARNA 64
Query: 63 LTEE--DKKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFARSIEMKEACYATTAGLTL 120
L D + I I GTES K SA ++ + +G P + + + AC A T L
Sbjct: 65 LKRAKIDPQKIRAIWFGTESKPYAVKPSATIIAEAIGATPDLEAADFEFACKAGTEALQA 124
Query: 121 ARDHVLLNPDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLI-TADPKILALNNDNVALT 179
A V + I +D A+ E T GAG A ++ + +A + +
Sbjct: 125 AIGFVGSGMAEYAMAIGADTAQGRPGDHLEFTAGAGGAAFIVGEKSNESVAYFEGSYSYV 184
Query: 180 QDIYDFWRPFGQAYPSVDGKFSNE-TYIDAFAKIWKEYSHRTNLKFEDFAAIAFHTPYTK 238
D DFWR + YP +F+ E Y K LK DF FH P K
Sbjct: 185 TDTPDFWRRQHEHYPRHGNRFTGEPAYFHHIINAAKTLMEELGLKPSDFDYAVFHQPNVK 244
Query: 239 MGKKALLPMLESEKPANAEELM----EQFEHGIVYNRRVGNLYTGSLYLSLISLLENSDK 294
P +++ E+ G++ R+GN Y+G+ + + ++L D
Sbjct: 245 F-------------PLTVAKILGIPKEKVLPGLL-TGRIGNTYSGATMVGVSAVL---DI 287
Query: 295 LSAGQRIGLFSYGSGTVAEFFS 316
G RI S+GSG + FS
Sbjct: 288 AKPGDRILWVSFGSGAGSNAFS 309
emb|CAB50274.1| (AJ248287) acyl carrier protein synthase (acaA) [Pyrococcus abyssi]
Length = 350
Score = 75.7 bits (183), Expect = 6e-13
Identities = 82/323 (25%), Positives = 130/323 (39%), Gaps = 31/323 (9%)
Query: 2 KVGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAAS 61
++GI G +VP + ++ V + F I +E AV +D +T AA +
Sbjct: 10 EIGIVGYGAYVPMYRIRNEEIGRVWGV--SNFPI----EEKAVPGLDEDAVTIGIEAARN 63
Query: 62 ILTEE--DKKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFARSIEMKEACYATTAGLT 119
L D + I I G+ES K SA ++ + +G P + + + AC A T L
Sbjct: 64 ALKRAKIDPREIRAIWFGSESKPYAVKPSATIIAEAIGATPDLEAADFEFACKAGTEALQ 123
Query: 120 LARDHVLLNPDTKVLVIASDIAKYGLNTGGEPTQGAGSVAMLI-TADPKILALNNDNVAL 178
A V + I +D A+ E T GAG A ++ + LA + +
Sbjct: 124 AAIGFVASGMAKYAMAIGADTAQGRPADHLEFTAGAGGAAFIVGEKSSETLAYFEGSYSY 183
Query: 179 TQDIYDFWRPFGQAYPSVDGKFSNE-TYIDAFAKIWKEYSHRTNLKFEDFAAIAFHTPYT 237
D DFWR + YP +F+ E Y K L DF FH P
Sbjct: 184 VTDTPDFWRRQHEHYPRHGNRFTGEPAYFHHVITAAKTLMDELGLTPADFDYAVFHQPNV 243
Query: 238 KMGKKALLPMLESEKPANAEELM----EQFEHGIVYNRRVGNLYTGSLYLSLISLLENSD 293
K P A +++ E+ G++ ++GN Y+G+ + + ++L D
Sbjct: 244 KF-------------PLTAAKILGIPKEKVLPGLL-TGKIGNTYSGATMVGISAVL---D 286
Query: 294 KLSAGQRIGLFSYGSGTVAEFFS 316
G RI S+GSG ++ FS
Sbjct: 287 IAKPGDRILWVSFGSGAGSDAFS 309
gb|AAF20927.1|AF207529_1 (AF207529) PhlA [Pseudomonas fluorescens]
Length = 362
Score = 67.9 bits (163), Expect = 1e-10
Identities = 85/340 (25%), Positives = 147/340 (43%), Gaps = 34/340 (10%)
Query: 2 KVGIDKLGFFVPNTFVDMRDLANA-RNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAA 60
K+GI G +P + ++++ N +N D + +G E AV +D+IT AA
Sbjct: 5 KIGIVSYGAGIPVCRLKVQEVINVWKNTDLKLVEENLGVTERAVLQPDEDVITLGVLAAQ 64
Query: 61 SILTEEDKKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFARSIEMKEACYATTAGLTL 120
L + I+ + +GT ++ +S+ASA ++ ++LG A +++ A + T+ L +
Sbjct: 65 RALDKVPGHQIEALYLGTCTNPYDSRASASIILEMLGSGYDAYCADVQFAGKSGTSALQI 124
Query: 121 ARDHVLLNPDTKVLVIASDIAKYGLNTGG--EPTQGAGSVAMLITADPKILALNNDNVAL 178
+ V L I +D G E GAG+ A+LI ++A + + +
Sbjct: 125 CQALVASGMTGSALAIGADTINRNTAPGDLTESYAGAGAAALLI-GSQDVIAEFDASFSC 183
Query: 179 TQDIYDFWRPFGQAY-PSVDGKFSNETYI---DAFAKIWKEYSHRTNLKFEDFAAIAFH- 233
D+ D RP G Y S G S++ I D + + + + D+ + F
Sbjct: 184 AADVADNIRPQGDRYIRSGMGLGSDKNSIGLEDQTRRAAEGLMAKLHTSPADYDYVVFQQ 243
Query: 234 ----TPYTKMGKKALLPMLESEKPANAEELMEQFEHGIVYNRRVGNLYTGSLYLSLISLL 289
TPY+ P +Q E GI Y VG+ + S L LI++L
Sbjct: 244 NLVSTPYSLAKHLGFNP--------------KQVEPGI-YAGNVGDAGSASPLLGLINVL 288
Query: 290 ENSDKLSAGQRIGLFSYGSGTVAEFFS---GELVEGYENH 326
D+ GQ+I L SYG G ++ + + +E Y+ H
Sbjct: 289 ---DQARPGQKILLVSYGFGAGSDAIALTVTDAIEQYQKH 325
gb|AAB48109.1| (U41818) PhlA [Pseudomonas fluorescens]
Length = 360
Score = 66.3 bits (159), Expect = 4e-10
Identities = 85/335 (25%), Positives = 147/335 (43%), Gaps = 31/335 (9%)
Query: 2 KVGIDKLGFFVPNTFVDMRDLANA-RNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAA 60
KVGI G +P + + D+ + +N D + +G E AV +D+IT + AA
Sbjct: 3 KVGIVSYGAGIPVCRLKVEDVIHVWKNTDLSLVTNQLGVVERAVLQPDEDVITLSVLAAQ 62
Query: 61 SILTEEDKKAIDMIIVGTESSLDESKASAVVVHDLLGIQPFARSIEMKEACYATTAGLTL 120
L + ++ + +GT ++ +S+ASA V+ ++LG A +++ A + T+ L +
Sbjct: 63 RALDKAPSCDLEALYLGTCTNPYDSRASAAVILEMLGCGYDAFCADVQFAGKSGTSALQI 122
Query: 121 ARDHVLLNPDTKVLVIASDIAKYGLNTGG--EPTQGAGSVAMLITADPKILALNNDNVAL 178
A V L I +D G E GAG+ A+L+ + ++A + + +
Sbjct: 123 AYALVASGMAGNALAIGADTINRNTAPGDLTESYAGAGAAALLLGTE-NVIAHFDASFSC 181
Query: 179 TQDIYDFWRPFGQAY-PSVDGKFSNETYI---DAFAKIWKEYSHRTNLKFEDFAAIAFH- 233
D+ D RP G Y S G S++ I D + + N++ DF + F
Sbjct: 182 AADVADNIRPQGDRYIRSGMGLGSDKNSIGLEDQTHRAASGLMAKMNVQASDFDYVVFQQ 241
Query: 234 ----TPYTKMGKKALLPMLESEKPANAEELMEQFEHGIVYNRRVGNLYTGSLYLSLISLL 289
TP++ +GK Q E GI Y + VG+ S L L+S+L
Sbjct: 242 NLVSTPFS-LGK-------------GLGFTKAQIEPGI-YAQSVGDAGAASPLLGLVSVL 286
Query: 290 ENSDKLSAGQRIGLFSYGSGTVAEFFSGELVEGYE 324
D+ G++I L SYG G ++ + + + E
Sbjct: 287 ---DRARPGEKILLVSYGFGAGSDAIALTVTDAIE 318
gi|555837 (U12791) HMG CoA synthase [Mus musculus]
Length = 139
Score = 59.3 bits (141), Expect = 5e-08
Identities = 41/107 (38%), Positives = 56/107 (52%), Gaps = 12/107 (11%)
Query: 274 GNLYTGSLYLSLISLLEN-SDKLSAGQRIGLFSYGSGTVAEFFS---------GELVEGY 323
GN+YT SLY L SLL + S + AG RIG FSYGSG A FFS G +E
Sbjct: 10 GNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSKDASPGSPLEKL 69
Query: 324 ENHLLKIEHQSMLDARTRLSIPEYENMFNQYLDLNHNISFNDETDYS 370
+ + + + LD+R R+S E+ + NQ H ++F+ D S
Sbjct: 70 VSSVSDLPKR--LDSRRRMSPEEFTEIMNQREQFYHKVNFSPPGDTS 114
sp|P54872|HMCS_DICDI HYDROXYMETHYLGLUTARYL-COA SYNTHASE (HMG-COA SYNTHASE)
(3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
>gi|1209283 (L24114) hydroxymethylglutaryl-CoA synthase
[Dictyostelium discoideum]
Length = 163
Score = 50.4 bits (118), Expect = 3e-05
Identities = 36/95 (37%), Positives = 54/95 (55%), Gaps = 9/95 (9%)
Query: 271 RRVGNLYTGSLYLSLISLLENSDKLSAGQRIGLFSYGSGTVAEFFSGELVEGYENHLL-K 329
+++GN Y GS Y L+SLL+ G+R+ FSYGSG A FS + VE NH++ K
Sbjct: 18 KQLGNTYCGSTYSGLLSLLDEKSNDLVGKRVLTFSYGSGLAASAFSFK-VEKPINHIVEK 76
Query: 330 IEHQSMLDARTRLSIPEYENMFNQYLDL---NHNI 361
++ ++ L R R+ PE +F + L L HN+
Sbjct: 77 VDLKNRLAKRVRVE-PE---IFTEKLSLRETRHNL 107
sp|O85139|FABH_SALTY 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III (BETA-KETOACYL-ACP
SYNTHASE III) (KAS III) >gi|3282802 (AF044668)
3-oxoacyl-acyl carrier protein synthase III [Salmonella
typhimurium]
Length = 317
Score = 48.0 bits (112), Expect = 1e-04
Identities = 66/284 (23%), Positives = 117/284 (40%), Gaps = 24/284 (8%)
Query: 36 GIGQDEMAVNPATQDIITFAANAAASILTEEDKKAIDMIIVGTESSLDESKASAVVVHDL 95
GI + +A T + F A A + DK I +I+V T S+ ++A + +
Sbjct: 38 GIRKRHIAAPNETVATMGFTAANRAIEMAGIDKDQIGLIVVATTSATHAFPSAACQIQSM 97
Query: 96 LGIQPFARSIEMKEACYATTAGLTLARDHVLLNPDTKVLVIASDIAKYGLNTGGEPT--- 152
LGI+ + ++ AC T L++A +V LV+ SD+ + G T
Sbjct: 98 LGIKG-CPAFDVAAACAGFTYALSIADQYVKSGAVKHALVVGSDVLARTCDPGDRGTIII 156
Query: 153 --QGAGSVAMLITADPKILA--LNND---NVALTQDIYDFWRPFGQAYPSVDGKFSNETY 205
GAG+ + + +P I++ L+ D LT D P Y ++ G +
Sbjct: 157 FGDGAGAAVLSASEEPGIISTHLHADGRYGELLTLPNADRVNPDNPIYLTMAGNEVFKVA 216
Query: 206 IDAFAKIWKEYSHRTNLKFEDFAAIAFHTPYTKMGKKALLPMLESEKPANAEELMEQFEH 265
+ A I E NL + + H +A L ++ A A++L ++
Sbjct: 217 VTELAHIVDETLAANNLDRSELDWLVPH--------QANLRIIS----ATAKKLGMSMDN 264
Query: 266 GIVYNRRVGNLYTGSLYLSLISLLENSDKLSAGQRIGLFSYGSG 309
+V R GN S+ +L + + ++ AGQ + L ++G G
Sbjct: 265 VVVTLDRHGNTSAASVPCALDEAVRDG-RIKAGQLVLLEAFGGG 307
gi|1235848 (U12788) HMG CoA synthase [Homo sapiens]
Length = 126
Score = 48.0 bits (112), Expect = 1e-04
Identities = 28/95 (29%), Positives = 47/95 (49%), Gaps = 2/95 (2%)
Query: 3 VGIDKLGFFVPNTFVDMRDLANARNVDPAKFQIGIGQDEMAVNPATQDIITFAANAAASI 62
VGI L + P +VD DL NV+ K+ +G+GQ M +DI + +
Sbjct: 19 VGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRL 78
Query: 63 L--TEEDKKAIDMIIVGTESSLDESKASAVVVHDL 95
+ + ++ + VGTE+ +D+SKA V+ +L
Sbjct: 79 MERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMEL 113
Posted date: Mar 2, 2000 12:24 PM
Number of letters in database: 140,871,481
Number of sequences in database: 457,798
Lambda K H
0.317 0.134 0.379
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 102435333
Number of Sequences: 457798
Number of extensions: 4227426
Number of successful extensions: 10944
Number of sequences better than 1.0e-02: 42
Number of HSP's better than 0.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 10759
Number of HSP's gapped (non-prelim): 60
length of query: 384
length of database: 140,871,481
effective HSP length: 58
effective length of query: 326
effective length of database: 114,319,197
effective search space: 37268058222
effective search space used: 37268058222
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 96 (41.8 bits)